Enalapril treatment does not modify the number and properties of angiotensin II receptors in tissues from normal or spontaneously hypertensive rats

.J Mel

Cell

23 (Supplement

Cardiol

IV)

(1991)

25

DIAGNOSTIC RELIABILITY OF CORONARY ANGIOGRAPHY FOR ASSESSMENT OF HEART GRAFT ATHEROSCLEROSIS. P. BOISSONNAT, R. LOIRE, M. DELORGERIL, J.P. GARE, 0. DE GEVIGNEY, R. ROSSI, J.P. DELAHAYE, G. CHAMPSAUR, 0. DUREAU. Hbpital Cardiologique ; INSERM U 37 et 63 - LYON - FRANCE. Of 15 heart transplant recipients undergoing coronary angiography 0 to 369 days (average 168 i 134) before autopsy (5 deaths and 10 retransplantations) the angiographic coronary arteries narrowing was compared with that observed histologically. Six coronary arteries subdivisions were analyzed with gradation of the angiographic diameter reduction or the histologic cross sectional area reduction as follows : 0 ; I from 1 to 25 % ; II from 26 to 50 % ; III from 51 to 75 % ; IV from 76 to 99 % ; V 100 %. An angiographic underestimation (AV) was defined as a difference of more than one grade between angiographic and histologic grade. 51 AV were made under the 88 studied subdivisions (58 %). The AV average number by patient was 3.3 + 1.9 (O(w:th .4W heWem the two 6:. The comoariscn for c.q subdivision showed signif&! -t differewe grades. Therefore coronary angiography doesn’t seem to be the good tool to rate the atherosclerosis seriousness. Although the reason is not certain, the presence of diffuse and young lesions may account for most of the angiographically missed narrowing in our patients.

26

ENhLAPRtL ANOIOTEkSfN I~YPERTENSlVE Souchet*.

TREATMENT DUES NOT MODIFY THE NUMRER II RECEPTORS IN TISSUES FROM NORMAL RATS. J.C. Bonnafous, B. Cantau, P. Desamaud,

Centre

Merk-Sharp

& bohme

purpose

The enalapril

later. aorta

situations

affinity

INTRACELLULAR

for

.I..

Cwffinhal

INgERM

u.8

de

The

endothellal

celLs

act,vatlon and

NDGA,

endothellal

cells

adhesion

to

caffeine,

phosphorylatlon

To

influence

of chronic

II (All)

&in.

were

receptors

Animals

were

sacrificed

and

recovery

constant

to

from

blocking tissues

by It Led protcln

adhesion

this

treatment,

no

were

GTP

bindiM

to krnase

EC

appears

protein. of

think

that C

secondary

washed

the

No

It Nat/H+ LDL

NDGA

appears

to

the

and of

LDL

receptor

s.9

LDL

were

to

of

)@

to

proteln

klnase

mmwcyte by

no

dependent

EGTA,

effect.

So.

lnteractlon C

and

activation

actlvatlons IS

E6

confluent

of

had

acid

to

Prot/l

abolIshed

receptor

adhesion activation.

was

LDL-LDL

arach,don,c

nonocyte

(100

added

indomthacin

the

the

adheslvlty

increase EC

I"

stawosparln.

significant

and

depending

ant,port activation

of

nwnocyte

and

induced of

liver. In alI

to All as density

adhesion

chlorcqwne,

adhesion

depending

this

nonocytes a

events

mMMcyte

IO

significant

reactivity All receptor

lnltal

with

toxin,

induce

Annloride,

of

preincubated

LDL

the of

responsible were

of

of

actlvatlon

by

The results

found.

CELLS.

one

an

pertussis

nn

activation

to

non-depend,ng us

15

staurosporine.

Mo

IS

period,

after

LDL

toxin.

IS

manocytes

*

or I nr

from adrenals, was determined.

receplors

ENDOTHELIAL

induce

heparin,

preincubation

tested This

to nechanlsms

caffeine.

After

a

TO

endothel,"" able

T.

from

for 4 weeks

of the treatment

fractions animal

of All

ACE

that changes in the vascular for by changes in peripheral

ADHESION

aortlc

appear

labelled

(EGTA,

celL.

the

LDL

"'lndiun

the

MONOCYTE

and S; and

in several submitted

at the end

binding to particulate and ennlapril-treated

intracellular

adheslvity

of

by

All

Cedex

I.

t"o,

lnvestlgate

pertussis

results

OF Bletz

lesions.

and

actlvetion

They control

OF

S. Jard

Montpellier

Pessac-F.

irdawthacin).

movement. These

C.,

elutrlated

pathway

calc,m

ACTIVATION

wxwcytes

endothelial

transduction

LDL

agents

heparin, LDL

of

different

amlLoride.

the SHR

or dissociation

Moreau 33600

(EC).

LDL,

from

possible

by enalapril

number

atherosclerotic

by

l/ml)

OF Th.,

adherence of

rats

mg/kg/24h).

G. Guillon,

34094

Atl.

Cardiologie,

development

the

of angiotensin

properties

PROPERTIES SPONTANEOIJSLY

Paris.

do not support the hypothesis patients might be accounted

"ECHANlSnS

Bonnet

75008

to investigate

treatment

total

in SHR tats in hyperlentive

Hoche

[ 12511-Sa,1from

chronic

Endocrinologie

and (l(1

Dose-dependent and adenohypophysis of either

(or)

was

hypertensive

explored,

obtained observed

LDL.

work

of enalapril

modifications

the

the

3, avenue

on the number

administration

3 weeks thoracic

de Pharmacologic

Chibret,

or sptonaesously

p.o.

27

of

treatment

normal

and

CNRS-INSERM

AND OR

lntegrln

by