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Experimental studies on the wound-healing process in diabetes mellitus rats: Second report
244
P23-3 Pathology (cyst and others)
11. Titanium Detected from the Soft Tissue Covering the Titanium Plate
Tateishi, A. 1, Kitamura, A. 2, Furuta, H, 1, Fukuda, Z 1, luokuchi, r..2 1First Department of Oral and Maxillofacial Surgery, Kyushu Dental College, 2Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Nagasaki University, Japan Introduction Titanium is known to be bicompatible and corrosion resistant. However, there have been some reports of the tissue due to passive dissolution wear, or fretting corrosion of implants. In this study the peak of titanium detected in the soft tissue surrounding pure titanium plates by X ray microanalyser(XMA). Material and methods Biopsies were retrieved 5 patients who had received the treatment of jaw fracture, reconstruction of mandible and orthognathic surgery using the pure titanium plate. At the time of plate removal, a small portion of grayish, discolored soft tissue saw at the adjacent to the plate. The specimen were divided into the pathological diagnosis and inspection of TEM. Results There are a lot of black particles in the fibloblast by the hematoxylinand eosin stain at all specimen. There are poorly infiltrated inflammatory cells. Electron microscopic findings showed two types of foreign bodies; one is the amorphous type and the other is the crystal type. These particles are often found to be isolated beside collagen fibers. By XMA, titanium was detected from the crystal type. Also the mapping of the particle showed the peak of titanium. Discussion and conclusion We showed the existence of titanium in the adjacent soft tissue to the pure titanium plate. There could be the risk with permanent implantation of the pure titanium plate. This is the truth that a young person whose life expectancy may be a half century after the implantation should be removed the titanium plate.
12. Experimental Studies on the Wound-Healing Process in Diabetes Mellitus Rats: Second report
To ascertain the effect of insulin administration on tissue wound-healing in diabetes patients, and to identify the indicators for the effect and duration of insulin control on noncontrolled diabetes patients, we have been conducting experiments using STZ-induced diabetes rats. In the past, we managed blood sugar levels using insulin four weeks after the administration of STZ, and measured the amount of collagen in the abdominal skin prior to insulin administration and 2, 4, and 8 weeks after administration. Measurements taken at different times were compared and analyzed, and the results of the analyses were presented at the 41st Japan Oral Surgery Society Conference. In this study, similar diabetes rats were divided as follows: insulin control was not performed prior to surgery in one group of rats, insulin control was performed for seven days in another group of rats, and insulin control was performed for fourteen days in yet another group of rats. A primary suture wound was then made on the abdominal skin of each rat to histopathologically and mechanically investigate the effect of insulin administration on the healing process of primary suture wounds on the skin.
13. The Ameloblastoma: a Radical Approach to Therapy
Vaskov, L, Lazareski, S., Popovski, V., Naumovski, S. Clinic for Maxillofacial Surgery, University "Ciril and Metodij", Skopje, Macedonia Ameloblastoma is the most frequent odontogenic tumor of the jaws and has received great attention in the literature. Nevertheless there is still controversy regarding its treatment, with most authors advising radical therapy. This study presents the results of 2 groups of patients treated conservatively and radically. The patients were operated in our clinic during the last ten years. The majority of the patients received radical treatment i.e. resections. Follow-up of at the least 5 years revealed a recurrence rate of 5%. The conservatively treated group had far more recurrences i.e. up to 36%. The currently applied radical treatment concept will be outlined including the planning of the reconstructive procedure.
14. Cell Components of Streptococcus mitis Activate Human Peripheral T Cells - The relationship between oral bacteria and oral lichen planus
Mizuki, H., Matsushima, R., Takahashi, Y, Yanagisawa, S. Takeda, E., Shibahara, T., Noma, H. Department of Oral Surgery, First Faculty of Dentistry, Tokyo Dental College, Tokyo, Japan In clinical dentistry for diabetes patients, postoperative infections and wound-healing failure are the most significant problems, but the mechanisms of the onset of these reactions have not been fully clarified.
Department of Oral and Max.-Fac. Surg., Oita Medical Univ., Oita, Japan Recent histological and immunological findings show that oral lichen planus (OLP) is a local immunological reaction. However, the antigen has not yet been clarified. Clinical findings suggest a relation between oral bacteria and the pathogenesis of OLR The toxins or cell components of bacteria
P23-3 Pathology (cyst and others)
11. Titanium Detected from the Soft Tissue Covering the Titanium Plate
Tateishi, A. 1, Kitamura, A. 2, Furuta, H, 1, Fukuda, Z 1, luokuchi, r..2 1First Department of Oral and Maxillofacial Surgery, Kyushu Dental College, 2Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Nagasaki University, Japan Introduction Titanium is known to be bicompatible and corrosion resistant. However, there have been some reports of the tissue due to passive dissolution wear, or fretting corrosion of implants. In this study the peak of titanium detected in the soft tissue surrounding pure titanium plates by X ray microanalyser(XMA). Material and methods Biopsies were retrieved 5 patients who had received the treatment of jaw fracture, reconstruction of mandible and orthognathic surgery using the pure titanium plate. At the time of plate removal, a small portion of grayish, discolored soft tissue saw at the adjacent to the plate. The specimen were divided into the pathological diagnosis and inspection of TEM. Results There are a lot of black particles in the fibloblast by the hematoxylinand eosin stain at all specimen. There are poorly infiltrated inflammatory cells. Electron microscopic findings showed two types of foreign bodies; one is the amorphous type and the other is the crystal type. These particles are often found to be isolated beside collagen fibers. By XMA, titanium was detected from the crystal type. Also the mapping of the particle showed the peak of titanium. Discussion and conclusion We showed the existence of titanium in the adjacent soft tissue to the pure titanium plate. There could be the risk with permanent implantation of the pure titanium plate. This is the truth that a young person whose life expectancy may be a half century after the implantation should be removed the titanium plate.
12. Experimental Studies on the Wound-Healing Process in Diabetes Mellitus Rats: Second report
To ascertain the effect of insulin administration on tissue wound-healing in diabetes patients, and to identify the indicators for the effect and duration of insulin control on noncontrolled diabetes patients, we have been conducting experiments using STZ-induced diabetes rats. In the past, we managed blood sugar levels using insulin four weeks after the administration of STZ, and measured the amount of collagen in the abdominal skin prior to insulin administration and 2, 4, and 8 weeks after administration. Measurements taken at different times were compared and analyzed, and the results of the analyses were presented at the 41st Japan Oral Surgery Society Conference. In this study, similar diabetes rats were divided as follows: insulin control was not performed prior to surgery in one group of rats, insulin control was performed for seven days in another group of rats, and insulin control was performed for fourteen days in yet another group of rats. A primary suture wound was then made on the abdominal skin of each rat to histopathologically and mechanically investigate the effect of insulin administration on the healing process of primary suture wounds on the skin.
13. The Ameloblastoma: a Radical Approach to Therapy
Vaskov, L, Lazareski, S., Popovski, V., Naumovski, S. Clinic for Maxillofacial Surgery, University "Ciril and Metodij", Skopje, Macedonia Ameloblastoma is the most frequent odontogenic tumor of the jaws and has received great attention in the literature. Nevertheless there is still controversy regarding its treatment, with most authors advising radical therapy. This study presents the results of 2 groups of patients treated conservatively and radically. The patients were operated in our clinic during the last ten years. The majority of the patients received radical treatment i.e. resections. Follow-up of at the least 5 years revealed a recurrence rate of 5%. The conservatively treated group had far more recurrences i.e. up to 36%. The currently applied radical treatment concept will be outlined including the planning of the reconstructive procedure.
14. Cell Components of Streptococcus mitis Activate Human Peripheral T Cells - The relationship between oral bacteria and oral lichen planus
Mizuki, H., Matsushima, R., Takahashi, Y, Yanagisawa, S. Takeda, E., Shibahara, T., Noma, H. Department of Oral Surgery, First Faculty of Dentistry, Tokyo Dental College, Tokyo, Japan In clinical dentistry for diabetes patients, postoperative infections and wound-healing failure are the most significant problems, but the mechanisms of the onset of these reactions have not been fully clarified.
Department of Oral and Max.-Fac. Surg., Oita Medical Univ., Oita, Japan Recent histological and immunological findings show that oral lichen planus (OLP) is a local immunological reaction. However, the antigen has not yet been clarified. Clinical findings suggest a relation between oral bacteria and the pathogenesis of OLR The toxins or cell components of bacteria