Erratum to “Enzyme Kinetics Far from the Standard Quasi-Steady-State and Equilibrium Approximations”

MATHEMATICAL COMPUTER MODELLING Mathematical

PERGAMON

and Computer

Modelling

36 (2002) 231-231 www.elsevier.com/Iocate/mcm

Erratum to “Enzyme Kinetics Far from the Standard Quasi-Steady-State and Equilibrium Approximations” Mathematical

and Computer

Modelling,

Vol. 35, No. l/2,

pp.

137-144, 2002

S. SCHNELL AND P. K. MAINI Centre for Mathematical Biology Mathematical Institute, 24-29 St Giles’, Oxford OX1 3LB, U.K. ~maini>@aaths.ox.ac.uk (Received

Figure 2 was mistakenly

April 2001)

duplicated as Figure 3. The correct Figure 3 is below.

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S (a) Initial conditions [So] = 10, [Eo] = 0.001; n = 0.0901, ag = 0.0090, K.,,, = 0.0991, E = 0.8115 x 10-5, p = 0.1000, (T = 0.9008. With these parameter values K = 1, KS = 0.1, Knf = 1.1, and both the sQSSA and tQSSA are valid.

(b) Initial n = 0.0901, p = 0.1000, K = 1, KS and tQSSA

conditions [Se] = 0.001, [Eo] n, = 0.0090, n, = 0.0991, E = (T = 0.0001. With these parameter = 0.1, Khf = 1.1, and both the are valid.

= 10; 0.0812, values rQSSA

Figure 3. Representation of the sQSSA [dashed curve] and rQSSA [dotted curve] veiocity equations for product formation obtained from the general velocity equation (6) along with the tQSSA velocity equation for product formation [cross symbols, (31)]. Parameter values are ki = 10; k-i = 1, kz = 10.

0895-7177/02/S - see front matter @ 2002 Elsevier Science Ltd. All rights reserved. PII: SO895-7177(02)00119-X

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