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Effects of bisphosphonates treatment on BMD in patients with postmenopausal osteoporosis
ABSTRACTS / Bone 43 (2008) S111–S126
Consumers bring the perspective of “street arthritis” to the research team discussion table. Conclusion: Over the last 10 years, CAN has demonstrated effective integration of industry, government and consumers needs into arthritis research and has shaped the way arthritis researchers and the community think about research. doi:10.1016/j.bone.2008.07.156
S26 Management of osteoporotic vertebral compression fractures: Bone cementoplasty versus calcitonin treatment Hai Tang, Yong-gang Li Department of Orthopedic of Affiliated Beijing Friendship Hospital of Capital University Of Medical Sciences, China Objective: To study the effectiveness of bone cementoplasty (percutaneous vertebroplasty and percutaneous kyphoplasty) and drug treatment (calcitonin, calcium carbonate and calcitriol) for the treatment of osteoporotic vertebral compression fractures (OVCFs). Materials and methods: We studied 68 cases of OVCFs, including 14 male cases and 54 female cases with average age 73.3 ± 18. Fourtysix cases of thoracolumbar vertebral compression fractures were treated with bone cementoplasty therapy, of which 25 cases were done by percutaneous vertebroplasty (PVP) and 21 cases were done by percutaneous kyphoplasty (PKP). Twenty-two cases were treated with drugs such as Calcitonin etc. During follow up (12–20 months; average 14 months), the following outcome measurements were recorded: visual analog scale (VAS), SF-12 health survey, change of vertebral height, Cobb angle and bone mineral density. Results: Treatments were successful in all cases, with good pain relief and without significant complications. For VAS the cementplasty's group is significantly better than the Calcitonin group a week after surgery (p b 0.05). The SF-12 score was lower in the Calcitonin group than the cementplasty groupp. For the recovery of compressing vertebra, Cobb angle and vertebral height were both improved in the cementplasty group, more so in the PKP group than that of the PVP group (p b 0.01). Bone mineral density in the Calcitonin group was significantly improved after therapy. Conclusion: For osteoporotic fracture management, bone cementoplasty (PVP and PKP) relieves pain quicker, improves vertebral height and Cobb angle and enhances vertebral stability which leads to the improvement of the quality of life of the patients' suffering OVCFs. Calcitonin can improve BMD and relieve pain with a lower cost, but the pain relief effect was 4 weeks later compared to the bone cementoplasty group. doi:10.1016/j.bone.2008.07.157
S119
“C” armed imaging guiding. The clinical effect was evaluated by observing the charging of visual analog scale (VAS), the use of pain-killer, locomotor activity, the Cobb's angle and height of vertebral bodies. Results: All cases were treated successfully. The mean height of the anterior and media vertebral bodies was increased and the mean kyphosis Cobb's angle was improved well after operation. The back pain was marked relieved and deformed correction was maintained well after 6–36 months, with an average of 20.4 months follow up. During the follow-up, there were no complications. Conclusions: The percutaneous kyphoplasty is simple and safe in treating osteoporotic thoracolumbar vertebral compressive fractures. It can quickly relieve pain, decreasing the usage of pain-killers and improving the patients' quality of life. doi:10.1016/j.bone.2008.07.158
S28 Effects of bisphosphonates treatment on BMD in patients with postmenopausal osteoporosis Hua Lin, Li-hua Bao, Zu-bin Han, Xin Chen The Center of Research for Metabolic Bone Disease, The Affiliated Drum Tower Hospital of Medical School, Nanjing University, China Objective: To focus on the study of the clinical efficacy of bisphosphonates treatment in postmenopausal osteoporotic women. Methods: A total of 360 postmenopausal women with lumbar spine bone mineral density (BMD) 2.5 SD or more below the young adult mean were randomly divided into three groups, there were 120 patients in each group: Etidronate group (etidronate 200 mg twice per day for 2 weeks every 13 weeks), Alendronate group (alendronate 10 mg/day), and risedronate group (risedronate 5 mg/day). All patients received calcium 500 mg and VitD 200ID daily. During 1 year of treatment, bone pain, marks of bone turnover (urinary Ntelopeptide, NTx and serum bone-specific alkaline phosphatase,BAP ), BMD, side-effect and new spinal vertebral fracture were assessed in every patient. Results: Bone pain and quality of life improved significantly, marks of bone turnover (NTx and BAP) decreases and BMD at lumbar spine (L2–4) and hip (neck, trochanter and Ward's) significant increases in all groups (alendronate group, L2–4: 5.51%, neck: 2.66%, trochanter: 4.37%, Ward's: 3.13%; resedronate group, L2-4: 4.18%, neck: 2.05%, trochanter: 2.81%, Ward's: 3.08%; etidronate group, L2-4: 3.70%, neck: 1.84%, trochanter: 1.96%, Ward's: 1.50% ). New vertebral fractures were seen in 4 patients of etidronate group, 1 patient of alendronate group and 1 patient of resedronate group. No serious side-effects were seen in any of the patients during follow-up. Conclusion: Bisphosphonates have good clinical effects for postmenopausal osteoporosis treatment, alendronic acid and risedronic acid have a more powerful efficacy. doi:10.1016/j.bone.2008.07.159
S27 The efficacy of percutaneous kyphoplasty in treating multi-osteoporotic thoracolumbar vertebral compressive fractures Hai Tang, Hao Chen, Yong-gang Li, He Dai Department of Orthopedic of Affiliated Beijing Friendship Hospital of Capital University of Medical Sciences, China Objective: To evaluate the efficacy and safety of percutaneous kyphoplasty in treating multi-osteoporotic thoracolumbar vertebral compressive fractures. Methods: 54 cases of osteoporotic thoracolumbar vertebral compressive fractures were treated by percutaneous kyphoplasty under
S29 The related variate analysis of blood lipid and bone mineral density in hypertension and/or coronary atherosclerotic heart disease Xiufen Zhu, Yongmei Zhang, Hua Lin Nanjing Drum Tower, Nanjing, China Objective: To study the related variate analysis of blood lipid and bone mineral density in hypertension and/or coronary atherosclerotic heart disease.
Consumers bring the perspective of “street arthritis” to the research team discussion table. Conclusion: Over the last 10 years, CAN has demonstrated effective integration of industry, government and consumers needs into arthritis research and has shaped the way arthritis researchers and the community think about research. doi:10.1016/j.bone.2008.07.156
S26 Management of osteoporotic vertebral compression fractures: Bone cementoplasty versus calcitonin treatment Hai Tang, Yong-gang Li Department of Orthopedic of Affiliated Beijing Friendship Hospital of Capital University Of Medical Sciences, China Objective: To study the effectiveness of bone cementoplasty (percutaneous vertebroplasty and percutaneous kyphoplasty) and drug treatment (calcitonin, calcium carbonate and calcitriol) for the treatment of osteoporotic vertebral compression fractures (OVCFs). Materials and methods: We studied 68 cases of OVCFs, including 14 male cases and 54 female cases with average age 73.3 ± 18. Fourtysix cases of thoracolumbar vertebral compression fractures were treated with bone cementoplasty therapy, of which 25 cases were done by percutaneous vertebroplasty (PVP) and 21 cases were done by percutaneous kyphoplasty (PKP). Twenty-two cases were treated with drugs such as Calcitonin etc. During follow up (12–20 months; average 14 months), the following outcome measurements were recorded: visual analog scale (VAS), SF-12 health survey, change of vertebral height, Cobb angle and bone mineral density. Results: Treatments were successful in all cases, with good pain relief and without significant complications. For VAS the cementplasty's group is significantly better than the Calcitonin group a week after surgery (p b 0.05). The SF-12 score was lower in the Calcitonin group than the cementplasty groupp. For the recovery of compressing vertebra, Cobb angle and vertebral height were both improved in the cementplasty group, more so in the PKP group than that of the PVP group (p b 0.01). Bone mineral density in the Calcitonin group was significantly improved after therapy. Conclusion: For osteoporotic fracture management, bone cementoplasty (PVP and PKP) relieves pain quicker, improves vertebral height and Cobb angle and enhances vertebral stability which leads to the improvement of the quality of life of the patients' suffering OVCFs. Calcitonin can improve BMD and relieve pain with a lower cost, but the pain relief effect was 4 weeks later compared to the bone cementoplasty group. doi:10.1016/j.bone.2008.07.157
S119
“C” armed imaging guiding. The clinical effect was evaluated by observing the charging of visual analog scale (VAS), the use of pain-killer, locomotor activity, the Cobb's angle and height of vertebral bodies. Results: All cases were treated successfully. The mean height of the anterior and media vertebral bodies was increased and the mean kyphosis Cobb's angle was improved well after operation. The back pain was marked relieved and deformed correction was maintained well after 6–36 months, with an average of 20.4 months follow up. During the follow-up, there were no complications. Conclusions: The percutaneous kyphoplasty is simple and safe in treating osteoporotic thoracolumbar vertebral compressive fractures. It can quickly relieve pain, decreasing the usage of pain-killers and improving the patients' quality of life. doi:10.1016/j.bone.2008.07.158
S28 Effects of bisphosphonates treatment on BMD in patients with postmenopausal osteoporosis Hua Lin, Li-hua Bao, Zu-bin Han, Xin Chen The Center of Research for Metabolic Bone Disease, The Affiliated Drum Tower Hospital of Medical School, Nanjing University, China Objective: To focus on the study of the clinical efficacy of bisphosphonates treatment in postmenopausal osteoporotic women. Methods: A total of 360 postmenopausal women with lumbar spine bone mineral density (BMD) 2.5 SD or more below the young adult mean were randomly divided into three groups, there were 120 patients in each group: Etidronate group (etidronate 200 mg twice per day for 2 weeks every 13 weeks), Alendronate group (alendronate 10 mg/day), and risedronate group (risedronate 5 mg/day). All patients received calcium 500 mg and VitD 200ID daily. During 1 year of treatment, bone pain, marks of bone turnover (urinary Ntelopeptide, NTx and serum bone-specific alkaline phosphatase,BAP ), BMD, side-effect and new spinal vertebral fracture were assessed in every patient. Results: Bone pain and quality of life improved significantly, marks of bone turnover (NTx and BAP) decreases and BMD at lumbar spine (L2–4) and hip (neck, trochanter and Ward's) significant increases in all groups (alendronate group, L2–4: 5.51%, neck: 2.66%, trochanter: 4.37%, Ward's: 3.13%; resedronate group, L2-4: 4.18%, neck: 2.05%, trochanter: 2.81%, Ward's: 3.08%; etidronate group, L2-4: 3.70%, neck: 1.84%, trochanter: 1.96%, Ward's: 1.50% ). New vertebral fractures were seen in 4 patients of etidronate group, 1 patient of alendronate group and 1 patient of resedronate group. No serious side-effects were seen in any of the patients during follow-up. Conclusion: Bisphosphonates have good clinical effects for postmenopausal osteoporosis treatment, alendronic acid and risedronic acid have a more powerful efficacy. doi:10.1016/j.bone.2008.07.159
S27 The efficacy of percutaneous kyphoplasty in treating multi-osteoporotic thoracolumbar vertebral compressive fractures Hai Tang, Hao Chen, Yong-gang Li, He Dai Department of Orthopedic of Affiliated Beijing Friendship Hospital of Capital University of Medical Sciences, China Objective: To evaluate the efficacy and safety of percutaneous kyphoplasty in treating multi-osteoporotic thoracolumbar vertebral compressive fractures. Methods: 54 cases of osteoporotic thoracolumbar vertebral compressive fractures were treated by percutaneous kyphoplasty under
S29 The related variate analysis of blood lipid and bone mineral density in hypertension and/or coronary atherosclerotic heart disease Xiufen Zhu, Yongmei Zhang, Hua Lin Nanjing Drum Tower, Nanjing, China Objective: To study the related variate analysis of blood lipid and bone mineral density in hypertension and/or coronary atherosclerotic heart disease.