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Evaluation of Super Stripe toothpaste
Evaluation of Super Stripe toothpaste T h e 2 - y e a r d a t a 1 i n d i c a t e a s ig n if ic a n t r e d u c t io n i n t h e i n c i d e n c e o f d e n t a l c a r i e s w h e n c o m
Council on Dental Therapeutics
p a r e d w ith t h e p l a c e b o d e n ti f r i c e . B a s e d o n i n c r e m e n t s i n d e c a y e d o r fille d s u r f a c e s , t h e 2 - y e a r r e s u l ts i n d i c a t e a p p r o x i m a t e l y a 1 9 p e r c e n t r e d u c ti o n . E a rly
The f u lly
C o u n c il o n r e v ie w e d
D e n ta l T h e ra p e u tic s h a s
th e
la b o ra to ry
and
c are
c li n i c a l d a t a
s u b m itte d b y L e v e r B ro th e r s C o m p a n y in s u p p o r t
a
in
th e
su b g ro u p
of
stu d y
th e
i n v e s ti g a to r s
a p p ro x im a te ly
240
s e l e c te d
i n d iv i d u a ls ,
w h ic h in c lu d e d th o s e c h ild r e n h a v in g 2 0 to
120
s u r f a c e s a t r is k . T h is s e l e c ti o n w a s m a d e t o e lim i
o f t h e e f fe c tiv e n e s s o f its s t a n n o u s f lu o r id e d e n
n a te th o s e s u b je c ts w h o h a d a h is to ry o f r a m p a n t
t if r i c e , S u p e r S t r i p e , a s a p r o d u c t f o r h o m e u s e
c a r i e s a s w e ll a s t h o s e w h o a p p e a r e d t o b e r e
in th e p a r tia l p r e v e n tio n o f d e n ta l c a rie s a n d h a s
s i s t a n t t o c a r ie s . T h e s u b g r o u p w a s f o u n d t o h a v e
c la s s if ie d t h e d e n ti f r i c e i n G r o u p B . T h e C o u n c il
a p p ro x im a te ly a 31 p e r c e n t re d u c tio n in c a rie s
h a s a u t h o r i z e d t h e u s e o f t h e f o llo w in g s t a t e m e n t
in c id e n c e .
in a d v e rtis e m e n ts in o r d e r th a t th e u s e fu ln e s s o f
A l t h o u g h t h e C o u n c il is o f t h e o p i n i o n t h a t t h e
t h e p r o d u c t w ill b e p l a c e d w i t h in t h e a p p r o p r i a t e
e f f e c tiv e n e s s
fra m e w o r k o f g o o d o r a l h y g ie n e a n d r e g u la r p r o
b e e s t a b l i s h e d b y c li n i c a l s t u d y , t h e c li n i c a l i n
fe ssio n a l c a r e :
fo r m a tio n c u rre n tly a v a ila b le f r o m s ta n n o u s
of
a
p a rtic u la r
f l u o r id e f o r m u l a t i o n s ,
fo rm u la tio n
m u st
a num ber of
to g e th e r w ith
a
S u p e r S t r i p e h a s b e e n s h o w n t o b e a n e ffe c tiv e
d e m o n s t r a t i o n o f a h i g h le v e l o f s t a n n o u s a n d flu
decay
o rid e
p re v e n tiv e
(a n ti-c a rie s )
d e n ti f r i c e
th a t
io n s
by
la b o ra to ry
p ro c e d u re s,
p ro v id e s
c a n b e o f s ig n if ic a n t v a lu e w h e n u s e d in a c o n
s t r o n g e v id e n c e t h a t a s t a n n o u s f l u o r id e f o r m u l a
s c ie n tio u s ly
t i o n w ill b e c lin ic a lly e f fe c tiv e . L a b o r a t o r y s tu d ie s
a p p lie d p r o g r a m
o f o r a l h y g ie n e
a n d r e g u la r p ro fe s s io n a l c a re .
on
th e
Super
S trip e
fo rm u la tio n
in d ic a te
th e
p r e s e n c e o f s u b s t a n t i a l le v e ls o f s t a n n o u s a n d f lu o T h e S u p e r S t r i p e f o r m u l a t i o n c o n ta i n s 0 . 4 p e r c e n t s ta n n o u s
f l u o r id e , 4 1 . 0
p e r c e n t i n s o l u b le
s o d iu m m e ta p h o s p h a te , 5 .0 p e r c e n t c a lc iu m p y r o p h o s p h a t e , 4 . 7 p e r c e n t g ly c e r in , s o r b i t o l, 4 . 0
1 7 .1 p e r c e n t
p e r c e n t o f a p o ly e th y le n e
g ly c o l,
2 3 . 9 p e r c e n t w a t e r , a n d 3 .9 p e r c e n t m is c e l la n e o u s f o r m u l a t i n g a g e n t s , i n c l u d i n g f la v o r , b i n d e r s , a n d f o a m i n g a g e n ts . A s u i t a b l e c o l o r ( D
and C
r i d e io n s a s w e ll a s a r e d u c t i o n i n t h e a c i d s o l u b ility o f t h e d e n t a l e n a m e l . S e v e r a l a d d it i o n a l c li n i c a l s t u d i e s a r e i n p r o g r e s s t o m e a s u r e t h e e f fe c tiv e n e s s o f t h e p r o d u c t a n d t o d e te r m i n e w h e t h e r s lig h t c h a n g e s i n f o r m u l a t i o n s w ill m o d if y i t s e f fe c tiv e n e s s . I t s h o u l d b e n o t e d t h a t t h e t r a d e n a m e , S tr ip e , has
been
a p p li e d
p r e v io u s ly
to
a
n o n f l u o r id e
R e d N o . 3 0 ) is e m p l o y e d t o p r o v i d e r e d s t r i p e s
d e n ti f r i c e . T h a t p r o d u c t w ill b e r e p l a c e d b y t h e
o n t h e p a s t e a s i t is e x t r u d e d f r o m t h e t u b e .
n e w s t a n n o u s f lu o r id e f o r m u l a t i o n , w h i c h w ill b e
The
m a n u fa c tu re r h a s
su p p lie d
d a ta
fro m
a
d e s i g n a t e d a s S u p e r S t r i p e i n o r d e r t o d i s t in g u i s h
c li n i c a l s t u d y o f 2 y e a r s ’ d u r a t i o n w h i c h w a s c o n
it f r o m th e e a rlie r f o rm u la tio n . C o n s u m e r a d v e r
d u c t e d o n a g r o u p o f s c h o o l c h i l d r e n r a n g in g i n
t is in g f o r S u p e r S t r i p e w ill n o t a p p e a r u n t i l th e
age fro m 7 to
n e w p r o d u c t h a s b e e n s u p p l i e d t o r e t a i l o u tle ts .
1 2 y e a r s . T h e s t u d y i n v o lv e d tw o
w e l l- b a la n c e d g r o u p s o f a p p r o x im a t e ly 3 0 0 c h il d r e n e a c h . T h e i n v e s ti g a to r s c o m p a r e d t h e c li n i c a l c a rie s e x p e rie n c e o f a g ro u p u s in g th e te s t d e n ti f r i c e w i t h a s i m i l a r g r o u p u s in g t h e c o n t r o l d e n t i f r ic e .
B o th
g ro u p s
had
s u p e rv is e d
c la s s r o o m
b ru s h in g o n c e a d a y d u rin g th e sc h o o l te rm .
1. Segal, A . H., and others. Caries inhibiting effec tiveness of a stannous fluoride-insoluble sodium metaphosphate (IM P ) dentifrice in children: two yenr re sults. 44th Annual Meeting, IADR, M arch 24-27, 1966, Abstract 250. 1515
Council on Dental Therapeutics
p a r e d w ith t h e p l a c e b o d e n ti f r i c e . B a s e d o n i n c r e m e n t s i n d e c a y e d o r fille d s u r f a c e s , t h e 2 - y e a r r e s u l ts i n d i c a t e a p p r o x i m a t e l y a 1 9 p e r c e n t r e d u c ti o n . E a rly
The f u lly
C o u n c il o n r e v ie w e d
D e n ta l T h e ra p e u tic s h a s
th e
la b o ra to ry
and
c are
c li n i c a l d a t a
s u b m itte d b y L e v e r B ro th e r s C o m p a n y in s u p p o r t
a
in
th e
su b g ro u p
of
stu d y
th e
i n v e s ti g a to r s
a p p ro x im a te ly
240
s e l e c te d
i n d iv i d u a ls ,
w h ic h in c lu d e d th o s e c h ild r e n h a v in g 2 0 to
120
s u r f a c e s a t r is k . T h is s e l e c ti o n w a s m a d e t o e lim i
o f t h e e f fe c tiv e n e s s o f its s t a n n o u s f lu o r id e d e n
n a te th o s e s u b je c ts w h o h a d a h is to ry o f r a m p a n t
t if r i c e , S u p e r S t r i p e , a s a p r o d u c t f o r h o m e u s e
c a r i e s a s w e ll a s t h o s e w h o a p p e a r e d t o b e r e
in th e p a r tia l p r e v e n tio n o f d e n ta l c a rie s a n d h a s
s i s t a n t t o c a r ie s . T h e s u b g r o u p w a s f o u n d t o h a v e
c la s s if ie d t h e d e n ti f r i c e i n G r o u p B . T h e C o u n c il
a p p ro x im a te ly a 31 p e r c e n t re d u c tio n in c a rie s
h a s a u t h o r i z e d t h e u s e o f t h e f o llo w in g s t a t e m e n t
in c id e n c e .
in a d v e rtis e m e n ts in o r d e r th a t th e u s e fu ln e s s o f
A l t h o u g h t h e C o u n c il is o f t h e o p i n i o n t h a t t h e
t h e p r o d u c t w ill b e p l a c e d w i t h in t h e a p p r o p r i a t e
e f f e c tiv e n e s s
fra m e w o r k o f g o o d o r a l h y g ie n e a n d r e g u la r p r o
b e e s t a b l i s h e d b y c li n i c a l s t u d y , t h e c li n i c a l i n
fe ssio n a l c a r e :
fo r m a tio n c u rre n tly a v a ila b le f r o m s ta n n o u s
of
a
p a rtic u la r
f l u o r id e f o r m u l a t i o n s ,
fo rm u la tio n
m u st
a num ber of
to g e th e r w ith
a
S u p e r S t r i p e h a s b e e n s h o w n t o b e a n e ffe c tiv e
d e m o n s t r a t i o n o f a h i g h le v e l o f s t a n n o u s a n d flu
decay
o rid e
p re v e n tiv e
(a n ti-c a rie s )
d e n ti f r i c e
th a t
io n s
by
la b o ra to ry
p ro c e d u re s,
p ro v id e s
c a n b e o f s ig n if ic a n t v a lu e w h e n u s e d in a c o n
s t r o n g e v id e n c e t h a t a s t a n n o u s f l u o r id e f o r m u l a
s c ie n tio u s ly
t i o n w ill b e c lin ic a lly e f fe c tiv e . L a b o r a t o r y s tu d ie s
a p p lie d p r o g r a m
o f o r a l h y g ie n e
a n d r e g u la r p ro fe s s io n a l c a re .
on
th e
Super
S trip e
fo rm u la tio n
in d ic a te
th e
p r e s e n c e o f s u b s t a n t i a l le v e ls o f s t a n n o u s a n d f lu o T h e S u p e r S t r i p e f o r m u l a t i o n c o n ta i n s 0 . 4 p e r c e n t s ta n n o u s
f l u o r id e , 4 1 . 0
p e r c e n t i n s o l u b le
s o d iu m m e ta p h o s p h a te , 5 .0 p e r c e n t c a lc iu m p y r o p h o s p h a t e , 4 . 7 p e r c e n t g ly c e r in , s o r b i t o l, 4 . 0
1 7 .1 p e r c e n t
p e r c e n t o f a p o ly e th y le n e
g ly c o l,
2 3 . 9 p e r c e n t w a t e r , a n d 3 .9 p e r c e n t m is c e l la n e o u s f o r m u l a t i n g a g e n t s , i n c l u d i n g f la v o r , b i n d e r s , a n d f o a m i n g a g e n ts . A s u i t a b l e c o l o r ( D
and C
r i d e io n s a s w e ll a s a r e d u c t i o n i n t h e a c i d s o l u b ility o f t h e d e n t a l e n a m e l . S e v e r a l a d d it i o n a l c li n i c a l s t u d i e s a r e i n p r o g r e s s t o m e a s u r e t h e e f fe c tiv e n e s s o f t h e p r o d u c t a n d t o d e te r m i n e w h e t h e r s lig h t c h a n g e s i n f o r m u l a t i o n s w ill m o d if y i t s e f fe c tiv e n e s s . I t s h o u l d b e n o t e d t h a t t h e t r a d e n a m e , S tr ip e , has
been
a p p li e d
p r e v io u s ly
to
a
n o n f l u o r id e
R e d N o . 3 0 ) is e m p l o y e d t o p r o v i d e r e d s t r i p e s
d e n ti f r i c e . T h a t p r o d u c t w ill b e r e p l a c e d b y t h e
o n t h e p a s t e a s i t is e x t r u d e d f r o m t h e t u b e .
n e w s t a n n o u s f lu o r id e f o r m u l a t i o n , w h i c h w ill b e
The
m a n u fa c tu re r h a s
su p p lie d
d a ta
fro m
a
d e s i g n a t e d a s S u p e r S t r i p e i n o r d e r t o d i s t in g u i s h
c li n i c a l s t u d y o f 2 y e a r s ’ d u r a t i o n w h i c h w a s c o n
it f r o m th e e a rlie r f o rm u la tio n . C o n s u m e r a d v e r
d u c t e d o n a g r o u p o f s c h o o l c h i l d r e n r a n g in g i n
t is in g f o r S u p e r S t r i p e w ill n o t a p p e a r u n t i l th e
age fro m 7 to
n e w p r o d u c t h a s b e e n s u p p l i e d t o r e t a i l o u tle ts .
1 2 y e a r s . T h e s t u d y i n v o lv e d tw o
w e l l- b a la n c e d g r o u p s o f a p p r o x im a t e ly 3 0 0 c h il d r e n e a c h . T h e i n v e s ti g a to r s c o m p a r e d t h e c li n i c a l c a rie s e x p e rie n c e o f a g ro u p u s in g th e te s t d e n ti f r i c e w i t h a s i m i l a r g r o u p u s in g t h e c o n t r o l d e n t i f r ic e .
B o th
g ro u p s
had
s u p e rv is e d
c la s s r o o m
b ru s h in g o n c e a d a y d u rin g th e sc h o o l te rm .
1. Segal, A . H., and others. Caries inhibiting effec tiveness of a stannous fluoride-insoluble sodium metaphosphate (IM P ) dentifrice in children: two yenr re sults. 44th Annual Meeting, IADR, M arch 24-27, 1966, Abstract 250. 1515