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EFFECT OF TRANSCATHETER MITRAL REPAIR WITH THE CARDIOBAND DEVICE ON 3-DIMENSIONAL GEOMETRY OF THE MITRAL ANNULUS
336 JACC April 5, 2016 Volume 67, Issue 13
ACC.i2 Interventional Cardiology EFFECT OF TRANSCATHETER MITRAL REPAIR WITH THE CARDIOBAND DEVICE ON 3-DIMENSIONAL GEOMETRY OF THE MITRAL ANNULUS Poster Contributions Poster Area, South Hall A1 Sunday, April 03, 2016, 3:45 p.m.-4:30 p.m. Session Title: ACC.i2 Interventional Cardiology: Mitral and Structural Heart Disease Abstract Category: 10. ACC.i2 Interventional Cardiology: Mitral and Structural Heart Disease Presentation Number: 1225-171 Authors: Mani Arsalan, Eustachio Agricola, Ottavio Alfieri, Stephan Baldus, Antonio Colombo, Giovanni Filardo, Christoph Hammerstingl, Michael Huntgeburth, Felix Kreidel, Karl-Heinz Kuck, Giovanni La Canna, David Messika-Zeitoun, Francesco Maisano, Georg Nickenig, Benjamin D. Pollock, Bradley J. Roberts, Alec Vahanian, Paul Grayburn, Baylor University Medical Center, Dallas, TX, USA, Baylor Research Institute, Dallas, TX, USA
Background: Several transcathether mitral repair devices are currently undergoing clinical studies. The Cardioband system employs direct anchoring to the mitral annulus from the left atrium. We report the acute intraprocedural effects of this device on three-dimensional anatomy of the mitral annulus. Methods: This retrospective studied 22 patients the with complete pre- and post-implant 3D TEE images stored in native data format that allowed off-line 3D reconstruction. All patients were participating in a single arm, multicenter, prospective trial to assess the performance and safety of the Cardioband system. Multiple measurements of annular geometry were compared from baseline to post-implant using paired t-tests with Bonferroni correction to account for multiple comparisons.
Results: The device was successfully implanted in all patients and MR was reduced to moderate in 2 patients, mild in 18 patients and trace in 2 patients after final device cinching. Compared to preprocedural TEE, postprocedural TEE showed statistically significant reductions in annular circumference (137±15mm vs. 128±17mm; p = 0.042), intercommissural distance (42.4±4.3mm vs. 38.6±4.4mm; p = 0.029), anteroposterior distance (40.0±5.4mm vs. 37.0±5.7mm; p = 0.025) and aortic-mitral angle (117±8° vs. 112±8°; p = 0.032). Conclusions: This study demonstrates that transcatheter direct mitral repair with the Cardioband device results in acute remodeling of the mitral annulus with successful reduction of functional MR.
ACC.i2 Interventional Cardiology EFFECT OF TRANSCATHETER MITRAL REPAIR WITH THE CARDIOBAND DEVICE ON 3-DIMENSIONAL GEOMETRY OF THE MITRAL ANNULUS Poster Contributions Poster Area, South Hall A1 Sunday, April 03, 2016, 3:45 p.m.-4:30 p.m. Session Title: ACC.i2 Interventional Cardiology: Mitral and Structural Heart Disease Abstract Category: 10. ACC.i2 Interventional Cardiology: Mitral and Structural Heart Disease Presentation Number: 1225-171 Authors: Mani Arsalan, Eustachio Agricola, Ottavio Alfieri, Stephan Baldus, Antonio Colombo, Giovanni Filardo, Christoph Hammerstingl, Michael Huntgeburth, Felix Kreidel, Karl-Heinz Kuck, Giovanni La Canna, David Messika-Zeitoun, Francesco Maisano, Georg Nickenig, Benjamin D. Pollock, Bradley J. Roberts, Alec Vahanian, Paul Grayburn, Baylor University Medical Center, Dallas, TX, USA, Baylor Research Institute, Dallas, TX, USA
Background: Several transcathether mitral repair devices are currently undergoing clinical studies. The Cardioband system employs direct anchoring to the mitral annulus from the left atrium. We report the acute intraprocedural effects of this device on three-dimensional anatomy of the mitral annulus. Methods: This retrospective studied 22 patients the with complete pre- and post-implant 3D TEE images stored in native data format that allowed off-line 3D reconstruction. All patients were participating in a single arm, multicenter, prospective trial to assess the performance and safety of the Cardioband system. Multiple measurements of annular geometry were compared from baseline to post-implant using paired t-tests with Bonferroni correction to account for multiple comparisons.
Results: The device was successfully implanted in all patients and MR was reduced to moderate in 2 patients, mild in 18 patients and trace in 2 patients after final device cinching. Compared to preprocedural TEE, postprocedural TEE showed statistically significant reductions in annular circumference (137±15mm vs. 128±17mm; p = 0.042), intercommissural distance (42.4±4.3mm vs. 38.6±4.4mm; p = 0.029), anteroposterior distance (40.0±5.4mm vs. 37.0±5.7mm; p = 0.025) and aortic-mitral angle (117±8° vs. 112±8°; p = 0.032). Conclusions: This study demonstrates that transcatheter direct mitral repair with the Cardioband device results in acute remodeling of the mitral annulus with successful reduction of functional MR.