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Effects of normal aging on brain atrophy of Japanese—A preliminary result from the Japanese human brain project
NeuroImage
11, Number
5, 2000,
Part 2 of 2 Parts ID
E al*
PHYSIOLOGY
Effects of Normal Aging on Brain Atrophy of JapaneseA Preliminary Result from the Japanese Human Brain Project Ryuta Kawashima*t,
Kaztm& St&?, Kazuya K tmekawa*, Kenji Yamada+, Hiroshi Fukuda*t
Kazuhito Shida*,
*Aoba Brain Imaging Research Center, TAO, Sendai, Japan ?IDAC, Tohoku University, Sendai, Japan Qendai Kose Hospital, Sendai, Japan The aim of the present hemispheres, and to create each gender.
study was to investigate the effects of normal ageing the Japanese standard brain of different age groups of
on regional
variability
in shape
of cerebral
Methods We studied the hemispheric shape using 3-D reconstructions from contiguous sequences of magnetic resonance images (GE-Yokogawa Signa OST; SPGR TR 40 ms, TE 7 ms, FA 30; matrix 256 x 256 x 128; voxel size 1.0 x 1.0 x 1.5 mm) of 45 male (age: 20 - 79) and 45 female (age: 20 - 78) right-handed Japanese normal subjects. After linear transformations and spatial smoothing of the 3-D data sets, SPMs showing correlation between MRI signals and subject’s age were calculated. In addition, average brain MRIs of different age groups of each gender were created. Results
and Conclusion
The Japanese males have wider and longer brain than females. The statistically significant negative correlation was observed in the fronto-parietal cortex, temporal cortex and the paraventricular area of the bilateral hemispheres for each gender. In addition, only males showed statistically significant negative correlation in the medial aspect of the frontal cortex, and only females showed significant negative correlation in the cortex lining in the lateral sulcus of the bilateral hemisphere (Figure 1). The results indicate that these brain regions showed brain atrophy during normal aging, and that gender differences in course of normal brain aging may exist.
s794
11, Number
5, 2000,
Part 2 of 2 Parts ID
E al*
PHYSIOLOGY
Effects of Normal Aging on Brain Atrophy of JapaneseA Preliminary Result from the Japanese Human Brain Project Ryuta Kawashima*t,
Kaztm& St&?, Kazuya K tmekawa*, Kenji Yamada+, Hiroshi Fukuda*t
Kazuhito Shida*,
*Aoba Brain Imaging Research Center, TAO, Sendai, Japan ?IDAC, Tohoku University, Sendai, Japan Qendai Kose Hospital, Sendai, Japan The aim of the present hemispheres, and to create each gender.
study was to investigate the effects of normal ageing the Japanese standard brain of different age groups of
on regional
variability
in shape
of cerebral
Methods We studied the hemispheric shape using 3-D reconstructions from contiguous sequences of magnetic resonance images (GE-Yokogawa Signa OST; SPGR TR 40 ms, TE 7 ms, FA 30; matrix 256 x 256 x 128; voxel size 1.0 x 1.0 x 1.5 mm) of 45 male (age: 20 - 79) and 45 female (age: 20 - 78) right-handed Japanese normal subjects. After linear transformations and spatial smoothing of the 3-D data sets, SPMs showing correlation between MRI signals and subject’s age were calculated. In addition, average brain MRIs of different age groups of each gender were created. Results
and Conclusion
The Japanese males have wider and longer brain than females. The statistically significant negative correlation was observed in the fronto-parietal cortex, temporal cortex and the paraventricular area of the bilateral hemispheres for each gender. In addition, only males showed statistically significant negative correlation in the medial aspect of the frontal cortex, and only females showed significant negative correlation in the cortex lining in the lateral sulcus of the bilateral hemisphere (Figure 1). The results indicate that these brain regions showed brain atrophy during normal aging, and that gender differences in course of normal brain aging may exist.
s794