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Electrocardiographic markers associated with myocardium metabolic changes, their relationship with components of metabolic syndrome in coronary atherosclerosis
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Abstracts / Atherosclerosis 241 (2015) e149ee229
* Corresponding author. Aim: To evaluate association between biomarkers of visceral tissue metabolism and type 2 diabetes mellitus (DM2) in patients with coronary artery disease (CAD). Methods: Total 429 consecutive patients (M/F 325/104; 61.3±9.4 yrs) who were underwent coronary angiography, were enrolled. Location and extent of coronary artery lesion were assessed using Gensini score (GS). The mean common carotid artery intima-media thickness (IMT) and carotid plaques (CP) were evaluated during ultrasound dopplerography. Results: 18% of patients had DM2; noteworthy, women suffered DM2 2.5 times more often than men: 32.7 vs 13.2%. DM2 patients had significantly higher GS (48 vs 46 points). DM2 appeared to be an independent risk factor for manifested (>45%) carotid lesions detection (OR¼2.4;95% CI¼1.0-5.6). Hypertriglyceridemia (1.7 mmol/l) was associated with higher risk of DM2 (OR¼2.1;95%CI¼1.3-3.4). Plasma leptin concentration was higher in diabetic males (median 18.8 vs 15.0 ng/ml). Adiponectin levels were lower in diabetics in both genders (males: 5.1 vs 7.1 mkg/ml; females: 8.4 vs 9.5 mkg/ml). No significant differences in insulin level between males and females with or without DM2 were detected. However, in diabetics the highest HOMA-IR was observed (males 3.6 vs 2.5; females 3.7 vs 2.5). There were no significant association between visceral tissue parameters and INT and GS in coronary patients depending on DM2 presence. Conclusion: High leptin level in males and low adiponectin level in both genders were associated with DM2 and CAD suggesting these parameters as additional markers of adipose tissue disturbances in patients with CAD aggravated by DM2.
EAS-0124. ELECTROCARDIOGRAPHIC MARKERS ASSOCIATED WITH MYOCARDIUM METABOLIC CHANGES, THEIR RELATIONSHIP WITH COMPONENTS OF METABOLIC SYNDROME IN CORONARY ATHEROSCLEROSIS Y. Ragino 1, *, N. Timoshenko 1, A. Chernjavskiy 2, O. Kamenskaja 2, M. Voevoda 3. 1 Laboratory of Biochemistry, Federal State Budgetary Institution of Internal and Preventive Medicine Siberian, Novosibirsk, Russia; 2 Laboratory of Cardiology, 2Research State of Circulation Pathology Ministry of Public Health and Social Development, Novosibirsk, Russia; 3 Laboratory of Genetics, Federal State Budgetary Institution of Internal and Preventive Medicine Siberian, Novosibirsk, Russia
* Corresponding author. Aim of this study was to investigate the electrocardiographic (ECG) markers associated with myocardium metabolic changes in men with coronary atherosclerosis (CA) and their associations with components of metabolic syndrome (MS). The study included 123 men aged 41-79 with CA. ECG markers associated with myocardium metabolic changes - corrected interval QT, ST segment above >0.5mm, ST segment depression >0.5mm non-ischemic type, Twave changes, syndrome TV1>TV6, signs of left ventricular hypertrophy (LVH), arrhythmias - were analyzed. All components of MS and insulin resistance associated inflammatory biomarkers - tumor necrosis factor alpha (TNF-alpha), interleukin 6 and high-sensitive C-reactive protein were estimated. In men with CA the following ECG markers of MK were registered: arrhythmias in 65% of patients, LVH e 65,9%, the syndrome TV1>TV6 e 24,4%, T-wave change e 58,5%, segment ST elevation e 48%, segment ST depression e 22%. Obesity (BMI30,0 kg/m2 was revealed in 56,9% of men. Abdominal obesity was in the majority of men (77,2%). MS in CA men was registered in 69,9%. Positive correlations between ECG signs of LVH and increased blood levels of total cholesterol, excess waist circumference above normal and the presence of the MS were founded. There was a negative correlation between elevated levels of TNF-alpha and the lengthening of interval QT. Thus, the presence of CA and MS or its components and their associations with ECG characteristics, associated with myocardium metabolic changes,
are indicated to the common metabolic disorders and pathogenesis factors of these diseases.
EAS-0230. METABOLIC SYNDROME IN PATIENTS WITH CLINICAL PHENOTYPE OF “HYPERTRIGLYCERIDEMIC WAIST” n Nún ~ ez-Corte s 1, *, T. Mantilla 2, J.J. Millan-Perez 1, X. Pinto 3, P. J. Milla Valdivielso 4, J.M. Mostaza 5, F. Civeira 6, J. Ascaso 7. 1 Internal Medicine, ~o n, Madrid, Spain; 2 Primary Care, CS Prosperidad, HGU Gregorio Maran Madrid, Spain; 3 Internal Medicine, Hospital Bellvitge, Barcelona, Spain; 4 Internal Medicine, Hospital Clinico, Malaga, Spain; 5 Internal Medicine, Hospital Carlos III, Madrid, Spain; 6 Internal Medicine, Hospital Miguel Servet, Zaragoza, Spain; 7 Endocrinology, Hospital Clinico, Valencia, Spain
* Corresponding author. Theassociation of hypertriglyceridemia with increase in waist circumference (Knownas “hypertriglyceridemic wais”) is a common clinical phenotype in patients withmetabolic syndrome. And some previous results show that indices of abdominalobesity are better discriminators of cardiovascular risk factors than otheranthropometric parameters. So, hypertriglyceridemia and waist circumferencecould be a predictor for cardiovascular risk and used as a clinical marker. The aim ofthis study is to evaluate the potential role of hypertriglyceridemic waist asclinical predictor of metabolic syndrome in patients with hypertriglyceridemia. Patientswere included in a national register of patients with hypertriglyceridemia(Spanish Society of Atherosclerosis). Evaluable patients included were 1.369.Clinical criteria used for metabolic syndrome and the range for waistcircumference were those included in ATPIII or IDF consensus. Prevalenceof “hypertriglyceridemic waist” in patients with hypertriglyderidemia was veryhigh with almost 50 % and 80 % of the patients according with anthropometriccriteria of ATPIII and IDF, respectively. The prevalence of metabolic syndromein those patients was 97 % (ATPIII criteria) and 63 % (IDF criteria). We havefound a significantly increase of prevalence of arterial hypertension and type2 diabetes mellitus. Nevertheless, the association with cardiovascular diseaseis not founded and it was not related with waist circumference phenotype, butwas associated with the presence of metabolic syndrome. Hypertriglyceridemicwaist circumference can be used in clinical practice as a clinical marker of metabolic syndrome and cardiometabolic risk.
EAS-0280. INFLAMMATION AND OXIDATIVE STRESS BIOMARKERS AS PREDICTORS OF DIASTOLIC DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME M. Mocan 1, *, R. Rahaian 2, S.N. Blaga 1. 1 1st Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; 2 Central Laboratory, Emergency County Hospital, Cluj Napoca, Romania
* Corresponding author. Aim: New paradigm regarding heart failure with preserved ejection fraction (HF-PLEF) development has recently evolved. The authors aimed evaluate the best combination of inflammation and oxidative stress biomarkers to predict left ventricular diastolic dysfunction (LVDD) with HFPLEF in patients with MetS. Material and method: 72 patients, (59.19þ/-5.26 years, 63.89% women, 36.11% men), with MetS (AHA/NHLBI/IDF 2009 definition), without symptomatic cardiac disease were evaluated for LVDD using Dopplerechocardiography and N terminal-pro Brain Natruretic Peptide (NTproBNP) levels. Inflammation was quantified by High sensitivity C Reactive Protein (hs-CRP), Interleukin 6 (IL-6) and Fibrinogen (Fbg) levels and
Abstracts / Atherosclerosis 241 (2015) e149ee229
* Corresponding author. Aim: To evaluate association between biomarkers of visceral tissue metabolism and type 2 diabetes mellitus (DM2) in patients with coronary artery disease (CAD). Methods: Total 429 consecutive patients (M/F 325/104; 61.3±9.4 yrs) who were underwent coronary angiography, were enrolled. Location and extent of coronary artery lesion were assessed using Gensini score (GS). The mean common carotid artery intima-media thickness (IMT) and carotid plaques (CP) were evaluated during ultrasound dopplerography. Results: 18% of patients had DM2; noteworthy, women suffered DM2 2.5 times more often than men: 32.7 vs 13.2%. DM2 patients had significantly higher GS (48 vs 46 points). DM2 appeared to be an independent risk factor for manifested (>45%) carotid lesions detection (OR¼2.4;95% CI¼1.0-5.6). Hypertriglyceridemia (1.7 mmol/l) was associated with higher risk of DM2 (OR¼2.1;95%CI¼1.3-3.4). Plasma leptin concentration was higher in diabetic males (median 18.8 vs 15.0 ng/ml). Adiponectin levels were lower in diabetics in both genders (males: 5.1 vs 7.1 mkg/ml; females: 8.4 vs 9.5 mkg/ml). No significant differences in insulin level between males and females with or without DM2 were detected. However, in diabetics the highest HOMA-IR was observed (males 3.6 vs 2.5; females 3.7 vs 2.5). There were no significant association between visceral tissue parameters and INT and GS in coronary patients depending on DM2 presence. Conclusion: High leptin level in males and low adiponectin level in both genders were associated with DM2 and CAD suggesting these parameters as additional markers of adipose tissue disturbances in patients with CAD aggravated by DM2.
EAS-0124. ELECTROCARDIOGRAPHIC MARKERS ASSOCIATED WITH MYOCARDIUM METABOLIC CHANGES, THEIR RELATIONSHIP WITH COMPONENTS OF METABOLIC SYNDROME IN CORONARY ATHEROSCLEROSIS Y. Ragino 1, *, N. Timoshenko 1, A. Chernjavskiy 2, O. Kamenskaja 2, M. Voevoda 3. 1 Laboratory of Biochemistry, Federal State Budgetary Institution of Internal and Preventive Medicine Siberian, Novosibirsk, Russia; 2 Laboratory of Cardiology, 2Research State of Circulation Pathology Ministry of Public Health and Social Development, Novosibirsk, Russia; 3 Laboratory of Genetics, Federal State Budgetary Institution of Internal and Preventive Medicine Siberian, Novosibirsk, Russia
* Corresponding author. Aim of this study was to investigate the electrocardiographic (ECG) markers associated with myocardium metabolic changes in men with coronary atherosclerosis (CA) and their associations with components of metabolic syndrome (MS). The study included 123 men aged 41-79 with CA. ECG markers associated with myocardium metabolic changes - corrected interval QT, ST segment above >0.5mm, ST segment depression >0.5mm non-ischemic type, Twave changes, syndrome TV1>TV6, signs of left ventricular hypertrophy (LVH), arrhythmias - were analyzed. All components of MS and insulin resistance associated inflammatory biomarkers - tumor necrosis factor alpha (TNF-alpha), interleukin 6 and high-sensitive C-reactive protein were estimated. In men with CA the following ECG markers of MK were registered: arrhythmias in 65% of patients, LVH e 65,9%, the syndrome TV1>TV6 e 24,4%, T-wave change e 58,5%, segment ST elevation e 48%, segment ST depression e 22%. Obesity (BMI30,0 kg/m2 was revealed in 56,9% of men. Abdominal obesity was in the majority of men (77,2%). MS in CA men was registered in 69,9%. Positive correlations between ECG signs of LVH and increased blood levels of total cholesterol, excess waist circumference above normal and the presence of the MS were founded. There was a negative correlation between elevated levels of TNF-alpha and the lengthening of interval QT. Thus, the presence of CA and MS or its components and their associations with ECG characteristics, associated with myocardium metabolic changes,
are indicated to the common metabolic disorders and pathogenesis factors of these diseases.
EAS-0230. METABOLIC SYNDROME IN PATIENTS WITH CLINICAL PHENOTYPE OF “HYPERTRIGLYCERIDEMIC WAIST” n Nún ~ ez-Corte s 1, *, T. Mantilla 2, J.J. Millan-Perez 1, X. Pinto 3, P. J. Milla Valdivielso 4, J.M. Mostaza 5, F. Civeira 6, J. Ascaso 7. 1 Internal Medicine, ~o n, Madrid, Spain; 2 Primary Care, CS Prosperidad, HGU Gregorio Maran Madrid, Spain; 3 Internal Medicine, Hospital Bellvitge, Barcelona, Spain; 4 Internal Medicine, Hospital Clinico, Malaga, Spain; 5 Internal Medicine, Hospital Carlos III, Madrid, Spain; 6 Internal Medicine, Hospital Miguel Servet, Zaragoza, Spain; 7 Endocrinology, Hospital Clinico, Valencia, Spain
* Corresponding author. Theassociation of hypertriglyceridemia with increase in waist circumference (Knownas “hypertriglyceridemic wais”) is a common clinical phenotype in patients withmetabolic syndrome. And some previous results show that indices of abdominalobesity are better discriminators of cardiovascular risk factors than otheranthropometric parameters. So, hypertriglyceridemia and waist circumferencecould be a predictor for cardiovascular risk and used as a clinical marker. The aim ofthis study is to evaluate the potential role of hypertriglyceridemic waist asclinical predictor of metabolic syndrome in patients with hypertriglyceridemia. Patientswere included in a national register of patients with hypertriglyceridemia(Spanish Society of Atherosclerosis). Evaluable patients included were 1.369.Clinical criteria used for metabolic syndrome and the range for waistcircumference were those included in ATPIII or IDF consensus. Prevalenceof “hypertriglyceridemic waist” in patients with hypertriglyderidemia was veryhigh with almost 50 % and 80 % of the patients according with anthropometriccriteria of ATPIII and IDF, respectively. The prevalence of metabolic syndromein those patients was 97 % (ATPIII criteria) and 63 % (IDF criteria). We havefound a significantly increase of prevalence of arterial hypertension and type2 diabetes mellitus. Nevertheless, the association with cardiovascular diseaseis not founded and it was not related with waist circumference phenotype, butwas associated with the presence of metabolic syndrome. Hypertriglyceridemicwaist circumference can be used in clinical practice as a clinical marker of metabolic syndrome and cardiometabolic risk.
EAS-0280. INFLAMMATION AND OXIDATIVE STRESS BIOMARKERS AS PREDICTORS OF DIASTOLIC DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME M. Mocan 1, *, R. Rahaian 2, S.N. Blaga 1. 1 1st Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; 2 Central Laboratory, Emergency County Hospital, Cluj Napoca, Romania
* Corresponding author. Aim: New paradigm regarding heart failure with preserved ejection fraction (HF-PLEF) development has recently evolved. The authors aimed evaluate the best combination of inflammation and oxidative stress biomarkers to predict left ventricular diastolic dysfunction (LVDD) with HFPLEF in patients with MetS. Material and method: 72 patients, (59.19þ/-5.26 years, 63.89% women, 36.11% men), with MetS (AHA/NHLBI/IDF 2009 definition), without symptomatic cardiac disease were evaluated for LVDD using Dopplerechocardiography and N terminal-pro Brain Natruretic Peptide (NTproBNP) levels. Inflammation was quantified by High sensitivity C Reactive Protein (hs-CRP), Interleukin 6 (IL-6) and Fibrinogen (Fbg) levels and