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Effect of very short-term weight reduction on blood pressure
Journal of the American Society of Hypertension 9(4S) (2015) e103–e106
OBESITY AND HYPERTENSION
P-185 Obese hypertensive patients have higher central pressures and arterial stiffness compared with non-obese patients at similar office blood pressure level Ricardo M. Cabrera Sole,3 Caridad Turpin Lucas,3 Liliana Urrega Rivera,3 Santiago Garcia Ruiz,3 Juan Ca~nas,2 Erik Luepke Estephan.1 1National Health System, London, United Kingdom; 2Sescam, Albacete, Spain; 3University General Hospital of Albacete, Albacete, Spain Introduction: It is well known that hypertensive obese patients (HOP) have more cardiovascular risk respect to those hypertensive patients with normal body mass index (NHOP), at the same peripheral blood pressure levels. However, we do nt know the behavior of the central pressure (CP) and arterial stiffness (AS) in these patients. Objective: The aims of this study were to compare the differences of CP and AS in HOP and NHOP. Material and Methods: We studied 136 patients from them 56 were HOP (body mass index 30, 584years old, 30 females and 26 males ) and 80 NHOP (<30 BMI, 576 years old,35 males and 45females). All of them received their treatment given by their primary care doctors to get 140/90 blood pressure level at the office. Diabetic, renal insufficiency and smokers were excluded. They were submitted to following measures: standard 24 hr., blood pressure monitoring (ABPM), augmentation index (AI), systolic and diastolic central pressures (SCP and DCP) in a cross-sectional and prospective study. Results: Are shown in the following table below ( where * means p values less than 0.05): Conclusion: HOP apart from having more difficulties to control the blood pressure, have also higher arterial stiffness and central pressure compared with those hypertensive patients which BMI are better, placing them in a group of more risk. These data are indicating the needs to improve the follow up and treatment of obesity, to reduce their cardiovascular risk and not only to control their peripheral blood pressure. Keywords: Obesity; arterial stiffness; central pressure.
Method: In our retrospective investigation, we included patients, who participated in our one-week long, hospitalized weight reduction program of Saint Imre Hospital’s Metabolic Center with dietary intervention. At admission and emission, we measured anthropometric parameters (bodyweight, BMI, waist circumference, body fat percentage), lipid profile, fasting glucose, systolic and diastolic blood pressure, heart rate; and we calculated pulse pressure (PP) and mean arterial pressure (MAP). Antihypertensive therapy was not changed during our observation in hypertensive patients, and if the patient haven’t had antihypertensive drug, we didn’t started any of them. Results: We involved 121 patients all together (81 women, 40 men). Their age was 5114.47. Their body weight was 107.1127.76 kg; their BMI was 37.798.91 kg/m2 at admission. The patient’s systolic blood pressure was 123.2213.18 mmHg and their diastolic blood pressure was 78.5710.87 mmHg at the beginning. The PP was 44.6512.66 mmHg, while MAP was 93.4510.06 mmHg. The heart rate of them was 71.608.06/min. The patients were on an average of 684183.94 kcal/ day diet. As an effect of the one week long low calorie diet, their body weight was decreased to 104.2426,67 kg, their BMI diminished to 36.88,63 kg/m2 (p<0.0001). The patients systolic blood pressure decreased to 118.4312.16 mmHg (-4.713.64 mmHg p<0.0001), and their diastolic blood pressure reduced to 76.9010.39 mmHg (-1.6712.34 mmHg p<0.0001). PP diminished to 41.5212.27 mmHg (p<0.0001), MAP decreased to 90.749.37 mmHg (p<0.0001) accompanied by a slight but significant (p<0.0001) reduction of pulse rate. Conclusions: In our study a short-term, approx. 3 kg (-2.6%) weight reduction was associated with a significant systolic and diastolic blood pressure lowering. Importance of these results is that - according to literature data - on population level a slight (2-3 mmHg), systolic blood pressure difference may cause 6-9% reduction in stroke mortality and 4-6 % decrease in coronary mortality risk among obese patients. Keywords: obesity; blood pressure; weight reduction
Table of Results: DATE
OFFICE BP
ABPM
AI
SCP
DCP
HOP NHOP
133/822/4 128/812/3
131/813/2 125/792/3
264 173*
1263 1054*
793 722*
P-186 Effect of very short-term weight reduction on blood pressure Gerg} o Csit ari,1 Reka Koll ar,1 Kristına Gencsi,1 Robert J. Bedros,1 Tam as Ferenci,2 G abor Simonyi.1 1Szent Imre Teaching Hospital, Budapest, Hungary; 2University of Obuda, Budapest, Hungary Introduction: Obesity and hypertension are often present together. According to literature data weight reduction also involves a decrease is blood pressure, and every 1 kg weight loss can cause approx. 1-4/1-2 mmHg reduction of blood pressure. In our study, we examined the effect of very short-term weight reduction on blood pressure. 1933-1711/$ - see front matter Ó 2015 American Society of Hypertension. All rights reserved.
Fig. Change of blood pressure by sex.
OBESITY AND HYPERTENSION
P-185 Obese hypertensive patients have higher central pressures and arterial stiffness compared with non-obese patients at similar office blood pressure level Ricardo M. Cabrera Sole,3 Caridad Turpin Lucas,3 Liliana Urrega Rivera,3 Santiago Garcia Ruiz,3 Juan Ca~nas,2 Erik Luepke Estephan.1 1National Health System, London, United Kingdom; 2Sescam, Albacete, Spain; 3University General Hospital of Albacete, Albacete, Spain Introduction: It is well known that hypertensive obese patients (HOP) have more cardiovascular risk respect to those hypertensive patients with normal body mass index (NHOP), at the same peripheral blood pressure levels. However, we do nt know the behavior of the central pressure (CP) and arterial stiffness (AS) in these patients. Objective: The aims of this study were to compare the differences of CP and AS in HOP and NHOP. Material and Methods: We studied 136 patients from them 56 were HOP (body mass index 30, 584years old, 30 females and 26 males ) and 80 NHOP (<30 BMI, 576 years old,35 males and 45females). All of them received their treatment given by their primary care doctors to get 140/90 blood pressure level at the office. Diabetic, renal insufficiency and smokers were excluded. They were submitted to following measures: standard 24 hr., blood pressure monitoring (ABPM), augmentation index (AI), systolic and diastolic central pressures (SCP and DCP) in a cross-sectional and prospective study. Results: Are shown in the following table below ( where * means p values less than 0.05): Conclusion: HOP apart from having more difficulties to control the blood pressure, have also higher arterial stiffness and central pressure compared with those hypertensive patients which BMI are better, placing them in a group of more risk. These data are indicating the needs to improve the follow up and treatment of obesity, to reduce their cardiovascular risk and not only to control their peripheral blood pressure. Keywords: Obesity; arterial stiffness; central pressure.
Method: In our retrospective investigation, we included patients, who participated in our one-week long, hospitalized weight reduction program of Saint Imre Hospital’s Metabolic Center with dietary intervention. At admission and emission, we measured anthropometric parameters (bodyweight, BMI, waist circumference, body fat percentage), lipid profile, fasting glucose, systolic and diastolic blood pressure, heart rate; and we calculated pulse pressure (PP) and mean arterial pressure (MAP). Antihypertensive therapy was not changed during our observation in hypertensive patients, and if the patient haven’t had antihypertensive drug, we didn’t started any of them. Results: We involved 121 patients all together (81 women, 40 men). Their age was 5114.47. Their body weight was 107.1127.76 kg; their BMI was 37.798.91 kg/m2 at admission. The patient’s systolic blood pressure was 123.2213.18 mmHg and their diastolic blood pressure was 78.5710.87 mmHg at the beginning. The PP was 44.6512.66 mmHg, while MAP was 93.4510.06 mmHg. The heart rate of them was 71.608.06/min. The patients were on an average of 684183.94 kcal/ day diet. As an effect of the one week long low calorie diet, their body weight was decreased to 104.2426,67 kg, their BMI diminished to 36.88,63 kg/m2 (p<0.0001). The patients systolic blood pressure decreased to 118.4312.16 mmHg (-4.713.64 mmHg p<0.0001), and their diastolic blood pressure reduced to 76.9010.39 mmHg (-1.6712.34 mmHg p<0.0001). PP diminished to 41.5212.27 mmHg (p<0.0001), MAP decreased to 90.749.37 mmHg (p<0.0001) accompanied by a slight but significant (p<0.0001) reduction of pulse rate. Conclusions: In our study a short-term, approx. 3 kg (-2.6%) weight reduction was associated with a significant systolic and diastolic blood pressure lowering. Importance of these results is that - according to literature data - on population level a slight (2-3 mmHg), systolic blood pressure difference may cause 6-9% reduction in stroke mortality and 4-6 % decrease in coronary mortality risk among obese patients. Keywords: obesity; blood pressure; weight reduction
Table of Results: DATE
OFFICE BP
ABPM
AI
SCP
DCP
HOP NHOP
133/822/4 128/812/3
131/813/2 125/792/3
264 173*
1263 1054*
793 722*
P-186 Effect of very short-term weight reduction on blood pressure Gerg} o Csit ari,1 Reka Koll ar,1 Kristına Gencsi,1 Robert J. Bedros,1 Tam as Ferenci,2 G abor Simonyi.1 1Szent Imre Teaching Hospital, Budapest, Hungary; 2University of Obuda, Budapest, Hungary Introduction: Obesity and hypertension are often present together. According to literature data weight reduction also involves a decrease is blood pressure, and every 1 kg weight loss can cause approx. 1-4/1-2 mmHg reduction of blood pressure. In our study, we examined the effect of very short-term weight reduction on blood pressure. 1933-1711/$ - see front matter Ó 2015 American Society of Hypertension. All rights reserved.
Fig. Change of blood pressure by sex.