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Effects of regional guanethidine infusion in certain painful states
ABSTRACTS
221
may be a contributing factor in the pathogenesis of hemiparesis.--Th. Angerpointner
A Study of Childhood Renal Tumors Using Xenogeneic A n t i s e r u m . S. Kumar, H. B. Marsden, and P. Kumar. Br J
Urol 52:245-252, 1980. Effects of Regional Guanethidine Infusion in Certain Painful S t a t e s . L. Loh, P. HI. Nathan, G. D. Schott, et al. J Neurol
Neurosurg Psychiatr 43:446-451, (May), 1980. Guanethidine was infused by the regional intravenous technique into upper and lower limbs of patients with painful hyperpathic states, due to peripheral or central lesions. Vasodilatation developed gradually. Pain was relieved for 3-128 hours. Six of the 30 patients have had relief for six months or more. The exact mode of action is unknown, but various possibilities are discussed.--R. J. Brereton NEOPLASMS Results of Surgical Staging in Hodgkin's Disease. P. G. Gill,
R. G. Souter, and P. G. Morris. Br J Surg 67:478-481, (July), 1980. The results of surgical staging in Hodgkin's disease in 107 patients are presented. Forty three per cent of patients had their disease stage altered by surgical staging. This was achieved with no mortality and with low morbidity. Spleen size was not an indication of involvement and splenic involvement was found in the absence of nodal involvement in 6 patients. Lymphangiogram was not a good general indicator of abdominal disease--false positive (6 percent) and false negative (25 percent) interpretations occurred. The authors conclude that at present surgical staging forms an essential part in the overall staging of management of patients with Hodgkin's disease.--Lewis Spitz Neoplasms Associated With Hemihypertrophy. BeckwithWiedemann Syndrome and Aniridia. E. S. Tank and R.
Kay. J Urol 124:266-268, (August), 1980. Four infants and children are described with nephroblastoma in combination with hemihypertrophy. These conditions also are associated with Beckwith-Wiedemann syndrome, adrenocortical carcinoma, aniridia and nodular renal blastema. Optimally, these anomalies should be detected at birth. Surveillance should include a careful physical examination every three months until the patient is 15 years old. An IVP is recommended at the discovery of the congenital abnormalities and every six months thereafter until the patient is seven years of age, then at yearly intervals. Also, annual liver function tests, liver-spleen scans and serum alpha-fetoprotein evaluations should be done for early detection of hepatocellular carcinoma.--George Holcomb, Jr.
The authors described a method of producing xenogeneic anti-Wilms' antiserum prepared by injecting Wilms' tumor extracts into 6-month-old rabbits which had been made tolerant in utero by injecting pooled normal kidney extracts. Mesoblastic nephroma and 94% of the tubular Wilms' tumors produced positive fluorescent staining of the tubules by the antiserum. The non-tubular Wilms' and renal carcinomas produced a diffuse fluorescent staining. Six of the 7 bone metastasising renal tumors of childhood did not fluoresce when treated with the antiserum. The one with positive staining did this only in isolated focal areas. The authors have therefore suggested that this tumor with its markedly worse prognosis than Wilms' tumor has a different origin from the other childhood renal tumors. They have also identified a new oncofetal antigen (oncofetal Wilms' antigen) present in the majority of Wilms' tumors, especially the tubular variety and in 9 and 10 week old but no older fetal kidneys.--Andrew Wong
N e c r o s i s of W i l m s T u m o r s . G. F. Gates, J. H. Miller, and P. Stanley. J Urol 123: 916-920, (June), 1980.
Gray scale ultrasonography, arteriography and excretory urography were done in 17 children with Wilms tumor. The results of these studies were correlated with the pathological specimen. At the time of operation 71% of the tumors were necrotic. Ultrasonography predicted correctly the internal consistency of Wilms tumors in 94% of the cases, while arteriography was 64 percent and excretory urography was 41% accurate. This information regarding neoplastic degeneration added to the completeness of the radiographic examination and forewarned the surgeon of a potentially difficult resection.--George Holcomb, Jr,
Intestinal Obstruction as a Late Complication in Roentgen Therapy of Wilms' Tumor. A. Marcihski. K. Wermehski, J.
Swiatkowska, et al. Z Kinderchir 29/4: 375-377, 1980. Tumor irradiation may result in damage of intraabdominal organs. The authors describe an obstruction of the descending colon 4 years after irradiation of a Wilms' tumor. Additionally, maldevelopment of the vertebral columns, trophic changes of the skin and a marked dysplasia of the left flank within the irradiation field were observed. The stricture of the left colon was due to a fibrosis of the bowel wall and extensive adhesions.--Th. Angerpointner
221
may be a contributing factor in the pathogenesis of hemiparesis.--Th. Angerpointner
A Study of Childhood Renal Tumors Using Xenogeneic A n t i s e r u m . S. Kumar, H. B. Marsden, and P. Kumar. Br J
Urol 52:245-252, 1980. Effects of Regional Guanethidine Infusion in Certain Painful S t a t e s . L. Loh, P. HI. Nathan, G. D. Schott, et al. J Neurol
Neurosurg Psychiatr 43:446-451, (May), 1980. Guanethidine was infused by the regional intravenous technique into upper and lower limbs of patients with painful hyperpathic states, due to peripheral or central lesions. Vasodilatation developed gradually. Pain was relieved for 3-128 hours. Six of the 30 patients have had relief for six months or more. The exact mode of action is unknown, but various possibilities are discussed.--R. J. Brereton NEOPLASMS Results of Surgical Staging in Hodgkin's Disease. P. G. Gill,
R. G. Souter, and P. G. Morris. Br J Surg 67:478-481, (July), 1980. The results of surgical staging in Hodgkin's disease in 107 patients are presented. Forty three per cent of patients had their disease stage altered by surgical staging. This was achieved with no mortality and with low morbidity. Spleen size was not an indication of involvement and splenic involvement was found in the absence of nodal involvement in 6 patients. Lymphangiogram was not a good general indicator of abdominal disease--false positive (6 percent) and false negative (25 percent) interpretations occurred. The authors conclude that at present surgical staging forms an essential part in the overall staging of management of patients with Hodgkin's disease.--Lewis Spitz Neoplasms Associated With Hemihypertrophy. BeckwithWiedemann Syndrome and Aniridia. E. S. Tank and R.
Kay. J Urol 124:266-268, (August), 1980. Four infants and children are described with nephroblastoma in combination with hemihypertrophy. These conditions also are associated with Beckwith-Wiedemann syndrome, adrenocortical carcinoma, aniridia and nodular renal blastema. Optimally, these anomalies should be detected at birth. Surveillance should include a careful physical examination every three months until the patient is 15 years old. An IVP is recommended at the discovery of the congenital abnormalities and every six months thereafter until the patient is seven years of age, then at yearly intervals. Also, annual liver function tests, liver-spleen scans and serum alpha-fetoprotein evaluations should be done for early detection of hepatocellular carcinoma.--George Holcomb, Jr.
The authors described a method of producing xenogeneic anti-Wilms' antiserum prepared by injecting Wilms' tumor extracts into 6-month-old rabbits which had been made tolerant in utero by injecting pooled normal kidney extracts. Mesoblastic nephroma and 94% of the tubular Wilms' tumors produced positive fluorescent staining of the tubules by the antiserum. The non-tubular Wilms' and renal carcinomas produced a diffuse fluorescent staining. Six of the 7 bone metastasising renal tumors of childhood did not fluoresce when treated with the antiserum. The one with positive staining did this only in isolated focal areas. The authors have therefore suggested that this tumor with its markedly worse prognosis than Wilms' tumor has a different origin from the other childhood renal tumors. They have also identified a new oncofetal antigen (oncofetal Wilms' antigen) present in the majority of Wilms' tumors, especially the tubular variety and in 9 and 10 week old but no older fetal kidneys.--Andrew Wong
N e c r o s i s of W i l m s T u m o r s . G. F. Gates, J. H. Miller, and P. Stanley. J Urol 123: 916-920, (June), 1980.
Gray scale ultrasonography, arteriography and excretory urography were done in 17 children with Wilms tumor. The results of these studies were correlated with the pathological specimen. At the time of operation 71% of the tumors were necrotic. Ultrasonography predicted correctly the internal consistency of Wilms tumors in 94% of the cases, while arteriography was 64 percent and excretory urography was 41% accurate. This information regarding neoplastic degeneration added to the completeness of the radiographic examination and forewarned the surgeon of a potentially difficult resection.--George Holcomb, Jr,
Intestinal Obstruction as a Late Complication in Roentgen Therapy of Wilms' Tumor. A. Marcihski. K. Wermehski, J.
Swiatkowska, et al. Z Kinderchir 29/4: 375-377, 1980. Tumor irradiation may result in damage of intraabdominal organs. The authors describe an obstruction of the descending colon 4 years after irradiation of a Wilms' tumor. Additionally, maldevelopment of the vertebral columns, trophic changes of the skin and a marked dysplasia of the left flank within the irradiation field were observed. The stricture of the left colon was due to a fibrosis of the bowel wall and extensive adhesions.--Th. Angerpointner