Effects of dexfenfluramine and fluoxetine on weight loss among female carbohydrate cravers

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ABSTRACTS

Effects of dexfenfluramine and fluoxetine on weight loss among female carbohydrate cravers. J. WURTMAN, R. WURTMAN, E. BERRY, R. GLEASON, H. GOLDBERG, J. McDERMOlT, M. KAHNE and R. TSAY. Department of Brain and Cognitive Science, MIT Cambridge, MA 02116, U.S.A.

To examine serotonin’s role in CHO intake of obese female snack cravers, subjects were treated with dexfenfluramine (DF 30 mg), fluoxetine (FL 60mg) or placebo (PL). Weekly weight loss for the 25 (of 29) PL completers was 0.22 kgf0.06; for the 21 (of 28) DF completers, 0.56 kg kO.08 kg and for the 18 (of 30) FL completers: 0.58 f0.09 (PL DF = FL, p = 0.039). DF and FL treatment were associated with significantly greater decreases in CHO snack intake than placebo (p