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EP-1422: Pregnancy outcomes in cancer patients received radiotherapy: a nationwide population-based study
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to 5 cc (31.6%), and > 5cc (32,5%). Mean margin dose 15 Gy ( 12-18 Gy) and the maximal 30 Gy Results PF Obliteration PF<1: complete 60% , partial 35%, no change 4.5%; PF 1.01-1.5: complete 43.5%, partial 47.5% , no change 9%; PF 1.51-2: complete 45%, partial 50%, no change 5%; PF > 2: 1.5% complete, partial 78.5%, no change 6.1%. Rebleeding PF <1: 2.4%; PF 1.01-1.5: 3%; PF 1.51-2: 3.8% and PF > 2 had no rebleeding, Toxicity PF <1: acute 13.5%, late 10,6% (clinical 4.7% radiological 3.5%, radiological and clinical 2.4%); PF 1.01-1.5: acute 16%, late 13% (clinical 8%, radiological 2%, clinical and radiological 3%); PF 1.51-2: acute 11.5%, late 12% (clinical 5%, radiological 3.5%, radiological and clinical 3.5%); PF > 2 : acute 17.5%, late 21% (clinical 18%, clinical and radiological toxicity 3%) SM Obliteration Grade I: complete 65%, partial 35%; Grade II: 50% complete, partial 45%, no change 5%; Grade III: complete 46% , partial 46% ,no change 8%; Grade IV : complete 17% , partial 72 % , no change 11%, and Grade V: any complete obliteration. Rebleeding Grade I: 5%, Grade II: 1,4%, Grade III: 3%, Grade IV: 13.%, Grade V no rebleeding. Toxicity Grade I: acute 12.5%, late 8.6% (clinical 4.3% , radiological 4.3%); Grade II: acute 3.7% , late 14% (clinical 7.5%, radiological 4%, radiological and clinical 2.5%); Grade III: acute 19.5 % , late 14%(clinical 4% radiological 3%, clinical and radiological 7%); Grado IV: acute 21%, late 29.5% (clinical 23.5 %, radiological and clinical 6%); Grade V: acute 100%, and no late Conclusion The experience of this single Institution are consistent with those published in the literature , low rate of rebleeding, acceptable toxicity, and obliteration rate that varies with the nidus size and the prognostic factors according to the (SM) and the (PF) EP-1422 Pregnancy outcomes in cancer patients received radiotherapy: a nationwide population-based study Y.J. Chiang1 1 Chang Gung Memorial Hospital- Linkou, Department of Radiation Oncology, Taoyuan, Taiwan Purpose or Objective To estimate the risks of adverse maternal outcomes in female cancer patients received radiotherapy (RT) compared with women without malignancy. Material and Methods We identified 2,350,335 singleton pregnancy using Taiwan National Health Insurance Database and Taiwan Birth Registry between 2001 and 2012, of which 607 pregnancies were in female cancer patients with RT. Odds ratios (ORs) and 95% confidence intervals (CIs) for maternal outcomes were estimated using generalized estimating equation model adjusted by maternal age, Charlson comorbidity index, urbanization, income, occupation and birth of year. Results From 2001 to 2012, pregnancies in female cancer patients received radiotherapy were associated with an adjusted OR (95% CIs) of 1.46 (1.02-2.09) for severe postpartum hemorrhage compared with women without malignancy. Otherwise there were no significant increasing risks with an adjusted OR of 0.95 (0.84-1.07) for Caesarean section, 0.56 (0.39-0.80) for preterm labor, 0.84 (0.64-1.11) for
antepartum hemorrhage, 0.48 (0.32-0.74) for pregnancy related hypertension, 0.60 (0.38-0.95) for preeclampsia, and 0.62 (0.46-0.85) for gestational diabetes. Conclusion For female cancer patients received radiotherapy, the risk of severe postpartum hemorrhage might be increased. EP-1423 the evaluation of sleep quality in cancer patients following the diagnosis of a metastatic site E. Yirmibesoglu Erkal1, D. Celik1, S. Ozmen1, G. Aksu1, H.S. Erkal2 1 Kocaeli University, Department of Radiation Oncology, Kocaeli, Turkey 2 Sakarya University, Department of Radiation Oncology, Sakarya, Turkey Purpose or Objective The aim of this study was the evaluate the sleep quality in cancer patients receiving palliative radiotherapy for the first time following the diagnosis of a metastatic site and to correlate the sleep quality with the depression status and the level of hopelessness. Material and Methods Forty-eight metastatic cancer patients about to receive palliative radiotherapy were evaluated using questionnaires for Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI) and Beck Hopelessness Scale (BHS). There were 12 females and 36 males, their ages ranging from 27 to 77 years (median, 60 years). 39 patients were married and 14 patients had at least high school education. Primary tumor site was listed as the respiratory system in 14 patients and the genitourinary system in 14. The time from the diagnosis of cancer to the diagnosis of the metastatic site was less than 1 month in 17 patients, 1 to 6 months in 10 and over 6 months in 21. Radiotherapy was delivered for bone metastases in 34 patients and brain metastases in 9. Results PSQI scores ranged from 0 to 17 (median, 10) and those with scores over 8 were classified as poor sleepers. BDI scores ranged from 0 to 36 (median, 15) and those with scores over 10 were classified as having mild to severe depression. BHS scores ranged from 0 to 16 (median, 4) and those with scores less than 4 were classified as having no hopelessness at all. Accordingly, there were 30 patients who were poor sleepers, 29 who had mild to severe depression and 25 who were hopeless. There was a strong, positive correlation between PSQI scores and BDI scores which was statistically significant (p=0.002). There was no correlation between PSQI scores and BHS scores. There was a statistically significant association between poor sleep quality and single marital status (p=0.04). Conclusion Self-administered measurements such as PSQI, BDI and BHS might be used as a simple means to collect data on multiple facets of the sleep quality, the depression status and the level of hopelessness. In this study, poor sleepers were prevalent among metastatic cancer patients. Poor sleep, associated with mild to severe depression, deserves adequate medical attention in terms of supportive care EP-1424 Fertility preserving high precision radiotherapy in non-uterine pelvic malignancies in female P.S. Sridhar1, N. Madhusudhan1, K. Roopesh1, J. Vijay kumar1, M. Praveen kumar1, A. Jerrin1, A. Pichandi1, B. Ajai kumar1 1 Health Care Global Enterprises Ltd, CyberknifeRadiation oncology, Bangalore, India Purpose or Objective Fertility is major issue in non-uterine pelvic malignancies in reproductive age requiring radiation. Primary pathology
to 5 cc (31.6%), and > 5cc (32,5%). Mean margin dose 15 Gy ( 12-18 Gy) and the maximal 30 Gy Results PF Obliteration PF<1: complete 60% , partial 35%, no change 4.5%; PF 1.01-1.5: complete 43.5%, partial 47.5% , no change 9%; PF 1.51-2: complete 45%, partial 50%, no change 5%; PF > 2: 1.5% complete, partial 78.5%, no change 6.1%. Rebleeding PF <1: 2.4%; PF 1.01-1.5: 3%; PF 1.51-2: 3.8% and PF > 2 had no rebleeding, Toxicity PF <1: acute 13.5%, late 10,6% (clinical 4.7% radiological 3.5%, radiological and clinical 2.4%); PF 1.01-1.5: acute 16%, late 13% (clinical 8%, radiological 2%, clinical and radiological 3%); PF 1.51-2: acute 11.5%, late 12% (clinical 5%, radiological 3.5%, radiological and clinical 3.5%); PF > 2 : acute 17.5%, late 21% (clinical 18%, clinical and radiological toxicity 3%) SM Obliteration Grade I: complete 65%, partial 35%; Grade II: 50% complete, partial 45%, no change 5%; Grade III: complete 46% , partial 46% ,no change 8%; Grade IV : complete 17% , partial 72 % , no change 11%, and Grade V: any complete obliteration. Rebleeding Grade I: 5%, Grade II: 1,4%, Grade III: 3%, Grade IV: 13.%, Grade V no rebleeding. Toxicity Grade I: acute 12.5%, late 8.6% (clinical 4.3% , radiological 4.3%); Grade II: acute 3.7% , late 14% (clinical 7.5%, radiological 4%, radiological and clinical 2.5%); Grade III: acute 19.5 % , late 14%(clinical 4% radiological 3%, clinical and radiological 7%); Grado IV: acute 21%, late 29.5% (clinical 23.5 %, radiological and clinical 6%); Grade V: acute 100%, and no late Conclusion The experience of this single Institution are consistent with those published in the literature , low rate of rebleeding, acceptable toxicity, and obliteration rate that varies with the nidus size and the prognostic factors according to the (SM) and the (PF) EP-1422 Pregnancy outcomes in cancer patients received radiotherapy: a nationwide population-based study Y.J. Chiang1 1 Chang Gung Memorial Hospital- Linkou, Department of Radiation Oncology, Taoyuan, Taiwan Purpose or Objective To estimate the risks of adverse maternal outcomes in female cancer patients received radiotherapy (RT) compared with women without malignancy. Material and Methods We identified 2,350,335 singleton pregnancy using Taiwan National Health Insurance Database and Taiwan Birth Registry between 2001 and 2012, of which 607 pregnancies were in female cancer patients with RT. Odds ratios (ORs) and 95% confidence intervals (CIs) for maternal outcomes were estimated using generalized estimating equation model adjusted by maternal age, Charlson comorbidity index, urbanization, income, occupation and birth of year. Results From 2001 to 2012, pregnancies in female cancer patients received radiotherapy were associated with an adjusted OR (95% CIs) of 1.46 (1.02-2.09) for severe postpartum hemorrhage compared with women without malignancy. Otherwise there were no significant increasing risks with an adjusted OR of 0.95 (0.84-1.07) for Caesarean section, 0.56 (0.39-0.80) for preterm labor, 0.84 (0.64-1.11) for
antepartum hemorrhage, 0.48 (0.32-0.74) for pregnancy related hypertension, 0.60 (0.38-0.95) for preeclampsia, and 0.62 (0.46-0.85) for gestational diabetes. Conclusion For female cancer patients received radiotherapy, the risk of severe postpartum hemorrhage might be increased. EP-1423 the evaluation of sleep quality in cancer patients following the diagnosis of a metastatic site E. Yirmibesoglu Erkal1, D. Celik1, S. Ozmen1, G. Aksu1, H.S. Erkal2 1 Kocaeli University, Department of Radiation Oncology, Kocaeli, Turkey 2 Sakarya University, Department of Radiation Oncology, Sakarya, Turkey Purpose or Objective The aim of this study was the evaluate the sleep quality in cancer patients receiving palliative radiotherapy for the first time following the diagnosis of a metastatic site and to correlate the sleep quality with the depression status and the level of hopelessness. Material and Methods Forty-eight metastatic cancer patients about to receive palliative radiotherapy were evaluated using questionnaires for Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI) and Beck Hopelessness Scale (BHS). There were 12 females and 36 males, their ages ranging from 27 to 77 years (median, 60 years). 39 patients were married and 14 patients had at least high school education. Primary tumor site was listed as the respiratory system in 14 patients and the genitourinary system in 14. The time from the diagnosis of cancer to the diagnosis of the metastatic site was less than 1 month in 17 patients, 1 to 6 months in 10 and over 6 months in 21. Radiotherapy was delivered for bone metastases in 34 patients and brain metastases in 9. Results PSQI scores ranged from 0 to 17 (median, 10) and those with scores over 8 were classified as poor sleepers. BDI scores ranged from 0 to 36 (median, 15) and those with scores over 10 were classified as having mild to severe depression. BHS scores ranged from 0 to 16 (median, 4) and those with scores less than 4 were classified as having no hopelessness at all. Accordingly, there were 30 patients who were poor sleepers, 29 who had mild to severe depression and 25 who were hopeless. There was a strong, positive correlation between PSQI scores and BDI scores which was statistically significant (p=0.002). There was no correlation between PSQI scores and BHS scores. There was a statistically significant association between poor sleep quality and single marital status (p=0.04). Conclusion Self-administered measurements such as PSQI, BDI and BHS might be used as a simple means to collect data on multiple facets of the sleep quality, the depression status and the level of hopelessness. In this study, poor sleepers were prevalent among metastatic cancer patients. Poor sleep, associated with mild to severe depression, deserves adequate medical attention in terms of supportive care EP-1424 Fertility preserving high precision radiotherapy in non-uterine pelvic malignancies in female P.S. Sridhar1, N. Madhusudhan1, K. Roopesh1, J. Vijay kumar1, M. Praveen kumar1, A. Jerrin1, A. Pichandi1, B. Ajai kumar1 1 Health Care Global Enterprises Ltd, CyberknifeRadiation oncology, Bangalore, India Purpose or Objective Fertility is major issue in non-uterine pelvic malignancies in reproductive age requiring radiation. Primary pathology