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EVALUATION OF CLINICAL RISK FACTORS FOR ORAL COMPLICATIONS OF HEAD AND NECK RADIOTHERAPY
OOOO Volume 129, Number 1
ABSTRACTS
e163
Conclusions: The benign oral neural lesions represent 1.04% of all diagnosed oral lesions and traumatic neuroma is the most common lesion.
inflammatory infiltrate in early clinical phases on PVL seems to be an important differential feature to OL and indicates an ongoing immune response in the development of this disease.
ACTINIC CHEILITIS: CLINICAL ANALYSIS INDEX. CRISTIANNE KALINNE SANTOS MEDEIROS, ANNA ELLYSE GRANT DE OLIVEIRA, ANA MYRIAM COSTA DE MEDEIROS, ERICKA JANINE DANTAS DA SILVEIRA, MARIA LUIZA DINIZ DE SOUZA LOPES, KENIO COSTA DE LIMA and, PATRICIA TEIXEIRA DE OLIVEIRA
EVALUATION OF CLINICAL RISK FACTORS FOR ORAL COMPLICATIONS OF HEAD AND NECK RADIOTHERAPY. VANESSA TONETTO MARQUES, ARIANE DE SOUZA OLIVEIRA, LARA MARIA ALENCAR RAMOS INNOCENTINI, TATIANE CRISTINA FERRARI, ANA LAURA POLIZEL RANIERI, HILTON MARCOS ALVES RICZ and, LEANDRO DORIGAN DE MACEDO
Objective: To develop a Clinical Index for Actinic Cheilitis (CIAC) with the intention of assisting in the identification of clinical characteristics that indicate a greater severity of this condition. Study Design: CIAC was developed through the opinion of experts, being applied in 20 patients with QA and indicated for biopsy. The scores obtained after application of the index were associated with the histopathologic grading for oral epithelial dysplasia from the World Health Organization (WHO) and the Binary System using Fisher exact test (P < .05). The reliability of the index was tested based on the percentage of sensitivity, specificity, positive predictive value (PPV), negative predictive value, accuracy, and receiver operating characteristic (ROC) curve. Results: There was no statistically significant association between clinical characteristics and degree of dysplasia. The cut-off point with value 11 exhibited better performance for ROC curve and higher percentage for specificity, PPV, and accuracy in both histopathologic grading analyzed. Conclusions: The cut-off point 11 can be used to indicate higher degree of severity of the AC, suggesting that out of this score patients are indicated for biopsy. The size of the sample and the need to verify the reproducibility of the index make it necessary to carry out further researches.
INTENSITY OF INFLAMMATORY INFILTRATE IN PROLIFERATIVE VERRUCOUS LEUKOPLAKIA. DARCY FERNANDES, HEITOR ALBERGONI DA SILVEIRA, MARIEL RUIVO BIANCARDI, ESTEBAN ALEXIS ARROYO, CAMILA and, OLIVEIRA BARBEIRO, JORGE ESQUICHE LEON ANDREIA BUFALINO Proliferative verrucous leukoplakia (PVL) may be difficult to diagnose in early stages because of the lack of specific features. Our aim was to compare the clinicopathologic features and inflammatory intensity between PVL and oral leukoplakia (OL). Clinical data were retrospectively collected from archives. The intensity of inflammatory infiltrate, the inflammatory cell counting was compared between the groups with the diagnosis of PVL and oral leukoplakia (OL). The intensity of the inflammatory infiltrate was showed in quartiles: Absence of inflammation, 0 cells (Q1); mild inflammation, 69 cells (Q2); moderate inflammation, >69 until 148 cells (Q3); severe inflammation, >149 cells (Q4). Univariate analysis showed significant association of PVL with higher grades of dysplasia, higher intensity, and presence of inflammatory infiltrate (Q3+Q4), and recurrence. A positive correlation was observed between PVL and the intensity of inflammatory infiltrate, high-grade dysplasia, recurrence, and malignant transformation rate. The presence of dense
Objective: The aim of this study was to evaluate the clinical risk factors (RF) for acute (mucositis and candidiasis) and chronic (radiation caries and xerostomia) complications of the treatment in patients undergoing intensity modulated radiotherapy (IMRT) for head and neck cancer. Study Design: Retrospective and observational study with 40 patients submitted to minimum dose of 5000 cGy of IMRT. The incidence of these complications was correlated to: Patient’s RF (age, DMFT), tumor RF (localization and staging), and treatment’s RF (surgery, chemotherapy, and submandibular gland surgical injury). Results: Cervical tumors had a lower incidence of mucositis than the other areas (P = .02); stages III-IV presented a higher incidence of Candida species infection (20.6%) than stages I-II (0%), P = .03; surgical injury of submandibular gland presented 4.8 higher risk of caries related to radiation (P = .05); none of the studied variables were associated with the risk of xerostomia. There was a strong correlation between caries and xerostomia (xerostomia: 33.3% vs 0% without xerostomia). Conclusions: Risk of mucositis is reduced in radiotherapy protocols for cervical tumors, while stages III and IV presented a higher risk of candidiasis. Surgical injury of submandibular glands and xerostomia increased the risk of caries related to radiotherapy.
CYTOTOXIC AND ANTITUMOR EFFECT OF THE ETHANOLIC EXTRACT OF THE BARK OF HIMATANTHUS BRACTEATUS (A. DC.) WOODSON. JOHN LENNON SILVA CUNHA, AMANDA FEITOZA DA SILVA, FRANCISCO DE ASSIS ALMEIDA LIMA JUNIOR, CLAUBERTO RODRIGUES DE OLIVEIRA, ROSE NELY PEREIRA-FILHO and, RICARDO LUIZ CAVALCANTI DE ALBUQUERQUE JUNIOR Introduction: Himatanthus bracteatus has been popularly used in the treatment of cancer, but its antitumor properties have not been scientifically reported yet. Objectives: The purpose of this study was to assess the antitumor effect of Himatanthus bracteatus ethanolic extract (HBEE) in mice. Design: The HBEE was obtained under high pressure conditions (100 bar, 2 mL/min, 25˚C) and its cytotoxic activity was assessed in vitro against MCF-7 and MCF-10 A cells. For the biologic assay, 180 sarcoma cells were transplanted into 40 mice assigned into 5 groups: CTR, 5-fluorouracil (5-FU), and HBEE10, 30, and 100 (treated with saline, 5-FU, and HBEE at 10, 30, and 100 mg/Kg, respectively). Hematologic and biochemical analyses, as well as gross and morphologic analyses of the tumors, were performed in order to evaluate the toxicologic aspects.
ABSTRACTS
e163
Conclusions: The benign oral neural lesions represent 1.04% of all diagnosed oral lesions and traumatic neuroma is the most common lesion.
inflammatory infiltrate in early clinical phases on PVL seems to be an important differential feature to OL and indicates an ongoing immune response in the development of this disease.
ACTINIC CHEILITIS: CLINICAL ANALYSIS INDEX. CRISTIANNE KALINNE SANTOS MEDEIROS, ANNA ELLYSE GRANT DE OLIVEIRA, ANA MYRIAM COSTA DE MEDEIROS, ERICKA JANINE DANTAS DA SILVEIRA, MARIA LUIZA DINIZ DE SOUZA LOPES, KENIO COSTA DE LIMA and, PATRICIA TEIXEIRA DE OLIVEIRA
EVALUATION OF CLINICAL RISK FACTORS FOR ORAL COMPLICATIONS OF HEAD AND NECK RADIOTHERAPY. VANESSA TONETTO MARQUES, ARIANE DE SOUZA OLIVEIRA, LARA MARIA ALENCAR RAMOS INNOCENTINI, TATIANE CRISTINA FERRARI, ANA LAURA POLIZEL RANIERI, HILTON MARCOS ALVES RICZ and, LEANDRO DORIGAN DE MACEDO
Objective: To develop a Clinical Index for Actinic Cheilitis (CIAC) with the intention of assisting in the identification of clinical characteristics that indicate a greater severity of this condition. Study Design: CIAC was developed through the opinion of experts, being applied in 20 patients with QA and indicated for biopsy. The scores obtained after application of the index were associated with the histopathologic grading for oral epithelial dysplasia from the World Health Organization (WHO) and the Binary System using Fisher exact test (P < .05). The reliability of the index was tested based on the percentage of sensitivity, specificity, positive predictive value (PPV), negative predictive value, accuracy, and receiver operating characteristic (ROC) curve. Results: There was no statistically significant association between clinical characteristics and degree of dysplasia. The cut-off point with value 11 exhibited better performance for ROC curve and higher percentage for specificity, PPV, and accuracy in both histopathologic grading analyzed. Conclusions: The cut-off point 11 can be used to indicate higher degree of severity of the AC, suggesting that out of this score patients are indicated for biopsy. The size of the sample and the need to verify the reproducibility of the index make it necessary to carry out further researches.
INTENSITY OF INFLAMMATORY INFILTRATE IN PROLIFERATIVE VERRUCOUS LEUKOPLAKIA. DARCY FERNANDES, HEITOR ALBERGONI DA SILVEIRA, MARIEL RUIVO BIANCARDI, ESTEBAN ALEXIS ARROYO, CAMILA and, OLIVEIRA BARBEIRO, JORGE ESQUICHE LEON ANDREIA BUFALINO Proliferative verrucous leukoplakia (PVL) may be difficult to diagnose in early stages because of the lack of specific features. Our aim was to compare the clinicopathologic features and inflammatory intensity between PVL and oral leukoplakia (OL). Clinical data were retrospectively collected from archives. The intensity of inflammatory infiltrate, the inflammatory cell counting was compared between the groups with the diagnosis of PVL and oral leukoplakia (OL). The intensity of the inflammatory infiltrate was showed in quartiles: Absence of inflammation, 0 cells (Q1); mild inflammation, 69 cells (Q2); moderate inflammation, >69 until 148 cells (Q3); severe inflammation, >149 cells (Q4). Univariate analysis showed significant association of PVL with higher grades of dysplasia, higher intensity, and presence of inflammatory infiltrate (Q3+Q4), and recurrence. A positive correlation was observed between PVL and the intensity of inflammatory infiltrate, high-grade dysplasia, recurrence, and malignant transformation rate. The presence of dense
Objective: The aim of this study was to evaluate the clinical risk factors (RF) for acute (mucositis and candidiasis) and chronic (radiation caries and xerostomia) complications of the treatment in patients undergoing intensity modulated radiotherapy (IMRT) for head and neck cancer. Study Design: Retrospective and observational study with 40 patients submitted to minimum dose of 5000 cGy of IMRT. The incidence of these complications was correlated to: Patient’s RF (age, DMFT), tumor RF (localization and staging), and treatment’s RF (surgery, chemotherapy, and submandibular gland surgical injury). Results: Cervical tumors had a lower incidence of mucositis than the other areas (P = .02); stages III-IV presented a higher incidence of Candida species infection (20.6%) than stages I-II (0%), P = .03; surgical injury of submandibular gland presented 4.8 higher risk of caries related to radiation (P = .05); none of the studied variables were associated with the risk of xerostomia. There was a strong correlation between caries and xerostomia (xerostomia: 33.3% vs 0% without xerostomia). Conclusions: Risk of mucositis is reduced in radiotherapy protocols for cervical tumors, while stages III and IV presented a higher risk of candidiasis. Surgical injury of submandibular glands and xerostomia increased the risk of caries related to radiotherapy.
CYTOTOXIC AND ANTITUMOR EFFECT OF THE ETHANOLIC EXTRACT OF THE BARK OF HIMATANTHUS BRACTEATUS (A. DC.) WOODSON. JOHN LENNON SILVA CUNHA, AMANDA FEITOZA DA SILVA, FRANCISCO DE ASSIS ALMEIDA LIMA JUNIOR, CLAUBERTO RODRIGUES DE OLIVEIRA, ROSE NELY PEREIRA-FILHO and, RICARDO LUIZ CAVALCANTI DE ALBUQUERQUE JUNIOR Introduction: Himatanthus bracteatus has been popularly used in the treatment of cancer, but its antitumor properties have not been scientifically reported yet. Objectives: The purpose of this study was to assess the antitumor effect of Himatanthus bracteatus ethanolic extract (HBEE) in mice. Design: The HBEE was obtained under high pressure conditions (100 bar, 2 mL/min, 25˚C) and its cytotoxic activity was assessed in vitro against MCF-7 and MCF-10 A cells. For the biologic assay, 180 sarcoma cells were transplanted into 40 mice assigned into 5 groups: CTR, 5-fluorouracil (5-FU), and HBEE10, 30, and 100 (treated with saline, 5-FU, and HBEE at 10, 30, and 100 mg/Kg, respectively). Hematologic and biochemical analyses, as well as gross and morphologic analyses of the tumors, were performed in order to evaluate the toxicologic aspects.