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Experimental arthritis
s215
VISCERAL
PAIN MODELS
IN ANIMALS
Chairman: L. Vykl’cky, Institute of Physiology, Czechoslovak Academy of Sciences, Pra!gue,Czechoslovakia
Participants: F. Cervero, Dept. of Physiology, Univ. of Bristol Med. School, Bristol, UK G. Carli, Istituto di Fisiologia Umana, Siena, Italy
424
Topical
Mon
4:00
ACC
Room
3
_A
Although it has been realized for a long time that knowledge about the neuronal mechanisms of cutaneous pain is not easily applicable to visceral pain, its research, until recently, has been a neglected area in the neurosciences. As there is no reason to believe that the basic mechanisms of pain are different in man and animals, there is growing interest in animal models which would allow a deeper insight into visceral pain. The seminar will be introduced by: (1) a short historical background of the topic (L. Vyklicky); (2) an overview of the present concepts on neuronal mechanisms of visceral pain as derived from the studies in animals (F. Cervero); and (3) comments on behavioral approaches for the evaluation of visceral pain in animals (G. Carli). The adequacy of the present models for the study of visceral pain will be discussed. The discussion should focus on animals models both in vivo and in vitro which promise to be perspective in further studies oriented to peripheral and central mechanisms of visceral pain and its treatment.
EXPERIMENTAL
ARTHRITIS
Chairman: H.-G. Scha ible, Physiologisches Inst., Univ. of Wuerzburg, Wuerzburg, West Ge Participants: R.F. Schmidt, Physiologisches Inst., Univ. of Wuerzburg, Wuerzburg, West Germany J.D. Levine, Dept. of Medicine, Univ. of California, San Francisco, CA USA Arthritic diseases are a major source of pain in the deep tissue. In order to get an understanding of the neurobiological mechanisms involved in arthritic pain, models of acute and chronic experimental arthritis are necessary to study the reactions of the netvous system to inflammatory stimuli in the joint. Concerning functional aspects, research is focused on the one hand on the afferent and central mechanism of nociception in the inflamed joint and on the other hand on the mechanisms by which the nervous system itself contributes to the development of arthritic lesions. The three presentations that make up this workshop will include: 1. Neurophysiological, ultrastructural and biochemical characteristics of afferent fibers in joint nerves. (R.F. Schmidt) 2. Neuronal activities in joint afferents and spinal cord neurons with articular input during joint inflammation. (H.-G. Schaible) 3. Neuronal mechanisms which contribute to the pathogenesis of arthritic lesions. (J.D. Levine) The closing remarks will stress the need to get an understanding of the neurobiological consequences of arthritis on an integrative level. In the discussion the emphasis will be made on the variety of neurophysiological and neuropharmacological changes which are observed in the nervous system in the course of acute and chronic arthritis and on the evaluation of the significance of these components for nociception in the joint and the severity of the arthritic lesions.
VISCERAL
PAIN MODELS
IN ANIMALS
Chairman: L. Vykl’cky, Institute of Physiology, Czechoslovak Academy of Sciences, Pra!gue,Czechoslovakia
Participants: F. Cervero, Dept. of Physiology, Univ. of Bristol Med. School, Bristol, UK G. Carli, Istituto di Fisiologia Umana, Siena, Italy
424
Topical
Mon
4:00
ACC
Room
3
_A
Although it has been realized for a long time that knowledge about the neuronal mechanisms of cutaneous pain is not easily applicable to visceral pain, its research, until recently, has been a neglected area in the neurosciences. As there is no reason to believe that the basic mechanisms of pain are different in man and animals, there is growing interest in animal models which would allow a deeper insight into visceral pain. The seminar will be introduced by: (1) a short historical background of the topic (L. Vyklicky); (2) an overview of the present concepts on neuronal mechanisms of visceral pain as derived from the studies in animals (F. Cervero); and (3) comments on behavioral approaches for the evaluation of visceral pain in animals (G. Carli). The adequacy of the present models for the study of visceral pain will be discussed. The discussion should focus on animals models both in vivo and in vitro which promise to be perspective in further studies oriented to peripheral and central mechanisms of visceral pain and its treatment.
EXPERIMENTAL
ARTHRITIS
Chairman: H.-G. Scha ible, Physiologisches Inst., Univ. of Wuerzburg, Wuerzburg, West Ge Participants: R.F. Schmidt, Physiologisches Inst., Univ. of Wuerzburg, Wuerzburg, West Germany J.D. Levine, Dept. of Medicine, Univ. of California, San Francisco, CA USA Arthritic diseases are a major source of pain in the deep tissue. In order to get an understanding of the neurobiological mechanisms involved in arthritic pain, models of acute and chronic experimental arthritis are necessary to study the reactions of the netvous system to inflammatory stimuli in the joint. Concerning functional aspects, research is focused on the one hand on the afferent and central mechanism of nociception in the inflamed joint and on the other hand on the mechanisms by which the nervous system itself contributes to the development of arthritic lesions. The three presentations that make up this workshop will include: 1. Neurophysiological, ultrastructural and biochemical characteristics of afferent fibers in joint nerves. (R.F. Schmidt) 2. Neuronal activities in joint afferents and spinal cord neurons with articular input during joint inflammation. (H.-G. Schaible) 3. Neuronal mechanisms which contribute to the pathogenesis of arthritic lesions. (J.D. Levine) The closing remarks will stress the need to get an understanding of the neurobiological consequences of arthritis on an integrative level. In the discussion the emphasis will be made on the variety of neurophysiological and neuropharmacological changes which are observed in the nervous system in the course of acute and chronic arthritis and on the evaluation of the significance of these components for nociception in the joint and the severity of the arthritic lesions.