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Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance
Cell Metabolism
Errata
Nuclear Receptors Reverse McGarry’s Vicious Cycle to Insulin Resistance David D. Moore1,* 1Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA *Correspondence: [email protected] DOI 10.1016/j.cmet.2012.05.003
(Cell Metabolism 15, 615–622, May 1, 2012) In the preparation of the above Perspective, the arrows in Figure 1 indicating the changes in serum insulin were incorrectly oriented. We provide the correct figure here (Figure 1), showing that serum insulin is elevated with insulin resistance (red) and decreased with increased sensitivity (green). This error does not affect the original figure legend. We regret our error and apologize for any inconvenience it may have caused.
Figure 1. Proposed Model for McGarry’s Lipogenic Vicious Cycle, and Its Reversal In the red, counterclockwise cycle, insulin resistance generates a self-reinforcing negative regulatory loop in which elevated insulin levels increase SREBP-1c expression and steatosis. This further decreases insulin sensitivity and increases in serum insulin levels to continue the negative cycle. Several NRs, including ERa CAR, LRH-1 TRb, and FXR/SHP, act to decrease SREBP-1c expression, lowering steatosis and setting up a positive, antilipogenic cycle to improved insulin sensitivity.
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance Kim Loh,1 Atsushi Fukushima,1,8 Xinmei Zhang,1 Sandra Galic,1,9 Dana Briggs,2 Pablo J. Enriori,2 Stephanie Simonds,2 Florian Wiede,1 Alexander Reichenbach,2 Christine Hauser,1 Natalie A. Sims,3 Kendra K. Bence,4 Sheng Zhang,5 Zhong-Yin Zhang,5 Barbara B. Kahn,6 Benjamin G. Neel,7 Zane B. Andrews,2 Michael A. Cowley,2 and Tony Tiganis1,* 1Department
of Biochemistry and Molecular Biology of Physiology Monash University, Victoria 3800, Australia 3St. Vincent’s Institute of Medical Research, Victoria 3065, Australia 4Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 5Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA 6Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA 7Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada 8Present address: Kochi Medical School, Nankoku, 783-8505, Japan 9Present address: St. Vincent’s Institute, Victoria 3065, Australia *Correspondence: [email protected] DOI 10.1016/j.cmet.2012.05.005 2Department
Cell Metabolism 15, 925–926, June 6, 2012 ª2012 Elsevier Inc. 925
Cell Metabolism Errata
(Cell Metabolism 14, 684–699, November 2, 2011) In the preparation of the above article, we inadvertently omitted the description of the cell culture conditions in the Supplemental Experimental Procedures; this has now been corrected online. This error does not affect the description of the results or the conclusions drawn from the paper. We regret our error and apologize for any inconvenience it may have caused.
926 Cell Metabolism 15, 925–926, June 6, 2012 ª2012 Elsevier Inc.
Errata
Nuclear Receptors Reverse McGarry’s Vicious Cycle to Insulin Resistance David D. Moore1,* 1Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA *Correspondence: [email protected] DOI 10.1016/j.cmet.2012.05.003
(Cell Metabolism 15, 615–622, May 1, 2012) In the preparation of the above Perspective, the arrows in Figure 1 indicating the changes in serum insulin were incorrectly oriented. We provide the correct figure here (Figure 1), showing that serum insulin is elevated with insulin resistance (red) and decreased with increased sensitivity (green). This error does not affect the original figure legend. We regret our error and apologize for any inconvenience it may have caused.
Figure 1. Proposed Model for McGarry’s Lipogenic Vicious Cycle, and Its Reversal In the red, counterclockwise cycle, insulin resistance generates a self-reinforcing negative regulatory loop in which elevated insulin levels increase SREBP-1c expression and steatosis. This further decreases insulin sensitivity and increases in serum insulin levels to continue the negative cycle. Several NRs, including ERa CAR, LRH-1 TRb, and FXR/SHP, act to decrease SREBP-1c expression, lowering steatosis and setting up a positive, antilipogenic cycle to improved insulin sensitivity.
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance Kim Loh,1 Atsushi Fukushima,1,8 Xinmei Zhang,1 Sandra Galic,1,9 Dana Briggs,2 Pablo J. Enriori,2 Stephanie Simonds,2 Florian Wiede,1 Alexander Reichenbach,2 Christine Hauser,1 Natalie A. Sims,3 Kendra K. Bence,4 Sheng Zhang,5 Zhong-Yin Zhang,5 Barbara B. Kahn,6 Benjamin G. Neel,7 Zane B. Andrews,2 Michael A. Cowley,2 and Tony Tiganis1,* 1Department
of Biochemistry and Molecular Biology of Physiology Monash University, Victoria 3800, Australia 3St. Vincent’s Institute of Medical Research, Victoria 3065, Australia 4Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 5Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA 6Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA 7Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada 8Present address: Kochi Medical School, Nankoku, 783-8505, Japan 9Present address: St. Vincent’s Institute, Victoria 3065, Australia *Correspondence: [email protected] DOI 10.1016/j.cmet.2012.05.005 2Department
Cell Metabolism 15, 925–926, June 6, 2012 ª2012 Elsevier Inc. 925
Cell Metabolism Errata
(Cell Metabolism 14, 684–699, November 2, 2011) In the preparation of the above article, we inadvertently omitted the description of the cell culture conditions in the Supplemental Experimental Procedures; this has now been corrected online. This error does not affect the description of the results or the conclusions drawn from the paper. We regret our error and apologize for any inconvenience it may have caused.
926 Cell Metabolism 15, 925–926, June 6, 2012 ª2012 Elsevier Inc.