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Effect of aging on coronary vascular reserve and energy metabolism
J Mol Cell Cardid
22 (Supplement
II) (1990)
52ANTURRHYTHMICEFFFLTOFEDIHW,A ITS BIOJ?LEClWC MECHANISM. EZ
SYNTHEXC ANALBGUB OF ACEI’YLCHOLINE AND Meerson, N.A Abdikaliev, LYa. Kalvinsh. Institute of General Pathology and Pathological Physiology of the USSR AMS, Moscow, Kazakh Scientific Research Institute of Institute of Organic Synthesis of the Cardiology of the KazssR Ministry of Public Health, Alma-Ata; Latvian SSR Academy of Sciences, Riga. Ethyl-3-(2,2dy ethyl-2ethylhydrasinium) propionate iodate (EDIHYP) has two orders less affinity for muscari& receptors than acetylcholine and induced no bradycardia in vivo. At the same time EDIHYP exerts a strong antiarrhythmic effect in ischemic and reperfusion arrhythmias, abolishes cardiac arrhythmias and fibrillation induced by toxic doses of catecholamines, calcium chloride or strophantine and is uneffective in aconitine-induced arrhythmias. It eliminates the fall of the ventricular fibrillation threshold and the ectopic activity which develop on the background of vagal bradycardia in experimental myocardial infarction and postinfarction cardiosclesrosis. When studying the bioelectric activity of cardiomyocytes in isolated contracting rat heart it was established that EDIHYP (10.’ M) induced three antiarrhythmogenic shifts in total ischemia and subsequent reperfusion: it limited the fall of resting potential, the decrease in action potential amplitude and the decrease in action potential duration. ln the same experiments EDIHYP reduced sixfold the total duration of ventricular tachycardia and in all cases prevented ventricular fibrillation which were observed without drug in 50% of hearts. Thus the question is a new antiarrhythmic drug with a broad spectrum of action.
~LARIZATI~IBDlKEDTBI@XIREDACTIVITX 53 DELAYED R. %ao,J.Ma. of Chi.na.
Departalantof
Phjslologg,
Sbuxl
Medial
AND CARMACLCA. College,Taiyuan,
P. R.
54EFFECT OF AGING ON CORONARY VASCULAR RESERVE AND ENERGY METABOLISM. M. Ishiki, T. Okumura, F. Tanaka, T. Takayama, M. Ejima, E. lJeaaka*, S. Mochisuki and M. Nagano Dpt. of Medicine, Aoto Hospital, Jikei University School of Medicine and *Otsuka Pharmaceutical Factory Coronary circulation is increased in response to mechanical activity to meet the metabolic needs of the heart. Present study was designed to investigate the regulation of coronary vascular reserve and energy metabolism amon different age groups of rat. Hearts from SD rata (8W, 7: ;nd 12M old Langendorff technique with aerobic e anoxic WereadPtfifauasTndebirdd)or dipyridamole (Di)added f An), conditions. Coronary flow was increased to 135% of the basal value in all groups of heart under An condition. Under Ad-added condition, however coronary flow in the aged group was significantly increased whereas there was no significant difference in the rest of conditions between young and aged group. Tissue ATP content in the young group was significantly lower in An, Ad- and Di-added conditions than in Ae condition, whereas AMP and ADP were increased in the young group when compared with Ae condition. In the aged group, on the contrary, tissue ATP was not significantly influenced by the addition of Ad or Di. These data indicated the regulation of energy metabolism regarding coronary vascular reserve seemed to be different with aging. s.45
22 (Supplement
II) (1990)
52ANTURRHYTHMICEFFFLTOFEDIHW,A ITS BIOJ?LEClWC MECHANISM. EZ
SYNTHEXC ANALBGUB OF ACEI’YLCHOLINE AND Meerson, N.A Abdikaliev, LYa. Kalvinsh. Institute of General Pathology and Pathological Physiology of the USSR AMS, Moscow, Kazakh Scientific Research Institute of Institute of Organic Synthesis of the Cardiology of the KazssR Ministry of Public Health, Alma-Ata; Latvian SSR Academy of Sciences, Riga. Ethyl-3-(2,2dy ethyl-2ethylhydrasinium) propionate iodate (EDIHYP) has two orders less affinity for muscari& receptors than acetylcholine and induced no bradycardia in vivo. At the same time EDIHYP exerts a strong antiarrhythmic effect in ischemic and reperfusion arrhythmias, abolishes cardiac arrhythmias and fibrillation induced by toxic doses of catecholamines, calcium chloride or strophantine and is uneffective in aconitine-induced arrhythmias. It eliminates the fall of the ventricular fibrillation threshold and the ectopic activity which develop on the background of vagal bradycardia in experimental myocardial infarction and postinfarction cardiosclesrosis. When studying the bioelectric activity of cardiomyocytes in isolated contracting rat heart it was established that EDIHYP (10.’ M) induced three antiarrhythmogenic shifts in total ischemia and subsequent reperfusion: it limited the fall of resting potential, the decrease in action potential amplitude and the decrease in action potential duration. ln the same experiments EDIHYP reduced sixfold the total duration of ventricular tachycardia and in all cases prevented ventricular fibrillation which were observed without drug in 50% of hearts. Thus the question is a new antiarrhythmic drug with a broad spectrum of action.
~LARIZATI~IBDlKEDTBI@XIREDACTIVITX 53 DELAYED R. %ao,J.Ma. of Chi.na.
Departalantof
Phjslologg,
Sbuxl
Medial
AND CARMACLCA. College,Taiyuan,
P. R.
54EFFECT OF AGING ON CORONARY VASCULAR RESERVE AND ENERGY METABOLISM. M. Ishiki, T. Okumura, F. Tanaka, T. Takayama, M. Ejima, E. lJeaaka*, S. Mochisuki and M. Nagano Dpt. of Medicine, Aoto Hospital, Jikei University School of Medicine and *Otsuka Pharmaceutical Factory Coronary circulation is increased in response to mechanical activity to meet the metabolic needs of the heart. Present study was designed to investigate the regulation of coronary vascular reserve and energy metabolism amon different age groups of rat. Hearts from SD rata (8W, 7: ;nd 12M old Langendorff technique with aerobic e anoxic WereadPtfifauasTndebirdd)or dipyridamole (Di)added f An), conditions. Coronary flow was increased to 135% of the basal value in all groups of heart under An condition. Under Ad-added condition, however coronary flow in the aged group was significantly increased whereas there was no significant difference in the rest of conditions between young and aged group. Tissue ATP content in the young group was significantly lower in An, Ad- and Di-added conditions than in Ae condition, whereas AMP and ADP were increased in the young group when compared with Ae condition. In the aged group, on the contrary, tissue ATP was not significantly influenced by the addition of Ad or Di. These data indicated the regulation of energy metabolism regarding coronary vascular reserve seemed to be different with aging. s.45