Elevated serum alpha-fetoprotein associated with Sertoli-Leydig cell tumors of the ovary

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Citations from the Literature

Elevated serum alpha-fetoprotein associated with SertoliLeydig cell tumors of the ovary Mann WJ; Chumas J; Rosenwaks Z; et al. Department of Obstetrics and Gynecology, State University of New York, Stony Brook, NY II 794, USA OBSTET. GYNECOL.; 67/l (141-144) 1986 Two young girls are described who presented with amenorrhea, large ovarian masses, elevated serum alpha-fetoprotein (AFP), and signs of androgen excess. Whereas the findings of an ovarian mass and elevated serum AFP typically suggest an ominous diagnosis, i.e ._endodermal sinus tumor of the ovary, both of these patients were found at laparotomy to have Sertoli-Leydig cell tumors of the ovary. Unilateraloophorectomy rapidly led to undetectable AFP levels in both patients, and resumption of menses. Foreign body granulomas in normal ovaries Mostafa SAM; Bargeron CB; Flower RW; et al. Department of Gynecology and Obstetrics, The Johns Hopkins Hospital, Baltimore, MD, USA OBSTET. GYNECOL.; 66/5 (701-702) 1985 In 100 consecutive cases in which grossly normal ovaries were removed at the time of pelvic surgery, 9% were found to contain crystalline foreign particles. An additional 9% contained cortical granulomas. In four of six cases, compuicrassisted x-ray analysis of the crystalline foreign particles was successful and revealed magnesium and silicon. Diagnosis and management of fetal teratomas Chervenak FA; Isaacson G; Touloukian R; et al. Department of Obstetrics and Gynecology, Yale-New Haven Medical Center, New Haven, CT, USA OBSTET. GYNECOL.: 66/5 (666-671) 1985 Teratomas are the most common neoplasms in newborns. It is now possible to detect these lesions with ultrasound before birth. Presented are six teratomas in a variety of locations diagnosed in utero (three sacrococcygeal, two oral cavity, and one intracranial). As these lesions are usually benign and often curable, the authors believe an aggressive, combined obstetric, pediatric, and surgical approach is warranted. Development of ovarian carcinoma in a cyclosporin A immunosuppressed patient Maung R; Pinto A. Robertson DI; et al. Department of Pathology, University of Calgary, Calgary, A&a., Canada OBSTET. GYNECOL.; 66/3 SUPPL. (89S-92s) 1985 This is the fist report of an ovarian carcinoma developing in a patient immunosuppressed by Cyclosporin A. Thirteen months before the diagnosis of malignancy, the patient received a living related donor kidney transplant whose rejection was controlled by Cyclosporin A and prednisone. The tumor was rapidly fatal five weeks from diagnosis. The literature on malignant transformation in the immunosuppressed patient is reviewed with emphasis on a gynecologic perspective. Int J Gynaecol Obstet 24

Cervical intraepithelial neoplasia treated by perilesional injection of interferon Choo YC; Seto WH; Hsu C; et al. Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong, Hong Kong BR. J. OBSTET. GYNAECOL.; 93/4 (372-379) 1986 Twelve patients with cervical intraepithchal neoplasia (GIN) were studied by colposcopy and cervical smears to elucidate the local response to interferon alpha and beta given by peribsional injections and to assess long-term discasc remission. In all patients, local inflammatory response was seen and persisted throughout the treatment period. Selective toxic effect was evident by exfoliation of increasing proportion of degenerate to viable dyskaryotic cells, while the normal epithelial cells appeared unaffected, and by the progressive regression of the lesion. Interferon alpha induced complete remission in six of seven (85.7%) patients but three had rccurrencc 12 to 24 months later, while interferon betainduced complete remission in only two of five (40%‘) patients. Risk factors for the development of diethylstilbestrolassociated clear cell adenocarcinoma: A case-control study Herbst AL; Anderson S; Hubby MM; et al. Department of Obstetrics and Gynecology, The University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA AM. J. OBSTET. GYNECOL.; 154/4 (814-822) 1986 Factors related to the risk of developing clear cell adenocarcinoma in diethylstilbestrolexposed women were investigated in 156 patients in the United States with clear cell adenocarcinoma and documented diethylstilbestrol exposure (Registry cases) and 1848 diethylstilbestrolexposed women of similar age without cancer (National Cooperative Diethylstilbestrol Adenosis Project). Diethylstilbestrol dosage patterns, the use of other hormones, mother’s age and pregnancy history, and daughter’s birth month, birth weight, and age at menarche were compared. The relative risk was higher for those whose mothers began dicthylstilbestrol before the twelfth week of pregnancy and for those who were born in the fall (winter conception). Maternal history of at least one prior spontaneous abortion elevdtcd the risk. Supportive evidence for the difference in birth month distribution was also found by a comparison with United States vital statistics. Each factor was confirmed to be significant in a multivariatc logistic model that examined all of them with region and year of birth adjusted. Human papillomavirus deoxyribonucleic acid in cervical carcinoma from primary and metastatic sites Lancaster WD; Castellano C; Santos C; et al. Department of Obstetrics and Gynecology, l’incent T. Lorrlbardi Cancer Research Center, Georgetouqn University Medical Center, Washington, DC, USA AM.J.OBSTET.GYNECOL.; 154/l (115-119) 1986 Tissue from 13 cervical cancers and pelvic or para-aortic lymph nodes from the s;Lme patient were evaluated by deo\) ribonucleic acid hybridization with a human papilloma\irus type 16 deoxyribonucleic acid probe for the prrscnce ot