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Effect of angiotensin and mineralocorticoid treatment during pregnancy on natriophilia of offspring in the rat
210
ABSTRACTS
Effects of Reversible Hypoyhslsmud Neuronal
Deficits on Monkey Lateral Amygdala Activity During Operant Feeding Behavior.
M. FUKUDA, T. ONO, K. NAKAMURA and R. TAMURA. Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan.
We used reversible deficits produced by amygdala (AM) cooling to investigate functional influence of the AM on the lateral hypothalamus (LHA) during monkey bar press feeding behavior. The AM cooling produced a slight increase of heart rate and error counting for discrimination. The AM cooling increased or decreased the spontaneous firing rates of some of 55 LHA neurons that were tested, and depressed visual and ingestion responses for food. Results suggest that some visual and ingestion signals related to food might come through the AM to the LHA, and mutual information processings might be important in feeding. Progressively Rising Glycemia High-fat Diet. C. FORNSINN,
and lnsulinemia in Obese Zucker M. KOMJATI and W. WALDHAUSL.
Universitatsklinik, Division of Clinical Endocrinology and Diabetology,
Rats on
Medical Vienna, Austria.
Genetically obese Zucker rats (M) were fed a lard- and sucrose-rich diet. Insulin secretion and glucose tolerance were tested in unrestrained animals by oral and iv. glucose as well as iv. arginine administration every three months. Lean Zucker rats on normal chow diet served as healthy controls (L). During 9 months diet obese rats progressively developed marked postabsorptive hyperglycemia (0: 8.7* 1.1, L: 5.8 f0.2mmol/l) and hyperinsulinemia (0: 288 f62, L: 18 + 3 mu/l). In spite of rising stimulated insulin release their glucose tolerance decreased with aging indicating progressive development of insulin resistance. Effect of Angiotensin Pregnancy on Natriophilia
and Mineralocorticoid Treatment During of Offspring in the Rat. OLIVER GALAVERNAand
STYLIANOS NICOLA’I’DIS. Laboratoire de Neurobiologie des Regulations C. N.R.S. LJA 637, lnstitut de Biologie du College de France, Paris 5, France.
We showed previously that both basal and stimulated salt appetite were higher in offspring from mothers that were dehydrated during their pregnancy. Since it was shown that aldosterone (A) and angiotensin II (AII) act synergistically to arouse salt intake (SI) and they do so in a persistent way, the possibility that the polyethylene glycol (PEG) (20% 1.5 ml/100 g body weight) induced extracellular dehydration affected foetuses status via the elevation of maternal A and AI1 was investigated. To assess such a mechanism, pregnant rats were treated either with DOCA (1 mg per rat per day) from the 14th to the 18th day of pregnancy and AI1 (250 /lg per rat) on the last DOCA day or with vehicle. Subsequently, in their adult offspring, both baseline and PEG induced SI were measured in a two bottle choice test. Baseline SI was elevated in females from treated mothers. When the offspring themselves received a PEG treatment, only the males from treated mothers showed an enhancement in SI whereas all the other offspring remained at their basal level of SI. These data suggest that dehydration from vomiting during human pregnancy may affect in the descendants the epidemiology of SI and the morbidity attached to it via AI1 and A secretion. Polyethylene of Offspring.
Glycol
Treatment
of Pregnant
Rats Enhances
Natriophilia
OLIVER GALAVERNA and STYLIANOS NICOLAIDIS. Laboratoire de Neurobiologie des Regulations C. N. R.S. LJA637, lnstitut de Biologie du College de France, Paris 5, France.
Salt appetite and the morbidity attached to it varies between subjects. To assess whether extracellular dehydration during pregnancy may enhance salt intake of offspring at adulthood pregnant rats were treated either with S.C.polyethylene glycol (PG) (20% 1.5 ml/100 g body
ABSTRACTS
Effects of Reversible Hypoyhslsmud Neuronal
Deficits on Monkey Lateral Amygdala Activity During Operant Feeding Behavior.
M. FUKUDA, T. ONO, K. NAKAMURA and R. TAMURA. Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan.
We used reversible deficits produced by amygdala (AM) cooling to investigate functional influence of the AM on the lateral hypothalamus (LHA) during monkey bar press feeding behavior. The AM cooling produced a slight increase of heart rate and error counting for discrimination. The AM cooling increased or decreased the spontaneous firing rates of some of 55 LHA neurons that were tested, and depressed visual and ingestion responses for food. Results suggest that some visual and ingestion signals related to food might come through the AM to the LHA, and mutual information processings might be important in feeding. Progressively Rising Glycemia High-fat Diet. C. FORNSINN,
and lnsulinemia in Obese Zucker M. KOMJATI and W. WALDHAUSL.
Universitatsklinik, Division of Clinical Endocrinology and Diabetology,
Rats on
Medical Vienna, Austria.
Genetically obese Zucker rats (M) were fed a lard- and sucrose-rich diet. Insulin secretion and glucose tolerance were tested in unrestrained animals by oral and iv. glucose as well as iv. arginine administration every three months. Lean Zucker rats on normal chow diet served as healthy controls (L). During 9 months diet obese rats progressively developed marked postabsorptive hyperglycemia (0: 8.7* 1.1, L: 5.8 f0.2mmol/l) and hyperinsulinemia (0: 288 f62, L: 18 + 3 mu/l). In spite of rising stimulated insulin release their glucose tolerance decreased with aging indicating progressive development of insulin resistance. Effect of Angiotensin Pregnancy on Natriophilia
and Mineralocorticoid Treatment During of Offspring in the Rat. OLIVER GALAVERNAand
STYLIANOS NICOLA’I’DIS. Laboratoire de Neurobiologie des Regulations C. N.R.S. LJA 637, lnstitut de Biologie du College de France, Paris 5, France.
We showed previously that both basal and stimulated salt appetite were higher in offspring from mothers that were dehydrated during their pregnancy. Since it was shown that aldosterone (A) and angiotensin II (AII) act synergistically to arouse salt intake (SI) and they do so in a persistent way, the possibility that the polyethylene glycol (PEG) (20% 1.5 ml/100 g body weight) induced extracellular dehydration affected foetuses status via the elevation of maternal A and AI1 was investigated. To assess such a mechanism, pregnant rats were treated either with DOCA (1 mg per rat per day) from the 14th to the 18th day of pregnancy and AI1 (250 /lg per rat) on the last DOCA day or with vehicle. Subsequently, in their adult offspring, both baseline and PEG induced SI were measured in a two bottle choice test. Baseline SI was elevated in females from treated mothers. When the offspring themselves received a PEG treatment, only the males from treated mothers showed an enhancement in SI whereas all the other offspring remained at their basal level of SI. These data suggest that dehydration from vomiting during human pregnancy may affect in the descendants the epidemiology of SI and the morbidity attached to it via AI1 and A secretion. Polyethylene of Offspring.
Glycol
Treatment
of Pregnant
Rats Enhances
Natriophilia
OLIVER GALAVERNA and STYLIANOS NICOLAIDIS. Laboratoire de Neurobiologie des Regulations C. N. R.S. LJA637, lnstitut de Biologie du College de France, Paris 5, France.
Salt appetite and the morbidity attached to it varies between subjects. To assess whether extracellular dehydration during pregnancy may enhance salt intake of offspring at adulthood pregnant rats were treated either with S.C.polyethylene glycol (PG) (20% 1.5 ml/100 g body