- Email: [email protected]
Einhorn of the Einhorn string test
10 WITT ET AL.
GASTROENTEROLOGY Vol. 117, No. 1
3. DiMagno EP, Layer P, Clain JE. Chronic pancreatitis. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, eds. The pancreas: biology, pathobiology, and disease. New York: Raven, 1993:665–706. 4. Comfort MW, Steinberg AG. Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterology 1952;21: 54–63. 5. Whitcomb DC, Preston RA, Aston CE, Sossenheimer MJ, Barua PS, Zhang Y, Wong CA, White GJ, Wood PG, Gates L J, Ulrich C, Martin SP, Post JC, Ehrlich GD. A gene for hereditary pancreatitis maps to chromosome 7q35. Gastroenterology 1996;110:1975– 1980. 6. Le Bodic L, Bignon JD, Raguenes O, Mercier B, Georgelin T, Schnee M, Soulard F, Gagne K, Bonneville F, Muller JY, Bachner L, Ferec C. The hereditary pancreatitis gene maps to long arm of chromosome 7. Hum Mol Genet 1996;5:549–554. 7. Pandya A, Blanton SH, Landa B, Javaheri R, Melvin E, Nance WE, Markello T. Linkage studies in a large kindred with hereditary pancreatitis confirms mapping of the gene to a 16-cM region on 7q. Genomics 1996;38:227–230. 8. Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LJ, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996;14:141–145. 9. Gorry MC, Gabbaizedeh D, Furey W, Gates LK, Preston RA, Aston
10. 11.
12.
13.
CE, Zhang Y, Ulrich C, Ehrlich GD, Whitcomb DC. Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology 1997;113:1063– 1068. Teich N, Mo¨ssner J, Keim V. Mutations of the cationic trypsinogen in hereditary pancreatitis. Hum Mutat 1998;12:39–43. Rowen L, Koop BF, Hood L. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science 1996;272:1755–1762. Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, Braganza J. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998;339:645–652. Cohn JA, Friedman KJ, Noone PG, Knowles MR, Silverman LM, Jowell PS. Relation between mutations of cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med 1998;339:653–658.
Received February 16, 1999. Accepted April 9, 1999. Address requests for reprints to: Heiko Witt, M.D., Kinderklinik, Charite ´ /Campus Virchow-Klinikum, Humboldt-Universita ¨t, Augustenburger Platz 1, 13353 Berlin, Germany. e-mail: [email protected]; fax: (49) 30-450-66917. The authors thank the members of the Gesellschaft fu ¨r Pa ¨diatrische Gastroenterologie und Erna ¨hrung (GPGE) for providing samples.
Einhorn of the Einhorn string test
Max Einhorn (1862–1953) was born in Suchowol, Poland, and educated in Berlin where he became a student of the celebrated Professor Carl Ewald. Encouraged to emigrate to the United States by Dr. Samuel Meltzer, in 1888 he was appointed the first professor of gastroenterology at the New York Postgraduate Medical School. His private practice was conducted at what was then the German Hospital, now the Lenox Hill Hospital. Max Einhorn was a founding member of the AGA and served as its third president (1899–1900). A prolific innovator, he devised, before the advent of radiography or endoscopy, an ingenious means of locating the site of upper gastrointestinal bleeding by observing stains on a swallowed, weighted string. Cast in the mold of an imperious Teutonic professor, he brooked no doubt of his authority. The story is told that once when visiting an elderly lady patient he announced, ‘‘I see you are better today.’’ The lady protested, ‘‘But, Dr. Einhorn, I don’t feel any better.’’ He remonstrated, ‘‘Ah! Professor Einhorn finds you better—so, you are better.’’ Copyright holder unknown. Photo obtained from the National Library of Medicine website (http://www.nlm. gov).
—Contributed by WILLIAM S. HAUBRICH, M.D. Scripps Clinic and Research Foundation, La Jolla, California
GASTROENTEROLOGY Vol. 117, No. 1
3. DiMagno EP, Layer P, Clain JE. Chronic pancreatitis. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, eds. The pancreas: biology, pathobiology, and disease. New York: Raven, 1993:665–706. 4. Comfort MW, Steinberg AG. Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterology 1952;21: 54–63. 5. Whitcomb DC, Preston RA, Aston CE, Sossenheimer MJ, Barua PS, Zhang Y, Wong CA, White GJ, Wood PG, Gates L J, Ulrich C, Martin SP, Post JC, Ehrlich GD. A gene for hereditary pancreatitis maps to chromosome 7q35. Gastroenterology 1996;110:1975– 1980. 6. Le Bodic L, Bignon JD, Raguenes O, Mercier B, Georgelin T, Schnee M, Soulard F, Gagne K, Bonneville F, Muller JY, Bachner L, Ferec C. The hereditary pancreatitis gene maps to long arm of chromosome 7. Hum Mol Genet 1996;5:549–554. 7. Pandya A, Blanton SH, Landa B, Javaheri R, Melvin E, Nance WE, Markello T. Linkage studies in a large kindred with hereditary pancreatitis confirms mapping of the gene to a 16-cM region on 7q. Genomics 1996;38:227–230. 8. Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LJ, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996;14:141–145. 9. Gorry MC, Gabbaizedeh D, Furey W, Gates LK, Preston RA, Aston
10. 11.
12.
13.
CE, Zhang Y, Ulrich C, Ehrlich GD, Whitcomb DC. Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology 1997;113:1063– 1068. Teich N, Mo¨ssner J, Keim V. Mutations of the cationic trypsinogen in hereditary pancreatitis. Hum Mutat 1998;12:39–43. Rowen L, Koop BF, Hood L. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science 1996;272:1755–1762. Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, Braganza J. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998;339:645–652. Cohn JA, Friedman KJ, Noone PG, Knowles MR, Silverman LM, Jowell PS. Relation between mutations of cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med 1998;339:653–658.
Received February 16, 1999. Accepted April 9, 1999. Address requests for reprints to: Heiko Witt, M.D., Kinderklinik, Charite ´ /Campus Virchow-Klinikum, Humboldt-Universita ¨t, Augustenburger Platz 1, 13353 Berlin, Germany. e-mail: [email protected]; fax: (49) 30-450-66917. The authors thank the members of the Gesellschaft fu ¨r Pa ¨diatrische Gastroenterologie und Erna ¨hrung (GPGE) for providing samples.
Einhorn of the Einhorn string test
Max Einhorn (1862–1953) was born in Suchowol, Poland, and educated in Berlin where he became a student of the celebrated Professor Carl Ewald. Encouraged to emigrate to the United States by Dr. Samuel Meltzer, in 1888 he was appointed the first professor of gastroenterology at the New York Postgraduate Medical School. His private practice was conducted at what was then the German Hospital, now the Lenox Hill Hospital. Max Einhorn was a founding member of the AGA and served as its third president (1899–1900). A prolific innovator, he devised, before the advent of radiography or endoscopy, an ingenious means of locating the site of upper gastrointestinal bleeding by observing stains on a swallowed, weighted string. Cast in the mold of an imperious Teutonic professor, he brooked no doubt of his authority. The story is told that once when visiting an elderly lady patient he announced, ‘‘I see you are better today.’’ The lady protested, ‘‘But, Dr. Einhorn, I don’t feel any better.’’ He remonstrated, ‘‘Ah! Professor Einhorn finds you better—so, you are better.’’ Copyright holder unknown. Photo obtained from the National Library of Medicine website (http://www.nlm. gov).
—Contributed by WILLIAM S. HAUBRICH, M.D. Scripps Clinic and Research Foundation, La Jolla, California