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Effects of caffeine and taurine in combination with caffeine on selective attention
Abstracts / Clinical Neurophysiology 126 (2015) e173–e184
In inherited polyneuropathies, CPK levels are within normal values. Recently, hereditary peripheral sensomotor axonal, autosomal recessive polyneuropathy, associated with neuromyotonia (HINT1 polyneuropathy) has been recognized. Frequency and levels of hyper-CPK determination in HINT1 polyneuropatahy were examined in 31 patients (11 male/20 female), with HINT1 polyneuropathy and founder R37P mutation in HINT1gene. Elevated CPK levels (183–1170 IU/L) were found in HINT1 polyneuropathy patients. Levels >500 IU/L were found in generalized myothonia patients. Elevated CPK blood levels may be a direct consequence of electrophysiologically confirmed generalized neuromyotonia. Electromyography with nerve conduction study is very important for recognition of axonal polyneuropathy with neuromyotonia, in differential diagnosis of myotonic dystrophy and other myotonic disorders. doi:10.1016/j.clinph.2015.04.043
Effects of caffeine and taurine in combination with caffeine on selective attention—M. Nešic´ a, D. Lovic´ a, J. Mitic´ a, M. Stankovic´ b (a Medical Faculty, University of Niš, Serbia, b Faculty of Philosophy, University of Niš, Serbia) The aim of this study was to compare the effects of caffeine, caffeine-taurine combination and placebo on selective attention. The sample consisted of 26 medical students, an equal number of females and males. The study was performed as a single-blind trial, using the Latin square design. The students solved PEBL Stroop test, which tested interference effects between different types of information: color and word. The students completed Spielberger’s test of anxiety (STAI Y). General linear model with repeated measures showed that reaction times for consistent, conflict and single feature stimulus conditions were significantly different (F(27.395) = 1.910, p = 0.005) under the different experimental condition. Univariate Tests showed the effects of caffeine (F = 3.793, p = 0.026) and combination of caffeine and taurine (F = 3.162, p = 0.056), but did not find effects of placebo condition (F = 0.808, p = 0.503) for different Stroop tasks. The effect of treatment was found for consistent, conflict and single feature condition, either for name or color condition, but facilitation and cost effects were found only for color condition. The trait and state anxiety did not have effects on selective attention. Caffeine individually, as well as combined with taurine showed different effects on selective attention compared to placebo condition.
e183
The EEG BA were found in 262 (51.3%) cases, significantly higher than expected in healthy children. The cases with BA were on average 9.2 year old at assessment compared to 9.5 year (the cases without BA) and had more often girls (59.1% vs. 48.8%). Initial positive response to MPH was similar (82% vs. 79%) as the use of MPH at one-year follow-up. No statistical differences were found between the groups with respect to age, gender or the use of MPH respectively. The EEG BA occur more often in ADHD children than in healthy children. Children with and without BA did not differ with respect to age, gender, and the use of MPH during one year follow-up. doi:10.1016/j.clinph.2015.04.045
Retinal nerve fiber layer thickness and multifocal visual evoked potentials in optic neuritis associated with multiple sclerosis – A ˇ olic´ a, S. Kostic´ a, case study—A. Pantovic´ a, R. Raicˇevic´ a, S. C b a a a B. Draganic´ , M. Vranic´ , E. Dincˇic´ ( Neurology Clinic, Military Medical Academy, Faculty of Medicine, University of Defence, Belgrade, Serbia, b Ophtalmology Clinic, Military Medical Academy, Faculty of Medicine, University of Defence, Belgrade, Serbia) Comparasion between the retinal nerve fiber layer (RNFL) thickness with latency delay of the multifocal visual evoked potential (mfVEP) in patients with multiple sclerosis (MS) was done. The measurements were determined among eyes with clinical signs of optic neuritis, without clinical signs of optic neuritis and eyes of healthy control. Total RNFL thickness, detectable by optic coherence tomography (OCT), and latency of the mfVEP were measured and analyzed in patients with relapse remitting MS. Comparation was assessed among 9 eyes (group I) with clinical signs of optic neuritis and 11 eyes (group II) without signs of optic neuritis in 10 patients with relapsing remitting MS and 8 eyes (group III) in 4 patients as healty control. The mean value of total RNFL thickness was reduced in eyes with or without signs of optic neuritis in comparison to control eyes. There is different level of total RNFL thickness reduction between group I and group II in comparison to control-group III. The latency of P(100) was delayed in eyes with and without signs of optic neuritis in comparison to controls. There are different levels of differences in RNFL thickness and latency delay mfVEP between eyes in patients with clinical signs of optic neuritis, without clinical signs of optic neuritis and control. doi:10.1016/j.clinph.2015.04.046
doi:10.1016/j.clinph.2015.04.044
Do EEG background abnormalities at ADHD assessment influence the use of methylphenidate for ADHD?—D. Socanski, A. Herigstad (Stavanger University Hospital, Stavanger, Norway) We investigated whether the occurrence of electroencephalography (EEG) background abnormalities (BA) at the attention-deficit/hyperactivity disorder (ADHD) assessment influenced the use of methylphenidate (MPH) during one-year follow-up. In our study, subjects were 517 ADHD children (82.4% male), aged between 5 and 14 years who were diagnosed between January 2000 and December 2005. EEG findings were coded as either EEG with or without BA. We compared age, sex, initial positive response to MPH treatment and the use of MPH at one year in cases with and without BA.
Painful monoparesis of the aim caused by plexopathy in unrecognised diabetes mellitus—R. Popovic´, D. Obradovic´, V. Martic´, R. Raicˇevic´ (Neurology Clinic, Military Medical Academy Faculty of Medicine, University of Defence, Belgrade, Serbia) We present a case of acute onset of the right arm monoparesis combined with moderate pain in the neck and right arm in a patient with diabetes. We present a case of 74-years old man who was admitted to Emergency Department of Military Medical Academy complaining of moderate pain and weakness of the right arm. Symptoms appeared night before admission, woke him up. Risk factors presented in our patient were obesity, smoking, hypertension. No previous history of elevated blood sugar. Neurological examination showed moderate weakness in several muscle groups in right arm, most notable right hand grip weakness. In laboratory findings
In inherited polyneuropathies, CPK levels are within normal values. Recently, hereditary peripheral sensomotor axonal, autosomal recessive polyneuropathy, associated with neuromyotonia (HINT1 polyneuropathy) has been recognized. Frequency and levels of hyper-CPK determination in HINT1 polyneuropatahy were examined in 31 patients (11 male/20 female), with HINT1 polyneuropathy and founder R37P mutation in HINT1gene. Elevated CPK levels (183–1170 IU/L) were found in HINT1 polyneuropathy patients. Levels >500 IU/L were found in generalized myothonia patients. Elevated CPK blood levels may be a direct consequence of electrophysiologically confirmed generalized neuromyotonia. Electromyography with nerve conduction study is very important for recognition of axonal polyneuropathy with neuromyotonia, in differential diagnosis of myotonic dystrophy and other myotonic disorders. doi:10.1016/j.clinph.2015.04.043
Effects of caffeine and taurine in combination with caffeine on selective attention—M. Nešic´ a, D. Lovic´ a, J. Mitic´ a, M. Stankovic´ b (a Medical Faculty, University of Niš, Serbia, b Faculty of Philosophy, University of Niš, Serbia) The aim of this study was to compare the effects of caffeine, caffeine-taurine combination and placebo on selective attention. The sample consisted of 26 medical students, an equal number of females and males. The study was performed as a single-blind trial, using the Latin square design. The students solved PEBL Stroop test, which tested interference effects between different types of information: color and word. The students completed Spielberger’s test of anxiety (STAI Y). General linear model with repeated measures showed that reaction times for consistent, conflict and single feature stimulus conditions were significantly different (F(27.395) = 1.910, p = 0.005) under the different experimental condition. Univariate Tests showed the effects of caffeine (F = 3.793, p = 0.026) and combination of caffeine and taurine (F = 3.162, p = 0.056), but did not find effects of placebo condition (F = 0.808, p = 0.503) for different Stroop tasks. The effect of treatment was found for consistent, conflict and single feature condition, either for name or color condition, but facilitation and cost effects were found only for color condition. The trait and state anxiety did not have effects on selective attention. Caffeine individually, as well as combined with taurine showed different effects on selective attention compared to placebo condition.
e183
The EEG BA were found in 262 (51.3%) cases, significantly higher than expected in healthy children. The cases with BA were on average 9.2 year old at assessment compared to 9.5 year (the cases without BA) and had more often girls (59.1% vs. 48.8%). Initial positive response to MPH was similar (82% vs. 79%) as the use of MPH at one-year follow-up. No statistical differences were found between the groups with respect to age, gender or the use of MPH respectively. The EEG BA occur more often in ADHD children than in healthy children. Children with and without BA did not differ with respect to age, gender, and the use of MPH during one year follow-up. doi:10.1016/j.clinph.2015.04.045
Retinal nerve fiber layer thickness and multifocal visual evoked potentials in optic neuritis associated with multiple sclerosis – A ˇ olic´ a, S. Kostic´ a, case study—A. Pantovic´ a, R. Raicˇevic´ a, S. C b a a a B. Draganic´ , M. Vranic´ , E. Dincˇic´ ( Neurology Clinic, Military Medical Academy, Faculty of Medicine, University of Defence, Belgrade, Serbia, b Ophtalmology Clinic, Military Medical Academy, Faculty of Medicine, University of Defence, Belgrade, Serbia) Comparasion between the retinal nerve fiber layer (RNFL) thickness with latency delay of the multifocal visual evoked potential (mfVEP) in patients with multiple sclerosis (MS) was done. The measurements were determined among eyes with clinical signs of optic neuritis, without clinical signs of optic neuritis and eyes of healthy control. Total RNFL thickness, detectable by optic coherence tomography (OCT), and latency of the mfVEP were measured and analyzed in patients with relapse remitting MS. Comparation was assessed among 9 eyes (group I) with clinical signs of optic neuritis and 11 eyes (group II) without signs of optic neuritis in 10 patients with relapsing remitting MS and 8 eyes (group III) in 4 patients as healty control. The mean value of total RNFL thickness was reduced in eyes with or without signs of optic neuritis in comparison to control eyes. There is different level of total RNFL thickness reduction between group I and group II in comparison to control-group III. The latency of P(100) was delayed in eyes with and without signs of optic neuritis in comparison to controls. There are different levels of differences in RNFL thickness and latency delay mfVEP between eyes in patients with clinical signs of optic neuritis, without clinical signs of optic neuritis and control. doi:10.1016/j.clinph.2015.04.046
doi:10.1016/j.clinph.2015.04.044
Do EEG background abnormalities at ADHD assessment influence the use of methylphenidate for ADHD?—D. Socanski, A. Herigstad (Stavanger University Hospital, Stavanger, Norway) We investigated whether the occurrence of electroencephalography (EEG) background abnormalities (BA) at the attention-deficit/hyperactivity disorder (ADHD) assessment influenced the use of methylphenidate (MPH) during one-year follow-up. In our study, subjects were 517 ADHD children (82.4% male), aged between 5 and 14 years who were diagnosed between January 2000 and December 2005. EEG findings were coded as either EEG with or without BA. We compared age, sex, initial positive response to MPH treatment and the use of MPH at one year in cases with and without BA.
Painful monoparesis of the aim caused by plexopathy in unrecognised diabetes mellitus—R. Popovic´, D. Obradovic´, V. Martic´, R. Raicˇevic´ (Neurology Clinic, Military Medical Academy Faculty of Medicine, University of Defence, Belgrade, Serbia) We present a case of acute onset of the right arm monoparesis combined with moderate pain in the neck and right arm in a patient with diabetes. We present a case of 74-years old man who was admitted to Emergency Department of Military Medical Academy complaining of moderate pain and weakness of the right arm. Symptoms appeared night before admission, woke him up. Risk factors presented in our patient were obesity, smoking, hypertension. No previous history of elevated blood sugar. Neurological examination showed moderate weakness in several muscle groups in right arm, most notable right hand grip weakness. In laboratory findings