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Effect of mupirocin (MUP) nasal ointment on surgical site infection (SSI)-related hospital stay
Abstracts
S46
Effect of mupirocin (MUP) nasal ointment on surgical site infection related hospital stay Vandenbergh
MFQ, Kluytmans
JAJW, Verbrugh
(SSI)-
HA
Department of Bacteriology, University Hospital Rotterdam, The Netherlancls SSIs are serious complications of thoracic surgery. We evaluated the effect of perioperative use of MUP on the postoperative length of stay (POLS) associated with SSIs in patients after thoracic surgery. Before the intervention with MUP, 68 (7.3%) of 928 patients developed an SSI; after the intervention 24 (2.8%) SSIs were found in 868 patients. 6 patients with an SSI died, all before the intervention with MUP. The mean POLS in patients with an SSI was 40 days before and 58 days after the intervention. To determine which part of the POLS could be attributed to the SSI, and thus might be prevented by the use of MUP, the Appropriateness Evaluation Protocol (AEP) was used. This is known to be a reliable objective method using explicit criteria to determine the need for each day of hospital care. Medical records of 75 patients (54 before and 21 after) with a SSI were available for reviewing. Each day of hospital care was reviewed twice: once
including all information related to symptoms and treatment of the SSI, and once excluding all this information. Days of hospitalization for which the first review indicated need for hospital care, were considered appropriate. Appropriate days were attributed to the SSI if the second review did not indicate need for hospital care. A mean SSI-attributable POLS of 10.5 days before intervention and 16.3 days after intervention was found. Therefore the observed reduction of 269 SSI-attributable days in 868 patients was lower than the expected reduction of 410 days. This may be explained by the decrease in SSI-related mortality after the intervention, resulting in a relative increase in mean (SSI-attributable) POLS. Conclusions: Perioperative use of MUP in patients after thoracic surgery reduced the SSIattributable POLS as assessed by a conservative method (AEP).
S46
Effect of mupirocin (MUP) nasal ointment on surgical site infection related hospital stay Vandenbergh
MFQ, Kluytmans
JAJW, Verbrugh
(SSI)-
HA
Department of Bacteriology, University Hospital Rotterdam, The Netherlancls SSIs are serious complications of thoracic surgery. We evaluated the effect of perioperative use of MUP on the postoperative length of stay (POLS) associated with SSIs in patients after thoracic surgery. Before the intervention with MUP, 68 (7.3%) of 928 patients developed an SSI; after the intervention 24 (2.8%) SSIs were found in 868 patients. 6 patients with an SSI died, all before the intervention with MUP. The mean POLS in patients with an SSI was 40 days before and 58 days after the intervention. To determine which part of the POLS could be attributed to the SSI, and thus might be prevented by the use of MUP, the Appropriateness Evaluation Protocol (AEP) was used. This is known to be a reliable objective method using explicit criteria to determine the need for each day of hospital care. Medical records of 75 patients (54 before and 21 after) with a SSI were available for reviewing. Each day of hospital care was reviewed twice: once
including all information related to symptoms and treatment of the SSI, and once excluding all this information. Days of hospitalization for which the first review indicated need for hospital care, were considered appropriate. Appropriate days were attributed to the SSI if the second review did not indicate need for hospital care. A mean SSI-attributable POLS of 10.5 days before intervention and 16.3 days after intervention was found. Therefore the observed reduction of 269 SSI-attributable days in 868 patients was lower than the expected reduction of 410 days. This may be explained by the decrease in SSI-related mortality after the intervention, resulting in a relative increase in mean (SSI-attributable) POLS. Conclusions: Perioperative use of MUP in patients after thoracic surgery reduced the SSIattributable POLS as assessed by a conservative method (AEP).