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Effects of body acupuncture versus auricular acupuncture on anthropometric, lipid profile, inflammatory and immunologic markers: a randomized controlled trial study
S156
Abstracts
Introduction: In this study we aimed to assess the changes in serum anti-heat shock protein (HSP)-27 antibody and oxidative stress levels assessed by pro-oxidant–antioxidant balance (PAB) after drug-eluting-stent (DES) versus bare-metal-stent (BMS) implantation in patients with stable coronary artery disease. Materials and methods: PCI with either BMS or DES were performed for 137 patients (80 in BMS group and 60 in DES group). Anti-HSP27 and PAB values were measured 24 h before and after PCI. Results: Median anti-HSP27 antibody levels decreased to 0.26 (0.17–0.49) and 0.21 (0.16–0.29) absorbency units in BMS and DES groups (P = 0.045 and P = 0.000, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P = 0.015). Moreover, baseline PAB values were not significantly different between the 2 groups (P > 0.05). Following PCI, median PAB values decreased to 72.10 (61.40–96.13) and 78.61 (52.97– 114.42) in BMS and DES groups, respectively. However the reduction was only significant in the BMS group (P = 0.001). Conclusion: We found that the clinical difference between DES and BMS implantations could not be attributed to difference in oxidative stress induction due to insignificant difference in PAB values changes between 2 groups. However, BMS and DES differ in stimulation of immune rather. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses. Keywords: Heat shock protein, Antibody, Pro-oxidant–antioxidant balance, Percutaneous coronary intervention
doi:10.1016/j.clinbiochem.2011.08.387
Poster – [A-10-689-3] Effects of body acupuncture versus auricular acupuncture on anthropometric, lipid profile, inflammatory and immunologic markers: a randomized controlled trial study Amir Ali Rahsepar, Shima Tavallaie, Hamid Abdi, Baixiao Zhao, Parisa Abbasi, Mohsen Nemati, Mohamoud Safarian, Seyyed Mohammad Reza Parizadeh, Maryam Mohammadi, Sara Darbandi, Mahsa Darbandi, Majid Ghayour-Mobarhan, Gordon Ferns E-mail address: [email protected] (A.A. Rahsepar) Introduction: A randomized clinical-trial in obese subjects were performed to examine the effectiveness of auricular and body acupuncture on body weight loss and their impact on lipid profile, immunologic [antiheat shock protein (Hsp)] and inflammatory markers [High-sensitivity C reactive protein (hs-CRP)]. Materials and Methods: Participants (n= 172), were randomized into 2 groups (auricular and body acupuncture). Subjects received acupuncture for 6-weeks (first period) in combination with low-calorie diet, while in the next 6-weeks (second period), followed by a lowcalorie diet alone. Subjects were assessed at the beginning of the study and at 6 and 12 weeks later. In addition to anthropometric and lipid profile, anti-Hsp 27, 60, 65, 70 and also hs-CRP levels were measured. Results: In the first period, we observed a significant reduction in anthropometric parameters and anti-Hsp antibodies in body and auricular groups, while in auricular and body group changes in lipid profile and hs-CRP levels were not obtained. In the second period of the study which shows the sustained effects of the therapy, changes in anthropometric and lipid profile in the acupuncture body group continued while in auricular group not. When the 2 groups were compared, we found that body acupuncture was more effective in changing the anthropometric and immunologic factors and lipid profile than auricular acupuncture except for HDL-C.
Conclusions: Although both auricular and body acupuncture is effective to have positive impact on weight loss, dyslipidemia, immune system, but this effect was more significant for body acupuncture. Keywords: Obesity, Acupuncture, Anti-heat shock protein antibody, High sensitivity C-reactive protein, Lipid profile doi:10.1016/j.clinbiochem.2011.08.388
Poster – [A-10-689-4] Oxidative levels and its relation with extent and severity of coronary artery disease Majid Ghayour-Mobarhan, Hossein Pourghadamyari, Amir Rahsepar Ali, Shima Tavallaie, Seyyed Mohammad Reza Parizadeh, Mohsen Moohebati, Mashallah Dehghani, Homa Falsoleiman, Roghayeh Paydar, Afsson Fazlinejad, Alamdari Daryoush Hamidi, Gordon Ferns Biochemical and Nutritional Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran E-mail address: [email protected] (M. Ghayour-Mobarhan) Introduction: In this study we aimed to assess the baseline levels in pro-oxidant–antioxidant balance (PAB) values between patients with defined coronary artery disease (CAD) and healthy control subjects. Material and methods: Four-hundred patients with stable Cad were selected and due to the results of angiography were divided into 2 groups [CAD-negative (50% > stenesis of involved artery) and CAD-positive (50%< stenesis of involved arteries). Moreover, in CAD-positive group patients were divided into 3 groups of single, double and triple vessel disease. Results: Different groups were matched well. Mean PAB values in control group were 45.16 ± 43.88, being significantly lower than CAD-negative and CAD + patients (including SVD, 2VD and 3VD) (P0.05). In CAD positive group, PAB values were 123.68 ± 37.87, 123.39 ± 42.32 and 121.81 ± 42.00 in SVD, 2VD and 3VD respectively. Mean PAB levels were not significantly different among SVD, 2VD and 3VD patients (P > 0.05). Discussion: In conclusion, we found that the level of oxidative stress is higher in patients with CAD, however, the analysis failed to show any relationship between PAB values and extent and severity of CAD. Keywords: Pro-oxidant–antioxidant balance, Coronary artery disease, Severity doi:10.1016/j.clinbiochem.2011.08.389
Poster — [A-10-695-1] Chemical synthesis and biological evaluation of two novel anti-malarial derivatives of amodiaquine against sensitive and resistant plasmodium falciparum Afra Khosravi, Eghbaleh Asadollahy Ilam University of Medical Sciences, Iran E-mail addresses: [email protected] (A. Khosravi), [email protected] (E. Asadollahy) Introduction: Amodiaquine (AQ) is one of the famous derivatives of 4-aminoquinoline antimalarial drug which is effectively used against many chloroquine-resistant strains of P. falciparum. As wide application of this drug can cause serious side effects such as hepatotoxicity, it cannot be used as a routine antimalarial medication in clinics. As such, synthesis of some derivatives of keeping the effective impact of it on plasmodium and without the amodiaquine-related complications can be necessary. The aim of the current study was to chemically synthesize the novel chloro and fleuro amodiaquine derivatives and evaluating their effects on plasmodium falciparum.
Abstracts
Introduction: In this study we aimed to assess the changes in serum anti-heat shock protein (HSP)-27 antibody and oxidative stress levels assessed by pro-oxidant–antioxidant balance (PAB) after drug-eluting-stent (DES) versus bare-metal-stent (BMS) implantation in patients with stable coronary artery disease. Materials and methods: PCI with either BMS or DES were performed for 137 patients (80 in BMS group and 60 in DES group). Anti-HSP27 and PAB values were measured 24 h before and after PCI. Results: Median anti-HSP27 antibody levels decreased to 0.26 (0.17–0.49) and 0.21 (0.16–0.29) absorbency units in BMS and DES groups (P = 0.045 and P = 0.000, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P = 0.015). Moreover, baseline PAB values were not significantly different between the 2 groups (P > 0.05). Following PCI, median PAB values decreased to 72.10 (61.40–96.13) and 78.61 (52.97– 114.42) in BMS and DES groups, respectively. However the reduction was only significant in the BMS group (P = 0.001). Conclusion: We found that the clinical difference between DES and BMS implantations could not be attributed to difference in oxidative stress induction due to insignificant difference in PAB values changes between 2 groups. However, BMS and DES differ in stimulation of immune rather. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses. Keywords: Heat shock protein, Antibody, Pro-oxidant–antioxidant balance, Percutaneous coronary intervention
doi:10.1016/j.clinbiochem.2011.08.387
Poster – [A-10-689-3] Effects of body acupuncture versus auricular acupuncture on anthropometric, lipid profile, inflammatory and immunologic markers: a randomized controlled trial study Amir Ali Rahsepar, Shima Tavallaie, Hamid Abdi, Baixiao Zhao, Parisa Abbasi, Mohsen Nemati, Mohamoud Safarian, Seyyed Mohammad Reza Parizadeh, Maryam Mohammadi, Sara Darbandi, Mahsa Darbandi, Majid Ghayour-Mobarhan, Gordon Ferns E-mail address: [email protected] (A.A. Rahsepar) Introduction: A randomized clinical-trial in obese subjects were performed to examine the effectiveness of auricular and body acupuncture on body weight loss and their impact on lipid profile, immunologic [antiheat shock protein (Hsp)] and inflammatory markers [High-sensitivity C reactive protein (hs-CRP)]. Materials and Methods: Participants (n= 172), were randomized into 2 groups (auricular and body acupuncture). Subjects received acupuncture for 6-weeks (first period) in combination with low-calorie diet, while in the next 6-weeks (second period), followed by a lowcalorie diet alone. Subjects were assessed at the beginning of the study and at 6 and 12 weeks later. In addition to anthropometric and lipid profile, anti-Hsp 27, 60, 65, 70 and also hs-CRP levels were measured. Results: In the first period, we observed a significant reduction in anthropometric parameters and anti-Hsp antibodies in body and auricular groups, while in auricular and body group changes in lipid profile and hs-CRP levels were not obtained. In the second period of the study which shows the sustained effects of the therapy, changes in anthropometric and lipid profile in the acupuncture body group continued while in auricular group not. When the 2 groups were compared, we found that body acupuncture was more effective in changing the anthropometric and immunologic factors and lipid profile than auricular acupuncture except for HDL-C.
Conclusions: Although both auricular and body acupuncture is effective to have positive impact on weight loss, dyslipidemia, immune system, but this effect was more significant for body acupuncture. Keywords: Obesity, Acupuncture, Anti-heat shock protein antibody, High sensitivity C-reactive protein, Lipid profile doi:10.1016/j.clinbiochem.2011.08.388
Poster – [A-10-689-4] Oxidative levels and its relation with extent and severity of coronary artery disease Majid Ghayour-Mobarhan, Hossein Pourghadamyari, Amir Rahsepar Ali, Shima Tavallaie, Seyyed Mohammad Reza Parizadeh, Mohsen Moohebati, Mashallah Dehghani, Homa Falsoleiman, Roghayeh Paydar, Afsson Fazlinejad, Alamdari Daryoush Hamidi, Gordon Ferns Biochemical and Nutritional Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran E-mail address: [email protected] (M. Ghayour-Mobarhan) Introduction: In this study we aimed to assess the baseline levels in pro-oxidant–antioxidant balance (PAB) values between patients with defined coronary artery disease (CAD) and healthy control subjects. Material and methods: Four-hundred patients with stable Cad were selected and due to the results of angiography were divided into 2 groups [CAD-negative (50% > stenesis of involved artery) and CAD-positive (50%< stenesis of involved arteries). Moreover, in CAD-positive group patients were divided into 3 groups of single, double and triple vessel disease. Results: Different groups were matched well. Mean PAB values in control group were 45.16 ± 43.88, being significantly lower than CAD-negative and CAD + patients (including SVD, 2VD and 3VD) (P0.05). In CAD positive group, PAB values were 123.68 ± 37.87, 123.39 ± 42.32 and 121.81 ± 42.00 in SVD, 2VD and 3VD respectively. Mean PAB levels were not significantly different among SVD, 2VD and 3VD patients (P > 0.05). Discussion: In conclusion, we found that the level of oxidative stress is higher in patients with CAD, however, the analysis failed to show any relationship between PAB values and extent and severity of CAD. Keywords: Pro-oxidant–antioxidant balance, Coronary artery disease, Severity doi:10.1016/j.clinbiochem.2011.08.389
Poster — [A-10-695-1] Chemical synthesis and biological evaluation of two novel anti-malarial derivatives of amodiaquine against sensitive and resistant plasmodium falciparum Afra Khosravi, Eghbaleh Asadollahy Ilam University of Medical Sciences, Iran E-mail addresses: [email protected] (A. Khosravi), [email protected] (E. Asadollahy) Introduction: Amodiaquine (AQ) is one of the famous derivatives of 4-aminoquinoline antimalarial drug which is effectively used against many chloroquine-resistant strains of P. falciparum. As wide application of this drug can cause serious side effects such as hepatotoxicity, it cannot be used as a routine antimalarial medication in clinics. As such, synthesis of some derivatives of keeping the effective impact of it on plasmodium and without the amodiaquine-related complications can be necessary. The aim of the current study was to chemically synthesize the novel chloro and fleuro amodiaquine derivatives and evaluating their effects on plasmodium falciparum.