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Endometrial cancer
622
Book Reviews
primary R, prevalence and prognosis; pathology and angiology; pathophysiology; diagnosis; secondary R; treatment; acrocyanosis and livedo reticularis. The Peripheral Actions of S-Hydroxytryptamine-Edited by J. R. FOZZARD.410~~. 1989. Oxford University Press, Oxford. $90. 5HT receptors have been classified as SHT,,, 5HT,, , SHT,, > 5HT,, and SHT,. The 5HT,, receptor has been cloned and is 460 amino acids with seven transmembrane spanning regions showing considerable sequence homologies with the receptors for muscarine, substance K, opsines and alpha and beta adrenoreceptors. The identification of the receptor classes has depended on the use of specific agonists and antagonists for each subclass. The receptors are also differentially distributed on specific organs and hence it is possible in many cases to have organ specific action of selected agonists and antagonists, although there is some overlap in many cases. This book deals with the synthesis, storage, release and metabolism of 5HT; quantification of action of agonists and antagonists; allosteric 5HT, receptor system; receptors and effector coupling systems; 5HT induced vasoconstriction; amplification mechanisms; 5HT induced vasodilatation; interaction of 5HT with endothelial cells; non vascular smooth muscle contraction and relaxation; autonomic and sensory neurons; enteric neurons; peripheral secretory mechanisms; cardiopulmonary and carotid body reflex mechanisms; experimental hypertension; MDL 7222; pathophysiology of 5HT. Brain Opioid Systems in Reproduction-Edited by R. G. DYERand R. J. BICKNELL.365~~. 1989. Oxford University Press, Oxford. $89. It was known for more than 50 years that morphine inhibits the secretion of pituitary gonadotrophins. It is now thought that the opioid peptides (0) can also modify sexual behaviour, pregnancy, parturition, and lactation. The chapters deal with the role of 0 in control of rat LH surge; endocrine regulation of brain 0 receptors; 0 and seasonal reproduction; 0 and the onset of puberty; 0 inhibition of the brain stem projections to the medial preoptic area in female rats; 0 and GnRH neurones; endorphin in the hypophyseal portal blood; functions of 0 in sexual behaviour; 0 and oxytocin; 0 modulation of nociception and its relevance to neuroendocrinology. A lot of interesting information is presented and tied together. Pulmonary Physiology; Fetus, Newborn, Child, Adolescent. 2nd edition. Edited by E. M. SCARPELLI.500~~. 1989. Lea and Febiger, Philadelphia. $89.50. The chapters in this book deal with: respiration before birth; lung cells from embryo to maturity; extracellular matrix in developing lung; developmental biochemistry of alveoli; developmental immunology of the lung; pulmonary molecular biology; metabolic activity of vascular endothelium; mechanical defence mechanisms; pulmonary solute and liquid balance; normal pulmonary circulation; pulmonary mechanics and ventilation; oxygen diffusion and transport; NMR of the lung; pulmonary renal relationship and acid base balance; respiratory regulation in the newborn; developmental physiology of respiratory control; micromechanits of onset of air breathing at birth; pulmonary physiology of newborn infant; pulmonary function from infancy
through adolescence; pulmonary function testing; lung development and subsequent function in the adult. The material has been brought up to date in this new edition, and there is greater emphasis on the molecular biology of the lung. An excellent text on pediatric pulmonary physiology. Textbook of Hemodialysis for Patient Care PersonnelBy M. A. NEWBERRY.593~~. 1989. Charles C. Thomas, Springfield, IL. $80.75. Hemodialysis (H) produces profound physiological changes in the patient and this book provides the background to understand these changes. The chapters are on: history of H; end stage renal disease; body water and electrolytes; renal anatomy and physiology; acute renal failure; chronic renal failure; principles of H; H systems and technology; water and dialysate standards and chemistry; vascular access; H technique; maintenance H. The book will be very useful to all those involved in H or wish to know more about H. Biosynthetic Products for Cancer Chemotherapy-Edited by G. R. PETTIT, C. L. HERALD and C. R. SMITH.399~~. 1989. Elsevier. Amsterdam. $141.50 D. FL 290. Thirty per cent of cancer deaths in the USA are attributable to smoking; alcohol causes another 4-10%. It is probable that another 30% are due to environmental factors. This indicates that the majority of cancers could be preventable. On the other hand once cancer is established, it is necessary to find suitable treatment methods. This bood surveys the literature from 1983 through to 1986 on anti cancer (anti neoplastic and cell growth inhibitory) agents that have been extracted from land plants and animals, and marine plants and animals. For each compound it provides the chemical structure, the plant/animal source and a literature reference. Endometrinl Cancer-Edited by E. A. SLJRWITand D. S. 131~~. 1989. Kluwer Academic Publishers. Dordrecht. D.FI 215 $78.50.
ALBERTS.
Endometrial cancer increased in the USA with the use of postmenopausal estrogens. However progesterone supplementation of the postmenopausal estrogen reduces the incidence of endometrial cancer. The chapters in this book are on: epidemiology; surgical management; peritoneal cytology; post operative radiotherapy; radiotherapy and metastases; single agent and multi agent chemotherapy; in vitro sensitivity to cytotoxic agents. Breast Cancer: Progress in the Biology, Clinical Management and Prevention Edited by M. A. &ZH, J. C. HAGER-andI. KEYDAR.238~~. 1989. Kluwer Academic Publishers. Dordrecht, D.FI ‘c70 $65. The main sections in this book deal with breast cancer at the molecular level (transgenic mice and transgenic mammary glands; the int genes and proto-oncogenes; regulation of tissue specific casein gene expression; H23 breast tumor antigen; epithelial mucins); breast cancer detection and therapy (radiation therapy; surgical strategies; chemotherapy; anticancer drug resistance; multi drug resistance); laboratory and clinical research interface (mammary carcinogenesis; steroid receptors; estrogen induced cathepsin D; pre-invasive carcinoma; role of diet; breast cancer vaccine; monoclonal antibody therapy).
Book Reviews
primary R, prevalence and prognosis; pathology and angiology; pathophysiology; diagnosis; secondary R; treatment; acrocyanosis and livedo reticularis. The Peripheral Actions of S-Hydroxytryptamine-Edited by J. R. FOZZARD.410~~. 1989. Oxford University Press, Oxford. $90. 5HT receptors have been classified as SHT,,, 5HT,, , SHT,, > 5HT,, and SHT,. The 5HT,, receptor has been cloned and is 460 amino acids with seven transmembrane spanning regions showing considerable sequence homologies with the receptors for muscarine, substance K, opsines and alpha and beta adrenoreceptors. The identification of the receptor classes has depended on the use of specific agonists and antagonists for each subclass. The receptors are also differentially distributed on specific organs and hence it is possible in many cases to have organ specific action of selected agonists and antagonists, although there is some overlap in many cases. This book deals with the synthesis, storage, release and metabolism of 5HT; quantification of action of agonists and antagonists; allosteric 5HT, receptor system; receptors and effector coupling systems; 5HT induced vasoconstriction; amplification mechanisms; 5HT induced vasodilatation; interaction of 5HT with endothelial cells; non vascular smooth muscle contraction and relaxation; autonomic and sensory neurons; enteric neurons; peripheral secretory mechanisms; cardiopulmonary and carotid body reflex mechanisms; experimental hypertension; MDL 7222; pathophysiology of 5HT. Brain Opioid Systems in Reproduction-Edited by R. G. DYERand R. J. BICKNELL.365~~. 1989. Oxford University Press, Oxford. $89. It was known for more than 50 years that morphine inhibits the secretion of pituitary gonadotrophins. It is now thought that the opioid peptides (0) can also modify sexual behaviour, pregnancy, parturition, and lactation. The chapters deal with the role of 0 in control of rat LH surge; endocrine regulation of brain 0 receptors; 0 and seasonal reproduction; 0 and the onset of puberty; 0 inhibition of the brain stem projections to the medial preoptic area in female rats; 0 and GnRH neurones; endorphin in the hypophyseal portal blood; functions of 0 in sexual behaviour; 0 and oxytocin; 0 modulation of nociception and its relevance to neuroendocrinology. A lot of interesting information is presented and tied together. Pulmonary Physiology; Fetus, Newborn, Child, Adolescent. 2nd edition. Edited by E. M. SCARPELLI.500~~. 1989. Lea and Febiger, Philadelphia. $89.50. The chapters in this book deal with: respiration before birth; lung cells from embryo to maturity; extracellular matrix in developing lung; developmental biochemistry of alveoli; developmental immunology of the lung; pulmonary molecular biology; metabolic activity of vascular endothelium; mechanical defence mechanisms; pulmonary solute and liquid balance; normal pulmonary circulation; pulmonary mechanics and ventilation; oxygen diffusion and transport; NMR of the lung; pulmonary renal relationship and acid base balance; respiratory regulation in the newborn; developmental physiology of respiratory control; micromechanits of onset of air breathing at birth; pulmonary physiology of newborn infant; pulmonary function from infancy
through adolescence; pulmonary function testing; lung development and subsequent function in the adult. The material has been brought up to date in this new edition, and there is greater emphasis on the molecular biology of the lung. An excellent text on pediatric pulmonary physiology. Textbook of Hemodialysis for Patient Care PersonnelBy M. A. NEWBERRY.593~~. 1989. Charles C. Thomas, Springfield, IL. $80.75. Hemodialysis (H) produces profound physiological changes in the patient and this book provides the background to understand these changes. The chapters are on: history of H; end stage renal disease; body water and electrolytes; renal anatomy and physiology; acute renal failure; chronic renal failure; principles of H; H systems and technology; water and dialysate standards and chemistry; vascular access; H technique; maintenance H. The book will be very useful to all those involved in H or wish to know more about H. Biosynthetic Products for Cancer Chemotherapy-Edited by G. R. PETTIT, C. L. HERALD and C. R. SMITH.399~~. 1989. Elsevier. Amsterdam. $141.50 D. FL 290. Thirty per cent of cancer deaths in the USA are attributable to smoking; alcohol causes another 4-10%. It is probable that another 30% are due to environmental factors. This indicates that the majority of cancers could be preventable. On the other hand once cancer is established, it is necessary to find suitable treatment methods. This bood surveys the literature from 1983 through to 1986 on anti cancer (anti neoplastic and cell growth inhibitory) agents that have been extracted from land plants and animals, and marine plants and animals. For each compound it provides the chemical structure, the plant/animal source and a literature reference. Endometrinl Cancer-Edited by E. A. SLJRWITand D. S. 131~~. 1989. Kluwer Academic Publishers. Dordrecht. D.FI 215 $78.50.
ALBERTS.
Endometrial cancer increased in the USA with the use of postmenopausal estrogens. However progesterone supplementation of the postmenopausal estrogen reduces the incidence of endometrial cancer. The chapters in this book are on: epidemiology; surgical management; peritoneal cytology; post operative radiotherapy; radiotherapy and metastases; single agent and multi agent chemotherapy; in vitro sensitivity to cytotoxic agents. Breast Cancer: Progress in the Biology, Clinical Management and Prevention Edited by M. A. &ZH, J. C. HAGER-andI. KEYDAR.238~~. 1989. Kluwer Academic Publishers. Dordrecht, D.FI ‘c70 $65. The main sections in this book deal with breast cancer at the molecular level (transgenic mice and transgenic mammary glands; the int genes and proto-oncogenes; regulation of tissue specific casein gene expression; H23 breast tumor antigen; epithelial mucins); breast cancer detection and therapy (radiation therapy; surgical strategies; chemotherapy; anticancer drug resistance; multi drug resistance); laboratory and clinical research interface (mammary carcinogenesis; steroid receptors; estrogen induced cathepsin D; pre-invasive carcinoma; role of diet; breast cancer vaccine; monoclonal antibody therapy).