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INS;s disease computed by continuous wavelet coherence
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Abstracts / Journal of the Neurological Sciences 333 (2013) e292–e357
Abstract — WCN 2013 No: 2518 Topic: 5 — Dementia Rapidly progressive dementia in the “Attikon” University General Hospital of Athens. A one-year experience C. Liantinioti, C. Giavasi, G. Papadimitropoulos, I. Myta, C. Arvaniti, A. Bonakis, G. Tsivgoulis, C. Voumvourakis, L. Stefanis, S.G. Papageorgiou. Neurology, National Capodestrian University of Athens, o, Greece Introduction: Rapidly progressive dementia (RPD) is a rare neurological condition which progresses subacutely from days to months. A variety of possible causes of RPD have been reported, such as neurodegenerative, autoimmune, vascular, metabolic/toxic disorders, infections, malignancies, normal pressure hydrocephalus and psychiatric disorders. Objectives: To describe the causes and the clinical presentation of RPD in the University General Hospital of Athens “Attikon” within a year. Methods: From a total of 728 patients hospitalized in our department from January 2012 to February 2013, 21 patients presented with RPD. A detailed clinical and laboratory investigation was performed in all cases. Results: The most common cause of RPD reported in our department was probable sporadic CJD (6 cases). Two patients were diagnosed with normal pressure hydrocephalus (NPH) and four patients developed RPD due to vascular etiology (2 patients with probable CADASIL, 1 patient with probable cerebral amyloid angiopathy and 1 patient with vascular dementia). The rest of the cases had various neurodegenerative disorders: probable AD (1 patient), DLB (1 patient), PSP (2 patients) and frontotemporal dementia (1 patient). One patient developed hydrocephalus and cognitive decline on the basis of Mycobacterium tuberculosis infection and 1 patient developed dementia probably due to chronic abuse of benzodiazepines. Conclusion: RPD cases are not rare in a university general hospital. Besides CJD, neurodegenerative and secondary causes of RPD are frequent requiring a thorough investigation. doi:10.1016/j.jns.2013.07.1292
Abstract — WCN 2013 No: 3010 Topic: 5 — Dementia EEG microstates in Alzheimer's disease computed by continuous wavelet coherence J. Kopala, O. Vyšataa,b, A. Procházkaa, M. Schätza. aInstitute of Chemical Technology, Prague, Czech Republic; bDepartment of Neurology, Charles University Prague, Faculty Hospital, Hradec Králove, Czech Republic Background: Electrophysiological studies have demonstrated that the brain is active even in the absence of explicit input or output. Microstates represent subsequent coherent activation within the global functional brain networks. Continuous wavelet coherence is a measure of timefrequency changes in linear dependencies between EEG channels. Objective: Areas of EEG microstates were evaluated in patients with Alzheimer's disease (AD). Differences in areas pertinent to each pair of electrodes and for frequency bands between patients with AD and healthy controls were calculated. Patients and methods: EEG data were obtained for 110 patients with moderate dementia (MMSE score 10–19) and a control set of 110 agematched, healthy subjects who had no memory or other cognitive impairment. Continuous wavelet coherence maps were computed for EEG records using the Matlab computational environment. The values higher than the threshold were considered as microstates corresponding to the coherent activation within the global functional brain networks. Areas of time-frequency plots for the delta, theta, alpha, beta and gamma bands were compared for both groups.
Results: Statistically significant differences were observed, particularly in the alpha, beta and gamma frequency bands of the frontal and temporal regions. The accuracy of distinction between healthy individuals and AD patients for the Fp2-T5, F8-T5, F7-O2, Fp2-O2 pairs of electrodes in the alpha band was more than 0.8. Conclusion: These results can be interpreted as a decrease in the value of the parameter reflecting the ability of the system selforganization and thus suboptimal information processing clinically manifested as cognitive deficit. doi:10.1016/j.jns.2013.07.1293
Abstract — WCN 2013 No: 2898 Topic: 5 — Dementia Reproducibility of [18f]flutemetamol pet amyloid image interpretation Z. Walkera, F. Inglisb, C. Sadowskyc, B. Safirsteind, G. Farrare, C. Buckleye, L. Thurfjellf, P. Sherwing, K. Cardinale, S. De Santig, R. Vandenbergheh. a University College London, London; bGlasgow Memory Clinic Ltd, Glasgow, UK; cNova Southeastern University, Fort Lauderdale; dBeth Safirstein, Hallendale, FL, USA; eGE Healthcare, Amersham, UK; fGE Healthcare, Uppsala, Sweden; gGE Healthcare, Princeton, NJ, USA; hCatholic University, Leuven, Belgium Objective: The reproducibility of [18F]flutemetamol PET amyloid image interpretation measured by inter-reader agreement (IRA) and intra-reader reproducibility (IRR), and quantitative test–retest variability was assessed, using GE's clinical trials data. Methods: Blinded visual interpretations of color PET images from one Phase II study (Study 1) and two Phase III studies (Studies 2 and 3) were analyzed. In each study, five readers were trained to read [18F] flutemetamol scans via in-person training (Studies 1 and 2) or an electronic training program (Study 3). Readers then interpreted scans from healthy volunteers (HV), patients with Alzheimer's disease (AD), and amnestic mild cognitive impairment (aMCI) subjects as normal or abnormal for [18F]flutemetamol uptake. Included in each image set (to assess IRR) were randomly selected and inserted duplicates of ~10% of the images. In Study 1 only, intra-subject test-retest variability was calculated for five AD subjects who underwent two [18F]flutemetamol scans as the percentage difference between regional SUVR for a set of cortical regions. Results: Study 1: Across all groups, Fleiss' kappa for IRA (n = 67: 22 AD, 20 aMCI, and 25 HV) was 0.96 and IRR was 97.5%. Test–retest variability of regional SUVRs was 1% to 4%. Study 2: Fleiss' kappa for IRA (232 aMCI patients) was 0.76 and IRR ranged from 86% to 100%. Study 3: Fleiss' Kappa for IRA (80 aMCI patients) was 0.89, and IRR was 100%. Conclusions: Across the three studies, blinded visual interpretations of [18F]flutemetamol PET amyloid images had high IRA and IRR. Regional SUVR determinations had low test-retest variability. doi:10.1016/j.jns.2013.07.1294
Abstract — WCN 2013 No: 2940 Topic: 5 — Dementia Rationale, design and preliminary baseline data of the ADEX study: The effect of physical exercise in Alzheimer's disease K. Hoffmanna, K.S. Frederiksena, N.A. Sobolb, N. Beyerb, A. Vogela, A.H. Simonsena, P. Johannsena, A. Lolkc, O. Terkelsend, C.W. Cotmane,
Abstracts / Journal of the Neurological Sciences 333 (2013) e292–e357
Abstract — WCN 2013 No: 2518 Topic: 5 — Dementia Rapidly progressive dementia in the “Attikon” University General Hospital of Athens. A one-year experience C. Liantinioti, C. Giavasi, G. Papadimitropoulos, I. Myta, C. Arvaniti, A. Bonakis, G. Tsivgoulis, C. Voumvourakis, L. Stefanis, S.G. Papageorgiou. Neurology, National Capodestrian University of Athens, o, Greece Introduction: Rapidly progressive dementia (RPD) is a rare neurological condition which progresses subacutely from days to months. A variety of possible causes of RPD have been reported, such as neurodegenerative, autoimmune, vascular, metabolic/toxic disorders, infections, malignancies, normal pressure hydrocephalus and psychiatric disorders. Objectives: To describe the causes and the clinical presentation of RPD in the University General Hospital of Athens “Attikon” within a year. Methods: From a total of 728 patients hospitalized in our department from January 2012 to February 2013, 21 patients presented with RPD. A detailed clinical and laboratory investigation was performed in all cases. Results: The most common cause of RPD reported in our department was probable sporadic CJD (6 cases). Two patients were diagnosed with normal pressure hydrocephalus (NPH) and four patients developed RPD due to vascular etiology (2 patients with probable CADASIL, 1 patient with probable cerebral amyloid angiopathy and 1 patient with vascular dementia). The rest of the cases had various neurodegenerative disorders: probable AD (1 patient), DLB (1 patient), PSP (2 patients) and frontotemporal dementia (1 patient). One patient developed hydrocephalus and cognitive decline on the basis of Mycobacterium tuberculosis infection and 1 patient developed dementia probably due to chronic abuse of benzodiazepines. Conclusion: RPD cases are not rare in a university general hospital. Besides CJD, neurodegenerative and secondary causes of RPD are frequent requiring a thorough investigation. doi:10.1016/j.jns.2013.07.1292
Abstract — WCN 2013 No: 3010 Topic: 5 — Dementia EEG microstates in Alzheimer's disease computed by continuous wavelet coherence J. Kopala, O. Vyšataa,b, A. Procházkaa, M. Schätza. aInstitute of Chemical Technology, Prague, Czech Republic; bDepartment of Neurology, Charles University Prague, Faculty Hospital, Hradec Králove, Czech Republic Background: Electrophysiological studies have demonstrated that the brain is active even in the absence of explicit input or output. Microstates represent subsequent coherent activation within the global functional brain networks. Continuous wavelet coherence is a measure of timefrequency changes in linear dependencies between EEG channels. Objective: Areas of EEG microstates were evaluated in patients with Alzheimer's disease (AD). Differences in areas pertinent to each pair of electrodes and for frequency bands between patients with AD and healthy controls were calculated. Patients and methods: EEG data were obtained for 110 patients with moderate dementia (MMSE score 10–19) and a control set of 110 agematched, healthy subjects who had no memory or other cognitive impairment. Continuous wavelet coherence maps were computed for EEG records using the Matlab computational environment. The values higher than the threshold were considered as microstates corresponding to the coherent activation within the global functional brain networks. Areas of time-frequency plots for the delta, theta, alpha, beta and gamma bands were compared for both groups.
Results: Statistically significant differences were observed, particularly in the alpha, beta and gamma frequency bands of the frontal and temporal regions. The accuracy of distinction between healthy individuals and AD patients for the Fp2-T5, F8-T5, F7-O2, Fp2-O2 pairs of electrodes in the alpha band was more than 0.8. Conclusion: These results can be interpreted as a decrease in the value of the parameter reflecting the ability of the system selforganization and thus suboptimal information processing clinically manifested as cognitive deficit. doi:10.1016/j.jns.2013.07.1293
Abstract — WCN 2013 No: 2898 Topic: 5 — Dementia Reproducibility of [18f]flutemetamol pet amyloid image interpretation Z. Walkera, F. Inglisb, C. Sadowskyc, B. Safirsteind, G. Farrare, C. Buckleye, L. Thurfjellf, P. Sherwing, K. Cardinale, S. De Santig, R. Vandenbergheh. a University College London, London; bGlasgow Memory Clinic Ltd, Glasgow, UK; cNova Southeastern University, Fort Lauderdale; dBeth Safirstein, Hallendale, FL, USA; eGE Healthcare, Amersham, UK; fGE Healthcare, Uppsala, Sweden; gGE Healthcare, Princeton, NJ, USA; hCatholic University, Leuven, Belgium Objective: The reproducibility of [18F]flutemetamol PET amyloid image interpretation measured by inter-reader agreement (IRA) and intra-reader reproducibility (IRR), and quantitative test–retest variability was assessed, using GE's clinical trials data. Methods: Blinded visual interpretations of color PET images from one Phase II study (Study 1) and two Phase III studies (Studies 2 and 3) were analyzed. In each study, five readers were trained to read [18F] flutemetamol scans via in-person training (Studies 1 and 2) or an electronic training program (Study 3). Readers then interpreted scans from healthy volunteers (HV), patients with Alzheimer's disease (AD), and amnestic mild cognitive impairment (aMCI) subjects as normal or abnormal for [18F]flutemetamol uptake. Included in each image set (to assess IRR) were randomly selected and inserted duplicates of ~10% of the images. In Study 1 only, intra-subject test-retest variability was calculated for five AD subjects who underwent two [18F]flutemetamol scans as the percentage difference between regional SUVR for a set of cortical regions. Results: Study 1: Across all groups, Fleiss' kappa for IRA (n = 67: 22 AD, 20 aMCI, and 25 HV) was 0.96 and IRR was 97.5%. Test–retest variability of regional SUVRs was 1% to 4%. Study 2: Fleiss' kappa for IRA (232 aMCI patients) was 0.76 and IRR ranged from 86% to 100%. Study 3: Fleiss' Kappa for IRA (80 aMCI patients) was 0.89, and IRR was 100%. Conclusions: Across the three studies, blinded visual interpretations of [18F]flutemetamol PET amyloid images had high IRA and IRR. Regional SUVR determinations had low test-retest variability. doi:10.1016/j.jns.2013.07.1294
Abstract — WCN 2013 No: 2940 Topic: 5 — Dementia Rationale, design and preliminary baseline data of the ADEX study: The effect of physical exercise in Alzheimer's disease K. Hoffmanna, K.S. Frederiksena, N.A. Sobolb, N. Beyerb, A. Vogela, A.H. Simonsena, P. Johannsena, A. Lolkc, O. Terkelsend, C.W. Cotmane,