- Email: [email protected]
Evaluation of the Activities of Klaipėda Anonymous Consultative Centres for Drug Users
ISMH Congress 2010 Abstracts Conclusions: Sexual subscale of the AMS in combination with IIEF may play a role as a good screening tool for hypogonadism. Longitudinal studies are needed to confirm these findings. doi:10.1016/j.jomh.2010.09.199
ISMH World Congress 2010 Abstract 201 GENDER DIFFERENCES IN TERMINAL CARE B. Skulason a,∗ , R. Asgeir b a
ISMH World Congress 2010 Abstract 199 EXAMINING THE RELATION BETWEEN STUDENTS’ HAPPINESS AND MENTAL HEALTH IN TABRIZ AZAD ISLAMIC UNIVERSITY夽 Akbar Mohammadi ∗ Islamic Azad University of Branch Garmsar, Shahid Sajadiyan Street Parvin Etesami Alley No 3 Emam khomini Avenu Roudehin, Tehran 3973163631 Iran E-mail address: a mohammadi [email protected]. Methods: The research sample was including 569 student (356 female-213 male). Tests such as: OHI, mental health, G-H-Q-2 was used, these tests were validated and authenticated. Studied variables were happiness, mental health (mental problems) with principles of physical signs, tension, social acts disorder and depression, which have separately been examined in each boy and girl, Results: and has the maximum correlation index of r - 0.59 which were meaningful in the level if p < 0.0001, these results are corresponding to the results of the other results in the other countries. doi:10.1016/j.jomh.2010.09.200
ISMH World Congress 2010 Abstract 200 LAPAROSCOPIC RADICAL PROSTATECTOMY: OPERATIVE, ONCOLOGICAL AND FUNCTIONAL RESULTS WITH MINIMUM 12 MONTH FOLLOW UP K. Low a,b,c,∗ , C. Chabert a,b,c , D. Kerle a,b,c , L. Osgood a,b,c Lismore Base Hospital, Lismore, Australia, b St Vincents Private Hospital, Lismore, Australia, c John Flynn Private Hospital Tugun Australia
a
E-mail address: [email protected] (K. Low). Introduction: Radical prostatectomy is one treatment option to cure localised prostate cancer. The laparoscopic technique was first described in 1997 and whilst there have been many advances it remains a technically demanding procedure. In the worldwide setting the majority of cases are performed in major metropolitan centres. This report outlines our operative, oncological and functional results with minimum 12 month follow up during a laparoscopic radical prostatectomy program performed in a rural setting. Method: Data on 77 patients was prospectively collected from the period February 2008 to August 2009. There were no case selections and all procedures were performed by a single fellowship trained laparoscopic surgeon with the assistance of a urology fellow during part of the series. Results: Preoperative risk group analysis using D’Amico criteria revealed that 87% of patients had intermediate or high risk disease. There were no conversions to open surgery and no intraoperative bowel, rectal or major vascular injuries. Only one patient required a blood transfusion. The pT2 and pT3 positive surgical margin rates were 2.3% and 29.4% respectively. Using a PSA < 0.2ng/mL as being “biochemically free” over 95% were free of disease at all time points to 12 months. Pad free rates were 31.2% immediately and 98.6% at 12 months. Of those patients having at least a unilateral nerve sparing procedure 74.5% reported erectile function sufficient for penetrative intercourse at 12 months. Conclusions: Laparoscopic radical prostatectomy can be donely safely and effectively in a rural setting. Our results are comparable to those of major centres and show that with proper training and resources even technically demanding urological procedures can be done with excellent results. doi:10.1016/j.jomh.2010.09.201
夽 This research has been designed and performed to examine the relation between students’ happiness and mental health in Tabriz Azad Islamic University.
344 jmh
Vol. 7, No. 3, pp. 282–351, October 2010
National University Hospital, Reykjavik Iceland, School of Health and Education, Reykjavík University, (Menntavegur 1) Reykjavik (IS101), Iceland. Iceland University (Saemundargata 2) Reykjavik (IS101), Iceland, b Helgason, School of Health and Education, Reykjavík University, (Menntavegur 1) Reykjavik (IS101), Iceland. & Department of Public Health Sciences, Social Medicine, Karolinska Institutet, Stockholm (SE17177), Sweden E-mail address: [email protected] (B. Skulason). Background: The long-term benefits of having information concerning significant others impending death may significantly lower the psychological trauma and morbidity in bereavement. In many countries, a functioning communication between the health care personnel and the dying patient is often a perquisite for communication with patientˇıs significant others. Being able to communicate with the dying patient also lowers the chances of experiencing severe psychological trauma and morbidity for the relative. At the National University Hospital in Iceland, all terminal patients are offered a service from a team of hospital chaplains specialized in psychological and spiritual palliative care. The hospital chaplains work in close collaboration with other health care personnel. The aim: of the presented project was to document in a systematic way if and how dying patients initiate a talk about own impending death with a hospital chaplain. Further, to assess to what extent a simple intervention may enhance the prevalence of “death talk”. Methods: Before data collection began, certain ground rules were set, including confidentiality, and respect for patient’s wishes, evocation methods inspired by Motivational Interviewing were used. Results: A majority of the women interviewed (80%) had spontaneous death talk with chaplain, compared to 30% of the men. Conclusion: 1. In an interview with a chaplain, a great majority of dying female patients initiate a talk about death. 2. In an interview with a chaplain, dying male patients seem to benefit from a pastor’s evocation to talk about death to a greater extent compared to women. 3. For a person with an incurable disease most common reasons for seeking a pastoral interview are spiritual/religious needs or concerns about family. doi:10.1016/j.jomh.2010.09.202
ISMH World Congress 2010 Abstract 202 ˙ EVALUATION OF THE ACTIVITIES OF KLAIPEDA ANONYMOUS CONSULTATIVE CENTRES FOR DRUG USERS Rozˇ e˙ Perminiene˙ (MPH) a,∗ , Aurelijus Veryga (Dr. Sc. Assoc. Professor) b a
Klaip˙eda City Municipality Administration, Klaip˙eda, Lithuania, b Kaunas University of Medicine, Kaunas, Lithuania ˙ E-mail address: [email protected] (Rozˇ e˙ Perminiene). Background: Aim of the study — to evaluate the activities of the anonymous ˙ consultative centres (ACC), which are an element of Klaipeda city drugtaking harm reduction programme. Methods: analysis of the documentation of ACC; questionnairing and comparison of the collected data. The adapted anonymous questionaire of high risk HIV contamination persons behaviour researches of International Family Health Organization was used in the study. Results: More frequent injection drug was associated with more frequent visits to ACC (p < 0.05). In 2001, 26.0% of respondents gave their used syringes to others and in 2007 — 2.0%. In 2001, 25,0% of respondents never used other people‘s used syringes, and in 2007 — 42,4%. Having compared the research results of 2001 and 2007, clients started using condoms with regular partners more frequently by 1.5 times and by 5.5 times with accidental partners. The more frequently injection drug users (IDU) visited ACC, the greater part went for HIV examination. IDU noted that they could be encouraged for treatment from the addiction to drugs by their neighbours, the improvement of their environment, their own willingness, changes of health, information about the harm of drugs.
ISMH Congress 2010 Abstracts ˙ Conclusion: The number of new clients of Klaipeda ACC and the number of their visits to ACC was constantly growing throughout 1997-2006. The number of disinfection and contraception means, handed out to the ACC clients, was increasing during 1997-2006 subject to the increasing number of ACC clients. Consultations of social workers, preventive information, training and consultation about the possibilities for treatment from the drug addiction were most often held for IDU. The service of mediation and directing of clients to other institutions and distribution of editions about safe sexual relations were carried out at least. The activity of ACC encouraged positive changes of IDU behaviour — it became safer both in the field of drug use and in the field of sexual relations. The more frequently IDU visit ACC, the more real possibility of stopping drug use they see. doi:10.1016/j.jomh.2010.09.203
ISMH World Congress 2010 Abstract 203 DOES GENDER HEALTH DISPARITY BEGIN IN ADOLESCENCE?
the proliferation of prostate cancer cells by activating a DNA damage response. Materials and Methods: The effects of isoflavones and curcumin on the expression and phosphorylation of ATM (ataxia-telangiectasia-mutated kinase), H2AX (histone H2AX variant), and Chk2 (checkpoint kinase2) were examined in LNCaP cells. The induction of apoptosis in LNCaP cells was evaluated by poly(ADP-ribose) polymerase (PARP) cleavage. Furthermore, the effects of a testosterone supplement on modulation of the DNA damage response were examined. Results: Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2, and p53. Testosterone augmented the activation of the DNA damage response and PARP cleavage induced by curcumin. Conclusion: Our results indicate that the activation of the DNA damage response by the polyphenols might suppress the malignant transformation of prostate cancer. In addition, testosterone, when combined with the polyphenols, may have suppressive effects on the progression of prostate cancer. doi:10.1016/j.jomh.2010.09.205
S. Ghannam, S. Shabsigh, D. Hajo, J. Jhaveri, R. Shabsigh ∗
ISMH World Congress 2010 Abstract 205
Maimonides Medical Center, Brooklyn, USA E-mail address: [email protected] (R. Shabsigh). Background: Contributing to the health disparity between adult men and women are health risk behaviors. Although potentially modifiable, a first step requires us to ask, when do these behavioral differences begin? Methods: Using data from the 2009 Youth Risk Behavior Surveillance Study we examined responses of 16,000+ American teenagers. Answers to a variety of health risk behavior questions were analyzed for differences in prevalence between genders. Results: Compared to girls, boys were more likely to drive while drinking alcohol (11.6% n = 7,890 vs. 7.6% n = 8.173 p < 0.001), carry a weapon (27.1% n = 7,848 vs. 7.1% n = 8,203 p < 0.001), and engage in fighting (39.1% n = 7,890 vs. 22.9% n = 8,183 p < 0.001). Compared to girls, prevalence of recent tobacco use (29.8% n = 7,301 vs. 21.8% n = 7,641 p < 0.001) and “heavy” smoking (11.1% n = 1,570 vs. 4.1% n = 1,354 p < 0.001) was more common in boys. Compared to girls, boys were more likely to experiment with drugs: marijuana (39.0% n = 7,849 vs. 34.3% n = 8,148 p < 0.001), cocaine (7.3% n = 7,927 vs. 5.3% n = 8,214 p < 0.001), heroin (3.2% n = 7,750 vs. 1.7% n = 7,923 p < 0.001), ecstasy (7.6% n = 7,811 vs. 5.5% n = 8,016 p < 0.001), methamphetamine (4.7% n = 7,982 vs. 3.3% n = 8,244 p < 0.001), other intravenous drugs (2.7% n = 7,923 vs. 1.4% n = 8,157 p < 0.001). Compared to girls, boys were more likely to have multiple sexual partners (16.2% n = 7,261 vs. 11.2% n = 7,672 p < 0.001) and have sex while using drugs or alcohol (25.9% n = 2,692 vs. 17.1% n = 2,829 p < 0.001). 76% of boys did not eat five servings of fruits and vegetables daily (n = 7,851). Over half of all boys did not have regular physical activity (54.4% n = 7,881). Prevalence of obesity was higher in boys than girls (15.3% n = 7,572 vs. 8.3% n = 7,606 p < 0.001). Conclusion: Regarding health behaviors among teenagers, boys demonstrated riskier behavior than girls. Injurious and violent behavior, tobacco and drug use, risky sexual practices and obesity were more prevalent in boys. Lifelong behavioral patterns are established in adolescence, possibly becoming risk factors for chronic disease later in adulthood. Identifying differences in teen behavior allows for targeted intervention, bringing us closer to improving future outcomes of men’s health. doi:10.1016/j.jomh.2010.09.204
ISMH World Congress 2010 Abstract 204 TESTOSTERONE AUGMENTS POLYPHENOL-INDUCED DNA DAMAGE RESPONSE IN PROSTATE CANCER CELLS Hisamitsu Ide, Lu Yan, Yu Jingsong, Satoru Muto, Shigeo Horie
THE [-2]PROPSA AND THE PROSTATE HEALTH INDEX (PHI) IMPROVE THE DETECTION OF PROSTATE CANCER FOR PATIENTS WITH TOTAL PSA BETWEEN 1.8 AND 8.0 NG/ML J-S Blanchet a,∗,1 , A. Houlgatte b , X. Durand b , J.N. Ramirez c , K. Bensalah d , B. Guille d , S. Vincendeau d Beckman Coulter, Inc., Nyon, Switzerland, b Paris, Val de Grace Hospital, Department of Urology, c Paris, Val de Grace Hospital, Department of Biochemistry, d Rennes, Hôpital Pontchaillou, Department of Urology
a
E-mail address: [email protected] (J.-S. Blanchet). Introduction: The benefit of screening for prostate cancer (PCa) using the prostate specific antigen (PSA) as a biochemical marker is currently the focus of intense debate because of inadequate clinical performance. Beckman Coulter has recently developed a new approach with the Prostate Health Index (phi)2 which combines the results of total PSA, free PSA and [-2]proPSA, a molecular isoform of free PSA. The clinical performance of this index for the detection of PCa is currently being evaluated in a multicenter study. Material and Methods: After six months of recruitment, 250 men (107 with and 143 without PCa) with total PSA levels between 1.8 - 8.0 ng/mL (WHO Calibration) and non-suspicious digital rectal examination (DRE) were included in the study. All PCa cases were confirmed by biopsies with 10 cores or more. The total serum PSA, free PSA and [-2]proPSA were measured on a Beckman Coulter DxI800 automated immunoassay analyzer. Results: Unlike the total PSA and free PSA, serum levels of [-2]proPSA were significantly higher in the PCa group compared with the group without PCa. The parameters % free PSA, %[-2]proPSA and phi were significantly different for the group of patients with PCa. A strong relationship between the percentage of positive biopsies and phi was confirmed. The diagnostic performance of the 4 parameters by ROC curve analysis showed a highly significant superiority for %[-2]proPSA (AUC: 0.72) and phi (AUC: 0.72) compared to total PSA (AUC: 0.53) and % free PSA (AUC: 0.58). If prostate biopsy indication would have been based on %fPSA value with a 25% cut off, 14 PCa would not have been detected. The phi index, with a cut of at 23, would have detected 12 of these 14 cancers. Conclusion: The results of this evaluation confirmed the clinical superiority of [-2]proPSA and phi for the detection of PCa in the concentration range of 1.8 - 8.0 ng/mL total PSA. The phi index improves the detection of PCa patients with %fPSA > 25%. doi:10.1016/j.jomh.2010.09.206
∗
Teikyo University School of Medicine, Tokyo, Japan E-mail address: [email protected] (S. Horie). Background: Recently, we reported that combined ingestion of soy isoflavones and curcumin significantly decreased serum level of prostatespecific antigen based on a randomized placebo-controlled double-blind clinical study. We investigated whether these polyphenols inhibited
1 Not intended as off-label promotion of any Beckman Coulter product. 2 Not available in the United States.
jmh Vol. 7, No. 3, pp. 282–351, October 2010 345
ISMH World Congress 2010 Abstract 201 GENDER DIFFERENCES IN TERMINAL CARE B. Skulason a,∗ , R. Asgeir b a
ISMH World Congress 2010 Abstract 199 EXAMINING THE RELATION BETWEEN STUDENTS’ HAPPINESS AND MENTAL HEALTH IN TABRIZ AZAD ISLAMIC UNIVERSITY夽 Akbar Mohammadi ∗ Islamic Azad University of Branch Garmsar, Shahid Sajadiyan Street Parvin Etesami Alley No 3 Emam khomini Avenu Roudehin, Tehran 3973163631 Iran E-mail address: a mohammadi [email protected]. Methods: The research sample was including 569 student (356 female-213 male). Tests such as: OHI, mental health, G-H-Q-2 was used, these tests were validated and authenticated. Studied variables were happiness, mental health (mental problems) with principles of physical signs, tension, social acts disorder and depression, which have separately been examined in each boy and girl, Results: and has the maximum correlation index of r - 0.59 which were meaningful in the level if p < 0.0001, these results are corresponding to the results of the other results in the other countries. doi:10.1016/j.jomh.2010.09.200
ISMH World Congress 2010 Abstract 200 LAPAROSCOPIC RADICAL PROSTATECTOMY: OPERATIVE, ONCOLOGICAL AND FUNCTIONAL RESULTS WITH MINIMUM 12 MONTH FOLLOW UP K. Low a,b,c,∗ , C. Chabert a,b,c , D. Kerle a,b,c , L. Osgood a,b,c Lismore Base Hospital, Lismore, Australia, b St Vincents Private Hospital, Lismore, Australia, c John Flynn Private Hospital Tugun Australia
a
E-mail address: [email protected] (K. Low). Introduction: Radical prostatectomy is one treatment option to cure localised prostate cancer. The laparoscopic technique was first described in 1997 and whilst there have been many advances it remains a technically demanding procedure. In the worldwide setting the majority of cases are performed in major metropolitan centres. This report outlines our operative, oncological and functional results with minimum 12 month follow up during a laparoscopic radical prostatectomy program performed in a rural setting. Method: Data on 77 patients was prospectively collected from the period February 2008 to August 2009. There were no case selections and all procedures were performed by a single fellowship trained laparoscopic surgeon with the assistance of a urology fellow during part of the series. Results: Preoperative risk group analysis using D’Amico criteria revealed that 87% of patients had intermediate or high risk disease. There were no conversions to open surgery and no intraoperative bowel, rectal or major vascular injuries. Only one patient required a blood transfusion. The pT2 and pT3 positive surgical margin rates were 2.3% and 29.4% respectively. Using a PSA < 0.2ng/mL as being “biochemically free” over 95% were free of disease at all time points to 12 months. Pad free rates were 31.2% immediately and 98.6% at 12 months. Of those patients having at least a unilateral nerve sparing procedure 74.5% reported erectile function sufficient for penetrative intercourse at 12 months. Conclusions: Laparoscopic radical prostatectomy can be donely safely and effectively in a rural setting. Our results are comparable to those of major centres and show that with proper training and resources even technically demanding urological procedures can be done with excellent results. doi:10.1016/j.jomh.2010.09.201
夽 This research has been designed and performed to examine the relation between students’ happiness and mental health in Tabriz Azad Islamic University.
344 jmh
Vol. 7, No. 3, pp. 282–351, October 2010
National University Hospital, Reykjavik Iceland, School of Health and Education, Reykjavík University, (Menntavegur 1) Reykjavik (IS101), Iceland. Iceland University (Saemundargata 2) Reykjavik (IS101), Iceland, b Helgason, School of Health and Education, Reykjavík University, (Menntavegur 1) Reykjavik (IS101), Iceland. & Department of Public Health Sciences, Social Medicine, Karolinska Institutet, Stockholm (SE17177), Sweden E-mail address: [email protected] (B. Skulason). Background: The long-term benefits of having information concerning significant others impending death may significantly lower the psychological trauma and morbidity in bereavement. In many countries, a functioning communication between the health care personnel and the dying patient is often a perquisite for communication with patientˇıs significant others. Being able to communicate with the dying patient also lowers the chances of experiencing severe psychological trauma and morbidity for the relative. At the National University Hospital in Iceland, all terminal patients are offered a service from a team of hospital chaplains specialized in psychological and spiritual palliative care. The hospital chaplains work in close collaboration with other health care personnel. The aim: of the presented project was to document in a systematic way if and how dying patients initiate a talk about own impending death with a hospital chaplain. Further, to assess to what extent a simple intervention may enhance the prevalence of “death talk”. Methods: Before data collection began, certain ground rules were set, including confidentiality, and respect for patient’s wishes, evocation methods inspired by Motivational Interviewing were used. Results: A majority of the women interviewed (80%) had spontaneous death talk with chaplain, compared to 30% of the men. Conclusion: 1. In an interview with a chaplain, a great majority of dying female patients initiate a talk about death. 2. In an interview with a chaplain, dying male patients seem to benefit from a pastor’s evocation to talk about death to a greater extent compared to women. 3. For a person with an incurable disease most common reasons for seeking a pastoral interview are spiritual/religious needs or concerns about family. doi:10.1016/j.jomh.2010.09.202
ISMH World Congress 2010 Abstract 202 ˙ EVALUATION OF THE ACTIVITIES OF KLAIPEDA ANONYMOUS CONSULTATIVE CENTRES FOR DRUG USERS Rozˇ e˙ Perminiene˙ (MPH) a,∗ , Aurelijus Veryga (Dr. Sc. Assoc. Professor) b a
Klaip˙eda City Municipality Administration, Klaip˙eda, Lithuania, b Kaunas University of Medicine, Kaunas, Lithuania ˙ E-mail address: [email protected] (Rozˇ e˙ Perminiene). Background: Aim of the study — to evaluate the activities of the anonymous ˙ consultative centres (ACC), which are an element of Klaipeda city drugtaking harm reduction programme. Methods: analysis of the documentation of ACC; questionnairing and comparison of the collected data. The adapted anonymous questionaire of high risk HIV contamination persons behaviour researches of International Family Health Organization was used in the study. Results: More frequent injection drug was associated with more frequent visits to ACC (p < 0.05). In 2001, 26.0% of respondents gave their used syringes to others and in 2007 — 2.0%. In 2001, 25,0% of respondents never used other people‘s used syringes, and in 2007 — 42,4%. Having compared the research results of 2001 and 2007, clients started using condoms with regular partners more frequently by 1.5 times and by 5.5 times with accidental partners. The more frequently injection drug users (IDU) visited ACC, the greater part went for HIV examination. IDU noted that they could be encouraged for treatment from the addiction to drugs by their neighbours, the improvement of their environment, their own willingness, changes of health, information about the harm of drugs.
ISMH Congress 2010 Abstracts ˙ Conclusion: The number of new clients of Klaipeda ACC and the number of their visits to ACC was constantly growing throughout 1997-2006. The number of disinfection and contraception means, handed out to the ACC clients, was increasing during 1997-2006 subject to the increasing number of ACC clients. Consultations of social workers, preventive information, training and consultation about the possibilities for treatment from the drug addiction were most often held for IDU. The service of mediation and directing of clients to other institutions and distribution of editions about safe sexual relations were carried out at least. The activity of ACC encouraged positive changes of IDU behaviour — it became safer both in the field of drug use and in the field of sexual relations. The more frequently IDU visit ACC, the more real possibility of stopping drug use they see. doi:10.1016/j.jomh.2010.09.203
ISMH World Congress 2010 Abstract 203 DOES GENDER HEALTH DISPARITY BEGIN IN ADOLESCENCE?
the proliferation of prostate cancer cells by activating a DNA damage response. Materials and Methods: The effects of isoflavones and curcumin on the expression and phosphorylation of ATM (ataxia-telangiectasia-mutated kinase), H2AX (histone H2AX variant), and Chk2 (checkpoint kinase2) were examined in LNCaP cells. The induction of apoptosis in LNCaP cells was evaluated by poly(ADP-ribose) polymerase (PARP) cleavage. Furthermore, the effects of a testosterone supplement on modulation of the DNA damage response were examined. Results: Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2, and p53. Testosterone augmented the activation of the DNA damage response and PARP cleavage induced by curcumin. Conclusion: Our results indicate that the activation of the DNA damage response by the polyphenols might suppress the malignant transformation of prostate cancer. In addition, testosterone, when combined with the polyphenols, may have suppressive effects on the progression of prostate cancer. doi:10.1016/j.jomh.2010.09.205
S. Ghannam, S. Shabsigh, D. Hajo, J. Jhaveri, R. Shabsigh ∗
ISMH World Congress 2010 Abstract 205
Maimonides Medical Center, Brooklyn, USA E-mail address: [email protected] (R. Shabsigh). Background: Contributing to the health disparity between adult men and women are health risk behaviors. Although potentially modifiable, a first step requires us to ask, when do these behavioral differences begin? Methods: Using data from the 2009 Youth Risk Behavior Surveillance Study we examined responses of 16,000+ American teenagers. Answers to a variety of health risk behavior questions were analyzed for differences in prevalence between genders. Results: Compared to girls, boys were more likely to drive while drinking alcohol (11.6% n = 7,890 vs. 7.6% n = 8.173 p < 0.001), carry a weapon (27.1% n = 7,848 vs. 7.1% n = 8,203 p < 0.001), and engage in fighting (39.1% n = 7,890 vs. 22.9% n = 8,183 p < 0.001). Compared to girls, prevalence of recent tobacco use (29.8% n = 7,301 vs. 21.8% n = 7,641 p < 0.001) and “heavy” smoking (11.1% n = 1,570 vs. 4.1% n = 1,354 p < 0.001) was more common in boys. Compared to girls, boys were more likely to experiment with drugs: marijuana (39.0% n = 7,849 vs. 34.3% n = 8,148 p < 0.001), cocaine (7.3% n = 7,927 vs. 5.3% n = 8,214 p < 0.001), heroin (3.2% n = 7,750 vs. 1.7% n = 7,923 p < 0.001), ecstasy (7.6% n = 7,811 vs. 5.5% n = 8,016 p < 0.001), methamphetamine (4.7% n = 7,982 vs. 3.3% n = 8,244 p < 0.001), other intravenous drugs (2.7% n = 7,923 vs. 1.4% n = 8,157 p < 0.001). Compared to girls, boys were more likely to have multiple sexual partners (16.2% n = 7,261 vs. 11.2% n = 7,672 p < 0.001) and have sex while using drugs or alcohol (25.9% n = 2,692 vs. 17.1% n = 2,829 p < 0.001). 76% of boys did not eat five servings of fruits and vegetables daily (n = 7,851). Over half of all boys did not have regular physical activity (54.4% n = 7,881). Prevalence of obesity was higher in boys than girls (15.3% n = 7,572 vs. 8.3% n = 7,606 p < 0.001). Conclusion: Regarding health behaviors among teenagers, boys demonstrated riskier behavior than girls. Injurious and violent behavior, tobacco and drug use, risky sexual practices and obesity were more prevalent in boys. Lifelong behavioral patterns are established in adolescence, possibly becoming risk factors for chronic disease later in adulthood. Identifying differences in teen behavior allows for targeted intervention, bringing us closer to improving future outcomes of men’s health. doi:10.1016/j.jomh.2010.09.204
ISMH World Congress 2010 Abstract 204 TESTOSTERONE AUGMENTS POLYPHENOL-INDUCED DNA DAMAGE RESPONSE IN PROSTATE CANCER CELLS Hisamitsu Ide, Lu Yan, Yu Jingsong, Satoru Muto, Shigeo Horie
THE [-2]PROPSA AND THE PROSTATE HEALTH INDEX (PHI) IMPROVE THE DETECTION OF PROSTATE CANCER FOR PATIENTS WITH TOTAL PSA BETWEEN 1.8 AND 8.0 NG/ML J-S Blanchet a,∗,1 , A. Houlgatte b , X. Durand b , J.N. Ramirez c , K. Bensalah d , B. Guille d , S. Vincendeau d Beckman Coulter, Inc., Nyon, Switzerland, b Paris, Val de Grace Hospital, Department of Urology, c Paris, Val de Grace Hospital, Department of Biochemistry, d Rennes, Hôpital Pontchaillou, Department of Urology
a
E-mail address: [email protected] (J.-S. Blanchet). Introduction: The benefit of screening for prostate cancer (PCa) using the prostate specific antigen (PSA) as a biochemical marker is currently the focus of intense debate because of inadequate clinical performance. Beckman Coulter has recently developed a new approach with the Prostate Health Index (phi)2 which combines the results of total PSA, free PSA and [-2]proPSA, a molecular isoform of free PSA. The clinical performance of this index for the detection of PCa is currently being evaluated in a multicenter study. Material and Methods: After six months of recruitment, 250 men (107 with and 143 without PCa) with total PSA levels between 1.8 - 8.0 ng/mL (WHO Calibration) and non-suspicious digital rectal examination (DRE) were included in the study. All PCa cases were confirmed by biopsies with 10 cores or more. The total serum PSA, free PSA and [-2]proPSA were measured on a Beckman Coulter DxI800 automated immunoassay analyzer. Results: Unlike the total PSA and free PSA, serum levels of [-2]proPSA were significantly higher in the PCa group compared with the group without PCa. The parameters % free PSA, %[-2]proPSA and phi were significantly different for the group of patients with PCa. A strong relationship between the percentage of positive biopsies and phi was confirmed. The diagnostic performance of the 4 parameters by ROC curve analysis showed a highly significant superiority for %[-2]proPSA (AUC: 0.72) and phi (AUC: 0.72) compared to total PSA (AUC: 0.53) and % free PSA (AUC: 0.58). If prostate biopsy indication would have been based on %fPSA value with a 25% cut off, 14 PCa would not have been detected. The phi index, with a cut of at 23, would have detected 12 of these 14 cancers. Conclusion: The results of this evaluation confirmed the clinical superiority of [-2]proPSA and phi for the detection of PCa in the concentration range of 1.8 - 8.0 ng/mL total PSA. The phi index improves the detection of PCa patients with %fPSA > 25%. doi:10.1016/j.jomh.2010.09.206
∗
Teikyo University School of Medicine, Tokyo, Japan E-mail address: [email protected] (S. Horie). Background: Recently, we reported that combined ingestion of soy isoflavones and curcumin significantly decreased serum level of prostatespecific antigen based on a randomized placebo-controlled double-blind clinical study. We investigated whether these polyphenols inhibited
1 Not intended as off-label promotion of any Beckman Coulter product. 2 Not available in the United States.
jmh Vol. 7, No. 3, pp. 282–351, October 2010 345