Abstracts / Journal of the Neurological Sciences 405S (2019) 116543
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median ages of AEDs-experienced; AED-naïve and healthy participants were 30.0, 26.0 and 37.0 years respectively. PWE had significantly higher blood levels of malondialdehyde and uric acid and lower levels of enzymatic antioxidants than healthy controls. Also, PWE on AED polytherapy had significantly higher blood levels of malondialdehyde and uric acid, and lower levels of enzymatic antioxidants than AEDnaïve PWE and PWE on AED monotherapy respectively.
unlike the typical course of CJD. Acute or hyper acute onset coma with non progressive changes in imaging and EEG were seen in those cases. Conclusion No patient should be given any label of a fatal disorder without thorough history, clinical examination, targeted investigations and follow up. Acute onset, male gender, coma at onset with nonprogression of EEG and MRI finding are points which hint at alternate non-prion disease process. On the contrary, delirium at onset, older age group, sub-acute onset and rapid progression of clinical and laboratory features suggest CJD when histopathology and genetics is not possible.
doi:10.1016/j.jns.2019.10.1742
Conclusion Epilepsy and AEDs significantly altered blood levels of malondialdehyde, uric acid and enzymatic antioxidants and/or their homeostatic kinetics; thus the need for constant monitoring of their levels in PWE, particularly those on AED polytherapy. Key words: Antiepileptic drugs, Enzymatic antioxidants, Malondialdehyde, Persons with epilepsy, Uric acid doi:10.1016/j.jns.2019.10.1743
WCN19-2093 Journal of the Neurological Sciences 405S (2019) 105405 Poster Session 4
WCN19-2087 Journal of the Neurological Sciences 405S (2019) 105404 Poster Session 4 Effect of epilepsy and antiepileptic drug therapy on erythrocyte malondialdehyde and some antioxidants in persons with epilepsy E. Iwuozoa, J. Ejioforb, O. Obiakoc, S. Abubakarc a Federal Medical Centre, Internal Medicine Department, Makurdi, Nigeria b Ahmadu Bello University, Department of Pharmacology & Therapeutics, Zaria, Nigeria c Ahmadu Bello University, Internal Medicine Department, Zaria, Nigeria Background Antiepileptic drugs (AEDs) are very necessary for successful treatment of epilepsy. Epilepsy and some AEDs are said to provoke or worsen seizure frequency by altering blood levels of some antioxidants. Objective This study investigated the effect of epilepsy and AEDs on blood levels of some oxidants and antioxidants. Methodology Blood samples were obtained from 35 AED-experienced PWE; 35 AED-naïve PWE; and 35 age- and- sex matched apparently healthy controls; and analysed for malondialdehyde and antioxidants (uric acid, superoxide dismutase, glutathione peroxidase and catalase) using enzyme-linked immunosorbent assay. Results One-hundred and five subjects (35 patients on AEDs, 35 newly diagnosed, AED-naive and 35 healthy controls) were investigated. The
Leisure, domestic or professional activities so as to prevent cognitive decline: Results fréle C. Dupréabc, D. Hupinb, F. Bélandd, F. Rocheb, T. Célariere, B. Bonguebc a CETAF, Statistics, Saint-Etienne, France b Laboratoire SNA-EPIS EA 4607, Université Jean Monnet, Saint-Etienne, France c Chaire Santé des aînés et Ingénierie de la prévention, Université Jean Monnet, Saint-Etienne, France d Département de Médecine gériatrique, Université Mc Gill, Montréal, Canada e Service de gérontologie, Hôpital Nord- CHU de Saint-Étienne, SaintÉtienne, France Background The objective of this work was to analyse the relation between different type of physical activity and cognitive decline in older people living in community. Methods The study used data from the longitudinal and observational study, FrèLE (FRagility: Longitudinal Study of Expressions). Cognitive decline was assessed by using: MMSE (Mini-Mental State Examination) and MoCA (Montreal Cognitive Assessment). Physical activity was assessed by the PASE (Physical Activity Scale for the Elderly). This tool is structured in three sections: the leisure activity, the domestic activity and the professional activity. Logistic regressions and proportional hazards regression models (Cox) were used to estimate the risk of cognitive disorders. Results At baseline, the prevalence of cognitive disorders was 6.9% according to MMSE. In total, 1326 participants without cognitive disorders were included in the analysis. The mean age was 77.4 years, and 52.1% of the participants were women. After a 2 years long follow-up, we found cognitive disorders on 92 participants (6.9%). Physical activity at baseline is lower in older adults for whom