Epidemiology of Common Lymphoid Malignancies in the Veteran Health Administration

Abstracts Survival, sustained virological response (SVR). Results: We enrolled 7 patients (4 male, 3 female, mean age at hematologic diagnosis of 52 years), 1 had Mantle Cell Lymphoma, 2 Splenic DLBCL, 1 Gastric DLBCL, 1 Salivary Gland Lymphoma, 1 DLBCL, 1 Chronic Lymphocytic Leukemia. 2 Died, 1 dropped out of treatment and 4 were cured, with mean overall survival greater than 10 years. Other information shown in Table 1. Conclusions: As standard-of-care, antiviral treatment achieves virological and hematological remission in indolent lymphomas, while more aggressive lymphomas require combinations of antiviral treatment and chemotherapy. However, in clinical practice, results found may differ from Literature, as we report in this study. Clinical Trials are needed to properly address treatment of HCV-related B-NHL, especially in interferon-free regimens.

and Veterans. Age-adjusted incidence rates were comparable to SEER rates. African Americans were significantly more likely to be diagnosed at an earlier age, and to live in urban areas. Vital status was available for the majority of the cohort, allowing estimation of survival rates. Conclusions: Identifiation of cancer patients in the VHA using EMR data is feasible. CLL, FL, and DLBCL demographics were compatible with SEER reports for general population. This will allow study of real world practice patterns and outcomes using EMR individual pt level information.

NHL-180 Epidemiology of Common Lymphoid Malignancies in the Veteran Health Administration Ahmad Halwani,1 Zachary Burningham,2,3 Brian Sauer2,3 1

Huntsman Cancer Institute, University of Utah, Salt Lake City, United

States; 2George E Whalen VA Medical Center, Salt Lake City, Utah, United States; 3Dpt. of Internal Medicine, University of Utah, Salt Lake City, Utah, United States

Context: The Veterans Health Administration (VHA) is the largest integrated health care system in the US, with 1,700 clinics and 152 hospitals in 50 states serving up to 8.5 million Veterans per year. VHA electronic medical record (EMR) information is collected in a single corporate data warehouse (CDW). There has been little to no research into the epidemiology of common lymphoid malignancies in the VHA, or associated practice patterns and outcomes. We therefore piloted a study of the incidence of three common lymphoid malignancies in the VHA using EMR data. Objective: Describe incidence, demographic characteristics, and survival of pts with Chronic Lymphocytic Leukemia (CLL), Follicular Lymphoma (FL) and Diffuse Large B Cell Lymphoma (DLBCL) in VHA. Setting: The VHA is the largest integrated health care system in the United States. Methods: Patients were identified using the “Oncology” module of the VHA’s EMR. CDW queries were performed in the VA Informatics and Computing Infrastructure (VINCI), using Structured Query Language (SQL) pass-through from within the R statistical environment. Data cleaning routines and analysis were performed in R. Descriptive statistics and comparisons were performed using frequencies and Chi-square for categorical variables; medians and t-test for continuous variables. Survival estimated using Kaplan Meier. Results: Between 2001-2015, 8,966 pt with CLL, 2957 with FL, and 5,960 pts with DLBCL were diagnosed/treated in the VHA (Table 1). Median age was 69.6 (CLL), 65.3 (FL) & 67 (DLBCL). Cohorts were mostly male; African Americans comprised 8-12% of patients- both in line with known demographics of US population

Clinical Lymphoma, Myeloma & Leukemia September 2016

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