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Exercise-induced increases in fibrinolytic potential exceed those produced by epinephrine infusion
.hKC
Vol.
1‘7. No.
February
1991: I33A
Toronto,
Toronto,
1
, Louise effects
Harris. Canada
Nisar
Shaikh,
wniv@rsity
of
of
iodarsne (A), a wn phospholipase ted porcine heart whether this inhibition could preserve (EP) integrity during reversible In untreated hearts (n-5). ulted in rapid onset of ST 1 min. t plateauing at 8 mins. increased by 26% d 52% at 5 LPC) levels I.
el to determine electrophysiologic
.5-7 q in n moles/g 35.4k4.3 44.tkk4.P
wet
weight 36.5f3.9 57.2i5.6*
*s 9.9f4.0
mV
-m .6f6.0
*p
ECT OF AFTERLOAD REDUCTION ON POST-ISCHEhIC SYSTOLIC CTION IN HYPRRTROPHIED CANINE MYOCARDIUM. Anne L. Sidney hurphree, Robert Winter, Robin Eckels sity of Texas Southwestern Yedical School, Dallas, TX and Case Western Reserve University, Cleveland, Ohio
ocafdiurn in rats 6 weeks after of the lefl ventricle (LV). natnics in this model, was
iations 01 animals exist after large rnonstrafe her rns the
Despite increased infarct size when left ventricular hypertrophy and hypertension (LVH-HT) are present, we have shown that recovery of segmental systolic thickening with reperfusion after ischemia in hearts with LVH-HT parallels (C) hearts that of nonhypertrophied-normotensive Reduction in blood pressure (RBP) in LVH-HT has been shown to decrease infarct size, however, the influence of RBP on systolic thickening in LVH-HT is RBP in canine left ventricles with recovery of segmental systolic n ischemia and 24 hrs reperfusion. groups of conscious dogs (LVH-HT. LVH-RRP, and odynamic catheters, coronary artery occluders, and sonomicrometers underwent 15 q in ischemia and 24 hrs reperfusion. hyocardial segments were grouped by X of segmental systolic thickening (as X control systolic thickening) at 15 min ischemia (Class 1 2 67%, Class 2, O66%. Class 3 e 0% control systolic thickening) and the recovery of each class was measured serially during and blood flow were also reperfusion. Hemodynamics 2 SystoIic QEasured. ents was signif d reperfusion (p ) -HT) and systolic thickening S segments showed a similar trend. with LVH-HT. reduced blood pressure was associated with (rather than improvement) significantly greater In hearts of systolic thickening compared to C hearts. with LVH-HT, RBP may exaggerate rather than ameliorate myocardial stunning.
Vol.
1‘7. No.
February
1991: I33A
Toronto,
Toronto,
1
, Louise effects
Harris. Canada
Nisar
Shaikh,
wniv@rsity
of
of
iodarsne (A), a wn phospholipase ted porcine heart whether this inhibition could preserve (EP) integrity during reversible In untreated hearts (n-5). ulted in rapid onset of ST 1 min. t plateauing at 8 mins. increased by 26% d 52% at 5 LPC) levels I.
el to determine electrophysiologic
.5-7 q in n moles/g 35.4k4.3 44.tkk4.P
wet
weight 36.5f3.9 57.2i5.6*
*s 9.9f4.0
mV
-m .6f6.0
*p
ECT OF AFTERLOAD REDUCTION ON POST-ISCHEhIC SYSTOLIC CTION IN HYPRRTROPHIED CANINE MYOCARDIUM. Anne L. Sidney hurphree, Robert Winter, Robin Eckels sity of Texas Southwestern Yedical School, Dallas, TX and Case Western Reserve University, Cleveland, Ohio
ocafdiurn in rats 6 weeks after of the lefl ventricle (LV). natnics in this model, was
iations 01 animals exist after large rnonstrafe her rns the
Despite increased infarct size when left ventricular hypertrophy and hypertension (LVH-HT) are present, we have shown that recovery of segmental systolic thickening with reperfusion after ischemia in hearts with LVH-HT parallels (C) hearts that of nonhypertrophied-normotensive Reduction in blood pressure (RBP) in LVH-HT has been shown to decrease infarct size, however, the influence of RBP on systolic thickening in LVH-HT is RBP in canine left ventricles with recovery of segmental systolic n ischemia and 24 hrs reperfusion. groups of conscious dogs (LVH-HT. LVH-RRP, and odynamic catheters, coronary artery occluders, and sonomicrometers underwent 15 q in ischemia and 24 hrs reperfusion. hyocardial segments were grouped by X of segmental systolic thickening (as X control systolic thickening) at 15 min ischemia (Class 1 2 67%, Class 2, O66%. Class 3 e 0% control systolic thickening) and the recovery of each class was measured serially during and blood flow were also reperfusion. Hemodynamics 2 SystoIic QEasured. ents was signif d reperfusion (p ) -HT) and systolic thickening S segments showed a similar trend. with LVH-HT. reduced blood pressure was associated with (rather than improvement) significantly greater In hearts of systolic thickening compared to C hearts. with LVH-HT, RBP may exaggerate rather than ameliorate myocardial stunning.