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Elastin content of normal and emphysematous lung parenchyma
OR
Immunoglobulln-secreting Disease activity
cells
Glucocorticoids
Desmosine/iaodesmoslne
Continued
E&tin content was measured in pulmonary parenchyma from eight patients with panacinar emphysema, three of whom had received glucocorticoid therapy, and from six normal adults. Concentrations of the efastin-specific amino acids, desmosine and isodesmosine, were determined in the crude connective tissue of lung parenchyma and separately in elastin isolated by a modified Lansing procedure. E&tin proportions were then calculated as a percent of lung parenchymal connective tissue. In the five patients who had not received gfucocorticoid therapy the pmpcrtions of lung etastin averaged 12.1 percent, significantly below that of the six control subjects with a mean of 30.5 percent. In the three glucocorticoi&treated patients elastin poportlonswtresimilartothosein~sub/ects.Theamiroacid~itionofisobtedelsstin did not differ significantly among the three groups.
Chrzanowski P, Keller S, Cerreta J. Mandl I. Turin0 GM: Elastin content of normal and emphysematcus lung parenchyma. Am J Med 1960: 69: 35 l-359.
Emphysema
Connective tissue
Lung parenchyma
Elastin
1,25_dlhydroxyvitamin D3 24,25-dihydroxyvttamln
D3
Vitamin D
page A29
Present concepts propose that 1,25(DH)2Ds deficiency leads to osteomabcia in patients with vitamin D deficiency, but recent studies suggest that lack of other D metabolites may play a pathogenic role. In the three patients described there is no correlation between plasma 1,25(DH)& and the presence or absence of osteomalacia. It is concluded that osteomalacia can occur as a consequence of a tack of D metabolite other than 1,25(OH)&Js. or because of areducedmirx3ralicnpmductbutnotasaconsequence of 1,25@t&Ds defiiiency if the mineral ion product is normally maintained.
Rasmussen H, Baron R, Broadus A, DeFronzo R, Lang Ft. Hcrst R: 1,25(OH)& is not the only D metabolite involved in the pathogenesis of osteomalacia. Am J Med 1980: 69: 360-368.
Bone mlneralizatlon
Dsteomalacla
Peripheral blood lymphocytes secreting immunoglobulins were measured in 24 patients with systemic lupus erythematosus (EXE). and cells secreting LgGand IgA were found to be significantly increased compared with healthy controls. The patients were ranked in order by clinical assessment of disease activity, and correlations with various laboratory tests were determined. Disease activity was significantly correlated with serum IgD (p
Antl-DNA antibodies
Systemk lupus erythematosus
Eighteen patients with hypertension were studied during a low-sodium diet for seven days, a high-sodium diet for seven days and after the oral administration of furosemide. They were classified as “salt-sensitive” (SS) or “nonsalt-sensitive” (NSS) from the increase in 24hwr averages of mean blood pressure with changes in sodium intake from 9 meq to 249 meq/day. With the high-sodivn diet, SS patients gained more weight. retained more sodium, had a geater increase in cardiic output (CC), showed higher plasma norepinephrine levels on day 4, showed lesser decrements in PRA and phsrna aldosterone concentration than the NSS patients and no change in winary prostaglandin Es (PGE2) which decreased in the NSS patients. With fur& semide. SS patients showed geater decrements in CO and no change in urinary PGEp, whereas NSS patients showed increases. Results suggest that the greater increase in blood pressure in SS patifmts with sodium loading can be attributed to greater sodium retention, feeding in turn to an increase in CO.
Sodium
Bfaese RM. Grayson J. Steinberg AD: Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythernatosus. Am J Med 1960; 69: 345350.
Hypertension Norepinephrine
Fujita T. Henry WL. Bartter FC, Lake CR, Delea CS: Factors influencing blood pressure in saft-sensitive patients with hypertension. Am J bled 1980; 69: 334-344.
Furosemlde
Blood pressure
Immunoglobulln-secreting Disease activity
cells
Glucocorticoids
Desmosine/iaodesmoslne
Continued
E&tin content was measured in pulmonary parenchyma from eight patients with panacinar emphysema, three of whom had received glucocorticoid therapy, and from six normal adults. Concentrations of the efastin-specific amino acids, desmosine and isodesmosine, were determined in the crude connective tissue of lung parenchyma and separately in elastin isolated by a modified Lansing procedure. E&tin proportions were then calculated as a percent of lung parenchymal connective tissue. In the five patients who had not received gfucocorticoid therapy the pmpcrtions of lung etastin averaged 12.1 percent, significantly below that of the six control subjects with a mean of 30.5 percent. In the three glucocorticoi&treated patients elastin poportlonswtresimilartothosein~sub/ects.Theamiroacid~itionofisobtedelsstin did not differ significantly among the three groups.
Chrzanowski P, Keller S, Cerreta J. Mandl I. Turin0 GM: Elastin content of normal and emphysematcus lung parenchyma. Am J Med 1960: 69: 35 l-359.
Emphysema
Connective tissue
Lung parenchyma
Elastin
1,25_dlhydroxyvitamin D3 24,25-dihydroxyvttamln
D3
Vitamin D
page A29
Present concepts propose that 1,25(DH)2Ds deficiency leads to osteomabcia in patients with vitamin D deficiency, but recent studies suggest that lack of other D metabolites may play a pathogenic role. In the three patients described there is no correlation between plasma 1,25(DH)& and the presence or absence of osteomalacia. It is concluded that osteomalacia can occur as a consequence of a tack of D metabolite other than 1,25(OH)&Js. or because of areducedmirx3ralicnpmductbutnotasaconsequence of 1,25@t&Ds defiiiency if the mineral ion product is normally maintained.
Rasmussen H, Baron R, Broadus A, DeFronzo R, Lang Ft. Hcrst R: 1,25(OH)& is not the only D metabolite involved in the pathogenesis of osteomalacia. Am J Med 1980: 69: 360-368.
Bone mlneralizatlon
Dsteomalacla
Peripheral blood lymphocytes secreting immunoglobulins were measured in 24 patients with systemic lupus erythematosus (EXE). and cells secreting LgGand IgA were found to be significantly increased compared with healthy controls. The patients were ranked in order by clinical assessment of disease activity, and correlations with various laboratory tests were determined. Disease activity was significantly correlated with serum IgD (p
Antl-DNA antibodies
Systemk lupus erythematosus
Eighteen patients with hypertension were studied during a low-sodium diet for seven days, a high-sodium diet for seven days and after the oral administration of furosemide. They were classified as “salt-sensitive” (SS) or “nonsalt-sensitive” (NSS) from the increase in 24hwr averages of mean blood pressure with changes in sodium intake from 9 meq to 249 meq/day. With the high-sodivn diet, SS patients gained more weight. retained more sodium, had a geater increase in cardiic output (CC), showed higher plasma norepinephrine levels on day 4, showed lesser decrements in PRA and phsrna aldosterone concentration than the NSS patients and no change in winary prostaglandin Es (PGE2) which decreased in the NSS patients. With fur& semide. SS patients showed geater decrements in CO and no change in urinary PGEp, whereas NSS patients showed increases. Results suggest that the greater increase in blood pressure in SS patifmts with sodium loading can be attributed to greater sodium retention, feeding in turn to an increase in CO.
Sodium
Bfaese RM. Grayson J. Steinberg AD: Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythernatosus. Am J Med 1960; 69: 345350.
Hypertension Norepinephrine
Fujita T. Henry WL. Bartter FC, Lake CR, Delea CS: Factors influencing blood pressure in saft-sensitive patients with hypertension. Am J bled 1980; 69: 334-344.
Furosemlde
Blood pressure