Efficacy observation on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan (, Extra) acupoint

Efficacy observation on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan (, Extra) acupoint

ELSEVIER World Journal ofAcupuncture-Moxibustion (WJAM) Vol. 23, No.4, 30th Dec. 2013 • 15 • Clinical Research Efficacy observation on herpes zost...

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ELSEVIER

World Journal ofAcupuncture-Moxibustion (WJAM) Vol. 23, No.4, 30th Dec. 2013

• 15 •

Clinical Research

Efficacy observation on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan (11"&, Extra) acupoint

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450008, 9='00; 2. ~fN*~jjl.li~mI~~#ffd4; 3.

9='00)d~~fint~jjlI539='JL'~~)

ARTICLE INFO

ABSTRACT

First author: SHIVue (1958-), male, Chief

Objective To observe the analgesic effect on herpes zoster treated by the

physician.

comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan (:ft~lt Extra) acupoint. Methods According to the random mumber table, 104 cases of herpes zoster were randomized into an observation group and a control group, 52 cases in each one. In the observation group, the blocking method was used at the starting site and the ending site of herpetic zone, the surrounding needling method was applied toward the center of the painful zone, with horizontal needling technique; and the local pricking and cupping methods as well as the bloodletting at Longyan (Extra) acupoint were adopted. In the control group, Jiaji (~lf EX-B 2) at the corresponding affected nerve segments and the local Ashi points were selected and stimulated with electroacupuncture. The visual analogue scale (VAS) was adopted to determine the analgesic effect 20 min, 1, 6, 12, 24 and 48 h after treatment separately in each group. Results The onset time of analgesic effect in the observation group was shorter than that in the control group and the efficacy time of duration was longer than that in the control group (all P<0.05). The analgesic effect and the result of comprehensive efficacy assessment were superior to those of the control group (both P<0.05). Conclusion The comprehensive therapy of blocking, surrounding needling, pricking and cupping method combined with bloodletting at Longyan (Extra) achieves the significant analgesic effect on herpes zoster.

Researchfield: impacts of acupuncture and moxibustion on clinical treatment of pain and

zang-fu functions.

E-mail: [email protected] Accepted on August 8, 2013

KEY WORDS: herpes zoster; blocking; surrounding needling; pricking and cupping; bloodletting; Longyan (:ft~i Extra) acupoint; analgesia

Herpes zoster (HZ) is the acute inflammatory skin disease induced by varicella-zoster virus (VZV), characterized as acute onset, blister-like pimples, intensive clustering, unilateral invasion, along-nerve distribution, complicated with sharp pain. A part of patients complain with neuropathic pain-postherpetic

neuralgia (PHN) after healing of skin lesion [I], especially in the elderly. It results in violent pain and seriously disturbs the life quality of the patients. In recent years, the authors adopted the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan

WorldJournal ofAcupuncture-Moxibustion (WJAM) Vol. 23, No.4, 30th Dec. 2013

• 16 •

ELSEVIER

(:Jt~~, Extra) acupoint in the treatment of HZ. The report is as follows.

herpetic zone, :Jt~)[3l and Ashi points.

CLINICAL DATA

Manipulation: the patient was in a comfortable position. After iodine sterilization, the needles, 0.35 mmX40 mm in size, were used to puncture horizontally Longtou and Longwei, 20-25 mm in depth. Additionally, the surrounding needling technique was applied toward the center of the painful area with horizontal puncture, 20-25 mm in depth. After the arrival of qi, the needles were rotated swiftly for I min with even needling technique. The needles were manipulated once every 10 min and retained for 20 min.

General data One hundred and four cases of HZ were from the outpatients of the Fifth Affiliated Hospital of Zhengzhou University. Of them, 45 cases were male, 59 cases were female, aged from 23 to 73 years. According to the random number table, they were divided into an observation group and a control group, 52 cases in each one. In the statistical management, the difference in sex, age, duration of sickness and the results of visual analogue scale (VAS) were not significant before treatment (P>0.05), indicating the comparability between the two groups (Table I). Table 1 Comparison of the general data of HZ patients between the two groups Sex (cases)

Age (X±s, years)

Duration VAS(X±s, of sickness (X±s, days) scores)

Groups

Patients

Observation

52

24

28

54.8±12.6

3.5±1.6

6.31±1.6

Control

52

21

31

53.3±12.9

3.5±1.6

6.12±1.5

Female Male

Diagnostic criteria In reference to Practical Dermatology'", the diagnostic standard of HZ was drafted: a cluster of blisters in the local affected skin, belt-like and alongnerve distribution on one side of body, combined with obvious neuralgia; local lymph node enlargement and skin paresthesia at the early stage; general symptoms for individual patients such as fever and general malaise.

Inclusive criteria The cases should be in compliance with the standard of HZ, herpes were found for 1-7 days, 4 scores or over 4 scores in VAS, and no medication or other therapeutic program involved in recent time.

Exclusive criteria

CD In pregnancy, or in menstruation and cancer; ® allergic constitution and those who had hemorrhagic

disease; ® severe heart and kidney dysfunction, mental disorders.

METHODS Observation group

(2) Pricking and cupping method and bloodletting at Longyan (Extra) acupoint [4] After needles withdrawal and routine sterilization, the disposable blood lancet was used to prick herpes and skin around to cause slightly bleeding and the cupping method was followed immediately and the cups were retained for 5-8 min to get yellowish liquid and blood. After cups removal, the local area was dried up with dry cotton and sterilized with iodine. During cups retaining, the three-edged needle was used to prick Longyan (Extra) acupoint on the affected side. This point is located between the 2nd and 3rd joints on the ulnar side of the small finger, at the end of transverse crease when a fist is made. After the local routine sterilization, the physician held the sterilized three-edged needle to prick the point and squeeze it to get 2-3 drops of blood or yellowish thick liquid. The treatment was given once every 2 days. Ten treatments made I session. The efficacy was observed after I treatment.

Control group Jiajl (~~ EX-B 2) of the affected nerve segments and local Ashi points were selected. The needles, 0.35 mm X 40 mm in size, were used to puncture the points, 20-25 mm in depth. After the arrival of qi, the electric stimulation was attached with disperse-dense wave and tolerable intensity. The needles were retained for 20 min. The treatment was given once every 2 days. Ten treatments made I session. The efficacy was observed after I treatment.

Observation indices (1) Analgesic effect assessment

(I) Blocking and surrounding needling methods Point selection: Longtou (the starting site of herpetic zone, :Jt~), Longwei (the ending site of

VAS score was graded 20 min, I, 6, 12, 24 and 48 h after treatment separately to evaluate the degree of pain. 0 score: no pain, 10 scores: the worst pain.

ELSEVIER

WorldJournal ofAcupuncture-Moxibustion (WJAM) Vol. 23, No.4, 30th Dec. 2013

• 17 • Table 3 Comparison of efficacy 1 h after treatment in HZ patients between the two groups Case (%)

Improvement in pain=(pain score before treatment - pain score after treatment) / pain score before treatment X 100% (2) Efficacy assessment Remarkably effective: improvement in pain >60%; Effective: improvement in pain 30%-60%; Failed: improvement in pain <30%.

Statistical analysis SPSS 13.0 statistical software was adopted. The measurement data in each group were expressed as mean±standard deviation (x±s). The paired t-test was used for the comparison between the two groups. Chi-squared test was adopted for the comparison of the clinical effect. P<0.05 indicated the statistically significant difference.

RESULTS Comparison of analgesic effect between the two groups Table 2 indicated that the analgesic effect was the most obvious 1 h after treatment in the two groups. Concerning to the improvements in pain at each time point, the differences were significant statistically between the two groups (P<0.05). It was shown that the analgesic effect at each time point of the observation group was superior to that of the control group.

Comparison of efficacy between the two groups Table 3 showed that the total effective rate was 96.2% I h after treatment in the observation group and was 84.6% in the control group . .1=6.359, P<0.05 in comparison between the two groups. The efficacy in the observation group was better than that in the control group. The difference in the total effective rate at the rest time points were not significant between the two groups (all P>0.05).

DISCUSSION TCM thinks that HZ is differentiated as heat pattern/syndrome and caused by heat stagnation in the Liver Meridian, damp retention due to spleen deficiency, qi deficiency and blood stagnation. Table 2

Groups

P ti ts Remarkably Effi ti a en effective ec ve

Total effective rate

Failed

Observation

52

13 (25.0)

37 (71.2)

2 (3.9)

Control

52

5 (9.6)

39 (75.0)

8 (15.4)

96.2%1) 84.6%

Note: compared with that in the control group, I) P<0.05.

Deficiency of qi and blood is Ben, the heat toxin and blockage of stasis in the collateral is Biao. Damp heat in the liver and gallbladder and internal retention of damp in the spleen are the substantial of the disease [5]. The modem medicine believes that this virus invades the body via the respiratory tract and causes a kind of viral skin disease manifested as herpes in cluster and neuralgia. This virus is incubated initially in the dorsal root ganglion of spinal nerve or the other nerve cells at the affected site. When the human body immunity is declined, the incubated virus will be activated and neuralgia will happen. In the treatment, blocking Longtou and Longwei at the affected site is the approach to cut the spreading of disease and control the progression. The local surrounding needling technique promotes the local qi and blood circulation, repairs the damaged nervous tissue, blocks the further damage of virus to nerve and achieves analgesia and anesthesia [6]. TCM has early recorded the mechanism of pain in Neijing: Jutonglun ( «I*J ~.~~~», Classic of Internal Medicine: Treaties on Pain). It emphasizes that disturbance of qi and blood circulation is the substance of the pathological change of pain pattern/syndrome. Hence, "taking the pain site as the acupoint" was followed in treatment, and the local acupuncture or bloodletting method was adopted. Lingshu: Jiuzhen Shier Yuan «3Z~. iLtf+=J*», Miraculous Pivot: Nine Needles and Twelve Primary Points) said: "reinforcing is for deficiency, reducing for excess, and removing for stagnation". In the treatment, bloodletting method on the skin and herpes eliminated the toxic heat directly from the interior. Cupping method removed the local stagnant toxin and stasis. Eventually, the disease was controlled, the herpes were dried up, neuralgia was removed and the duration of sickness was shortened [7]. Longyan acupoint [8] is the extraordinary point, belongs to the Small Intestine Meridian of HandTaiyang. It acts on reducing heat, removing damp,

(

Comparison of the improvement in pain at each time point in HZ patients between the two groups Ih

(X±s, %)

Groups

Patients

20 min

6h

12h

24h

48h

Observation

52

32.30±8.l1 ')

52.13±10.29 1)

33.71±7.661)

29.70±6.43 1)

22.39±5.95 1)

14.83±4.441)

Control

52

21.16±7.l0

43.25±10.49

24.79±7.58

18.10±6.58

11.38±5.62

6.04±4.09

Note: compared with that in the control group,

I)

P<0.05.

World Journal ofAcupuncture-Moxibustion (WJAM)

• 18 •

Vol. 23, No.4, 30th Dec. 2013

activating blood circulation and resolving stasis in acupuncture. The Small Intestine Meridian is related to the Heart Meridian externally and internally. The Heart Meridian belongs to fire and dominates blood and vessels. Bloodletting method at Longyan (Extra) acupoint reduced heart fire and cleared away blood heat. Bloodletting method can remove the stagnation of blood and promote the circulation in collaterals according to "removing for stagnation". Hence, it is the unique therapy in treatment of HZ. In the entire treatment, this comprehensive therapy did not induce adverse reactions. It resulted in the short duration of sickness, quick effect, good analgesic effect and extremely less PHN.

REFERENCES [1]

[2]

Wang LQ. Seventy-eight cases of herpes zoster treated with acupuncture. Tradit Chin Med Res (Chin) 2008; 21 (5): 45-46. Liu FR. Practical Dermatology (Chin). 3rd edition. Beijing: People's Medical Publishing House; 2005: 208.

[3]

[4]

[5]

[6]

[7]

[8]

ELSEVIER

Jin J, Zhou YJ. Thirty-three cases of herpes zoster treated with Longyan (1tN~ Extra) acupoint combined with blocking method. Guangming J Chin Med (Chin) 2011; 26(8): 1647. Zhang JY. WANG Le-ting's Experience Collection of Application of Golden Needle (Chin). Beijing: People's Medical Publishing House; 2004: 215. State Administration of Traditional Chinese Medicine. Standard of Diagnosis and Efficacy on the Disorders of Traditional Chinese Medicine (Chin). Nanjing: Nanjing University Press; 1994: 144. Tan XH, Liu HT, Wang LY, Wei D. Thirty cases postherpetic neuralgia treated with herbal-thread moxibustion combined with electric therapy of surrounding needling. J ClinAcup-Mox (Chin) 2009; 25(4): 33-34. Ouyang Q, Wei ZJ, Hou YL. Herpes zoster treated with bloodletting therapy combined with ultraviolet irradiation. Chin Acup-Mox (Chin) 2009; 29 (4): 285-288. Yuan ZT. Fifty-seven cases herpes zoster treated with acupuncture at Longyan (1tN~ Extra) acupoint. Shanghai J Acup-Mox (Chin) 2008; 27 (5): 7. (Editor: HANYan-jing Translator: WANGFang)

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