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Evaluation of nitrofurazone in the postpartum patient
Volume 100 Number +
Communications
Fig. 2. Primordial follicle in noncystic accessory ovary.
It must be concluded that this is a case of multiple accessory ovaries, two with development of serous cystadenomas and onc with primordial follicles. No evidence of hypcrfunction was notcd in the present case. IEFEltENCES
1. Editorial: New England J. Med. 276: 57, 1967. 2. Wharton, L. R.: AM. J. Os ST. & GVNEC. 78: 1101, 1959.
2701 Fourteenth Avenul Oakland, California
Evaluation of nitrofurazone postpartum patient
In
the
ROBERT S. ELLISON, M.D., F.A.C.O.C. EUGENE SHERMAN, M .D., F.A.C.O.C. Mansfield, Ohio
I TIS generally agreed that there is some relationship between chronic cervicitis and carcinoma of the cervix. 1 It is further agrced that chronic
In
brief
593
cervicitis may result in discharge and other discomforts. 2 Certainly, some "erosions" of the cervix with concomitant cervicitis occur as the result of pregnancy and childbirth. If there were a product available to prevent or reduce "erosion" and cervicitis it would be useful in treating postpartum patients. Nitrofurazone (Furacin) has been studied for this purpose. However, in neither stud y3. 4 was there a comparison of the patient's cervix at her first prcnatal visit with her cervix at the 6 weeks' postpartum examination. It was thought that a study such as this would be definitive in determining if nitrofurazone were of value in this area. Therefore this double blind study was done. The authors were provided with eight preparations. Four of these were in suppository form and four were in the form of vaginal cream. These preparations were labeled "A" through "H." Two of the suppositories and two of the creams contained as their active ingredient nitrofurazone. The other preparations were inert. The contents of the products were not known to the authors. Five hundred consecutive patients, who were dl'livl'red of viable infants, were used in the study. Each patient's initial antenatal pelvic examination was recorded as to the clinical appt"arance of the cervix. Then, at the time of discharge from the hospital the patient was instructed by the authors in the use of the cream or the suppositories. She was instructed to begin use on the eighth postpartum day and continue for 21 days. Each fifth patient received no medication. Observation of the cervix was repeated at the routine 6 week postpartum examination. Representative pictures were taken at the first prenatal visit and at the 6 week examination in order to complement the notation of the examinations. Thirty-two patients of the 500 were eliminated from the study because of failure to follow instructions or because of failure to return for examination. In a further attempt to make this an objective work, the charts of the last 100 patients prior to onset of study were examined as to information concerning the cervix at the first prenatal visit and at the 6 week postpartum checkup. It was found by tabulating the findings in each group under study that there were similar numbers of "erosions" in the treated groups, the placebo groups, the untreated groups and in the
594 Communications
In
brief
Am.
February 15, 1968 & Gynec.
J. Obst.
Table I. Evaluation of nitrofurazone in the postpartum patient Prestudy evaluation Clinical appearance of cervix
Clean
I No medications I
Nitrofurazone su p pository
Nitrofurazone cream
Placebo cream/ suppository
PostPostPostPostPostpartum First partum First First First First partum part urn part urn (6 (6 prenatal (6 (6 prenatal prenatal prenatal prenatal (6 weeks) weeks) weeks) visit visit weeks) visit visit visit weeks)
90
77 85.6%
82
58 70.8%
77
59 84.3%
70
56 72.8%
144
117 81.3%
"Erosion"
13 14.4%
24 29.2%
11 15.7%
21 27.2%
27 18.7%
Clean
5 50%
6 31.5%
7 33.3%
5 31.2%
16 41.0%
"Erosion"
Total
10 100
5 50% 100
19 101
13 68.5% 101
groups prior to the onset of the study. This can be seen in Table 1. There was no untoward reaction due to medications in any of the patients. In view of the obvious similarity of all groups we did not believe that it was necessary to subj ect the study to statistical analysis. \. A double blind study of the value of nitrofurazone in the prevention of postpartum cervicitis and "erosion" was conducted in 500 patients. 2. There was no evidence that the treated group had a decreased amount of "erosion" and cervicitis.
21
14 66.7%
16
11 68.8%
91
91
93
93
39 183
23 59 .0% 183
3. The nitrofurazone used in this study apparently has no ability to decrease "erosion" and/or chronic cervicitis in the postpartum patient. REFERENCES
1. Fluhman, C. F.: AM. J. OBST. & 970, 1961. 2. Schwartz, J.: AM. J. OBST. & 579, 1952.
GYNEC.
82:
GYNEC .
63:
3. McClanahan, H. L., and Woodward, H. B., Jr.: AM. J. OBST. & GYNEC. 14: 632-4, 1959. 4. Stweart, S. F., Jr., and Lammert, A. C.: AM.
J.
OBST.
&
GYNEC.
85: 532-34, 1963.
Communications
Fig. 2. Primordial follicle in noncystic accessory ovary.
It must be concluded that this is a case of multiple accessory ovaries, two with development of serous cystadenomas and onc with primordial follicles. No evidence of hypcrfunction was notcd in the present case. IEFEltENCES
1. Editorial: New England J. Med. 276: 57, 1967. 2. Wharton, L. R.: AM. J. Os ST. & GVNEC. 78: 1101, 1959.
2701 Fourteenth Avenul Oakland, California
Evaluation of nitrofurazone postpartum patient
In
the
ROBERT S. ELLISON, M.D., F.A.C.O.C. EUGENE SHERMAN, M .D., F.A.C.O.C. Mansfield, Ohio
I TIS generally agreed that there is some relationship between chronic cervicitis and carcinoma of the cervix. 1 It is further agrced that chronic
In
brief
593
cervicitis may result in discharge and other discomforts. 2 Certainly, some "erosions" of the cervix with concomitant cervicitis occur as the result of pregnancy and childbirth. If there were a product available to prevent or reduce "erosion" and cervicitis it would be useful in treating postpartum patients. Nitrofurazone (Furacin) has been studied for this purpose. However, in neither stud y3. 4 was there a comparison of the patient's cervix at her first prcnatal visit with her cervix at the 6 weeks' postpartum examination. It was thought that a study such as this would be definitive in determining if nitrofurazone were of value in this area. Therefore this double blind study was done. The authors were provided with eight preparations. Four of these were in suppository form and four were in the form of vaginal cream. These preparations were labeled "A" through "H." Two of the suppositories and two of the creams contained as their active ingredient nitrofurazone. The other preparations were inert. The contents of the products were not known to the authors. Five hundred consecutive patients, who were dl'livl'red of viable infants, were used in the study. Each patient's initial antenatal pelvic examination was recorded as to the clinical appt"arance of the cervix. Then, at the time of discharge from the hospital the patient was instructed by the authors in the use of the cream or the suppositories. She was instructed to begin use on the eighth postpartum day and continue for 21 days. Each fifth patient received no medication. Observation of the cervix was repeated at the routine 6 week postpartum examination. Representative pictures were taken at the first prenatal visit and at the 6 week examination in order to complement the notation of the examinations. Thirty-two patients of the 500 were eliminated from the study because of failure to follow instructions or because of failure to return for examination. In a further attempt to make this an objective work, the charts of the last 100 patients prior to onset of study were examined as to information concerning the cervix at the first prenatal visit and at the 6 week postpartum checkup. It was found by tabulating the findings in each group under study that there were similar numbers of "erosions" in the treated groups, the placebo groups, the untreated groups and in the
594 Communications
In
brief
Am.
February 15, 1968 & Gynec.
J. Obst.
Table I. Evaluation of nitrofurazone in the postpartum patient Prestudy evaluation Clinical appearance of cervix
Clean
I No medications I
Nitrofurazone su p pository
Nitrofurazone cream
Placebo cream/ suppository
PostPostPostPostPostpartum First partum First First First First partum part urn part urn (6 (6 prenatal (6 (6 prenatal prenatal prenatal prenatal (6 weeks) weeks) weeks) visit visit weeks) visit visit visit weeks)
90
77 85.6%
82
58 70.8%
77
59 84.3%
70
56 72.8%
144
117 81.3%
"Erosion"
13 14.4%
24 29.2%
11 15.7%
21 27.2%
27 18.7%
Clean
5 50%
6 31.5%
7 33.3%
5 31.2%
16 41.0%
"Erosion"
Total
10 100
5 50% 100
19 101
13 68.5% 101
groups prior to the onset of the study. This can be seen in Table 1. There was no untoward reaction due to medications in any of the patients. In view of the obvious similarity of all groups we did not believe that it was necessary to subj ect the study to statistical analysis. \. A double blind study of the value of nitrofurazone in the prevention of postpartum cervicitis and "erosion" was conducted in 500 patients. 2. There was no evidence that the treated group had a decreased amount of "erosion" and cervicitis.
21
14 66.7%
16
11 68.8%
91
91
93
93
39 183
23 59 .0% 183
3. The nitrofurazone used in this study apparently has no ability to decrease "erosion" and/or chronic cervicitis in the postpartum patient. REFERENCES
1. Fluhman, C. F.: AM. J. OBST. & 970, 1961. 2. Schwartz, J.: AM. J. OBST. & 579, 1952.
GYNEC.
82:
GYNEC .
63:
3. McClanahan, H. L., and Woodward, H. B., Jr.: AM. J. OBST. & GYNEC. 14: 632-4, 1959. 4. Stweart, S. F., Jr., and Lammert, A. C.: AM.
J.
OBST.
&
GYNEC.
85: 532-34, 1963.