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Elevated neutrophils, monocytes and white cell counts in patients with myocardial infarction compared with stable coronary artery disease
Atherosclerosis XXX (2016) e1ee196
Contents lists available at ScienceDirect
Atherosclerosis journal homepage: www.elsevier.com/locate/atherosclerosis
EAS 2016 CONGRESS ABSTRACTS POSTERS EAS16-0014, CVD RISK FACTORS. ELEVATED NEUTROPHILS, MONOCYTES AND WHITE CELL COUNTS IN PATIENTS WITH MYOCARDIAL INFARCTION COMPARED WITH STABLE CORONARY ARTERY DISEASE I. Trakarnwijitr, B. Li, H. Adams, J. Layland, J. Garlick, A. Wilson. The University of Melbourne, St. Vincent's Hospital Melbourne, Department of Medicine, Melbourne, Australia Objectives: Myocardial infarction (MI) is associated with significant inflammation. Leukocyte subtypes are also associated with cardiovascular disease (CVD) risk factors. However, little is known on the levels of leukocyte subtypes during MI. We hypothesized that components of leukocytes are significantly elevated during MI compared with stable CAD, and are correlated with the severity of MI. Methods: We evaluated 511 patients who underwent coronary angiography (stable CAD:n¼310, MI:n¼201). Patients were divided into tertiles based on admission leukocyte values, with tertile3 and tertile1 representing high and low values respectively. Multivariate logistic regression was performed to determine associations of leukocyte components with MI, peak TnI>5mg/L and peak CK>300U/L. Results: Patients with MI had high WCC (OR2.90, 95CI1.84-4.56,p<0.001), neutrophils (OR2.95,95CI1.87-4.66,p<0.001) and monocytes (OR1.77,95CI1.17-2.70,p¼0.007). In multivariate analysis adjusting for risk factors, high neutrophils (OR3.40, 95CI1.80-6.42,p<0.001), monocytes (OR1.89, 95CI1.09-3.30,p¼0.024) and WCC (OR3.48, 95CI1.856.52,p<0.001) were associated with MI. Peak CK>300 U/L was correlated with both high neutrophil (OR2.77,95CI1.19-6.46,p¼0.018) and monocytes (OR2.54, 95CI1.16-5.57,p¼0.020) independently of each other. There was also an independent relationship between high neutrophil (OR3.63, 95CI1.43-9.23,p¼0.007) and monocytes (OR2.90, 95CI1.24-6.74,p¼0.014) with peak TnI>5 mg/L. Conclusions: WCC>8.1109/L, neutrophils>5.2109/L and monocytes>0.5109/L were independent markers of MI. These were also correlated with peak CK>300U/L and TnI>5mg/L, postulating their associations with the degree of necrosis. The role of monocytes as an independent marker of severity in MI has not been previously described. These findings support the growing body of literature that associates inflammation with CVD. Further studies are warranted to assess the role of WCC subtypes and their clinical use in clinical risk stratification.
EAS16-0741, CVD RISK FACTORS. THE RISK FACTORS OF ATHEROSCLEROSIS IN ROMA POPULATION IN SOUTH BOHEMIA V. Adamkova 1, J. Hubacek 2, D. Novakova 3, V. Adamek 4, V. Lanska 5, V. Tothova 3. 1 Institute for Clinical and Experimental Medicine, Preventive Cardiology, Prague 4, Czech Republic; 2 Institute for Clinical and Experimental Medicine, Centre of Experimental Medicine, Prague 4, Czech Republic; 3 South Bohemia University, Faculty of Health and Social Studies,
http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.235
Ceske Budejovice, Czech Republic; 4 Czech Technical University, Faculty of Biomedical Engineering, Kladno, Czech Republic; 5 Institute for Clinical and Experimental Medicine, Statistical methods, Prague 4, Czech Republic Objectives Aim: Atherosclerosis is in the Roma population frequent phenomenon, but good quality information is not available in sufficient quantity.The research was conducted for improvement of knowledge of the risks of complications of atherosclerotic process. Methods: Groups: persons aged 18 years (men and women), domiciled in South Bohemia. The Roma population (302 people) snowball selection. The control non-Roma group were people from 2% random sample of the South Bohemia ( 1695 persons). After signing the informed consent of all probands completed a lifestyle questionnaire, were measured, weighed, measured blood pressure, heart rate. The groups were not different representation of men and women, and we consider them regardless of gender. Statistical evaluation was performed using ANOVA, using chisquare (c2), analysis of contingency tables and one-way (one way) analysis Results: Roma persons had higher body mass index 27.45± 6,49 x control group 25.2± 4,40 kg/m2, p < 0,001, higher heart frequency 74.9± 10.35 x 73.0±8.10, p¼ 0,0081. In Roma population were more smokers and smoked more cigarettes daily 15.9±10.0 x 8.3±5.9 p < 0,001, in Roma population was 6% passive smokers( daily)x 0.5% controls , p < 0,001. Conclusions: Lifestyle Roma population is failing, despite all efforts to improve the educational, very likely they may be to early complications of atherosclerotic process. Supported by AZV Ministery of Health, Czech Republic, No 15-31000A
EAS16-0573, CVD RISK FACTORS. LIPOPROTEIN PHENOTYPE IN NAÏVE PATIENTS WITH KLINEFELTER SYNDROME A. Antonucci, A. Bonaldo, P. Scarinzi, M. Barichello, P. Bigolin, N. Caretta, M. Ghezzi, R. Selice, M. Terrin, D. Vianello, R. Marin, A. Ferlin, C. Foresta, E. Manzato, F. Fabris, S. Bertocco, S. Zambon, A. Zambon. University of Padova, Medicine - DIMED, Padova, Italy Objectives: Klinefelter Syndrome (KS) is associated with an increased cardiovascular disease morbidity and mortality. This study aims to investigate quantitative and qualitative lipoprotein abnormalities, including LDL density and oxidation, in naïve KS patients, focusing on lipoprotein phenotypes as compared to age-matched controls. Methods: Anthropometric data, fasting blood samples (glycaemia, HbA1c, HOMA, LH, FSH, testosterone, SHBG, TSH), lipid profile, qualitative lipoprotein analysis by density gradient ultracentrifugation (DGUC), and oxidized LDL (ox-LDL) were analyzed in 30 naïve KS patients, 30 male and 40 age-matched female controls. Results: KS patients are characterized by significantly higher total and HDLcholesterol, and triglycerides than male controls, and significantly higher total, LDL-cholesterol, and triglycerides than female controls. By DGUC, KS
Contents lists available at ScienceDirect
Atherosclerosis journal homepage: www.elsevier.com/locate/atherosclerosis
EAS 2016 CONGRESS ABSTRACTS POSTERS EAS16-0014, CVD RISK FACTORS. ELEVATED NEUTROPHILS, MONOCYTES AND WHITE CELL COUNTS IN PATIENTS WITH MYOCARDIAL INFARCTION COMPARED WITH STABLE CORONARY ARTERY DISEASE I. Trakarnwijitr, B. Li, H. Adams, J. Layland, J. Garlick, A. Wilson. The University of Melbourne, St. Vincent's Hospital Melbourne, Department of Medicine, Melbourne, Australia Objectives: Myocardial infarction (MI) is associated with significant inflammation. Leukocyte subtypes are also associated with cardiovascular disease (CVD) risk factors. However, little is known on the levels of leukocyte subtypes during MI. We hypothesized that components of leukocytes are significantly elevated during MI compared with stable CAD, and are correlated with the severity of MI. Methods: We evaluated 511 patients who underwent coronary angiography (stable CAD:n¼310, MI:n¼201). Patients were divided into tertiles based on admission leukocyte values, with tertile3 and tertile1 representing high and low values respectively. Multivariate logistic regression was performed to determine associations of leukocyte components with MI, peak TnI>5mg/L and peak CK>300U/L. Results: Patients with MI had high WCC (OR2.90, 95CI1.84-4.56,p<0.001), neutrophils (OR2.95,95CI1.87-4.66,p<0.001) and monocytes (OR1.77,95CI1.17-2.70,p¼0.007). In multivariate analysis adjusting for risk factors, high neutrophils (OR3.40, 95CI1.80-6.42,p<0.001), monocytes (OR1.89, 95CI1.09-3.30,p¼0.024) and WCC (OR3.48, 95CI1.856.52,p<0.001) were associated with MI. Peak CK>300 U/L was correlated with both high neutrophil (OR2.77,95CI1.19-6.46,p¼0.018) and monocytes (OR2.54, 95CI1.16-5.57,p¼0.020) independently of each other. There was also an independent relationship between high neutrophil (OR3.63, 95CI1.43-9.23,p¼0.007) and monocytes (OR2.90, 95CI1.24-6.74,p¼0.014) with peak TnI>5 mg/L. Conclusions: WCC>8.1109/L, neutrophils>5.2109/L and monocytes>0.5109/L were independent markers of MI. These were also correlated with peak CK>300U/L and TnI>5mg/L, postulating their associations with the degree of necrosis. The role of monocytes as an independent marker of severity in MI has not been previously described. These findings support the growing body of literature that associates inflammation with CVD. Further studies are warranted to assess the role of WCC subtypes and their clinical use in clinical risk stratification.
EAS16-0741, CVD RISK FACTORS. THE RISK FACTORS OF ATHEROSCLEROSIS IN ROMA POPULATION IN SOUTH BOHEMIA V. Adamkova 1, J. Hubacek 2, D. Novakova 3, V. Adamek 4, V. Lanska 5, V. Tothova 3. 1 Institute for Clinical and Experimental Medicine, Preventive Cardiology, Prague 4, Czech Republic; 2 Institute for Clinical and Experimental Medicine, Centre of Experimental Medicine, Prague 4, Czech Republic; 3 South Bohemia University, Faculty of Health and Social Studies,
http://dx.doi.org/10.1016/j.atherosclerosis.2016.07.235
Ceske Budejovice, Czech Republic; 4 Czech Technical University, Faculty of Biomedical Engineering, Kladno, Czech Republic; 5 Institute for Clinical and Experimental Medicine, Statistical methods, Prague 4, Czech Republic Objectives Aim: Atherosclerosis is in the Roma population frequent phenomenon, but good quality information is not available in sufficient quantity.The research was conducted for improvement of knowledge of the risks of complications of atherosclerotic process. Methods: Groups: persons aged 18 years (men and women), domiciled in South Bohemia. The Roma population (302 people) snowball selection. The control non-Roma group were people from 2% random sample of the South Bohemia ( 1695 persons). After signing the informed consent of all probands completed a lifestyle questionnaire, were measured, weighed, measured blood pressure, heart rate. The groups were not different representation of men and women, and we consider them regardless of gender. Statistical evaluation was performed using ANOVA, using chisquare (c2), analysis of contingency tables and one-way (one way) analysis Results: Roma persons had higher body mass index 27.45± 6,49 x control group 25.2± 4,40 kg/m2, p < 0,001, higher heart frequency 74.9± 10.35 x 73.0±8.10, p¼ 0,0081. In Roma population were more smokers and smoked more cigarettes daily 15.9±10.0 x 8.3±5.9 p < 0,001, in Roma population was 6% passive smokers( daily)x 0.5% controls , p < 0,001. Conclusions: Lifestyle Roma population is failing, despite all efforts to improve the educational, very likely they may be to early complications of atherosclerotic process. Supported by AZV Ministery of Health, Czech Republic, No 15-31000A
EAS16-0573, CVD RISK FACTORS. LIPOPROTEIN PHENOTYPE IN NAÏVE PATIENTS WITH KLINEFELTER SYNDROME A. Antonucci, A. Bonaldo, P. Scarinzi, M. Barichello, P. Bigolin, N. Caretta, M. Ghezzi, R. Selice, M. Terrin, D. Vianello, R. Marin, A. Ferlin, C. Foresta, E. Manzato, F. Fabris, S. Bertocco, S. Zambon, A. Zambon. University of Padova, Medicine - DIMED, Padova, Italy Objectives: Klinefelter Syndrome (KS) is associated with an increased cardiovascular disease morbidity and mortality. This study aims to investigate quantitative and qualitative lipoprotein abnormalities, including LDL density and oxidation, in naïve KS patients, focusing on lipoprotein phenotypes as compared to age-matched controls. Methods: Anthropometric data, fasting blood samples (glycaemia, HbA1c, HOMA, LH, FSH, testosterone, SHBG, TSH), lipid profile, qualitative lipoprotein analysis by density gradient ultracentrifugation (DGUC), and oxidized LDL (ox-LDL) were analyzed in 30 naïve KS patients, 30 male and 40 age-matched female controls. Results: KS patients are characterized by significantly higher total and HDLcholesterol, and triglycerides than male controls, and significantly higher total, LDL-cholesterol, and triglycerides than female controls. By DGUC, KS