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Endometrial carcinoma
Radiation
60
Oncology
??Biology ??Physics
October
1984, Volume
10, Sup. 2
206 FRACTION
SIZE AND PROTRACTION
H. Rodney Withers Department Department
and Lester
IN CLINICAL
RADIATION
THERAPY
J. Peters
of Radiation Oncology, University of California at Los Angeles, of Radiotherapy, M.D. Anderson Hospital, Houston, TX 77030
Los Angeles,
CA 90024
The evolution of dose fractionation over several decades has been associated with an improved therapeutic ratio but there is reason to believe that results could be further improved, for example, by more individualization of treatment strategies based on biological parameters of the tumor and host The biological processes that may occur in tumors and normal tissues during fractionated dose tissues. regimen (e.g. repair of cellular injury, regeneration, reoxygenation and redistribution) will be described and the potential for a therapeutic gain through hyperfractionation or accelerated fractionation discussed.
207 ENDOMETRIAL
CARCINOMA
John R. Glassburn, Professor
M.D.
of Radiation
Therapy,
Hahnemann
Medical
College
and Hospital
There exists at the present time controversy over the role of radiation therapy in the treatment of patients with endometrial carcinoma, particularly for those patients with Stage I disease. A significant fund of knowledge now exists with regard to the prognostic factors found with this disease which can aid us in selecting those patients who are most likely to benefit from a combined treatment approach. These factors will be discussed in detail along with the advantages and disadvantages of both preoperative and postoperative radiation therapy. The integration of surgery, radiation therapy and systemic therapy in a rational fashion for patients with advanced disease to optimize treatment results will also be outlined.
208 UPPER ABDOMINAL Ralph Mayo
MALIGNANCIES:
R. Dobelbower, Clinic,
STOMACH,
Jr., M.D.,
Rochester,
Ph.D.,
Minnesota;
PANCREAS, Leonard
Medical
GALLBLADDER,
Gunderson,
College
AND BILIARY
TREE
M.D.
of Ohio, Toledo,
Ohio
The role of radiotherapy in the management of upper abdominal neoplasms is rapidly expanding. This refresher course will review the etiology, diagnosis and especially the clinical management of tumors of The role of radiation as an adjuvant and as a the stomach, pancreas, gallbladder and the biliary tree. definitive treatment modality will be discussed. Recent innovations and new applications of existing intra-operative irradiation; precision high dose techniques, intraluminal technology will be presented: isotope techniques, particle irradiation, etc. Time will be reserved for questions and answers. A syllabus will be available. Supported
in part by NC1 Grant # R26 CA 292518
209 RADIOTHERAPEUTIC
MANAGEMENT
A.
r1.D.
Robert
Radiation
Kaqan, Therapy
Department,
OF METASTASES
Southern
California
Permanente
cledical
Group,
LosAngeles,Ca.
As much as 60% of a radiation oncologist's consultative and treatment efforts are spent Although the management of metastasis and locally in the management of noncurative disease. Who should be for the treatment are few. incurable cancer is a common problem, guidelines What techniques should be used, simple or complex? treated and why?
60
Oncology
??Biology ??Physics
October
1984, Volume
10, Sup. 2
206 FRACTION
SIZE AND PROTRACTION
H. Rodney Withers Department Department
and Lester
IN CLINICAL
RADIATION
THERAPY
J. Peters
of Radiation Oncology, University of California at Los Angeles, of Radiotherapy, M.D. Anderson Hospital, Houston, TX 77030
Los Angeles,
CA 90024
The evolution of dose fractionation over several decades has been associated with an improved therapeutic ratio but there is reason to believe that results could be further improved, for example, by more individualization of treatment strategies based on biological parameters of the tumor and host The biological processes that may occur in tumors and normal tissues during fractionated dose tissues. regimen (e.g. repair of cellular injury, regeneration, reoxygenation and redistribution) will be described and the potential for a therapeutic gain through hyperfractionation or accelerated fractionation discussed.
207 ENDOMETRIAL
CARCINOMA
John R. Glassburn, Professor
M.D.
of Radiation
Therapy,
Hahnemann
Medical
College
and Hospital
There exists at the present time controversy over the role of radiation therapy in the treatment of patients with endometrial carcinoma, particularly for those patients with Stage I disease. A significant fund of knowledge now exists with regard to the prognostic factors found with this disease which can aid us in selecting those patients who are most likely to benefit from a combined treatment approach. These factors will be discussed in detail along with the advantages and disadvantages of both preoperative and postoperative radiation therapy. The integration of surgery, radiation therapy and systemic therapy in a rational fashion for patients with advanced disease to optimize treatment results will also be outlined.
208 UPPER ABDOMINAL Ralph Mayo
MALIGNANCIES:
R. Dobelbower, Clinic,
STOMACH,
Jr., M.D.,
Rochester,
Ph.D.,
Minnesota;
PANCREAS, Leonard
Medical
GALLBLADDER,
Gunderson,
College
AND BILIARY
TREE
M.D.
of Ohio, Toledo,
Ohio
The role of radiotherapy in the management of upper abdominal neoplasms is rapidly expanding. This refresher course will review the etiology, diagnosis and especially the clinical management of tumors of The role of radiation as an adjuvant and as a the stomach, pancreas, gallbladder and the biliary tree. definitive treatment modality will be discussed. Recent innovations and new applications of existing intra-operative irradiation; precision high dose techniques, intraluminal technology will be presented: isotope techniques, particle irradiation, etc. Time will be reserved for questions and answers. A syllabus will be available. Supported
in part by NC1 Grant # R26 CA 292518
209 RADIOTHERAPEUTIC
MANAGEMENT
A.
r1.D.
Robert
Radiation
Kaqan, Therapy
Department,
OF METASTASES
Southern
California
Permanente
cledical
Group,
LosAngeles,Ca.
As much as 60% of a radiation oncologist's consultative and treatment efforts are spent Although the management of metastasis and locally in the management of noncurative disease. Who should be for the treatment are few. incurable cancer is a common problem, guidelines What techniques should be used, simple or complex? treated and why?