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Evaluation of titanium implants in the temporal bone by Accuitomo
Program Poster Presentations
Evaluation of titanium implants in the temporal bone by Accuitomo Abstract withdrawn SP131 – Fever and hearing loss Mary Theresa A Adams, MD (presenter) OBJECTIVES: 1) Be able to differentiate auditory neuropathy from other types of hearing loss through the use of ABR and OAEs. 2) Understand the disease of temperature-induced auditory neuropathy. METHODS: Study design: retrospective case review. A case report is presented with review of literature of auditory neuropathy and its variant temperature-induced auditory neuropathy. RESULTS: A 25-year-old female initially presented at one year of age with hearing loss during fever. Audiograms documented severe hearing loss during these events as well as near-complete resolution during afebrile periods. Further audiologic testing demonstrated abnormal brainstem responses with preserved cochlear function during febrile episodes, supporting a diagnosis of auditory neuropathy. As an adult she continues to have three to four episodes a year and keeps acetaminophen on hand to combat fevers. It has been hypothesized that this particular subset of auditory neuropathy is caused by temperature-induced demyelination of the vestibular nerve. CONCLUSIONS: We report a rare case of temperature-induced auditory neuropathy. While the pathophysiologic features continue to be debated, ABRs and OAEs continue to support the clinical diagnosis. SP157 – Gene analysis of VX2 carcinoma after treatment with O3/O2-PP Robert Mandic, MD (presenter); Eberhard Weihe, MD; Jochen Werner, MD; Michael Bette, PhD OBJECTIVES: The rabbit VX2 carcinoma serves as a model for human head and neck squamous cell carcinomas
(HNSCCs). Recently we reported that intraperitoneal insufflation of an ozone/oxygen gas mixture (O3/O2-PP) into VX2 carcinoma bearing rabbits resulted in a significant regression of the tumors and associated metastases. Involvement of the body’s own immune system was likely since reimplantation of the VX2 tumor in cured rabbits was only possible after immune-suppression with dexamethasone and cyclosporine A. The aim of the present study was to further analyze the mechanisms underlying the observed anti-tumorous effect of O3/ O2-PP. METHODS: Four rabbits were inoculated with VX2 tumor cell suspension and tumor growth was allowed for 14 days as previously described, then two of the rabbits were either treated or not treated (sham) with O3/O2-PP. Progressive tumors and such in regression were isolated and RNA was extracted with the Trizol method. Microarray analysis was performed with the Rabbit Oligo Microarray Kit (1 slide, 4 microarrays/slide, format: 4 x 44K, product #: G2519F, design ID: 020908) from Agilent at the EMBL GeneCore Facility (European Molecular Biology Laboratory, Heidelberg, Germany). RESULTS: Tumors in rabbits of the sham group exhibited progressive tumor growth whereas O3/O2-PP treated rabbits showed tumor regression. Micro array analysis identified several putative, particularly immune system related, candidate genes. CONCLUSIONS: Identification of immune-relevant candidate genes is further underlining the significance of the immune system as a key player of the anti tumorous O3/O2-PP effect. SP147 – Medical vs surgical treatment of peritonsillar abscesses Jacob Husseman, MD (presenter); Paul Bernstein, MD; Joanie Chung, MA, MPH; Alex Battaglia, MD OBJECTIVES: To determine whether surgical drainage of peritonsillar abscesses provides superior outcomes compared to medical management. METHODS: Twenty-one patients with a clinically diagnosed peritonsillar abscess were randomized to medical or surgical treatment. Medical management consisted of initial treatment with intravenous Ceftriaxone, Clindamycin, Decadron, and fluids. Patients were discharged with oral Clindamycin and pain medicine and returned the following day for re-evaluation and a second dose of Ceftriaxone. The surgical treatment group received the same medical care but also underwent needle aspiration. The major outcome measurements were pain (0-10 scale), days until return to work, and time before oral intake. Patients were evaluated at 1, 24, 48, and 72 hours, then at 7 and 42 days. RESULTS: Statistical analysis showed no significant advan-
POSTERS
RESULTS: The maximum and mean values of the resting UES pressure and the length of the resting UES pressure in NSF, HSS, and HOS were 55.8}20.0 (mmHg, mean}standard deviation), 138.5}79.1, 28.9}15.0, and 32.3}9.2, 56.8}23.5, 17.8}5.9, and 3.6}0.7 (cm), 3.8}0.7, 2.4}1.0, respectively. The maximum and mean values of the resting UES pressure in HSS and HOS were statistically higher and lower than those in NSF, respectively. The length of the resting UES pressure in HOS was statistically shorter than that in NSF. CONCLUSIONS: The present study provides physiological information of the normal UES pressure about the head rotation, which will be an aid to the future clinical and investigative swallowing studies.
P137
Evaluation of titanium implants in the temporal bone by Accuitomo Abstract withdrawn SP131 – Fever and hearing loss Mary Theresa A Adams, MD (presenter) OBJECTIVES: 1) Be able to differentiate auditory neuropathy from other types of hearing loss through the use of ABR and OAEs. 2) Understand the disease of temperature-induced auditory neuropathy. METHODS: Study design: retrospective case review. A case report is presented with review of literature of auditory neuropathy and its variant temperature-induced auditory neuropathy. RESULTS: A 25-year-old female initially presented at one year of age with hearing loss during fever. Audiograms documented severe hearing loss during these events as well as near-complete resolution during afebrile periods. Further audiologic testing demonstrated abnormal brainstem responses with preserved cochlear function during febrile episodes, supporting a diagnosis of auditory neuropathy. As an adult she continues to have three to four episodes a year and keeps acetaminophen on hand to combat fevers. It has been hypothesized that this particular subset of auditory neuropathy is caused by temperature-induced demyelination of the vestibular nerve. CONCLUSIONS: We report a rare case of temperature-induced auditory neuropathy. While the pathophysiologic features continue to be debated, ABRs and OAEs continue to support the clinical diagnosis. SP157 – Gene analysis of VX2 carcinoma after treatment with O3/O2-PP Robert Mandic, MD (presenter); Eberhard Weihe, MD; Jochen Werner, MD; Michael Bette, PhD OBJECTIVES: The rabbit VX2 carcinoma serves as a model for human head and neck squamous cell carcinomas
(HNSCCs). Recently we reported that intraperitoneal insufflation of an ozone/oxygen gas mixture (O3/O2-PP) into VX2 carcinoma bearing rabbits resulted in a significant regression of the tumors and associated metastases. Involvement of the body’s own immune system was likely since reimplantation of the VX2 tumor in cured rabbits was only possible after immune-suppression with dexamethasone and cyclosporine A. The aim of the present study was to further analyze the mechanisms underlying the observed anti-tumorous effect of O3/ O2-PP. METHODS: Four rabbits were inoculated with VX2 tumor cell suspension and tumor growth was allowed for 14 days as previously described, then two of the rabbits were either treated or not treated (sham) with O3/O2-PP. Progressive tumors and such in regression were isolated and RNA was extracted with the Trizol method. Microarray analysis was performed with the Rabbit Oligo Microarray Kit (1 slide, 4 microarrays/slide, format: 4 x 44K, product #: G2519F, design ID: 020908) from Agilent at the EMBL GeneCore Facility (European Molecular Biology Laboratory, Heidelberg, Germany). RESULTS: Tumors in rabbits of the sham group exhibited progressive tumor growth whereas O3/O2-PP treated rabbits showed tumor regression. Micro array analysis identified several putative, particularly immune system related, candidate genes. CONCLUSIONS: Identification of immune-relevant candidate genes is further underlining the significance of the immune system as a key player of the anti tumorous O3/O2-PP effect. SP147 – Medical vs surgical treatment of peritonsillar abscesses Jacob Husseman, MD (presenter); Paul Bernstein, MD; Joanie Chung, MA, MPH; Alex Battaglia, MD OBJECTIVES: To determine whether surgical drainage of peritonsillar abscesses provides superior outcomes compared to medical management. METHODS: Twenty-one patients with a clinically diagnosed peritonsillar abscess were randomized to medical or surgical treatment. Medical management consisted of initial treatment with intravenous Ceftriaxone, Clindamycin, Decadron, and fluids. Patients were discharged with oral Clindamycin and pain medicine and returned the following day for re-evaluation and a second dose of Ceftriaxone. The surgical treatment group received the same medical care but also underwent needle aspiration. The major outcome measurements were pain (0-10 scale), days until return to work, and time before oral intake. Patients were evaluated at 1, 24, 48, and 72 hours, then at 7 and 42 days. RESULTS: Statistical analysis showed no significant advan-
POSTERS
RESULTS: The maximum and mean values of the resting UES pressure and the length of the resting UES pressure in NSF, HSS, and HOS were 55.8}20.0 (mmHg, mean}standard deviation), 138.5}79.1, 28.9}15.0, and 32.3}9.2, 56.8}23.5, 17.8}5.9, and 3.6}0.7 (cm), 3.8}0.7, 2.4}1.0, respectively. The maximum and mean values of the resting UES pressure in HSS and HOS were statistically higher and lower than those in NSF, respectively. The length of the resting UES pressure in HOS was statistically shorter than that in NSF. CONCLUSIONS: The present study provides physiological information of the normal UES pressure about the head rotation, which will be an aid to the future clinical and investigative swallowing studies.
P137