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Emerging concept of oral cancer metastasis induced from analysis of a cancer metastasis model
E-Poster Presentation with pain and swelling punctuated by meals. Other symptoms included chronic pain and recurrent infections. A ductal exploration could be performed in all patients until the fourth divisions. Primary lesions found were stones (30%), stenosis (30%), and chronic injuries (22%). No adverse effects of the technique were noted. Four catheterization failures (15%) were reported. Conclusions: 3D-CBCT sialography was helpful in diagnosing salivary gland lesions and establishing a precise three-dimensional map of salivary ducts to guide the endoscopic procedure. This innovative imaging technique appears to be suitable for the first-line screening of non-tumour salivary pathologies.
Emerging concept of oral cancer metastasis induced from analysis of a cancer metastasis model H. Miyashita
1
2
, S. Mori , T. Kodama , T. Takahashi
far. However, to the best of our knowledge, lymphatic metastasis and hematogenous metastasis is not intended to be clearly distinguishable. In other words, the metastatic lymph nodes reveals a critical point for starting the hematogenous metastases. From the new concept of cancer metastasis which proposed in this work, conventional strategies for diagnosis and treatment of cancer should be re-examined according to a result from various viewpoints. http://dx.doi.org/10.1016/j.ijom.2015.08.242 Outcome of neck dissection in patients with oral squamous cell carcinoma
http://dx.doi.org/10.1016/j.ijom.2015.08.241
1,∗
e263
1
1
Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan 2 Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, Japan Background: In general, the size of the human and mouse cells are equal. Additionally, the diameter of human capillaries, arterioles, venules, and peripheral lymphatics are also equal to those of mouse. Moreover, the vascular system of the micro-environment in the metastatic lymph node of both of human and mouse is composed of capillaries, arterioles, venules, and lymphatics. Thus, if the size of mouse lymph node is comparable to that of human, events observed in the metastatic lymph node of mice is considered to be very close to those which observed in the metastatic lymph node of humans. Methods: We have established a recombinant inbred mice, MXH10/Mo-lpr/lpr, in which the size of lymph nodes is similar to that of human. By using this mouse as a study model for lymph node metastasis, we have examined the process of formation of metastatic lesions in the lymph nodes. Results: As a result, when experimental tumor cells were injected into the subiliac lymph node of the mice, a metastatic lesion was formed in the same side of the axillary lymph node via the lymphatics between the both lymph nodes. Furthermore, it is also revealed that tumor cells injected into the subiliac lymph nodes cause lung metastases via blood vessels in the lymph nodes. These findings suggested a possibility that the hematogenous metastases to the lung were formed in parallel with the lymphatic metastases. Discussion: Distant metastasis, which is to mean hematogenous metastasis has a decisive factor for the patient’s prognosis. If the lymphatic and hematogeneous metastases progress in parallel with the metastatic lymph node, each metastatic lymph node has equivalently higher and danger level in life prognosis, regardless of the anatomical site or the extranodal invasion. Since the density of blood vessel in lymph nodes is high, once metastatic lesion is formed in the lymph node, the tumor cells invade the blood vessels easily, and migrate to distant organ. The event of lymph node-mediated hematogenous metastases above mentioned is also supported the fact that, in most distant metastasis cases of head and neck cancer, lymph node metastases occur prior to the distant metastases. Conclusions: Lymphatic metastasis and hematogenous metastasis has been considered as a major mechanism of metastasis so
A. Miyazaki ∗ , J. Kobayashi, K. Ogi, H. Dehari, H. Hiroyoshi Sapporo Medical University, Sapporo, Japan Objectives: In order to evaluate the efficacy of supraomohyoid neck dissection (SOHND) compared to that of modified radical neck dissection (MRND), a retrospective cohort study on the outcome and survival rate of patients with oral squamous cell carcinoma (OSCC) was conducted. Methods: 110 OSCC patients who underwent ND for the first time between 2004 and 2012 at Sapporo Medical University Hospital’s Oral Surgery Clinic were analyzed. Findings and conclusions: Out of the 110 cases, 63(57.3%) were pathologically node negative (pN0) and 47(42.7%) showed neck node metastasis (pN+). Among the pN+ cases, 25(53.2%) had no recurrence, whereas 15(31.9%) had local recurrence, 6(12.8%) had regional recurrence, and 1(2.1%) developed distant metastasis after ND. Five-year cumulative survival rates were 96.0%, 22.2%, 16.7% and 0.0%, respectively. According to the pathologic N classification (pN), there were 19 cases in pN1, 14 in pN2b, and 14 in pN2c, with survival rates of 78.6%, 64.3%, 34.3%, respectively. There were nodal metastasis in 15 cases at level I, 12 at level II, 17 at level III, 2 at level IV and 1 at level V. Among the pN+ cases, 93.6% developed nodal metastasis at levels I to III. Survival rates according to the levels were 80.0%, 45.7%, 52.9%, 100.0%, and 0.0%, respectively. Among the 6 patients who developed regional recurrence, 3 underwent SOHND and 3underwent MRND. Survival rates were 33.3% and 0.0%, respectively. The present showed similar rates of regional recurrence after SOHND (3/21, 14.3%) compared with that of MRND (3/22, 13.6%). SOHND is effective procedure equally to MRND in the management of regional metastasis in levels I to III in patients with OSCC. http://dx.doi.org/10.1016/j.ijom.2015.08.243 Surgical training program for general dental practitioners M. Mizutani ∗ , S. Toya, A. Yamaguchi The Nippon Dental University, Oral and Maxillofacial Surgery, Niigata Hospital, Niigata, Japan Background: Various surgical procedures are required to be undertaken by General Dental Practitioners (GPs) on a daily basis. The learning objective of Japanese dental undergraduates is to be competent in performing simple extractions, and to be knowledgeable only about other surgical treatments. Therefore, after graduation, GPs require continual training to master surgical skills. In response, we developed a new surgical training model to match the educational needs of GPs. The simulator is used in the training of various minor surgeries such as: impacted tooth
Emerging concept of oral cancer metastasis induced from analysis of a cancer metastasis model H. Miyashita
1
2
, S. Mori , T. Kodama , T. Takahashi
far. However, to the best of our knowledge, lymphatic metastasis and hematogenous metastasis is not intended to be clearly distinguishable. In other words, the metastatic lymph nodes reveals a critical point for starting the hematogenous metastases. From the new concept of cancer metastasis which proposed in this work, conventional strategies for diagnosis and treatment of cancer should be re-examined according to a result from various viewpoints. http://dx.doi.org/10.1016/j.ijom.2015.08.242 Outcome of neck dissection in patients with oral squamous cell carcinoma
http://dx.doi.org/10.1016/j.ijom.2015.08.241
1,∗
e263
1
1
Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan 2 Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, Japan Background: In general, the size of the human and mouse cells are equal. Additionally, the diameter of human capillaries, arterioles, venules, and peripheral lymphatics are also equal to those of mouse. Moreover, the vascular system of the micro-environment in the metastatic lymph node of both of human and mouse is composed of capillaries, arterioles, venules, and lymphatics. Thus, if the size of mouse lymph node is comparable to that of human, events observed in the metastatic lymph node of mice is considered to be very close to those which observed in the metastatic lymph node of humans. Methods: We have established a recombinant inbred mice, MXH10/Mo-lpr/lpr, in which the size of lymph nodes is similar to that of human. By using this mouse as a study model for lymph node metastasis, we have examined the process of formation of metastatic lesions in the lymph nodes. Results: As a result, when experimental tumor cells were injected into the subiliac lymph node of the mice, a metastatic lesion was formed in the same side of the axillary lymph node via the lymphatics between the both lymph nodes. Furthermore, it is also revealed that tumor cells injected into the subiliac lymph nodes cause lung metastases via blood vessels in the lymph nodes. These findings suggested a possibility that the hematogenous metastases to the lung were formed in parallel with the lymphatic metastases. Discussion: Distant metastasis, which is to mean hematogenous metastasis has a decisive factor for the patient’s prognosis. If the lymphatic and hematogeneous metastases progress in parallel with the metastatic lymph node, each metastatic lymph node has equivalently higher and danger level in life prognosis, regardless of the anatomical site or the extranodal invasion. Since the density of blood vessel in lymph nodes is high, once metastatic lesion is formed in the lymph node, the tumor cells invade the blood vessels easily, and migrate to distant organ. The event of lymph node-mediated hematogenous metastases above mentioned is also supported the fact that, in most distant metastasis cases of head and neck cancer, lymph node metastases occur prior to the distant metastases. Conclusions: Lymphatic metastasis and hematogenous metastasis has been considered as a major mechanism of metastasis so
A. Miyazaki ∗ , J. Kobayashi, K. Ogi, H. Dehari, H. Hiroyoshi Sapporo Medical University, Sapporo, Japan Objectives: In order to evaluate the efficacy of supraomohyoid neck dissection (SOHND) compared to that of modified radical neck dissection (MRND), a retrospective cohort study on the outcome and survival rate of patients with oral squamous cell carcinoma (OSCC) was conducted. Methods: 110 OSCC patients who underwent ND for the first time between 2004 and 2012 at Sapporo Medical University Hospital’s Oral Surgery Clinic were analyzed. Findings and conclusions: Out of the 110 cases, 63(57.3%) were pathologically node negative (pN0) and 47(42.7%) showed neck node metastasis (pN+). Among the pN+ cases, 25(53.2%) had no recurrence, whereas 15(31.9%) had local recurrence, 6(12.8%) had regional recurrence, and 1(2.1%) developed distant metastasis after ND. Five-year cumulative survival rates were 96.0%, 22.2%, 16.7% and 0.0%, respectively. According to the pathologic N classification (pN), there were 19 cases in pN1, 14 in pN2b, and 14 in pN2c, with survival rates of 78.6%, 64.3%, 34.3%, respectively. There were nodal metastasis in 15 cases at level I, 12 at level II, 17 at level III, 2 at level IV and 1 at level V. Among the pN+ cases, 93.6% developed nodal metastasis at levels I to III. Survival rates according to the levels were 80.0%, 45.7%, 52.9%, 100.0%, and 0.0%, respectively. Among the 6 patients who developed regional recurrence, 3 underwent SOHND and 3underwent MRND. Survival rates were 33.3% and 0.0%, respectively. The present showed similar rates of regional recurrence after SOHND (3/21, 14.3%) compared with that of MRND (3/22, 13.6%). SOHND is effective procedure equally to MRND in the management of regional metastasis in levels I to III in patients with OSCC. http://dx.doi.org/10.1016/j.ijom.2015.08.243 Surgical training program for general dental practitioners M. Mizutani ∗ , S. Toya, A. Yamaguchi The Nippon Dental University, Oral and Maxillofacial Surgery, Niigata Hospital, Niigata, Japan Background: Various surgical procedures are required to be undertaken by General Dental Practitioners (GPs) on a daily basis. The learning objective of Japanese dental undergraduates is to be competent in performing simple extractions, and to be knowledgeable only about other surgical treatments. Therefore, after graduation, GPs require continual training to master surgical skills. In response, we developed a new surgical training model to match the educational needs of GPs. The simulator is used in the training of various minor surgeries such as: impacted tooth