Effect of penicillin on the transient bacteremia following dental extraction

115

Abstracts ELKTROPHORETIC STUDY OF SERA FROM PA-IXENTSWITH PINV~AAND YAWS

over a twenty-four-hour tion.

In this group,

period prior to extrac-

approximately

of the postextraction

h’i. L.

DIL.LON,

Durham,

alpha-hemolytic

M.D.

JV.

organism

(Introduced by GRANTTAYLOR,Ph.D.) It has been and

Beard

kala-azar

demonstrated

with that

sera

the

from

mia, hyperglobulinemia, linemia

Rein

two patients

with

of hyperproteine-

or hypergammaglobu-

could not be used to prove or disprove

the specificity

of positive

serological

for syphilis. This report extends by

a study

pinta and phoretic

of sera

from

three patients

studies and

performed,

reactions

the above work

three

patients

with

yaws.

serodiagnostic

protein

concentrations

no

with

correlation

of

the

hyperproteinemia,

Electrowere

were

mined and again it was demonstrated is

with

tests

deter-

that there

serodiagnostic

tests

hyperglobulinemia

or

hypergammaglobulinemia.

GLASER,

(4-v invitation)

M.D.,

and

M.D.,

SYDNEY B.

*ARNOLD DANKNER,

study was undertaken

known

to follow dental

sidered

that

evaluation

such

extraction.

a study

in patients with rheumatic cultures

mediately

were

in two series of patients, In the first, or control recovered extraction patients

aid

AMERICAN

JOURNAL

positive

taken

before

im-

of one or more teeth each forty in number. series,

alpha-hemolytic streptococci

were

large OF

doses

MEDICINE

of penicillin

result

decrease

in incidence

was noted.

of positive

blood

gingivitis

of

teeth

follow-

patients

with

from this investigation

to extraction

rheumatic cillin

to a

or pyorrhea.

It was concluded prior

from

the

cultures

of bacteremia

in the incidence

extraction

of

Indeed,

decrease ing

in a

of bac-

was due entirely

of teeth

or congenital

should

in

heart

that

patients

with

disease,

peni-

be given for at least twenty-four

in high

gingivitis

dosage

to those

or pyorrhea

patients

with

and should be continued

for two or three days after extraction.

In patients

whose gums are normal penicillin

may be begun

immediately

but should

continued

prior

to extraction

for approximately

the

earliest

bacterial

endocarditis

following

extraction.

extraction possible

treatment

of

established

this method

will

awaits further experience.

RHEUMATIC-LIKE

LESIONS

IN UNSELECTED GEORGE H.

for two

represents,

if it becomes N’hether

prove totally effective

be

two to three days.

that the use of penicillin

days following

effect,

FOUND

AUTOPSIES

REIFENSTEIN, ml).

Syracuse, ,V. 2”. A clinical hearts

and

not

with the use of penicillin

use of penicillin heart

predominated.

did

in those with gingivitis

a definite

reduction

former

in the peni-

of teeth in patients with

blood cultures

over-all

in the

from over 60 per cent of the postcultures, In the second series, the given

or pyorrhea

It was con-

and congenital

or non-hemolytic

were

gums; however,

the

dental operations.

after extraction

streptococci

after extraction

normal

bacteremia

would

of the prophylactic

disease who require Blood

to determine

on the transient

series the

whereas

in the occurrence

teremia

in

From the Department of Internal Medicine, Washington University School of Medicine, the Oscar Johnson Institute for Medical Research and the Barnes Hospital, St. Louis, MO.

of penicillin

decrease

It is postulated

HARFORD, M.D.

This

significant

for

or non-hemolytic

control

use of penicillin

or three

MATHES, M.D. and CARL G.

effect

The

hours

EFFECT OF PENICILLINON THE TRANSIENT BACTEREMIA FOLLOWING DENTAL EXTRACTION ROBERT J.

In the

predominated,

40 per cent

were positive

cillin series the latter organism

by Cooper,

presence

streptococci

streptococci.

c.

cultures

from

conditions The

results

pathological 145

study

unselected

favorable

was made

autopsies

to unbiased

of

under

observations.

of this study may be summarized

as follows: 1. Rheumatic

or rheumatic-like

microscopic

nodules were found in almost 52 per cent of the hearts. These nodules occurred in various parts of the heart, most frequently atria1 endocardium,

in the myocardium,

and annuli

and spongiosa