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Effect of a novel strontium containing titanium oxide coating on osseointegration: an in vivo study
21st ICOMS 2013—Abstracts: Oral Papers vestibuloplasty. The membrane was found to be easy to handle as an oral-dressing material. It adhered well to the bare connective and muscular tissues. No remarkable adverse effects were observed in the process of wound healing. Conclusions: The results suggested that hyperdry AM is biologically acceptable to oral wounds and could be a suitable clinical alternative for the repair of the oral mucosa. http://dx.doi.org/10.1016/j.ijom.2013.07.054 T2.OR011 Effect of a novel strontium containing titanium oxide coating on osseointegration: an in vivo study V. Offermanns 1,∗ , O. Andersen 2 , G. Falkensammer 1 , M. Rasse 1 , I. Andersen 3 , S. Sørensen 3 , C.Sloth Jeppesen 2 , M. Sillassen 2 , M. Foss 2 , F. Kloss 1 1 Department for Cranio-Maxillofacial and Oral Surgery, Medical University Innsbruck, Austria 2 Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus, Denmark 3 Tribology Center, Danish Technological Institute, Aarhus, Denmark
In this study we took advantage of known impact of strontium (Sr) on bone metabolism and evaluated the effect of sustained supply of Sr on local bone healing. Four distinct surface modifications prepared by a magnetron co-sputtering process with different Sr-release profiles were investigated in a rat model. Four weeks after surgery bone blocks with implants (1.1 mm diameter, 5 mm length), which were inserted bicortically in the femoral shaft, were harvested and subsequently evaluated via histomorphology. Eight implants of each group were analyzed. 8–9% Sr containing surfaces showed statistically significant increase in new bone formation in comparison to the 5.5% Sr containing groups and the reference. In detail data was 14.4% for pure titanium, 22.6% for SrTi 5.5% 1500 nm with 60 min washout, 40.4% for SrTi 5.5% 1500 nm, 47.4% for SrTi 8–9% 1500 nm with 60 min washout and 62.1% for SrTi 8–9% 1500 nm with 20 min washout. No inflammation was found in any of the animals. The development of a new bioactive surface with local supply of strontium is a promising approach for enhancement of bone healing and thereby accelerating osseointegration. http://dx.doi.org/10.1016/j.ijom.2013.07.055 T2.OR012 Management of severe zygomatico orbital deficiencies using three dimensionally contoured calverial bone graft H. Shaheen ∗ , E. Helmy Esha Integrated Dentofacial Center, Egypt Introduction: Reconstruction of zygomatic-orbital complex remains as one of the challenging problems in the field of maxillofacial reconstruction regarding severe deficiencies as in syndromic Caesars, post traumatic deformities and deficiencies due to pathological conditions. The unique three dimensional anatomy of zygomatico-orbital complex lends it very difficult to get satisfactory results especially in severe deficiencies. The purpose of the current study is to provide and evaluate a simple technique for reconstruction using three dimensionally contoured calverial.
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Materials and methods: Ten patients were included in the study, age range from 6 years to 40 years (three patients with Treacher’ Collin’s Syndrome, two patients with Goldenhar Syndrome, three patient post traumatic and two patients where the deficiencies were due to pathological conditions). Exposure for reconstruction provided by coronal incision without need for peri orbital incisions, the zygomatico-orbital complex was reconstructed using full thickness calverial bone grafts that have been recontoured three dimensionally and then inset and stabilized using plates and screws. Any remaining orbital defects were reconstructed. Lateral canthopexies were completed and secured to new orbital rim if needed. Results: CT scans done before and immediately after surgeries as well clinical pictures revealed zygomatico-orbital morphological improvement that was achieved in all patients with follow up period ranging from 6 to 24 months at the close of the study. Conclusions: We believe the reconstruction of zygomaticoorbital complex using three dimensionally contoured calverial bone graft provides simple but reliable method for management of severe deficiencies. http://dx.doi.org/10.1016/j.ijom.2013.07.056 T2.OR013 Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells S. Srouji Department of Oral and Maxillofacial Surgery, Carmel Medical Center, Haifa, Israel Department of Anatomy and Cell Biology, Faculty of Medicine, Technion-I.I.T, Haifa, Israel Background and objectives: Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical use. Materials and methods: Materials tested were Bio-Oss, Bi-Ostetic, OraGraft, and ProOsteon. These simple and composite bone substitutes were embedded with osteoprogenitor cells derived from either the human maxillary sinus schneiderian membrane (hMSSM) or from maxillary tuberosity bone marrow (MTB) and then monitored both in vitro and in vivo. Results: Cell adherence and proliferation was most pronounced in OraGraft, followed by ProOsteon. In vivo bone formation, within the bone graft, was also observed, with most marked results in OraGraft and ProOsteon grafts. Conclusions: The proposed osteoconductivity testing method proved simple, informative and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation. Key words: biomaterials; bone; osteoprogenitors; screening; sinus augmentation http://dx.doi.org/10.1016/j.ijom.2013.07.057
In this study we took advantage of known impact of strontium (Sr) on bone metabolism and evaluated the effect of sustained supply of Sr on local bone healing. Four distinct surface modifications prepared by a magnetron co-sputtering process with different Sr-release profiles were investigated in a rat model. Four weeks after surgery bone blocks with implants (1.1 mm diameter, 5 mm length), which were inserted bicortically in the femoral shaft, were harvested and subsequently evaluated via histomorphology. Eight implants of each group were analyzed. 8–9% Sr containing surfaces showed statistically significant increase in new bone formation in comparison to the 5.5% Sr containing groups and the reference. In detail data was 14.4% for pure titanium, 22.6% for SrTi 5.5% 1500 nm with 60 min washout, 40.4% for SrTi 5.5% 1500 nm, 47.4% for SrTi 8–9% 1500 nm with 60 min washout and 62.1% for SrTi 8–9% 1500 nm with 20 min washout. No inflammation was found in any of the animals. The development of a new bioactive surface with local supply of strontium is a promising approach for enhancement of bone healing and thereby accelerating osseointegration. http://dx.doi.org/10.1016/j.ijom.2013.07.055 T2.OR012 Management of severe zygomatico orbital deficiencies using three dimensionally contoured calverial bone graft H. Shaheen ∗ , E. Helmy Esha Integrated Dentofacial Center, Egypt Introduction: Reconstruction of zygomatic-orbital complex remains as one of the challenging problems in the field of maxillofacial reconstruction regarding severe deficiencies as in syndromic Caesars, post traumatic deformities and deficiencies due to pathological conditions. The unique three dimensional anatomy of zygomatico-orbital complex lends it very difficult to get satisfactory results especially in severe deficiencies. The purpose of the current study is to provide and evaluate a simple technique for reconstruction using three dimensionally contoured calverial.
1183
Materials and methods: Ten patients were included in the study, age range from 6 years to 40 years (three patients with Treacher’ Collin’s Syndrome, two patients with Goldenhar Syndrome, three patient post traumatic and two patients where the deficiencies were due to pathological conditions). Exposure for reconstruction provided by coronal incision without need for peri orbital incisions, the zygomatico-orbital complex was reconstructed using full thickness calverial bone grafts that have been recontoured three dimensionally and then inset and stabilized using plates and screws. Any remaining orbital defects were reconstructed. Lateral canthopexies were completed and secured to new orbital rim if needed. Results: CT scans done before and immediately after surgeries as well clinical pictures revealed zygomatico-orbital morphological improvement that was achieved in all patients with follow up period ranging from 6 to 24 months at the close of the study. Conclusions: We believe the reconstruction of zygomaticoorbital complex using three dimensionally contoured calverial bone graft provides simple but reliable method for management of severe deficiencies. http://dx.doi.org/10.1016/j.ijom.2013.07.056 T2.OR013 Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells S. Srouji Department of Oral and Maxillofacial Surgery, Carmel Medical Center, Haifa, Israel Department of Anatomy and Cell Biology, Faculty of Medicine, Technion-I.I.T, Haifa, Israel Background and objectives: Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical use. Materials and methods: Materials tested were Bio-Oss, Bi-Ostetic, OraGraft, and ProOsteon. These simple and composite bone substitutes were embedded with osteoprogenitor cells derived from either the human maxillary sinus schneiderian membrane (hMSSM) or from maxillary tuberosity bone marrow (MTB) and then monitored both in vitro and in vivo. Results: Cell adherence and proliferation was most pronounced in OraGraft, followed by ProOsteon. In vivo bone formation, within the bone graft, was also observed, with most marked results in OraGraft and ProOsteon grafts. Conclusions: The proposed osteoconductivity testing method proved simple, informative and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation. Key words: biomaterials; bone; osteoprogenitors; screening; sinus augmentation http://dx.doi.org/10.1016/j.ijom.2013.07.057