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Experimental coronary sclerosis. I. Medial degeneration as the primary lesion in coronary sclerosis of cockerels
992
AMERICAN
HEART
JOURNAL
progressively pooled in a!! the extremities by cuffs inflated to the diastolic level, recumbent position was nullified. When the volume of blood in the extremities by cuffs inflated to the systolic level, there was no change in vita! capacity.
the decrease in the was kept constant HECHT.
Froment, Arch.
R., and Gallavardin, d. ma!. du coeur 41:113
L.: Sinus Arrest (March), 1948.
With
Intermittent
Electrocardiograms of a 55-year-old man are presented which strated a peculiar arrhythmia. Careful analysis of many records sinus rhythm (rate 70) and an A-V nodal rhythm. Frequently intrinsic arrest of the impulse formation within the sinus node were compensated for by the slower nodal rhythm. When the activity the sinus recommenced its activity. The sinus pauses could clearly sinoauricular block anl were accentuated by vaga! stimulation. clinical symptoms or signs of heart disease.
Nodal
Rhythm.
over a four-year period demonreveals the coexistence of a shorter and longer periods of observed which were regularly of the nodal center decreased, be differentiated from ordinary The patient did not reveal any HECHT.
Paterson, J. C., Slinger, S. J., and Gartley, I. Medial Degeneration as the Primary Arch. Path. 45:306 (March), 1948.
K. M.: Lesion
Experimental in Coronary
Coronary Sclerosis. Sclerosis of Cockerels.
The authors report on the occurrence of a media! lesion which they consider to be of prime importance in the genesis of coronary sclerosis in chickens. They found that the incidence of coronary sclerosis in cockerels was the same whether or not dry cholesterol was added to their diet. The addition of cholesterol, however, accelerated the sclerotic process already established. They also found that a degenerative media! lesion preceded the intima! changes in treated and control cockerels. The majority of control birds showed spontaneous arteriosclerosis, the most being in the media. The feature of this lesion was a hydropic degeneration with elastica; a total lack of calcification sets this avian lesion aside from media! changes Round cell infiltration in the adjacent adventitia and some slight fibroblastic overlying intima complete the picture of spontaneous coronary sclerosis as seen
important change disruption of the in other species. thickening in the in these chickens.
Cholesterol feeding did not alter the incidence of this arterial degeneration, but added significantly to the intima! thickening, resulting in prominent foam cell aggregations, filled with lipoid material. These cells infiltrated the areas of medial hydropic degeneration and also the adventitial thickening, obscuring a!! other details by the formation of a nodular foam cell mass, sharply demarcated from the rest of the arterial circumference, and pouching inward into the lumen and outWith massive foam cell infiltration, small points ward beyond the normal adventitia! confines. of calcification appeared. The authors are unable to explain the pathogenesis of spontaneous arteriosclerosis in chickens. It involves the coronary arteries predominantly, and is often accompanied by a focal found cell infiltration of the myocardium, suggesting that infection may be the basis for the combined arteriomyocardia! disease. The lesion is admittedly different from human atherosclerosis. GOULEY. Guenther, tions.
B., and Garcia Campo, Rev. argent. de cardio!.
M.: 15~53
New Aspects (March-April),
of the 1948.
Problem
of Pressure
Reac-
The authors suggest that evaluation of the reactivity to “cold pressor” tests be based on the A pressure reaction of more than 20 per cent is conratio of rise in pressure to basal pressure. sidered excessive. This maximal limit is compared with the pressure volume curves of the aorta By applying this concept, the authors given by Bazett and a correlation between the two is found. find that hyperreaction is as frequent in normal subjects as in hypertensive patients. LUISADA.
AMERICAN
HEART
JOURNAL
progressively pooled in a!! the extremities by cuffs inflated to the diastolic level, recumbent position was nullified. When the volume of blood in the extremities by cuffs inflated to the systolic level, there was no change in vita! capacity.
the decrease in the was kept constant HECHT.
Froment, Arch.
R., and Gallavardin, d. ma!. du coeur 41:113
L.: Sinus Arrest (March), 1948.
With
Intermittent
Electrocardiograms of a 55-year-old man are presented which strated a peculiar arrhythmia. Careful analysis of many records sinus rhythm (rate 70) and an A-V nodal rhythm. Frequently intrinsic arrest of the impulse formation within the sinus node were compensated for by the slower nodal rhythm. When the activity the sinus recommenced its activity. The sinus pauses could clearly sinoauricular block anl were accentuated by vaga! stimulation. clinical symptoms or signs of heart disease.
Nodal
Rhythm.
over a four-year period demonreveals the coexistence of a shorter and longer periods of observed which were regularly of the nodal center decreased, be differentiated from ordinary The patient did not reveal any HECHT.
Paterson, J. C., Slinger, S. J., and Gartley, I. Medial Degeneration as the Primary Arch. Path. 45:306 (March), 1948.
K. M.: Lesion
Experimental in Coronary
Coronary Sclerosis. Sclerosis of Cockerels.
The authors report on the occurrence of a media! lesion which they consider to be of prime importance in the genesis of coronary sclerosis in chickens. They found that the incidence of coronary sclerosis in cockerels was the same whether or not dry cholesterol was added to their diet. The addition of cholesterol, however, accelerated the sclerotic process already established. They also found that a degenerative media! lesion preceded the intima! changes in treated and control cockerels. The majority of control birds showed spontaneous arteriosclerosis, the most being in the media. The feature of this lesion was a hydropic degeneration with elastica; a total lack of calcification sets this avian lesion aside from media! changes Round cell infiltration in the adjacent adventitia and some slight fibroblastic overlying intima complete the picture of spontaneous coronary sclerosis as seen
important change disruption of the in other species. thickening in the in these chickens.
Cholesterol feeding did not alter the incidence of this arterial degeneration, but added significantly to the intima! thickening, resulting in prominent foam cell aggregations, filled with lipoid material. These cells infiltrated the areas of medial hydropic degeneration and also the adventitial thickening, obscuring a!! other details by the formation of a nodular foam cell mass, sharply demarcated from the rest of the arterial circumference, and pouching inward into the lumen and outWith massive foam cell infiltration, small points ward beyond the normal adventitia! confines. of calcification appeared. The authors are unable to explain the pathogenesis of spontaneous arteriosclerosis in chickens. It involves the coronary arteries predominantly, and is often accompanied by a focal found cell infiltration of the myocardium, suggesting that infection may be the basis for the combined arteriomyocardia! disease. The lesion is admittedly different from human atherosclerosis. GOULEY. Guenther, tions.
B., and Garcia Campo, Rev. argent. de cardio!.
M.: 15~53
New Aspects (March-April),
of the 1948.
Problem
of Pressure
Reac-
The authors suggest that evaluation of the reactivity to “cold pressor” tests be based on the A pressure reaction of more than 20 per cent is conratio of rise in pressure to basal pressure. sidered excessive. This maximal limit is compared with the pressure volume curves of the aorta By applying this concept, the authors given by Bazett and a correlation between the two is found. find that hyperreaction is as frequent in normal subjects as in hypertensive patients. LUISADA.