Enzimatic and electrophoretic alterations in cirrhotic patients

Cirrhosis

and its complicutions,

BIOCHEMICAL ALTERATIONS TIC FACTORS IN CIRRHOTIC

pathophysiology

und clinical

OF CHOLESTEROL

AND HEMOSTA-

Dr Rolanda Zaganjori,Dr.Neki Beqari,Dr.Stelian Buzo, Dr.Jovan Basho,Dr.Ilir Bibolli. University Hospital Center "Mother Theresa" of Tirana ,Albania. Aim of the study: To appropriate biochemical alterations of cholesterol and hemostatic factors in cirrhotic patients. Patienes and methods: For 20 patients (dtudy group) with ascitic liver cirrhosis were evalueted total and HDL-cholesterol,cholest./HDL-cholest. ratio, fibrinogen and prothrombin time-The same parameters were determinated in 8he control group without statistical differences by sex and age). The results are shown Results. Parameters Study Group Xfsd

171

aspects

in table below: Control group Xfsd

P

Cholesterol mg/dl 135.8f 30.5 HDL-choles.mg/dl 40.6* 6.7 Chol/HDL-chol 4.6f 2.22 Fibrinoqen mgjdl 230f 122 Prothromb.time % 60.7f 11.5

p
THE

SPONTANEOUS BACTERIAL ASCITES-PEIUTOMTIS AND BACTERIAL TBANS~ATION ON PATJENTS wrrHTHELIVERclRRHosI!3 A.Pereiaslov, S.Chooklin Me&CalUmvennty, LVN, Ukraine The spontaneous ascites-peritonitis developed on approximately of 20% patients with decompensativc liver cmhosis. It connected, in the first turn, with the bacterial transkxxtion henomena. The main link of its development is the damage of &owe1 wall. The ascites-peritonitis evokes, as the rule, by the monomicrobial gram-negative flora (more often Escherichia taneous bacterial coli). Examination of patients with the s ascites-peritonitis showed, that in it JGz ostic the great importance belongs to the clinical data (resistant ascites, abdominal pain, tenderness on palpation, hyp+erm@) and cytologic and bacteriologic inves@ations_ of ascetic fled also. The main criterion of the ascites’ contammation is the quantity of polymorphonuclear leukocytes more than 250/mm3 and often more than 5000/n& and the presence of bacterial endotoxin in ascitic fluid. It is possible three mechanisms of bacterial

The complex radioimmunological inve?@ation also shows the obvious mmnme d&egulation on liver crrhosis patients. with the aim of the intestinal decontamination it is necessary to use the norfloxach lactulosa, neomycin.

ENZIMATIC

AND ELECTROPHORETIC

CIRRHOTIC Dr. Stelian Dr.Jovan

ALTERATIONS

IN

PATIENTS Buzo,Dr.Neki

Basho,

Dr.Ilir

Beqari,Dr.Rolanda

Zaganjori

Bibolli.

University Hospital Center "Mother Theresa" of Tirana ,Albania Aim of the Study: To evaluate enzimatic and electrophoretic alteratiuons in cirrhotic patients. In a 20 patients group (study Material and Methods group) with assitic liver cirrhosis phosphatases elektrophoresis,and enzima. and blood protein The same parameters were evaluated in an other volountiers group (control group,without differences by sex and age). For statistical analysis exact t-test and linear correlation were used where appropriate. in table below: Results: The results are shown Study group Cont.group P Parameters GOT U/l

Xtsd 35.6k17.1

GPT U/l GGT U/l

36.3514.5

30.52

15.5 n.s

89.4242.6

30.82

18.2 o< 0.0001

Alc.phosphat. dLGlobulins % Flobulins

U/l

%

x+ sd 30.5* 15.5 n.s

2505 161 11.22 1.3

190f 128 7.32 2.8

23.9+

16.42 4.6

4.4

n.s p< 0.0001

p<

0.0001 l.GGT, and Globulins were higher in Conclusions: oatients with ascitic liver cirrhosis.2.There was a good correlation (r=0.92) between globulins,GGT alc.phoshp.