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EP 82. Lateralization of auditory-motor and somatosensory-motor loops during bimanual auditory-paced finger tapping
Abstracts / Clinical Neurophysiology 127 (2016) e210–e303
patients compared to the controls (Fig. 1) (p < 0.05 (FDR corr.)). The covariant analysis showed the strongest negative regression between the BDI and the volume of left Fp2 of the complete group (Fp2_L BDI (r = 0.32)) and within the patients of all sites (Fp2_L BDI (r = 0.26)). Duration as well as episodes also correlates negatively with the volume of left Fp2 within the patients (Fp2_L duration (r = 0.35); Fp2_L episodes (r = 0.34)). Histologically uninformed multivariate voxel-wise statistics provided converging evidence for structural aberrations specific to the microstructurally defined medial area of the frontal pole in depressed patients (Fig. 2). Conclusions: Across disparate methods, subregion specificity in the left medial frontal pole volume in depressed patients was demonstrated. Indeed, the frontal pole was shown to structurally and functionally connect to other key regions in major depression pathology, such as the anterior cingulate cortex and the amygdala via the uncinate fasciculus. Present and previous findings consolidate the left medial portion of the frontal pole as particularly altered in major depression.
References Bludau S, Eickhoff SB, Mohlberg H, Caspers S, Laird AR, Fox PT, Schleicher A, Zilles K, Amunts K. Cytoarchitecture, probability maps and functions of the human frontal pole. Neuroimage 2014;93(Pt 2):260–75. Mayberg. Mayberg HS. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br Med Bull 2003;65:193–207. doi:10.1016/j.clinph.2016.05.130
e275
interest were randomized, blocked, and contrasted against silent baseline. EPI images were standard pre-processed and analyzed using a general linear model in SPM 12. Results are presented at p. Results: Right auditory association cortex activated more strongly in bimanual slow compared to fast tapping. The non-preferred asymmetric bimanual condition (left hand fast / right slow) activated the right SMA and right secondary somatosensory cortex (S2) more strongly than the preferred symmetric condition. This effect was independent of the left hand tapping frequency, as it was observed when tapping frequency was controlled for. Conclusion: These findings indicate that the right auditory association cortex specifically engages for slow tapping when 1:4 tapping requires auditory processing of larger time windows in the absence of timing information from the motor system. Our results suggest processing during the non-preferred asymmetric bimanual tapping engages an additional right-hemispheric somatosensorimotor feedback loop (involving S2 and SMA).The left hemisphere does not require this loop to the same extent when performing the identical movement. We speculate that this is a consequence of a left hemispheric dominance in auditory-motor integration (4). We conclude that only the non-dominant right hemisphere uses more somatosensory feedback when it is forced to perform precisely timed finger tapping at higher relative frequencies. This could be taken as indirect evidence for a left hemispheric specialization for auditory-motor integration at higher relative frequencies. References Ivry RB, Robertson LC. The two sides of perception. MIT Press; 1998. Jäncke L, Peters M, Himmelbach M, Nösselt T, Shah J, Steinmetz H. Neuropsychologia 2000;38(2):164–74. doi:10.1016/j.clinph.2016.05.131
EP 82. Lateralization of auditory-motor and somatosensorymotor loops during bimanual auditory-paced finger tapping— F. Gompf *, A. Pflug, C. Kell (Klinikum der JWG-Universität, Neurologie, CNS, Frankfurt am Main, Germany) ⇑
Corresponding author.
Introduction: During asymmetric bimanual movements the right hand usually performs the faster movement compared to the left hand. This left hemisphere preference for processing of higher relative frequencies has been postulated in the sensory domain. The left hemisphere is thought to excel in analyzing higher relative stimulus frequencies while the right hemisphere is more engaged in processing lower relative frequencies (Ivry and Robertson, 1998). The observed preference of right hand tapping the faster rhythm in 1:n bimanual tapping could potentially mirror this left hemisphere dominance for processing higher relative frequencies in the motor domain. The bimanual coordination of preferred movements has been related with activation of the left more than right supplementary motor area (SMA) (Jäncke et al., 2000). The intra- and interhemispheric interactions during asymmetric finger tapping and their relationship to hemispheric specialization for relative frequencies are not understood. We thus investigated the lateralization of neural networks engaged in bimanual coordination and explored the effect of tapping frequencies. Methods: In an EEG-fMRI experiment, 32 right-handed subjects performed an auditory-paced finger tapping task during which the tapping frequency (low/high) and the executing hand (unimanual left/right and bimanual) were modulated. Auditory clicks were presented at 2.5 Hz. The ratio of low versus high tapping frequency was 1:4 clicks. Here, we report the fMRI results first. Conditions of
EP 83. Neural correlates of age-related changes in cognitive action control—A. Latz a,b,*, F. Hoffstädter a,b, E. Cieslik a,b, S. Caspers b,c, K. Amunts b,c, S. Moebus d, N. Pundt d, S. Eickhoff a,b, R. Langner a,b (a Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, b Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany, c Cécile and Oskar Vogt Institute of Brain Research, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, d Center for Urban Epidemiology, University of Duisburg-Essen, Essen, Germany) ⇑
Corresponding author.
Introduction: Healthy aging has been associated with a decrease in cognitive action control, but the underlying neural mechanisms are still elusive. The spatial stimulus-response compatibility (SRC) task captures this aspect of cognitive control, as it requires overcoming predominant but incorrect action tendencies to enable correct responding. Aim: To identify brain areas that change their action-controlrelated activity with age. Methods: Using fMRI we measured brain activity in a large sample of adults recruited from the population-based 1000BRAINS study (n = 234; mean age 52.5 years; 130 males) while performing an SRC task. Participants were instructed to give a speeded response to lateralized visual stimuli with the ipsilateral (spatially compatible) or contralateral (spatially incompatible) hand. Effects of incompatibility and age on performance [reaction time (RT) and error rate (ER)] were tested via an analysis of covariance (ANCOVA) with
patients compared to the controls (Fig. 1) (p < 0.05 (FDR corr.)). The covariant analysis showed the strongest negative regression between the BDI and the volume of left Fp2 of the complete group (Fp2_L BDI (r = 0.32)) and within the patients of all sites (Fp2_L BDI (r = 0.26)). Duration as well as episodes also correlates negatively with the volume of left Fp2 within the patients (Fp2_L duration (r = 0.35); Fp2_L episodes (r = 0.34)). Histologically uninformed multivariate voxel-wise statistics provided converging evidence for structural aberrations specific to the microstructurally defined medial area of the frontal pole in depressed patients (Fig. 2). Conclusions: Across disparate methods, subregion specificity in the left medial frontal pole volume in depressed patients was demonstrated. Indeed, the frontal pole was shown to structurally and functionally connect to other key regions in major depression pathology, such as the anterior cingulate cortex and the amygdala via the uncinate fasciculus. Present and previous findings consolidate the left medial portion of the frontal pole as particularly altered in major depression.
References Bludau S, Eickhoff SB, Mohlberg H, Caspers S, Laird AR, Fox PT, Schleicher A, Zilles K, Amunts K. Cytoarchitecture, probability maps and functions of the human frontal pole. Neuroimage 2014;93(Pt 2):260–75. Mayberg. Mayberg HS. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br Med Bull 2003;65:193–207. doi:10.1016/j.clinph.2016.05.130
e275
interest were randomized, blocked, and contrasted against silent baseline. EPI images were standard pre-processed and analyzed using a general linear model in SPM 12. Results are presented at p. Results: Right auditory association cortex activated more strongly in bimanual slow compared to fast tapping. The non-preferred asymmetric bimanual condition (left hand fast / right slow) activated the right SMA and right secondary somatosensory cortex (S2) more strongly than the preferred symmetric condition. This effect was independent of the left hand tapping frequency, as it was observed when tapping frequency was controlled for. Conclusion: These findings indicate that the right auditory association cortex specifically engages for slow tapping when 1:4 tapping requires auditory processing of larger time windows in the absence of timing information from the motor system. Our results suggest processing during the non-preferred asymmetric bimanual tapping engages an additional right-hemispheric somatosensorimotor feedback loop (involving S2 and SMA).The left hemisphere does not require this loop to the same extent when performing the identical movement. We speculate that this is a consequence of a left hemispheric dominance in auditory-motor integration (4). We conclude that only the non-dominant right hemisphere uses more somatosensory feedback when it is forced to perform precisely timed finger tapping at higher relative frequencies. This could be taken as indirect evidence for a left hemispheric specialization for auditory-motor integration at higher relative frequencies. References Ivry RB, Robertson LC. The two sides of perception. MIT Press; 1998. Jäncke L, Peters M, Himmelbach M, Nösselt T, Shah J, Steinmetz H. Neuropsychologia 2000;38(2):164–74. doi:10.1016/j.clinph.2016.05.131
EP 82. Lateralization of auditory-motor and somatosensorymotor loops during bimanual auditory-paced finger tapping— F. Gompf *, A. Pflug, C. Kell (Klinikum der JWG-Universität, Neurologie, CNS, Frankfurt am Main, Germany) ⇑
Corresponding author.
Introduction: During asymmetric bimanual movements the right hand usually performs the faster movement compared to the left hand. This left hemisphere preference for processing of higher relative frequencies has been postulated in the sensory domain. The left hemisphere is thought to excel in analyzing higher relative stimulus frequencies while the right hemisphere is more engaged in processing lower relative frequencies (Ivry and Robertson, 1998). The observed preference of right hand tapping the faster rhythm in 1:n bimanual tapping could potentially mirror this left hemisphere dominance for processing higher relative frequencies in the motor domain. The bimanual coordination of preferred movements has been related with activation of the left more than right supplementary motor area (SMA) (Jäncke et al., 2000). The intra- and interhemispheric interactions during asymmetric finger tapping and their relationship to hemispheric specialization for relative frequencies are not understood. We thus investigated the lateralization of neural networks engaged in bimanual coordination and explored the effect of tapping frequencies. Methods: In an EEG-fMRI experiment, 32 right-handed subjects performed an auditory-paced finger tapping task during which the tapping frequency (low/high) and the executing hand (unimanual left/right and bimanual) were modulated. Auditory clicks were presented at 2.5 Hz. The ratio of low versus high tapping frequency was 1:4 clicks. Here, we report the fMRI results first. Conditions of
EP 83. Neural correlates of age-related changes in cognitive action control—A. Latz a,b,*, F. Hoffstädter a,b, E. Cieslik a,b, S. Caspers b,c, K. Amunts b,c, S. Moebus d, N. Pundt d, S. Eickhoff a,b, R. Langner a,b (a Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, b Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany, c Cécile and Oskar Vogt Institute of Brain Research, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, d Center for Urban Epidemiology, University of Duisburg-Essen, Essen, Germany) ⇑
Corresponding author.
Introduction: Healthy aging has been associated with a decrease in cognitive action control, but the underlying neural mechanisms are still elusive. The spatial stimulus-response compatibility (SRC) task captures this aspect of cognitive control, as it requires overcoming predominant but incorrect action tendencies to enable correct responding. Aim: To identify brain areas that change their action-controlrelated activity with age. Methods: Using fMRI we measured brain activity in a large sample of adults recruited from the population-based 1000BRAINS study (n = 234; mean age 52.5 years; 130 males) while performing an SRC task. Participants were instructed to give a speeded response to lateralized visual stimuli with the ipsilateral (spatially compatible) or contralateral (spatially incompatible) hand. Effects of incompatibility and age on performance [reaction time (RT) and error rate (ER)] were tested via an analysis of covariance (ANCOVA) with