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Examination of estrogen levels in patients receiving ammonium chloride medication
842 Selected abstracts
Martins and Allwein: Chloraquin in Pregnancy
With Serological !ncompatihi!ity, p. 273. In view of the known effect of Chloraquin on the Coombs test, an attempt was made to prevent severe erythroblastosis fetalis by the administration of Chloraquin to sensitized mothers during pregnancy. The concentration of Chloraquin required in vitro is 80 times the level in the plasma with adequate therapeutic dosage, but a known storage of the drug in the reticuloendothelial system is a possible answer to this discrepancy. Preliminary clinical experience is limited to 7 cases of seroincompatible pregnancies. Six children survived in good health and the seventh had hydrops fetalis despite the prophylactic treatment. From this limited series, no definite conclusion can be drawn. However, in view of the scarcity of side effects, further experimPnts on the subject arc justified. Walter F. Tauber Dordelmann and Ohnsorge: Nephropathy in Pregnancy in Relation to Erythroblastosis Fetalis, p. 282. The evaluation of 169 mothers with Rh-sensitization and associated erythroblastotic pregnancies \VaS undertaken. Except in cases of associated hydrops fetalis, no elevation of incidence of single symptoms of the triad of hypertension, proteinuria, and edema could be observed. The incidence was 27.6 per cent with nonhydropic erythroblastosis compared to 29 per cent in control patients without Rh incompatibility. On tht> other hand, in 46 mothers who had fetuses with hydrops, the incidence of single symptoms of toxemia was 39.1 per cent. The full-blown picture of edema, hypertension, and proteinuria occurred in 8. 7 per cent of the mothers who had infants with hydrops. This is approximately three times that in the control group. It is concluded that Rh-sensitization, per se, does not predispose to toxemia. However, hydrops fetalis does cause changes in the maternal and fetal physiology to a degree that predisposes to severe toxemia. Walter F. Tauber
No. 10, March 9, 1963. *Krabisch, H., and Seidel, K.-H.: Examination of Estrogen Levels in Patients Receiving Ammonium Chloride Medication, p. 321.
March 15, 1964 Am. ]. Obst. & Gynec,
Krabisch and Seidel: Examination of Estrogen Levels in Patients Receh-ing "~mmo .. nium Chloride Medication, p. 321. The influence of ammonium chloride on estrogen levels in disturbed cycles was investigated. It was shown that there is marked increase in all estrogen fractions and norntalization of values following treatment. Walter F. Tauber
No. 12, March 23, 1963. *Ehrler, P.: Intramural Tubenastamosis, p. 393. *Rothe, K., Bilek, K., and Piskazeck, K.: Contribution on the Cause of So-called Myoma Anemia, p. 400. Ehrler: Intramural Tubenastamosis, p. 393. A new technique for reimplantation of the tube is described, which the author feels is a distinct improvement over the previous methods for surgical correction of tubal occlusion in the proximal portion. No statistics are presented. Walter F. Tauber Rothe, Bilek, and Piskazeck: Contribution on the Cause of So-Called Myoma Anemia, p. 400. Hemoglobin concentration and serum iron levels were determined in 82 patients with fibromyomas of the uterus. Forty norn1al won1en with the same age distribution served as controls. It was demonstrated that serum iron does not, of itself, drop in the presence of fibromyomas of the uterus. However, increased blood loss due to prolonged and profuse periods in the presence of intramural and submucous myomas can lead to secondary iron deficiency anemia. The terms ''toxic myoma" "and myoma heart" have no justification. Clinical situations which have been previously adduced to prove the existence of these syndromes can always be explained by the sPrnnrlarv anemia; which responds readily to therapy once the source of bleeding is removed. Walter F. Tauber
No. 13, March 30, 1963. *Warm, R.: On the Frequency of Obstetrical Operation for Vaginal Delivery Following Previous Cesarean Section, p. 441. Warm: On the Frequency of Obstetrical Operation for Vaginal Delivery Following Previous Cesarean Section, p. 441. Based on a series of 500 deliveries following cesarean section, of which 282 (57 per cent) could be terminated vaginally, the frequency of
Martins and Allwein: Chloraquin in Pregnancy
With Serological !ncompatihi!ity, p. 273. In view of the known effect of Chloraquin on the Coombs test, an attempt was made to prevent severe erythroblastosis fetalis by the administration of Chloraquin to sensitized mothers during pregnancy. The concentration of Chloraquin required in vitro is 80 times the level in the plasma with adequate therapeutic dosage, but a known storage of the drug in the reticuloendothelial system is a possible answer to this discrepancy. Preliminary clinical experience is limited to 7 cases of seroincompatible pregnancies. Six children survived in good health and the seventh had hydrops fetalis despite the prophylactic treatment. From this limited series, no definite conclusion can be drawn. However, in view of the scarcity of side effects, further experimPnts on the subject arc justified. Walter F. Tauber Dordelmann and Ohnsorge: Nephropathy in Pregnancy in Relation to Erythroblastosis Fetalis, p. 282. The evaluation of 169 mothers with Rh-sensitization and associated erythroblastotic pregnancies \VaS undertaken. Except in cases of associated hydrops fetalis, no elevation of incidence of single symptoms of the triad of hypertension, proteinuria, and edema could be observed. The incidence was 27.6 per cent with nonhydropic erythroblastosis compared to 29 per cent in control patients without Rh incompatibility. On tht> other hand, in 46 mothers who had fetuses with hydrops, the incidence of single symptoms of toxemia was 39.1 per cent. The full-blown picture of edema, hypertension, and proteinuria occurred in 8. 7 per cent of the mothers who had infants with hydrops. This is approximately three times that in the control group. It is concluded that Rh-sensitization, per se, does not predispose to toxemia. However, hydrops fetalis does cause changes in the maternal and fetal physiology to a degree that predisposes to severe toxemia. Walter F. Tauber
No. 10, March 9, 1963. *Krabisch, H., and Seidel, K.-H.: Examination of Estrogen Levels in Patients Receiving Ammonium Chloride Medication, p. 321.
March 15, 1964 Am. ]. Obst. & Gynec,
Krabisch and Seidel: Examination of Estrogen Levels in Patients Receh-ing "~mmo .. nium Chloride Medication, p. 321. The influence of ammonium chloride on estrogen levels in disturbed cycles was investigated. It was shown that there is marked increase in all estrogen fractions and norntalization of values following treatment. Walter F. Tauber
No. 12, March 23, 1963. *Ehrler, P.: Intramural Tubenastamosis, p. 393. *Rothe, K., Bilek, K., and Piskazeck, K.: Contribution on the Cause of So-called Myoma Anemia, p. 400. Ehrler: Intramural Tubenastamosis, p. 393. A new technique for reimplantation of the tube is described, which the author feels is a distinct improvement over the previous methods for surgical correction of tubal occlusion in the proximal portion. No statistics are presented. Walter F. Tauber Rothe, Bilek, and Piskazeck: Contribution on the Cause of So-Called Myoma Anemia, p. 400. Hemoglobin concentration and serum iron levels were determined in 82 patients with fibromyomas of the uterus. Forty norn1al won1en with the same age distribution served as controls. It was demonstrated that serum iron does not, of itself, drop in the presence of fibromyomas of the uterus. However, increased blood loss due to prolonged and profuse periods in the presence of intramural and submucous myomas can lead to secondary iron deficiency anemia. The terms ''toxic myoma" "and myoma heart" have no justification. Clinical situations which have been previously adduced to prove the existence of these syndromes can always be explained by the sPrnnrlarv anemia; which responds readily to therapy once the source of bleeding is removed. Walter F. Tauber
No. 13, March 30, 1963. *Warm, R.: On the Frequency of Obstetrical Operation for Vaginal Delivery Following Previous Cesarean Section, p. 441. Warm: On the Frequency of Obstetrical Operation for Vaginal Delivery Following Previous Cesarean Section, p. 441. Based on a series of 500 deliveries following cesarean section, of which 282 (57 per cent) could be terminated vaginally, the frequency of