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ERYTHEMA NODOSUM AND TUBERCULOSIS.
597
I
acid-base equilibrium, leads to speculation on the previous year’s total. There were 280 new names on influence of blood and tissue acidity upon vital the British list-of which 253 were registered with processes. At the site of inflammation there is a qualifications-2 on the Colonial, and 1 on the
local " acidosisdue to the tissue breakdown and Foreign list ; 146
names were
removed
on
evidence
associated with local vaso-dilatation, raised osmotic of death. The discrepancy is chiefly due to the pressure, increased heat, and the other changes of adjustment between names restored and removed on
technical grounds. It is noteworthy that the total number of those practising dentistry has scarcely according altered during the last five years. There were 306 in an alkaline In and medium. completely rapidly spite of much evidence indicating that the acid reaction dental students registered in 1930, being 8 more than may itself be the stimulus to new tissue formation, in 1929, and (as is the case with medical students) a Balint and Weiss bring forward experiments to show higher figure than any since 1922, but obviously an that in fact repair is more satisfactory in alkaline entry inadequate to make good the wastage. surroundings. This theory arose from the work of Balint who suggested that peptic ulceration is ERYTHEMA NODOSUM AND TUBERCULOSIS. associated with an acid reaction of the patient as a THE two latest studies of erythema nodosum lead whole, constitutionally. He brought forward evidence that the poor healing power of ulcer patients wasI their authors to discordant conclusions. Dr. Axel associated with abnormal acidity of their blood and Cedercreutz1 has inquired into the fate of the patients tissues. Although the changes of pH that Balint in his private and hospital practice who before 1910 recorded were very small, and this work has been had suffered from erythema nodosum or erythema seriously criticised, he suggests that small variations exudativum multiforme. Twenty-six of the 63 are capable of a profound influence over the proliferapatients suffering from erythema nodosum were tive processes of tissue repair. In the present mono- traced, and nine were found to have died ; but only graph numerous experiments are described which the two of the deaths were due to pulmonary tuberculosis.. authors consider point to the conclusion that an acid It should be noted incidentally that the subsequent reaction checks, while an alkaline stimulates, " all death-rate from pulmonary tuberculosis among the 78 types of tissue proliferation " ; such changes of cases of erythema exudativum multiforme was also reaction as may occur in life they consider active in low (five out of 36 patients traced). Very different are this respect. The observations cover experimental the conclusions to which Dr. H. d’U. A. Engelsgaard2 tuberculosis in animals, growth of carcinoma cells, comes in an investigation of the patients admitted to calcification of bone, " sterile inflammations," growth the Lyster public sanatorium in Norway from 1914 to of tissues in culture, and otlier similar tissue forma- 1929, who .gave a history of erythema nodosum, tions. Much of the work must impress the reader diagnosed as such by a medical practitioner. There
The
Balint’s
reparative phase, however, theory, takes place more
I
acid-base equilibrium, leads to speculation on the previous year’s total. There were 280 new names on influence of blood and tissue acidity upon vital the British list-of which 253 were registered with processes. At the site of inflammation there is a qualifications-2 on the Colonial, and 1 on the
local " acidosisdue to the tissue breakdown and Foreign list ; 146
names were
removed
on
evidence
associated with local vaso-dilatation, raised osmotic of death. The discrepancy is chiefly due to the pressure, increased heat, and the other changes of adjustment between names restored and removed on
technical grounds. It is noteworthy that the total number of those practising dentistry has scarcely according altered during the last five years. There were 306 in an alkaline In and medium. completely rapidly spite of much evidence indicating that the acid reaction dental students registered in 1930, being 8 more than may itself be the stimulus to new tissue formation, in 1929, and (as is the case with medical students) a Balint and Weiss bring forward experiments to show higher figure than any since 1922, but obviously an that in fact repair is more satisfactory in alkaline entry inadequate to make good the wastage. surroundings. This theory arose from the work of Balint who suggested that peptic ulceration is ERYTHEMA NODOSUM AND TUBERCULOSIS. associated with an acid reaction of the patient as a THE two latest studies of erythema nodosum lead whole, constitutionally. He brought forward evidence that the poor healing power of ulcer patients wasI their authors to discordant conclusions. Dr. Axel associated with abnormal acidity of their blood and Cedercreutz1 has inquired into the fate of the patients tissues. Although the changes of pH that Balint in his private and hospital practice who before 1910 recorded were very small, and this work has been had suffered from erythema nodosum or erythema seriously criticised, he suggests that small variations exudativum multiforme. Twenty-six of the 63 are capable of a profound influence over the proliferapatients suffering from erythema nodosum were tive processes of tissue repair. In the present mono- traced, and nine were found to have died ; but only graph numerous experiments are described which the two of the deaths were due to pulmonary tuberculosis.. authors consider point to the conclusion that an acid It should be noted incidentally that the subsequent reaction checks, while an alkaline stimulates, " all death-rate from pulmonary tuberculosis among the 78 types of tissue proliferation " ; such changes of cases of erythema exudativum multiforme was also reaction as may occur in life they consider active in low (five out of 36 patients traced). Very different are this respect. The observations cover experimental the conclusions to which Dr. H. d’U. A. Engelsgaard2 tuberculosis in animals, growth of carcinoma cells, comes in an investigation of the patients admitted to calcification of bone, " sterile inflammations," growth the Lyster public sanatorium in Norway from 1914 to of tissues in culture, and otlier similar tissue forma- 1929, who .gave a history of erythema nodosum, tions. Much of the work must impress the reader diagnosed as such by a medical practitioner. There
The
Balint’s
reparative phase, however, theory, takes place more