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Epidemiology of Squamous Cell Carcinoma of the Oral Cavity and Oropharynx in Chile
ORAL AND MAXILLOFACIAL PATHOLOGY e92 Abstracts Conclusions: Histopathological evaluation of AC, which is necessary for an accurate diagnosis, increases the rate of cancer diagnosis in initial stages, thus allowing the use of treatments that are more conservative.
PPC-043 - LOSS OF HETEROZYGOSITY IN LIP SQUAMOUS CELL CARCINOMA AND ACTINIC CHEILITIS. VANESSA DE FÁTIMA BERNARDES, GEFTER THIAGO BATISTA CORREA, RICARDO SANTIAGO GOMEZ, JOSÉ MARIA PORCARO SALLES, CAROLINA CAVALIÉRI GOMES. UNIVERSIDADE FEDERAL DE MINAS GERAIS. Objective: To investigate the loss of heterozygosity (LOH) in microsatellite regions close to tumor suppressor genes in squamous cell carcinoma of the lip and actinic cheilitis. Materials and Methods: The sample comprised 16 cases of actinic cheilitis and 17 cases of squamous cell carcinoma of the lip. LOH was assessed on chromosome loci 9p (D9S157, D9S162, D9S171, D9S287) and 17p (TP53, AFM238). Results: The genetic loci that most often exhibited LOH were D9S287 and D9S171 in actinic cheilitis, compared with D9S171 and D9S162 for squamous cell carcinoma of the lip. Conclusions: Our results suggest that LOH at chromosome 9p can be relevant to the pathogenesis of squamous cell carcinoma of the lip. Financial support: CAPES, CNPq, and FAPEMIG.
PPC-044 - BONE DYSPLASIA IMAGE ASSESSMENT: A RETROSPECTIVE STUDY USING CONE-BEAM COMPUTED TOMOGRAPHY. PRISCYLLA GONÇALVES CORREIA LEITE DE MARCELOS, PAULO HENRIQUE PEREIRA CAVALCANTI, DANYEL ELIAS DA CRUZ PEREZ, MARIA LUIZA DOS ANJOS PONTUAL, EDUARDA HELENA LEANDRO DO NASCIMENTO, MARCO ANTÔNIO GOMES FRAZÃO, FLÁVIA MARIA DE MORAES RAMOSPEREZ. UNIVERSIDADE FEDERAL DE PERNAMBUCO. Objective: To perform an epidemiological study of bone dysplasias in a Brazilian sample using cone-beam computed tomography. Materials and Methods: From among 22,400 patients treated over a 5-year period at a private radiology service, were selected the examinations of 112 who met the inclusion criteria. Two examiners evaluated the images, using sagittal, axial, and coronal reconstructions. Results: Twenty-two (19.64%) of the images were from male patients, and 90 (80.36%) were from females. The mean age was 50.4 years; 82 cases (73.21%) presented periapical bone dysplasia; 17 (15.18%) exhibited focal bone dysplasia, 8 (7.14%) revealed florid bone dysplasia, and 5 (4.46%) presented both periapical and focal bone dysplasia. In 106 cases (94.64%), only the mandible was affected. Conclusions: Bone dysplasia is more common among female patients, and the mandible is the site most often affected.
PPC-045 - EFFECTIVENESS OF TREATMENT OF ORAL PEMPHIGUS VULGARIS AT AN ORAL MEDICINE SERVICE IN BRAZIL. DARCY FERNANDES, THAÍS LUCARELO LAMONATO, CAMILA MARQUES COSTA, CLÁUDIA MARIA NAVARRO, ELAINE MARIA SGAVIOLI MASSUCATO, ANDREIA BUFALINO, MIRIAN APARECIDA ONOFRE. FACULDADE DE ODONTOLOGIA DE ARARAQUARA e UNESP.
OOOO August 2015 Objective: To evaluate the effectiveness of treatment of oral pemphigus vulgaris (OPV). Materials and Methods: Seventeen cases were selected (58.8% women and 41.2% men, aged 18e63 years) from among those treated between 1989 and 2013 (n ¼ 11,410). Results: These oral lesions showed an increase from 10 days to 12 months with pain, burning, and bleeding. All patients were initially treated with prednisone. Dapsone was added in 9 patients, with resolution of less than 50% of lesions, and in 2 cases the medication was replaced with deflazacort. The followup ranged from 3 to 144 months. Eleven cases had complete (75% or more) resolution of the lesions, 5 had partial (more than 50%) resolution, and 1 had no noticeable change. Three patients had recurrence because the medication was suspended on their own account. Conclusion: The treatment administered proved effective in reducing the signs and symptoms of OPV.
PPC-046 - EPIDEMIOLOGY OF SQUAMOUS CELL CARCINOMA OF THE ORAL CAVITY AND OROPHARYNX IN CHILE. WILFREDO ALEJANDRO GONZÁLEZ-ARRIAGADA, MARJORIE BORGEAT-MEZA, KARINA CORDERO-TORRES, BERNARDO VENEGASROJAS. FACULTY OF DENTISTRY e UNIVERSIDAD DE VALPARAÍSO. Objective: To describe the epidemiologic features of squamous cell carcinoma (SCC) of the oral cavity and oropharynx in Chile between January 1995 and December 2005. Materials and Methods: Three pathology services were included. The clinical information was obtained from patient charts. Data were tabulated using codes of the International Classification of Diseases for Oncology. A descriptive analysis was performed. Results: During this period, 211 cases of SCC were diagnosed, being more common among males (76.8%). The mean age was 64.4 years. One hundred and 8 cases were diagnosed in the oral cavity and 103 cases were diagnosed in the oropharynx. The tongue was the most frequently affected site (29.4%), followed by the tonsils (16.6%), lips (13.3%), hard palate (9.5%), floor of mouth (5.7%) and soft palate (5.2%). Conclusions: This report is important to obtain epidemiologic data on cancer of the oral cavity and oropharynx, because there have been few reports from Chile.
PPC-047 - SYNDECAN-1 EXPRESSION IN DIFFERENT AMELOBLASTOMA SUBTYPES. FÁBIO RAMOA PIRES, LUCIANA ARMADA, ÁGUIDA MARIA MENEZES AGUIAR MIRANDA, ANDRESSA INCERTE FILIZZOLA, JULIANA DE NORONHA SANTOS NETTO. UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO. Objective: To compare the expression of syndecan-1, a heparin sulfate proteoglycan involved in cell-cell adhesion and signaling, in different ameloblastoma subtypes. Materials and Methods: Immunohistochemical reactions directed to syndecan-1 were performed in different ameloblastoma subtypes, including peripheral, solid (follicular, plexiform, and angiomatous), unicystic, and desmoplastic subtypes. Results: Syndecan-1 expression was different in the ameloblastoma subtypes included in the study and when comparing subtypes associated with distinct behavior.
PPC-043 - LOSS OF HETEROZYGOSITY IN LIP SQUAMOUS CELL CARCINOMA AND ACTINIC CHEILITIS. VANESSA DE FÁTIMA BERNARDES, GEFTER THIAGO BATISTA CORREA, RICARDO SANTIAGO GOMEZ, JOSÉ MARIA PORCARO SALLES, CAROLINA CAVALIÉRI GOMES. UNIVERSIDADE FEDERAL DE MINAS GERAIS. Objective: To investigate the loss of heterozygosity (LOH) in microsatellite regions close to tumor suppressor genes in squamous cell carcinoma of the lip and actinic cheilitis. Materials and Methods: The sample comprised 16 cases of actinic cheilitis and 17 cases of squamous cell carcinoma of the lip. LOH was assessed on chromosome loci 9p (D9S157, D9S162, D9S171, D9S287) and 17p (TP53, AFM238). Results: The genetic loci that most often exhibited LOH were D9S287 and D9S171 in actinic cheilitis, compared with D9S171 and D9S162 for squamous cell carcinoma of the lip. Conclusions: Our results suggest that LOH at chromosome 9p can be relevant to the pathogenesis of squamous cell carcinoma of the lip. Financial support: CAPES, CNPq, and FAPEMIG.
PPC-044 - BONE DYSPLASIA IMAGE ASSESSMENT: A RETROSPECTIVE STUDY USING CONE-BEAM COMPUTED TOMOGRAPHY. PRISCYLLA GONÇALVES CORREIA LEITE DE MARCELOS, PAULO HENRIQUE PEREIRA CAVALCANTI, DANYEL ELIAS DA CRUZ PEREZ, MARIA LUIZA DOS ANJOS PONTUAL, EDUARDA HELENA LEANDRO DO NASCIMENTO, MARCO ANTÔNIO GOMES FRAZÃO, FLÁVIA MARIA DE MORAES RAMOSPEREZ. UNIVERSIDADE FEDERAL DE PERNAMBUCO. Objective: To perform an epidemiological study of bone dysplasias in a Brazilian sample using cone-beam computed tomography. Materials and Methods: From among 22,400 patients treated over a 5-year period at a private radiology service, were selected the examinations of 112 who met the inclusion criteria. Two examiners evaluated the images, using sagittal, axial, and coronal reconstructions. Results: Twenty-two (19.64%) of the images were from male patients, and 90 (80.36%) were from females. The mean age was 50.4 years; 82 cases (73.21%) presented periapical bone dysplasia; 17 (15.18%) exhibited focal bone dysplasia, 8 (7.14%) revealed florid bone dysplasia, and 5 (4.46%) presented both periapical and focal bone dysplasia. In 106 cases (94.64%), only the mandible was affected. Conclusions: Bone dysplasia is more common among female patients, and the mandible is the site most often affected.
PPC-045 - EFFECTIVENESS OF TREATMENT OF ORAL PEMPHIGUS VULGARIS AT AN ORAL MEDICINE SERVICE IN BRAZIL. DARCY FERNANDES, THAÍS LUCARELO LAMONATO, CAMILA MARQUES COSTA, CLÁUDIA MARIA NAVARRO, ELAINE MARIA SGAVIOLI MASSUCATO, ANDREIA BUFALINO, MIRIAN APARECIDA ONOFRE. FACULDADE DE ODONTOLOGIA DE ARARAQUARA e UNESP.
OOOO August 2015 Objective: To evaluate the effectiveness of treatment of oral pemphigus vulgaris (OPV). Materials and Methods: Seventeen cases were selected (58.8% women and 41.2% men, aged 18e63 years) from among those treated between 1989 and 2013 (n ¼ 11,410). Results: These oral lesions showed an increase from 10 days to 12 months with pain, burning, and bleeding. All patients were initially treated with prednisone. Dapsone was added in 9 patients, with resolution of less than 50% of lesions, and in 2 cases the medication was replaced with deflazacort. The followup ranged from 3 to 144 months. Eleven cases had complete (75% or more) resolution of the lesions, 5 had partial (more than 50%) resolution, and 1 had no noticeable change. Three patients had recurrence because the medication was suspended on their own account. Conclusion: The treatment administered proved effective in reducing the signs and symptoms of OPV.
PPC-046 - EPIDEMIOLOGY OF SQUAMOUS CELL CARCINOMA OF THE ORAL CAVITY AND OROPHARYNX IN CHILE. WILFREDO ALEJANDRO GONZÁLEZ-ARRIAGADA, MARJORIE BORGEAT-MEZA, KARINA CORDERO-TORRES, BERNARDO VENEGASROJAS. FACULTY OF DENTISTRY e UNIVERSIDAD DE VALPARAÍSO. Objective: To describe the epidemiologic features of squamous cell carcinoma (SCC) of the oral cavity and oropharynx in Chile between January 1995 and December 2005. Materials and Methods: Three pathology services were included. The clinical information was obtained from patient charts. Data were tabulated using codes of the International Classification of Diseases for Oncology. A descriptive analysis was performed. Results: During this period, 211 cases of SCC were diagnosed, being more common among males (76.8%). The mean age was 64.4 years. One hundred and 8 cases were diagnosed in the oral cavity and 103 cases were diagnosed in the oropharynx. The tongue was the most frequently affected site (29.4%), followed by the tonsils (16.6%), lips (13.3%), hard palate (9.5%), floor of mouth (5.7%) and soft palate (5.2%). Conclusions: This report is important to obtain epidemiologic data on cancer of the oral cavity and oropharynx, because there have been few reports from Chile.
PPC-047 - SYNDECAN-1 EXPRESSION IN DIFFERENT AMELOBLASTOMA SUBTYPES. FÁBIO RAMOA PIRES, LUCIANA ARMADA, ÁGUIDA MARIA MENEZES AGUIAR MIRANDA, ANDRESSA INCERTE FILIZZOLA, JULIANA DE NORONHA SANTOS NETTO. UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO. Objective: To compare the expression of syndecan-1, a heparin sulfate proteoglycan involved in cell-cell adhesion and signaling, in different ameloblastoma subtypes. Materials and Methods: Immunohistochemical reactions directed to syndecan-1 were performed in different ameloblastoma subtypes, including peripheral, solid (follicular, plexiform, and angiomatous), unicystic, and desmoplastic subtypes. Results: Syndecan-1 expression was different in the ameloblastoma subtypes included in the study and when comparing subtypes associated with distinct behavior.