Event related evoked potential P300 in frontotemporal dementia

Poster

Detection

Presentation:

prewon

of n I -PDX,

tutive

secretory

decrease

of

which

pathway,

stably expressing

blocks mammalian reverba

AP40/42

APPaendogenously

and Diagnosis

in

al-PDX

cells.

noticeably

this serpin affects endogenous a-secretase contrast.

al-PDX

congenera

linked

demonstrate hAPP

does

could

the

to some familial

that a prohormone

maturation

pathogenic

not alter

fulfill

such a role.

forms

cell,

These

the participation

amounl

of

I

lowers

FTD

Therefore,

or it\

disease.

contributes with

group had enlarged

and Atzheimer’s

and normal

P300 latency.

management.

with

Aknowledgements:

delayed in the At/hamer

control

groups. Only

d!\eaw

one pacwnt in the

Also, the reaction time was increawd

disease groups. Concluaionr:

of this process. the distinction

These findmg,

indicate

in FTD

that P300

in

and that thih fact could aid to the dlagnou\

AlThcimer’\

Supported

diaeaw

and po\\ihly

to it\ climcal

by grant FIS 991202

of

THE UTILITY OF MEDIAL TEMPORAL LOBE WlDTH IN DISCRIMINATING ALZHEIMER’S DISEASE FROM NORMAL AGING

the

suggest that PC7

respect to recent

the FTD

we

pathway

to slowing

to the constitutive

P300 latency was si&nificantly

with

not usually affected in patient? with FTD,

mutated

Altogether,

to the a-secretase

ot AP. Our data strongly

and ADAM10

group, compared

in distinct cell typea. By

of Alzheimer’s

data are discussed

function deficiencn.

as the

a Jurkat clone

of APPa.

presenilin

and concomitantly

of TACE

also

Finally,

activity/pathway

processing

route leading to the formation

wggeatmg

lower

as well

al-PDX

HEK293.

convertabe parttcipates

in human

convertases of the con&

APPolincrease

Interestingly,

hy mock~transfected

produca

s97

precursor

the PC7-Induced

HEK293

produced

II

papers

and regulated

APPnsecretion.

THE NEUROPSYCHOLOGICAL PERFORMANCE MER’S DISEASE IN STAGING OF DEMENTIA

pig

OF ALZHEIOBJECTIVE rMTLi

To tat

GROUND

In order to find out the cwdences patients

Disease

were

(AD).

examined

neuroprychological were determined cognmon,

for early dlagnobis

the neurop\ychological by the Aphasia

tests (MMSE, by CDR.

visuo\patlal

Battery

Dementia

and differential

of the probable

of Chine%

(ABC)

Scale,

HIS)

and staging

The results suggested that the impairments

function, of Daily

memory.

Living

axial

communication

abilities

of Activittes

declined

with the severity progress of the illness. Alterations

were changed

linear

and

monitoring

of AD

neuropsychological

of dementia

performances

from NC. METHODS

of language, and

the and

uIcu\

(ICS)

MTL

width

was appeared until thr

wab the most tmpottant

factor to mfluence

AD could he one of the evidences for earlier

and differential

the

at early stage of

diagnosis

of AD.

between

and Diagnosis

II

A,f;no W Lrmstro.

Willem

A Goal.

Acod

Med

14-3-3

TESTING

IN

Att takmg

To

information to suffer

study

could increax from

immunoassay

CJD,

an

algorithm

the specificity

Creutlfeldt-Jakoh

(CJD).

The

sensitivity

diagnostic

routine

CSF

condition!, in itself

that both (I) suggest

algorithm

wa\

is propored

before reprexnt

another

increase\

series of

destruction

I IO consecutive wa\

than CJD.

CJD of 35 % to 94% in case of a positwe

tool

In tha

was

patients.

87 % in this series. A of neuroimaging

testing. The algorithm

to 97 %, thu\ raing

14-3-3

CJD-suspected

known sources of false-positive

diagnosi\

the apecifnty

protem

of brain tissue a\ in Method.7:

that mcludes findings

14-3-3

14-3-3

diagnostic

protein expressed in variou\

97 % and the specificity

algorithm

examination

extensive

The

ah a premortem

aenes,

precludes test-rewtt\,

and m

and (2)

use of the clinical

the prior probabihty

tect result. Cwxluswn:

testing

of having

The 14-3-3 protein

I\ a highly sensitive and specific marker for CJD when uwd 111the appropnatr

ctmicat

context.

EVENT RELATED EVOKED POTENTIAL PORAL DEMENTIA

Objective:

To evaluate the event related potential

There

not studies

ae

dementia. Manchester compared

Design/Methods: criteria

controls.

an auditory

performed

reliably

related

IO patients with

and Nary

to I6 patients

and I5 normal wing

on the event

con~enw~

with

AD diagnosed

P300

latency,

oddball

paradigm.

in the FTD

P3OO in RD

cognitive FTD

criteria

(FTD).

potential

diagnosed

Background:

in Frontotemporat

according

to Lund and

were prorpcctively

according

amplitude, Results:

P300 IN FRONTOTEM-

NINCDSADRDA

and reaction

P300

patients notwithstandin&

evaluated

potential

time

and

criteria. were recorded

evaluation

their language

could

he

or executive

differed

(PiO.OOO.5 Into

predictive

\aIuc

(PPV)

of Yl’Z.

included.

negnti\r

new

hetwern

of

(YOE) X6%.

prcd~ct~\c

and area under ROC for AD

v\ NC waj

curve

exprr\\ed

l/(1 +e~’ ), in which 7. = I&20MRI

oriented

measure of the MTL accuracy.

and w..

could prove helpful

thew

7

O.Y6).

PPV 91%. A model

in the follrwing

O.OYage ~O.IZYOE along the I.AH

thl-wgh

NPV

and \cx.

O.XX\rx

11f 8drr

eta\\

PI-ohnhilit) (mate-

thr last

dlwaw

10 n11td ,l~‘iwq menrhcl

of AD

II 0 7ltMTI

of thr K‘S ptoducrd c\cn nlild AD t1on1

with easily known demogl-aphlc\

mea~ure~ could add \~duz to the dugno\tic

in monttormg

progrewon.

on

the hat

at\o .tpplir(t

fat predicting equation

NC

On togl\tl<

Y?‘k. o\adll

that could be u\ed to diffcrwt~ntc When combined

and

value tNPVl

NC (wnitlvity

\hip

AD

and

menrurcd

of 93%

AD \\

OSY,

gyru\

atw

\peoficit)

accuracy of 89% and area under ROC curve = 0.Y4. Thl\ 86%. specifiaty

the thintwt all meawl-ed

which wa\ P-- 0.007).

wn\itivity

AD and II

nerr recon\lructed

Parahlppocampnl

of education

with

tlnrat

199952

of the interxothcuIu\

(,iMTt.)

ugnlficantlq

age, year\

was tMTL

image\

at the lwel

thicknen

pow

in dt\tinguishing

and the area of MTL.

for all exceptjMTL

account

an MR

(27 mild. 27 moderate)

OS hrain\tem.

MTL

tot

hut

ct al, Neurology

IIIC~ISLII’C\ acre

width

tobc

BACK-

179).

We developed

(Gao

overall

35 age. YOE

dngnwtic

testmg in patients suspected

stroke and meningoencephalitis.

of a prospective

simple,

additional

Hackjiroutld:

testcharactertatica

and ita presence m CSF reflects

Results:

m&de\

the 14-3-3 protein is a normal cellular

hut also in ischaemic

tested in CSF

that

of the 14-3-3

diseaw

on CSF has favorable

in CJD. However, trues,

whether

1992;330:1

of our mcauw

(LAH)

horder\

and Johst’s

mrasure

NC <h rrawnabte O~jrcriw:

MTL

meuwements

regrasion

a rrtiahle

Ntvhrrlond\

the utility

agmp (NC,

can he hetptut clinically

Lancec

high reliability

The following

and pwterior

analyst\

CONCLUSION

Crr, Am.\rrrdrim

on (‘T

et al.

probable AD patient\

the midway

volumes.

MANOVA

Y?%

A CLINICAL ALGORITHM FOR CREUTZFELDT-JAKOB DISEASE

normal

MR scanning using 3D SPGR (I .ST). Axial

anterior

RESULTS

of the medtal temporal

tram

for this approach.

showing

of the midbrain.

hippocampus

po$iti\c

Detection

enthusiasm

Forty-nine

(tMTL),

differentlatlng

Poster Presentation:

(Job\t

to the long axis of the hippocampw

were not

stage of AD

(AD)

of the MT1

AD

and mve\tigated

NC underwent parallel

meawrement~

d~wa\e

meawre\

of the MTL

(Suppl2).A3531.

in personality

of AD; the language dlaturhances

haa drterred

meawremmt

and reveral

of AD and worsened tn the late stage. Their language disorder was ended

to a mute. The rtagtng

rehahitity

of dementia

ability

in the early

evident in the early stage, hut evident in the late stage. Apraxia middle age

dlagnosts

performance

ot linrnr

At/hclwcl’x

Stmple

diagnosing

Alzheimer’s

the abihty

to diwlgui\tr

pro‘c\\

wch a1d