- Email: [email protected]
Exercise Interventions to Mitigate Side Effects of Myeloid Leukemia: A Systematic Review of the Literature
e116 and language and decreases participation and quality of life for cancer survivors. The objective of this review is to identify and summarize the literature on rehabilitation interventions and coping techniques for CRCD in cancer survivors. Data Sources: A scoping review was performed using articles cited in PubMed, MEDLINE, PsychINFO, and CINAHL. Search terms were used to capture major rehabilitation disciplines as well as common terminology used to describe the population. Reference lists of the included articles were hand-searched for additional relevant titles. Study Selection: Articles must have been published in a peer-reviewed scientific journal between 1996 and 2014, written in English, and included a quantitative or qualitative nonpharmacological study of interventions and/or coping strategies for adult cancer survivors experiencing CRCD. Grey literature was excluded. Data Extraction: Data were extracted from the included studies and entered into a table. The following fields were included: author(s), year, country, study design, population, and findings. Data Synthesis: Ten articles met the inclusion criteria for final review. Six studies tested the efficacy of rehabilitation treatments on CRCD. Three involved cognitive behavioral therapy (CBT), while three tested neuropsychological and/or cognitive training interventions. Four qualitative studies investigated coping strategies used by survivors with CRCD. Awide range of interdisciplinary investigators was included, representing psychology, oncology, nursing, kinesiology, psychiatry, and rehabilitation science. Conclusions: CBT-based treatments and neuropsychological/cognitive training methods may ameliorate symptoms of CRCD. These interventions may be utilized by a variety of rehabilitation disciplines. The most commonly-reported coping strategy is utilization of assistive technology and memory aids. Further research is needed about efficacious rehabilitation techniques for this population. Key Words: Cancer, Chemotherapy, Cognitive dysfunction, Rehabilitation Disclosure(s): None disclosed. Systematic/Meta-Analytic Review Poster 3455 WITHDRAWN
Systematic/Meta-Analytic Review Poster 3456 WITHDRAWN
Systematic/Meta-Analytic Review Poster 3488 Exercise Interventions to Mitigate Side Effects of Myeloid Leukemia: A Systematic Review of the Literature Jenna Smith-Turchyn (McMaster University), Julie Richardson Objective(s): To investigate the current literature examining the feasibility, safety, and efficacy of exercise interventions for individuals with myeloid leukemia. Data Sources: A literature search was conducted in Ovid MEDLINE, AMED, Embase, PsycINFO, CINAHL, CENTRAL, and Web of Science using the terms “exercise” OR “physical activity” AND “myeloid leukemia.” Study Selection: Two reviewers performed duplicate title/abstract and full text screening of clinical trials comparing outcomes for people with
Systematic/Meta-Analytic Review Posters myeloid leukemia participating in an exercise program. Initial searches yielded 149 articles. Data Extraction: Two reviewers independently extracted data using piloted forms and assessed risk of bias using Cochrane’s tool. Data was extracted in relation to the study population, study intervention, comparator intervention, and outcomes assessed. Data Synthesis: Five trials were included in this review after 20 full text articles were screened. Risk of bias was determined to be high in all five studies. Adherence rates were found to be low (<30%) in all studies measuring this outcome. Positive improvements were found for fatigue, physical functioning, quality of life, and psychological distress for patients with acute myeloid leukemia (AML), however not all findings were significant. Leukocyte and BCR-ABL1 levels increased significantly post exercise for participants with chronic myeloid leukemia (CML). Only one adverse event was reported. Conclusions: Exercise interventions appear safe and feasible for individuals with AML. Not enough evidence was presented to comment on the feasibility of exercise programs for individuals with CML. Inconclusive evidence was found on the effectiveness of exercise to minimize side effects for participants with AML. Key Words: Leukemia, Myeloid, Exercise, Hematology, Cancer Disclosure(s): None Disclosed.
Systematic/Meta-Analytic Review Poster 3588 Misconceptions and Misattributions About Traumatic Brain Injury: An Integrated Conceptual Framework Cady Block (TIRR Memorial Hermann), Sarah West, Yelena Goldin Objective(s): To review existing research and provide a conceptual framework for a model addressing the development and persistence of common misconceptions of traumatic brain injury (TBI), while enhancing clinical and research practices and delivery to survivors and their families. Data Sources: Position papers, consensus guidelines, and original research articles in PubMed and PubMed Central databases published from 1970 to 2013. Search terms included combinations of the following: TBI, traumatic brain injury, brain injury, knowledge, beliefs, misconceptions, and misperceptions. Study Selection: All articles were in English, and involved human subjects or were reviews of studies with human subjects. Articles unrelated to misconceptions about TBI, editorials, and popular news pieces were excluded. Determination of study appropriateness was made by two independent reviewers, with 85 articles being included in the final review. Data Extraction: Publications were evaluated by two independent reviewers who extracted relevant findings, which were then integrated with existing social/cognitive psychological concepts to develop a conceptual model that can be used to guide future research efforts. Data Synthesis: Relevant findings were integrated with existing social/ cognitive psychological concepts to develop a framework that addressed: 1) antecedents of TBI-related misconceptions and misattributions including differing TBI terminology, the media, personal experience, and contact with healthcare providers; 2) development and persistence of inaccurate beliefs due to pre/post-injury cognitive operations such as informational cascades, attribution biases, and the survivor’s expectation of symptom etiology; and 3) the adverse consequences of these beliefs on survivors of TBI including physical health and mental health difficulties, stigma, discrimination, and negative impacts on a return to daily function. Conclusions: We provide a framework for understanding and addressing misconceptions of TBI, with specific recommendations focusing on the general public and healthcare providers Key Words: TBI (Traumatic Brain Injury), Health knowledge, Attitudes, Practice, Knowledge translation Disclosure(s): None Disclosed.
www.archives-pmr.org
Systematic/Meta-Analytic Review Poster 3456 WITHDRAWN
Systematic/Meta-Analytic Review Poster 3488 Exercise Interventions to Mitigate Side Effects of Myeloid Leukemia: A Systematic Review of the Literature Jenna Smith-Turchyn (McMaster University), Julie Richardson Objective(s): To investigate the current literature examining the feasibility, safety, and efficacy of exercise interventions for individuals with myeloid leukemia. Data Sources: A literature search was conducted in Ovid MEDLINE, AMED, Embase, PsycINFO, CINAHL, CENTRAL, and Web of Science using the terms “exercise” OR “physical activity” AND “myeloid leukemia.” Study Selection: Two reviewers performed duplicate title/abstract and full text screening of clinical trials comparing outcomes for people with
Systematic/Meta-Analytic Review Posters myeloid leukemia participating in an exercise program. Initial searches yielded 149 articles. Data Extraction: Two reviewers independently extracted data using piloted forms and assessed risk of bias using Cochrane’s tool. Data was extracted in relation to the study population, study intervention, comparator intervention, and outcomes assessed. Data Synthesis: Five trials were included in this review after 20 full text articles were screened. Risk of bias was determined to be high in all five studies. Adherence rates were found to be low (<30%) in all studies measuring this outcome. Positive improvements were found for fatigue, physical functioning, quality of life, and psychological distress for patients with acute myeloid leukemia (AML), however not all findings were significant. Leukocyte and BCR-ABL1 levels increased significantly post exercise for participants with chronic myeloid leukemia (CML). Only one adverse event was reported. Conclusions: Exercise interventions appear safe and feasible for individuals with AML. Not enough evidence was presented to comment on the feasibility of exercise programs for individuals with CML. Inconclusive evidence was found on the effectiveness of exercise to minimize side effects for participants with AML. Key Words: Leukemia, Myeloid, Exercise, Hematology, Cancer Disclosure(s): None Disclosed.
Systematic/Meta-Analytic Review Poster 3588 Misconceptions and Misattributions About Traumatic Brain Injury: An Integrated Conceptual Framework Cady Block (TIRR Memorial Hermann), Sarah West, Yelena Goldin Objective(s): To review existing research and provide a conceptual framework for a model addressing the development and persistence of common misconceptions of traumatic brain injury (TBI), while enhancing clinical and research practices and delivery to survivors and their families. Data Sources: Position papers, consensus guidelines, and original research articles in PubMed and PubMed Central databases published from 1970 to 2013. Search terms included combinations of the following: TBI, traumatic brain injury, brain injury, knowledge, beliefs, misconceptions, and misperceptions. Study Selection: All articles were in English, and involved human subjects or were reviews of studies with human subjects. Articles unrelated to misconceptions about TBI, editorials, and popular news pieces were excluded. Determination of study appropriateness was made by two independent reviewers, with 85 articles being included in the final review. Data Extraction: Publications were evaluated by two independent reviewers who extracted relevant findings, which were then integrated with existing social/cognitive psychological concepts to develop a conceptual model that can be used to guide future research efforts. Data Synthesis: Relevant findings were integrated with existing social/ cognitive psychological concepts to develop a framework that addressed: 1) antecedents of TBI-related misconceptions and misattributions including differing TBI terminology, the media, personal experience, and contact with healthcare providers; 2) development and persistence of inaccurate beliefs due to pre/post-injury cognitive operations such as informational cascades, attribution biases, and the survivor’s expectation of symptom etiology; and 3) the adverse consequences of these beliefs on survivors of TBI including physical health and mental health difficulties, stigma, discrimination, and negative impacts on a return to daily function. Conclusions: We provide a framework for understanding and addressing misconceptions of TBI, with specific recommendations focusing on the general public and healthcare providers Key Words: TBI (Traumatic Brain Injury), Health knowledge, Attitudes, Practice, Knowledge translation Disclosure(s): None Disclosed.
www.archives-pmr.org