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ERUPTION MESENCHYMAL CALCIFIED HAMARTOMA: A CASE REPORT
ABSTRACTS
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THAYNA MELO DE LIMA MARAIS, ERIKA GRAF PEDROSO, ALAN ROGER DOS SANTOS-SILVA, OSLEI PAES DE ALMEIDA and, MARCIO AJUDARTE LOPES Spindle cell carcinoma (SpCC) is considered a rare high malignant variant of squamous cell carcinoma (SCC) occurring predominantly in the upper aerodigestive tract. Lane tumor is a synonym for SpCC and is an uncommon poorly differentiated type of SCC comprising up to 3%. SpCC most commonly occurs in the sixth to seventh decades of life and usually affects men. A 66-year-old white patient was presenting an extensive ulcerated lesion affecting the lower lip with infiltrative fibroelastic consistency, local symptomatology, and 1 year of evolution. An incisional biopsy was performed, and the histopathologic findings were compatible with SpCC. Immunohistochemistry was also performed, which showed positivity for S-100. The association of clinical and histopathologic characteristics and the immunohistochemical analysis led to the diagnosis of SpCC. The patient was guided and referred to a head and neck surgeon for treatment.
CHERUBISM: IMPORTANCE OF REGULAR FOLLOW-UP AND MAINTENANCE OF HIGH-STANDARD ORAL CARE. ALESSANDRA MEIRELLES MASSAUD DE PINHO, ANDREIA MIRANDA ROCHA, LUIZ FERNANDO DELUIZ, SIMONE MACEDO AMARAL, HENRIQUE MARTINS DA SILVEIRA, AGUIDA MARIA MENEZES AGUIAR MIRANDA and, FABIO RAMOA PIRES Cherubism is a rare developmental condition of the gnathic bones that is usually inherited as an autosomal dominant trait with variable expressivity. An 11-year-old girl was referred because of an asymptomatic bilateral facial progressive swelling. Medical history was noncontributory. Locoregional physical examination revealed a bilateral firm swelling in the cheek and retromolar area covered by normal skin and normal oral mucosa, respectively. Panoramic radiograph and cone beam computed tomography scans showed bilateral extensive multilocular lesions in the mandibular posterior areas. Clinical diagnosis was cherubism, and histologic analysis of the specimen obtained by an incisional biopsy confirmed this hypothesis. The patient has been followed up and is under orthodontic treatment with satisfactory results.
ERUPTION MESENCHYMAL CALCIFIED HAMARTOMA: A CASE REPORT. ANA LUIZA ^ A ROZA, THAYSE BRANDI, OLIVEIRA CORRE KELLY TAMBASCO BEZERRA, NATHALIE HENRIQUES SILVA CANEDO, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, MICHELLE AGOSTINI and, MARIO JOSE e ROMANACH Eruption mesenchymal calcified hamartoma (formerly known as eruption sequestrum) is an uncommon proliferation of odontogenic calcified structures, usually observed in the opercula of lower first molars of delayed eruption. A 6-year-old Brazilian girl was seen for routine dental examination. A fragment of hard whitish tissue was observed in the gingiva overlying the erupting lower first permanent molar, which showed radiographic appearance of a 0.5-cm faint round radiopacity above and separated from the occlusal surface of the related molar. The patient was
OOOO January 2020 submitted to an excisional biopsy, and gross examination showed a hardened whitish fragment surrounded by gingival mucosa. Microscopically, limited proliferation of cords of odontogenic epithelium was observed in association with small concentric basophilic calcifications and few large, round osteodentin and pulp-like structures. There were numerous inflammatory cells and small blood vessels in the surrounding connective tissue. The final diagnosis was eruption mesenchymal calcified hamartoma.
DESMOID-TYPE FIBROMATOSIS OF THE BUCCAL MUCOSA: A CASE REPORT. ANTONIO ERNANDO CARLOS FERREIRA JUNIOR, CAMILA CARVALHO DE OLIVEIRA, FABRICIO SILVIA WALTER DE DE LAMARE RAMOS, ANDREA AGUIAR, FABRICIO BITU SOUSA, MARIO ROGERIO LIMA MOTA and, ANA PAULA NEGREIROS NUNES ALVES Desmoid-type fibromatosis is a rare benign mesenchymal lesion that originates from musculoaponeurotic structures and rarely occurs in the head and neck region. The 32-year-old male patient was referred for evaluation of a submucosal lesion located in the left buccal mucosa, which was hardened, was painless, and had 3 months of evolution. Ultrasonography showed a well-defined, anechoic, and hypovascular mass. The histopathologic analysis showed proliferation of elongated, spindle-shaped cells of uniform appearance exhibiting condensed chromatin and eosinophilic cytoplasm with imprecise limits, sometimes with fasciculate pattern, associated with areas of prominent fibrosis with thick bundles of collagen. The proliferation produces dissociation and degeneration of muscle fibers. Immunohistochemical reaction revealed, in tumor cells, negativity for protein S100 and CD34 besides immunoexpression focal positive for a actin and b catenin. The cells strongly expressed vimentin. Morphologic and immunohistochemical findings were compatible with desmoid type fibromatosis. The patient is under clinical follow-up of 8 months without relapse.
ORAL MANIFESTATION OF ULCERS BY IMMUNOSSUPRESSION: A CASE SERIES. TIAGO LUIS HERPICH, MICHELLE ROXO GONCALVES, ¸ RENATA ZIEGER, MARINA GIRARDI SCHUEIGART, ANDRESSA CRISTINA HASHIGUCHI DE ALMEIDA, CAROLINA DUMMEL and, MARCO ^ ANTONIO TREVIZANI MARTINS Immunosuppression is defined as the reduction of activity or efficiency of the immune system. Neutropenia is the decrease in the number of neutrophils, which can cause ulcers in the oral cavity. The first patient, a 32-year-old HIV-positive patient with tuberculosis, presented ulcers on the upper and lower labial mucosa, bilateral buccal mucosa, and tongue. The second, a 47year-old HIV-positive patient, had ulcers on the tongue and buccal mucosa. The third, a 17-year-old patient with osteosarcoma of the femur, metastasis in lung, lymph nodes, and tibia who is undergoing chemotherapy, had ulcers on bilateral buccal mucosa. In all 3 patients, incisional biopsy, histopathologic examination (chronic inflammatory infiltrate), and culture (negative for alcohol-acid resistant bacili, herpes, and cytomegalovirus) were performed. By exclusion, it was classified as ulcers by immunosuppression. The treatment of the patients occurred with
e110
THAYNA MELO DE LIMA MARAIS, ERIKA GRAF PEDROSO, ALAN ROGER DOS SANTOS-SILVA, OSLEI PAES DE ALMEIDA and, MARCIO AJUDARTE LOPES Spindle cell carcinoma (SpCC) is considered a rare high malignant variant of squamous cell carcinoma (SCC) occurring predominantly in the upper aerodigestive tract. Lane tumor is a synonym for SpCC and is an uncommon poorly differentiated type of SCC comprising up to 3%. SpCC most commonly occurs in the sixth to seventh decades of life and usually affects men. A 66-year-old white patient was presenting an extensive ulcerated lesion affecting the lower lip with infiltrative fibroelastic consistency, local symptomatology, and 1 year of evolution. An incisional biopsy was performed, and the histopathologic findings were compatible with SpCC. Immunohistochemistry was also performed, which showed positivity for S-100. The association of clinical and histopathologic characteristics and the immunohistochemical analysis led to the diagnosis of SpCC. The patient was guided and referred to a head and neck surgeon for treatment.
CHERUBISM: IMPORTANCE OF REGULAR FOLLOW-UP AND MAINTENANCE OF HIGH-STANDARD ORAL CARE. ALESSANDRA MEIRELLES MASSAUD DE PINHO, ANDREIA MIRANDA ROCHA, LUIZ FERNANDO DELUIZ, SIMONE MACEDO AMARAL, HENRIQUE MARTINS DA SILVEIRA, AGUIDA MARIA MENEZES AGUIAR MIRANDA and, FABIO RAMOA PIRES Cherubism is a rare developmental condition of the gnathic bones that is usually inherited as an autosomal dominant trait with variable expressivity. An 11-year-old girl was referred because of an asymptomatic bilateral facial progressive swelling. Medical history was noncontributory. Locoregional physical examination revealed a bilateral firm swelling in the cheek and retromolar area covered by normal skin and normal oral mucosa, respectively. Panoramic radiograph and cone beam computed tomography scans showed bilateral extensive multilocular lesions in the mandibular posterior areas. Clinical diagnosis was cherubism, and histologic analysis of the specimen obtained by an incisional biopsy confirmed this hypothesis. The patient has been followed up and is under orthodontic treatment with satisfactory results.
ERUPTION MESENCHYMAL CALCIFIED HAMARTOMA: A CASE REPORT. ANA LUIZA ^ A ROZA, THAYSE BRANDI, OLIVEIRA CORRE KELLY TAMBASCO BEZERRA, NATHALIE HENRIQUES SILVA CANEDO, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, MICHELLE AGOSTINI and, MARIO JOSE e ROMANACH Eruption mesenchymal calcified hamartoma (formerly known as eruption sequestrum) is an uncommon proliferation of odontogenic calcified structures, usually observed in the opercula of lower first molars of delayed eruption. A 6-year-old Brazilian girl was seen for routine dental examination. A fragment of hard whitish tissue was observed in the gingiva overlying the erupting lower first permanent molar, which showed radiographic appearance of a 0.5-cm faint round radiopacity above and separated from the occlusal surface of the related molar. The patient was
OOOO January 2020 submitted to an excisional biopsy, and gross examination showed a hardened whitish fragment surrounded by gingival mucosa. Microscopically, limited proliferation of cords of odontogenic epithelium was observed in association with small concentric basophilic calcifications and few large, round osteodentin and pulp-like structures. There were numerous inflammatory cells and small blood vessels in the surrounding connective tissue. The final diagnosis was eruption mesenchymal calcified hamartoma.
DESMOID-TYPE FIBROMATOSIS OF THE BUCCAL MUCOSA: A CASE REPORT. ANTONIO ERNANDO CARLOS FERREIRA JUNIOR, CAMILA CARVALHO DE OLIVEIRA, FABRICIO SILVIA WALTER DE DE LAMARE RAMOS, ANDREA AGUIAR, FABRICIO BITU SOUSA, MARIO ROGERIO LIMA MOTA and, ANA PAULA NEGREIROS NUNES ALVES Desmoid-type fibromatosis is a rare benign mesenchymal lesion that originates from musculoaponeurotic structures and rarely occurs in the head and neck region. The 32-year-old male patient was referred for evaluation of a submucosal lesion located in the left buccal mucosa, which was hardened, was painless, and had 3 months of evolution. Ultrasonography showed a well-defined, anechoic, and hypovascular mass. The histopathologic analysis showed proliferation of elongated, spindle-shaped cells of uniform appearance exhibiting condensed chromatin and eosinophilic cytoplasm with imprecise limits, sometimes with fasciculate pattern, associated with areas of prominent fibrosis with thick bundles of collagen. The proliferation produces dissociation and degeneration of muscle fibers. Immunohistochemical reaction revealed, in tumor cells, negativity for protein S100 and CD34 besides immunoexpression focal positive for a actin and b catenin. The cells strongly expressed vimentin. Morphologic and immunohistochemical findings were compatible with desmoid type fibromatosis. The patient is under clinical follow-up of 8 months without relapse.
ORAL MANIFESTATION OF ULCERS BY IMMUNOSSUPRESSION: A CASE SERIES. TIAGO LUIS HERPICH, MICHELLE ROXO GONCALVES, ¸ RENATA ZIEGER, MARINA GIRARDI SCHUEIGART, ANDRESSA CRISTINA HASHIGUCHI DE ALMEIDA, CAROLINA DUMMEL and, MARCO ^ ANTONIO TREVIZANI MARTINS Immunosuppression is defined as the reduction of activity or efficiency of the immune system. Neutropenia is the decrease in the number of neutrophils, which can cause ulcers in the oral cavity. The first patient, a 32-year-old HIV-positive patient with tuberculosis, presented ulcers on the upper and lower labial mucosa, bilateral buccal mucosa, and tongue. The second, a 47year-old HIV-positive patient, had ulcers on the tongue and buccal mucosa. The third, a 17-year-old patient with osteosarcoma of the femur, metastasis in lung, lymph nodes, and tibia who is undergoing chemotherapy, had ulcers on bilateral buccal mucosa. In all 3 patients, incisional biopsy, histopathologic examination (chronic inflammatory infiltrate), and culture (negative for alcohol-acid resistant bacili, herpes, and cytomegalovirus) were performed. By exclusion, it was classified as ulcers by immunosuppression. The treatment of the patients occurred with