Effect of terlipressin on portal pressure measured by direct puncture of oesophageal varices (I.O.V.P.) in patients with portal hypertension: A double-blind random study

Pharmacological Research Communications, Vol. 20, Supplement II, 1988 EFFECT OF TSRLIPRESSIN ON PORTAL ~

~

55

BY DIRECT ~

OF ~ ( ~ A L

VARICES

(I.O.V.P.) IN PATIENTS WITH PORTAL HYPERTENBI(~: A DOUBLE-BLInD RA~X~ STUDY M. Bra~a, R. Cestari, G. Missale and P. Ravelli Dept. of Surgical Pathology, University of Brescia, 25100 Brescia, ITALY Key words: Trig/ycyl-lysin-vasopressine , Forts/hyperter~ion

The study was carried out on 20 ~it~teer frcm

liver c i ~ i s

randcm a4ministration patients.

with portal

patients

hypertension

(mean age 57.4 years) suffering

and oesophageal

varices. A d~le-b!ind

of glypressin 2 ~g i.v.~ or placebo (mannitol) ~ms given to all

Intravascular

oesophageal variceal

pressure

was

assessed

described by Sta~itz et al (i). Experimental protocol required 2 b ~ l

using the technique I.O.V.P. n ' ~ s t ~ . ~ n t ~ _ ~

before and after bolus i.v. dr~g injection. The second measurement was taken as reference ~m determine whether the treatment was effective. Ohher m e ~ t s 5 and I0 minutes after drug a ~ s t r a t i o n .

For statistical

were taken i, 3,

analysis the [~xnett test

~as used. I.O.V.P. measurements (mean_+ S.E.) in the 1-1 patients wfm had received glypressin 19.6+_2.4, 16.7+_2.1, 14.5+~2.0, 13.8+_1.8 and 13.0+_/.6 n ~ spectively.

The corresponding

at O, i, 3, 5 and 10 minutes re-

values in the 9 patients who had been given placebo were

17.8+_2.2, 17. +].%2.3, 17.3+_2.1, 17.9+_2.0 and 18.8+_2.1 mm~.

The fall in I.O.V.P. at 3,5

end I0 minutes in the patients who had been adldnis%ered g/~pressin pr6ved statistically significant of

(p~O.Ol). In conclusion, triglycyl-lysine-vssc~pressin

causir~ statistically

i,~ortant

h e ~ c

variations

on

was found to be capable the

I.O.V.P. already at

3 minutes after administration. These variations persisted after 5 and i0 minutes.

i) Staritz M. eta/.: "/ntravascu/ar oesophageal variceal pressure (I.O.V.P.) assessed by endoscopic fine needle puncture under basal conditions, Valsalva's margeuvr~ end after glyceryltrinitrate application". (~T, 1985- 26:525-530.