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Effectiveness of Video-Assisted Thoracoscopic Surgery vs Closed Tube Thoracostomy in Parapneumonic Effusion: A Meta-Analysis
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Scientific Forum Abstracts
[CI]). Western blot was used to assess expression of DDIT4, pAMPK, and pS6 as direct and downstream targets of baicalein and metformin on the mTOR pathway. RESULTS: Cell proliferation decreased when baicalein and metformin were used separately and in combination in a dose-dependent manner at 48 and 72 hours. The combination of baicalein and metformin had a synergistic (CI < 1) antiproliferative effect in cells at 72 hours at almost every dose combination (Figure). Western blotting showed that there was an increase in DDIT4 by baicalein and an increase in pAMPK by metformin. The mTOR end target pS6 was markedly more suppressed by the combination of baicalein and metformin than by either alone. CONCLUSIONS: Our results showed that baicalein combined with metformin could exert synergistic antitumor effects in nonsmall cell carcinoma cells through mTOR inhibition. Baicalein has a promising antitumor potential for human lung cancer either alone or in combination with other agents.
Effectiveness of Video-Assisted Thoracoscopic Surgery vs Closed Tube Thoracostomy in Parapneumonic Effusion: A Meta-Analysis Mary Grace M Balunsat-Rojas, MD, Angelo Mark N Zamora, MD, Zabdiel Villanueva, MD, FPCS, FPATACSI East Avenue Medical Center, Quezon City, Philippines
J Am Coll Surg
INTRODUCTION: The primary treatment of parapneumonic effusion, specifically the fibrinopurulent type, remains controversial. The purpose of this review was to compare reported results of video-assisted thoracoscopic surgery (VATS) and chest-tube drainage (CTT) for the primary treatment of parapneumonic effusions. METHODS: A systematic comprehensive review of the scientific literature was conducted in the PubMed/Medline database until December 2014. This reproducible search identified all publications dealing with treatment of parapneumonic effusions (fibrinopurulent, empyema). A meta-analysis was performed with studies that had adequate data summaries for more than 1 outcome investigated. RESULTS: Seven studies were reviewed. These randomized controlled trials comprised 361 patients, with 184 randomized to VATS and 177 to CTT. The populations included both children and adults. Patients who underwent VATS had significantly shorter lengths of hospital stay as compared with those who underwent CTT. VATS also compared favorably against CTT for length of chest-tube days and days until patients were afebrile. Both treatment groups had the same failure rates and average total costs. CONCLUSIONS: These aggregate results suggest that VATS is associated with shorter hospital stay, time with tube thoracostomy, and time until afebrile. VATS and CTT have the same failure rates and total costs/charges.
Scientific Forum Abstracts
[CI]). Western blot was used to assess expression of DDIT4, pAMPK, and pS6 as direct and downstream targets of baicalein and metformin on the mTOR pathway. RESULTS: Cell proliferation decreased when baicalein and metformin were used separately and in combination in a dose-dependent manner at 48 and 72 hours. The combination of baicalein and metformin had a synergistic (CI < 1) antiproliferative effect in cells at 72 hours at almost every dose combination (Figure). Western blotting showed that there was an increase in DDIT4 by baicalein and an increase in pAMPK by metformin. The mTOR end target pS6 was markedly more suppressed by the combination of baicalein and metformin than by either alone. CONCLUSIONS: Our results showed that baicalein combined with metformin could exert synergistic antitumor effects in nonsmall cell carcinoma cells through mTOR inhibition. Baicalein has a promising antitumor potential for human lung cancer either alone or in combination with other agents.
Effectiveness of Video-Assisted Thoracoscopic Surgery vs Closed Tube Thoracostomy in Parapneumonic Effusion: A Meta-Analysis Mary Grace M Balunsat-Rojas, MD, Angelo Mark N Zamora, MD, Zabdiel Villanueva, MD, FPCS, FPATACSI East Avenue Medical Center, Quezon City, Philippines
J Am Coll Surg
INTRODUCTION: The primary treatment of parapneumonic effusion, specifically the fibrinopurulent type, remains controversial. The purpose of this review was to compare reported results of video-assisted thoracoscopic surgery (VATS) and chest-tube drainage (CTT) for the primary treatment of parapneumonic effusions. METHODS: A systematic comprehensive review of the scientific literature was conducted in the PubMed/Medline database until December 2014. This reproducible search identified all publications dealing with treatment of parapneumonic effusions (fibrinopurulent, empyema). A meta-analysis was performed with studies that had adequate data summaries for more than 1 outcome investigated. RESULTS: Seven studies were reviewed. These randomized controlled trials comprised 361 patients, with 184 randomized to VATS and 177 to CTT. The populations included both children and adults. Patients who underwent VATS had significantly shorter lengths of hospital stay as compared with those who underwent CTT. VATS also compared favorably against CTT for length of chest-tube days and days until patients were afebrile. Both treatment groups had the same failure rates and average total costs. CONCLUSIONS: These aggregate results suggest that VATS is associated with shorter hospital stay, time with tube thoracostomy, and time until afebrile. VATS and CTT have the same failure rates and total costs/charges.