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Ethanel reduces bone formation and may cause osteoporosis
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pattern. Transdermal oestradiol had no effect on measures of hepatic function whereas oral ethiny! oestradiol signibcattily altered levels of sex hormone binding globulin, plasma renin substrate and lipoproteins. Transdermal oestradiol has a comparable beneficiai effect on postmenopausal symptoms tr, ethinyl oestradiol without the adverse effects on hepatic proteins.
SpirPe!os:saptws!s in men Francis RM; Peacock M; Marshall DH; Horsman A; Aaron JE Newcastle General Hospital, Newcastle Upon 7jvte NE4 C;B& U.K. Bone Miner.; S/3 (347-3§7)/1989/ In 94 men with crush fracture, 40 were found to have primary osteoporosis. Cross-sectional tutisurements of a number of variables related to bone in these 40 patients were compared to the values in vsrious groups of healthy men aged 20-%. In healthy men, metacatpel and femcral cortical area/ total area, bone volume, osteoid surfaces, seam and trabecular width, plasma dihydroepiandrosterone and estrone. and radiocalcium absorption fell with age, whereas erooed surfaces, trabecuhu number, urine hydroxyproline and calcium/creatinine ratios, plasma alkaline phosybatase, estradio!, androstenedione, cortisol and testosterone remained constant with age. As compared with healthy men, men with primary osteoporosis had reduced fpmoral cortical area/total area (p < 0.05). and Singh grade (p < 0.081) and in seven there was a history of forearm or femoral fracture. On iliac crest biopsy, bone volume (P < 0.001) and trabeculer number IP < 0.01) were decreased. Plasma alkaline phosphatase (P < 0.02) was increased but urine hydroxyproline and calciuzn excretion were not significantly raised. Calcium balance was negative due to failure of absorption to match urinary calcium loss and radio4cium absorption (P < 0.01) and plasma 1.25-dihydroxyvitaminD (P < 0.05) were reduced. AdvaT-c: ‘q noniuvasive bone measurement KU: Barden H* Vetttr J; Ettinger M Osieoporosis Rove Da&node Laboratory, Stuart, FL; U.S.A. Ma7sss
Ann. Biomed. Eng.; 1712 (177-181)/1989/ several noninvasive measurement methods are used for evaluatiou of metabolic disease. Single-photon (r”I) scans of the peripheral skeleton are useful in some diseases but are ineffective in &eoporosis (even on the distal radius or OS c&is) because they cannot predict spinal or femoral density. Also, periph+ L c.-asurements show high percentagesof lalse negatives, that is many patients with fractures have nomA peripheraldensity. Dual-photon (Wd) scans of the spine, femur, and total skeleton are precise and accurate (2% error) and provide direct measurementsof hone strength at fracture sites. This gives the best discrimination of abnormality and the most sensitive monitoring. Quantitative computed tomography (QCT) allows measurement of the spine but not the critical proxin a: :I mur area. QCT has a large accuracy error becrusc (a) the limited area measured (under 5 cm’) fails to represent the total vertebral body, (b) technical errors, and (c) vana& fat and osteoid influence the results.
Ethanol reduces bone formation sad may cause os!coporosis Diamond T, Stiel D; Lunzer M; Wilkinson M; Posen S Departmeni fij’Gaslroenterology. Royal North Shore Hospital, Sydney, NS W 2065; Australia Am. 1. Med.; 86/3 (282-258)/1989/
Introduction: The etiology of ethanol-assnsiated ostcopenis is not fuiip understood. In order to define the role of ethanol in the pathogenesis oi hepatic osteodystrophy, -se coi.ipared two croups of alcoholic patients with histologically established alcoholic liver disease. Patients and methods: Twcu~feight patients currcnt!y drinking ethanol (drinkers’) and 12 claiming not to have consums; any ethanol for at least six mom&s (‘abstatazrs’) wete enrolled in the study. In addition. 35 nor.-alcoholic control subjects without clinical or biochemical evidence of liver diseztsewere also studicd. Bone min-
eral density and various biochemical biopsies were taken under local anest subjects. Results: Forearm bone mine lous bone areas were significantlylower in the alcoholicpatientscomparedwith c~ntt3 0.01 fnr all measurements),but !hcse %ahaes did not differ betwan the drinkerst?d TLCdrinkers, however, had significantly less osteoblastic activity than the abstainers, dynamic bone histomorphomary (f < 0.001). Serum bone Gla-protein concentrations the abstainers than in the drinkers (P < 0.001). No differences were seen rcl mctcr; of bone resorption. although the alcoholic patients who had lower serum free testosterooe concentrations than th- control subjects also had higher urinary lrydroxyproline excretion rates. Conclusion: These data suggest that ethanol may be responsible for o&oblastic dysfunction resuhiqz in diminished bone formation and reduced bone mineralization.
Diet and plasma oodrogens in ?ostme~opau~l pnusal women witb breast cancer
vegetarian
and omnivorous
women
8rsd post?le~l~-
Adlercreutz H; Hamalainen E; Gorbach SL; Goldin BR; Woods MN; Dwyer JT Department of ClitGcncol Chemistry. University of Helsinki, SF-00280 Helsinki: Fin/and Am. J. Clin. ?hctr.; 49/3 (433-442)/1989/ We
studied 27 postmenopausal women, 9 vegetarians, 10 omnivores, and 8 apparently healthy women with breast cancer (BC), four times during 1 year. Dietary intakes were recorded and plasma androgens and sex-hormone-binding globulin (SHBG) bindilg capacity were determined. Androstenedione (A), testosterone (T), free T (Fr). and SHBG were higher in omnivores ti’an in vegetarians. In multiple correlation analysis. intakes of protein and fat were positively correlated with A. T. and FT. whereas the intakes of carbohydrate, grain, total fiber, and grain fiber showed the opposite correlations. Protein intahe was positively correlated with percentage FT (@IoPT) and negativeti with SHBG. BC patients bad a ,irnilar paitern to omnivores with even higher levels of A and T (sit&cant compared with vegetar sns) and they showed !ignificantl, higher FT and lower SHBG than both control groups. We conclulle that a Western-type :iei in postmenopausal women is associated with high A, T, %FT. and low SHBG and this pattern was apparent in the BC patients.
Serum nod bile lipid levels in postmenopnusid woman after percntukeotu and oral nahral D’Amato G; C&ve!lini A: Me;>a C; Manyini V; Mkciagna G Deportment 7’ Obstetrrcs and Gynecologv, Istituto di Ricovero e Cura a Carattere Scientifico, 7GiJl3 Castellana. .Wy
Am. 1. Obstet. Gyneco!.: !KV? (6OO-&Il)/lrgL/ 17 betaBstradio1 was administered for 4 weeks percutaneously (5 me/day) and. after a 6--e& period to allow the drug to wash cut, orally (2 mg/day) to a postmenopausal woman in whom a Kerr tube had been paced because of an iarrogenic lesion of the cOlumon bile duct. After both methods of administration, there was an increase in the biliary cholesterol coaretrtration, but after oral dministration, bile flow also increased and cholesterol crystals appeared in the bile. The percutaneous metnui of -*r.idiol administrtion in postmcnqaus~l women seems to be less dangerous for the biliar) ‘-32.
Wormoaes rod breast cancer Wile AG; DiSaia PJ Divirion of SurgW sexology, University of Ctilifornig Irvine Cancer Center. Orange, CA MM; U.S.A. Am. J. Sure.; 157/4 (438--442)/1989/ Patients with successfully managed breast cancer have generaily ken denied subsequent exposure increased leveis of estrogen (endogenous or exogenous) based on the belief ihat exacerbation of
to
the
pattern. Transdermal oestradiol had no effect on measures of hepatic function whereas oral ethiny! oestradiol signibcattily altered levels of sex hormone binding globulin, plasma renin substrate and lipoproteins. Transdermal oestradiol has a comparable beneficiai effect on postmenopausal symptoms tr, ethinyl oestradiol without the adverse effects on hepatic proteins.
SpirPe!os:saptws!s in men Francis RM; Peacock M; Marshall DH; Horsman A; Aaron JE Newcastle General Hospital, Newcastle Upon 7jvte NE4 C;B& U.K. Bone Miner.; S/3 (347-3§7)/1989/ In 94 men with crush fracture, 40 were found to have primary osteoporosis. Cross-sectional tutisurements of a number of variables related to bone in these 40 patients were compared to the values in vsrious groups of healthy men aged 20-%. In healthy men, metacatpel and femcral cortical area/ total area, bone volume, osteoid surfaces, seam and trabecular width, plasma dihydroepiandrosterone and estrone. and radiocalcium absorption fell with age, whereas erooed surfaces, trabecuhu number, urine hydroxyproline and calcium/creatinine ratios, plasma alkaline phosybatase, estradio!, androstenedione, cortisol and testosterone remained constant with age. As compared with healthy men, men with primary osteoporosis had reduced fpmoral cortical area/total area (p < 0.05). and Singh grade (p < 0.081) and in seven there was a history of forearm or femoral fracture. On iliac crest biopsy, bone volume (P < 0.001) and trabeculer number IP < 0.01) were decreased. Plasma alkaline phosphatase (P < 0.02) was increased but urine hydroxyproline and calciuzn excretion were not significantly raised. Calcium balance was negative due to failure of absorption to match urinary calcium loss and radio4cium absorption (P < 0.01) and plasma 1.25-dihydroxyvitaminD (P < 0.05) were reduced. AdvaT-c: ‘q noniuvasive bone measurement KU: Barden H* Vetttr J; Ettinger M Osieoporosis Rove Da&node Laboratory, Stuart, FL; U.S.A. Ma7sss
Ann. Biomed. Eng.; 1712 (177-181)/1989/ several noninvasive measurement methods are used for evaluatiou of metabolic disease. Single-photon (r”I) scans of the peripheral skeleton are useful in some diseases but are ineffective in &eoporosis (even on the distal radius or OS c&is) because they cannot predict spinal or femoral density. Also, periph+ L c.-asurements show high percentagesof lalse negatives, that is many patients with fractures have nomA peripheraldensity. Dual-photon (Wd) scans of the spine, femur, and total skeleton are precise and accurate (2% error) and provide direct measurementsof hone strength at fracture sites. This gives the best discrimination of abnormality and the most sensitive monitoring. Quantitative computed tomography (QCT) allows measurement of the spine but not the critical proxin a: :I mur area. QCT has a large accuracy error becrusc (a) the limited area measured (under 5 cm’) fails to represent the total vertebral body, (b) technical errors, and (c) vana& fat and osteoid influence the results.
Ethanol reduces bone formation sad may cause os!coporosis Diamond T, Stiel D; Lunzer M; Wilkinson M; Posen S Departmeni fij’Gaslroenterology. Royal North Shore Hospital, Sydney, NS W 2065; Australia Am. 1. Med.; 86/3 (282-258)/1989/
Introduction: The etiology of ethanol-assnsiated ostcopenis is not fuiip understood. In order to define the role of ethanol in the pathogenesis oi hepatic osteodystrophy, -se coi.ipared two croups of alcoholic patients with histologically established alcoholic liver disease. Patients and methods: Twcu~feight patients currcnt!y drinking ethanol (drinkers’) and 12 claiming not to have consums; any ethanol for at least six mom&s (‘abstatazrs’) wete enrolled in the study. In addition. 35 nor.-alcoholic control subjects without clinical or biochemical evidence of liver diseztsewere also studicd. Bone min-
eral density and various biochemical biopsies were taken under local anest subjects. Results: Forearm bone mine lous bone areas were significantlylower in the alcoholicpatientscomparedwith c~ntt3 0.01 fnr all measurements),but !hcse %ahaes did not differ betwan the drinkerst?d TLCdrinkers, however, had significantly less osteoblastic activity than the abstainers, dynamic bone histomorphomary (f < 0.001). Serum bone Gla-protein concentrations the abstainers than in the drinkers (P < 0.001). No differences were seen rcl mctcr; of bone resorption. although the alcoholic patients who had lower serum free testosterooe concentrations than th- control subjects also had higher urinary lrydroxyproline excretion rates. Conclusion: These data suggest that ethanol may be responsible for o&oblastic dysfunction resuhiqz in diminished bone formation and reduced bone mineralization.
Diet and plasma oodrogens in ?ostme~opau~l pnusal women witb breast cancer
vegetarian
and omnivorous
women
8rsd post?le~l~-
Adlercreutz H; Hamalainen E; Gorbach SL; Goldin BR; Woods MN; Dwyer JT Department of ClitGcncol Chemistry. University of Helsinki, SF-00280 Helsinki: Fin/and Am. J. Clin. ?hctr.; 49/3 (433-442)/1989/ We
studied 27 postmenopausal women, 9 vegetarians, 10 omnivores, and 8 apparently healthy women with breast cancer (BC), four times during 1 year. Dietary intakes were recorded and plasma androgens and sex-hormone-binding globulin (SHBG) bindilg capacity were determined. Androstenedione (A), testosterone (T), free T (Fr). and SHBG were higher in omnivores ti’an in vegetarians. In multiple correlation analysis. intakes of protein and fat were positively correlated with A. T. and FT. whereas the intakes of carbohydrate, grain, total fiber, and grain fiber showed the opposite correlations. Protein intahe was positively correlated with percentage FT (@IoPT) and negativeti with SHBG. BC patients bad a ,irnilar paitern to omnivores with even higher levels of A and T (sit&cant compared with vegetar sns) and they showed !ignificantl, higher FT and lower SHBG than both control groups. We conclulle that a Western-type :iei in postmenopausal women is associated with high A, T, %FT. and low SHBG and this pattern was apparent in the BC patients.
Serum nod bile lipid levels in postmenopnusid woman after percntukeotu and oral nahral D’Amato G; C&ve!lini A: Me;>a C; Manyini V; Mkciagna G Deportment 7’ Obstetrrcs and Gynecologv, Istituto di Ricovero e Cura a Carattere Scientifico, 7GiJl3 Castellana. .Wy
Am. 1. Obstet. Gyneco!.: !KV? (6OO-&Il)/lrgL/ 17 betaBstradio1 was administered for 4 weeks percutaneously (5 me/day) and. after a 6--e& period to allow the drug to wash cut, orally (2 mg/day) to a postmenopausal woman in whom a Kerr tube had been paced because of an iarrogenic lesion of the cOlumon bile duct. After both methods of administration, there was an increase in the biliary cholesterol coaretrtration, but after oral dministration, bile flow also increased and cholesterol crystals appeared in the bile. The percutaneous metnui of -*r.idiol administrtion in postmcnqaus~l women seems to be less dangerous for the biliar) ‘-32.
Wormoaes rod breast cancer Wile AG; DiSaia PJ Divirion of SurgW sexology, University of Ctilifornig Irvine Cancer Center. Orange, CA MM; U.S.A. Am. J. Sure.; 157/4 (438--442)/1989/ Patients with successfully managed breast cancer have generaily ken denied subsequent exposure increased leveis of estrogen (endogenous or exogenous) based on the belief ihat exacerbation of
to
the