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Examination of the changes in the uterine mucosa following excessive doses of follicular hormone
540
AMERICAN
took place giving flora and vaginal by Socken.
JOURNAL
OF
OBSTETRICS
a H-ion concentration acidity associated with
of 5. normal
ANI3
A similar puberty
GYNECOLOGY but less abrupt change of in girls has been described
The results of similar observations on children, briefly detailed, indicate that this response to the injection of estrin may explain the favorable results which have been reported in the treatment of infantile gonorrhea1 vaginitis. J. TEIORNWELL
WITIZERSPOOK;.
Hisaw, Frederick L., and Lendrum, Frederick C.: Squamous Metaplasia. in the Cervical Glands of the Monkey Following Estrin administration, Endocrinology 20:
228,
1936.
The authors have confirmed the observations of Overholser and Allen, and of Engle and Smith, that prolonged estrin stimulation produces in the cervix of the monkey a condition of squamous cell metaplasia which resembles beginning malignancy in the human female. Stimulation of the monkey’s own ovaries to produce estrin by administration of anterior pituitary preparations, is usually not followed by squamous metaplasia. Simultaneous corporin therapy will inhibit the action of estrin in evoking squamous metaplasia in the cervix. The cervical lesions apparently undergo regression, either spontaneously when all treatment is withdrawn, or under the influence of corporin even when estrin is continued. J.
Dallera, Folia The during animals mental observed, cinoma
Nicolo:
Modification
gynaec:demogr.
of Uterine
(Genova)
33:
Epithelium
THORNWELL
WITHERSPOON.
Under Hormonal
Influences,
S, 1936.
author describes the histologic modiiications of the uterine mucosa of rats, the stage of prolan A blood saturation and during the injections into these of folliculin. He discusses on the basis of the alterations observed, experihormonal conditions which give rise to the marked epithelial transformations and those which occur normally in women during those years when carof the uterus is more prevalent.
The author makes a plea for further studies cause of carcinoma may be better approached.
along
this
line,
in
MARIO
Examination
Damm, P. N.: cessive Doses 58, 1935.
of
Follicular
of the Changes Hormone,
in Acta
the Uterine obst.
et.
Mucosa gynec.
order A.
Witherspoon,
J’. Thornwell:
Hormonal
Origin
of Endometrioma,
the
CASTALLO.
Following Scandinav.
In a twenty-nine-year-old castrated woman treated with 750,000 M. U. lar hormone, Damm observed changes in the atrophied endometrium which From this experience the author warns to glandular-cystic hyperplasia. doses of follicular hormone should not be used on patients with deficient ovaries unless followed up by treatment with progestin. J.
that
Ex15:
of follicucorrespond that large or inactive
P. GREENHILL.
Arch.
Path.
20:
22, 1935. Witherspoon advances the hypothesis the endometrial implant to proliferation morphologic and functional characteristics endometrism are similar; the integrity
that the igniting factor which stimulates The is the ovarian follicular hormone. of an endometrioma and of the uterine and function of the endometrioma are
AMERICAN
took place giving flora and vaginal by Socken.
JOURNAL
OF
OBSTETRICS
a H-ion concentration acidity associated with
of 5. normal
ANI3
A similar puberty
GYNECOLOGY but less abrupt change of in girls has been described
The results of similar observations on children, briefly detailed, indicate that this response to the injection of estrin may explain the favorable results which have been reported in the treatment of infantile gonorrhea1 vaginitis. J. TEIORNWELL
WITIZERSPOOK;.
Hisaw, Frederick L., and Lendrum, Frederick C.: Squamous Metaplasia. in the Cervical Glands of the Monkey Following Estrin administration, Endocrinology 20:
228,
1936.
The authors have confirmed the observations of Overholser and Allen, and of Engle and Smith, that prolonged estrin stimulation produces in the cervix of the monkey a condition of squamous cell metaplasia which resembles beginning malignancy in the human female. Stimulation of the monkey’s own ovaries to produce estrin by administration of anterior pituitary preparations, is usually not followed by squamous metaplasia. Simultaneous corporin therapy will inhibit the action of estrin in evoking squamous metaplasia in the cervix. The cervical lesions apparently undergo regression, either spontaneously when all treatment is withdrawn, or under the influence of corporin even when estrin is continued. J.
Dallera, Folia The during animals mental observed, cinoma
Nicolo:
Modification
gynaec:demogr.
of Uterine
(Genova)
33:
Epithelium
THORNWELL
WITHERSPOON.
Under Hormonal
Influences,
S, 1936.
author describes the histologic modiiications of the uterine mucosa of rats, the stage of prolan A blood saturation and during the injections into these of folliculin. He discusses on the basis of the alterations observed, experihormonal conditions which give rise to the marked epithelial transformations and those which occur normally in women during those years when carof the uterus is more prevalent.
The author makes a plea for further studies cause of carcinoma may be better approached.
along
this
line,
in
MARIO
Examination
Damm, P. N.: cessive Doses 58, 1935.
of
Follicular
of the Changes Hormone,
in Acta
the Uterine obst.
et.
Mucosa gynec.
order A.
Witherspoon,
J’. Thornwell:
Hormonal
Origin
of Endometrioma,
the
CASTALLO.
Following Scandinav.
In a twenty-nine-year-old castrated woman treated with 750,000 M. U. lar hormone, Damm observed changes in the atrophied endometrium which From this experience the author warns to glandular-cystic hyperplasia. doses of follicular hormone should not be used on patients with deficient ovaries unless followed up by treatment with progestin. J.
that
Ex15:
of follicucorrespond that large or inactive
P. GREENHILL.
Arch.
Path.
20:
22, 1935. Witherspoon advances the hypothesis the endometrial implant to proliferation morphologic and functional characteristics endometrism are similar; the integrity
that the igniting factor which stimulates The is the ovarian follicular hormone. of an endometrioma and of the uterine and function of the endometrioma are